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  1. AU="Chou, Tsung-Ching"
  2. AU="Mehdizadeh, Rana"
  3. AU="Sue Chen"
  4. AU=Smrcka A V
  5. AU="Costache, Oana"
  6. AU="Jungilligens, Johannes"
  7. AU="Kegel, S"
  8. AU="Frances P. Rodriguez-Rivera"
  9. AU="Viennet, Hervé"
  10. AU="Martínez-Silva, María G"
  11. AU="Christino, Melissa A"
  12. AU="Silva, Larissa L"
  13. AU="Tonks, Michael R."
  14. AU="Korhonen, H"
  15. AU="Mukendi, John T"
  16. AU="Athira S. Raj"
  17. AU="Corbacho, Belen"
  18. AU="Andrei, Adin Cristian" AU="Andrei, Adin Cristian"
  19. AU="Erminia Donnarumma"
  20. AU="Albores-Figueroa, Rosenberg"
  21. AU="Squillace, Lino"
  22. AU="Laufs, Sebastian"
  23. AU="McCanny, Suzette"
  24. AU="McHardy, John Alexander"
  25. AU="Erdal, Ranya"
  26. AU="Li, Long-Xia"
  27. AU="Esapa, Benjamina"

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  1. Artikel ; Online: Association between statin use and risk of gallstone disease and cholecystectomy: a meta-analysis of 590,086 patients.

    Chang, Yu / Lin, Hong-Min / Chi, Kuan-Yu / Lin, Wan-Ying / Chou, Tsung-Ching

    PeerJ

    2023  Band 11, Seite(n) e15149

    Abstract: Background: Statins have been reported to reduce the risk of gallstone disease. However, the impacts of different durations of statin use on gallstone disease have not been clarified. The aim of this study is toperform a systematic review with meta- ... ...

    Abstract Background: Statins have been reported to reduce the risk of gallstone disease. However, the impacts of different durations of statin use on gallstone disease have not been clarified. The aim of this study is toperform a systematic review with meta-analysis to update and to elucidate the association between statin use and the risk of gallstone disease and cholecystectomy.
    Methods: Medline, Embase and Cochrane Library were searched from the inception until August 2022 for relevant articles investigating the difference in the risk of gallstone disease between statin users and non-users (PROSPERO, ID: CRD42020182445). Meta-analyses were conducted using odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to compare the risk of gallstone disease and cholecystectomy between statin user and nonusers.
    Results: Eight studies enrolling 590,086 patients were included. Overall, the use of statins was associated with a marginally significant lower risk of gallstone disease than nonusers (OR, 0.91; 95% CI [0.82-1.00]). Further subgroup analysis showed that short-term users, medium-term users, and long-term users were associated with a significantly higher risk (OR, 1.18; 95% CI [1.11-1.25]), comparable risk (OR, 0.93; 95% CI [0.83-1.04]), and significantly lower risk of gallstone diseases (OR, 0.78; 95% CI [0.68-0.90]) respectively, compared to nonusers.
    Conclusions: Patients with medium-term or long-term use of statins without discontinuation are at a lower risk of gallstone disease or cholecystectomy.
    Mesh-Begriff(e) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Cholelithiasis ; Cholecystectomy/adverse effects ; Risk ; Odds Ratio
    Chemische Substanzen Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2023-04-07
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15149
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Application of indocyanine green for the detection of transplanted distal ureteral perfusion in renal transplantation.

    Hsu, Shang-Yuan / Chou, Tsung-Ching / Yang, Tsung-Han / Chang, Shen-Shin

    Asian journal of surgery

    2022  Band 46, Heft 5, Seite(n) 1983–1984

    Mesh-Begriff(e) Humans ; Kidney Transplantation ; Indocyanine Green ; Ureter/diagnostic imaging ; Ureter/surgery ; Transplants ; Perfusion
    Chemische Substanzen Indocyanine Green (IX6J1063HV)
    Sprache Englisch
    Erscheinungsdatum 2022-11-09
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.10.094
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  3. Artikel ; Online: Graft Inflow Modulation in Living-Donor Liver Transplantation: Hepatic Hemodynamic Changes in Splenic Artery Ligation and Splenectomy.

    Su, Che-Min / Chou, Tsung-Ching / Yang, Tsung-Han / Lin, Yih-Jyh

    Annals of transplantation

    2022  Band 27, Seite(n) e936609

    Abstract: BACKGROUND Excessive portal flow to an allograft was a key mechanism for small-for-size syndrome in living-donor liver transplantation (LDLT). Good outcomes in LDLT by graft inflow modulation (GIM) using a small graft were reported, but the effect on ... ...

    Abstract BACKGROUND Excessive portal flow to an allograft was a key mechanism for small-for-size syndrome in living-donor liver transplantation (LDLT). Good outcomes in LDLT by graft inflow modulation (GIM) using a small graft were reported, but the effect on hepatic hemodynamics is undefined. This report summarizes our experience with GIM and compares the effects of splenic artery ligation (SAL) and splenectomy on hepatic hemodynamic changes. MATERIAL AND METHODS Ninety-nine patients who underwent adult-to-adult LDLT from June 2014 to December 2020 were included in this study. GIM was performed in 36 patients (17 patients with SAL and 19 with splenectomy). RESULTS The GIM group had lower graft-to-recipient weight compared to the no-modulation group (median, 0.91% versus 1.04%, P=0.022). Initial portal venous flow (PVF) was higher in the GIM group (median, 311 versus 156 ml/min/100 g, P<0.001). After GIM, PVF decreased to 224 ml/min/100 g. One-year graft survival with GIM was 89.9%, and for the no-modulation group it was 86.6% (P=0.945). In the subgroup analysis, the efficacy of decompressing PVF was higher in the splenectomy subgroup (median, 14.3% versus 41.8%, P=0.002). CONCLUSIONS GIM was useful for grafts with high PVF. Splenectomy modulated excessive PVF more effectively than did SAL. Perioperative hepatic hemodynamic changes could assist surgeons in selecting different GIM strategies.
    Mesh-Begriff(e) Adult ; Hemodynamics ; Hepatic Artery/surgery ; Humans ; Liver/blood supply ; Liver/surgery ; Liver Transplantation/methods ; Living Donors ; Portal Vein/surgery ; Splenectomy ; Splenic Artery/surgery
    Sprache Englisch
    Erscheinungsdatum 2022-07-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.936609
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5093: Hefte anzeigen Standort:
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  4. Artikel ; Online: Higher Risk of Tumor Recurrence in NASH-Related Hepatocellular Carcinoma Following Curative Resection.

    Chien, Shih-Chieh / Lin, Yih-Jyh / Lee, Chun-Te / Chiu, Yen-Cheng / Chou, Tsung-Ching / Chiu, Hung-Chih / Tsai, Hung-Wen / Su, Che-Min / Yang, Tsung-Han / Chiang, Hsueh-Chien / Tsai, Wei-Chu / Yang, Kai-Chun / Cheng, Pin-Nan

    Viruses

    2022  Band 14, Heft 11

    Abstract: The outcomes for patients with NASH-related HCC after curative resection have not been clarified. This study compared the overall survival (OS), time-to-tumor recurrence (TTR), and recurrence-free survival (RFS) associated with NASH-related HCC and virus- ...

    Abstract The outcomes for patients with NASH-related HCC after curative resection have not been clarified. This study compared the overall survival (OS), time-to-tumor recurrence (TTR), and recurrence-free survival (RFS) associated with NASH-related HCC and virus-related HCC after resection.
    Mesh-Begriff(e) Humans ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/etiology ; Liver Neoplasms/surgery ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/surgery ; Retrospective Studies ; Neoplasm Recurrence, Local
    Sprache Englisch
    Erscheinungsdatum 2022-10-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112427
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Autophagy-related gene LC3 expression in tumor and liver microenvironments significantly predicts recurrence of hepatocellular carcinoma after surgical resection.

    Lin, Chih-Wen / Chen, Yaw-Sen / Lin, Chih-Che / Lee, Po-Huang / Lo, Gin-Ho / Hsu, Chia-Chang / Hsieh, Pei-Min / Koh, Kah Wee / Chou, Tsung-Ching / Dai, Chia-Yen / Huang, Jee-Fu / Chuang, Wan-Long / Chen, Yao-Li / Yu, Ming-Lung

    Clinical and translational gastroenterology

    2018  Band 9, Heft 6, Seite(n) 166

    Abstract: Background: The role of autophagy-related markers as the prognostic factor of post-operative hepatocellular carcinoma (HCC) recurrence remained controversial.: Methods: Overall, 535 consecutive HCC patients undergoing curative resection from 2010 to ... ...

    Abstract Background: The role of autophagy-related markers as the prognostic factor of post-operative hepatocellular carcinoma (HCC) recurrence remained controversial.
    Methods: Overall, 535 consecutive HCC patients undergoing curative resection from 2010 to 2014 were followed and classified with early (ER, <2 years) or late recurrence (LR). Autophagy-related markers, LC3, Beclin-1, and p62 expression was immunohistochemically assessed in HCC and adjacent non-tumor (ANT) tissues.
    Results: HCC recurred in 245 patients: 116 with ER and 129 with LR. The cumulative incidence of recurrence at 1, 3, 5, and 7 years was 9.7%, 33.9%, 53.3%, and 66.3%, respectively. In multivariate analysis, HCC recurrence was significantly associated with low LC3 expression in tumor and ANT tissues, HCC tissues only and ANT tissues only (hazard ratio/95% confidence interval: 6.12/2.473-17.53, 4.18/1.285-13.61, and 1.89/1.299-2.757) and macrovascular invasion (1.63/1.043-2.492) and cirrhosis (1.59/1.088-2.326). ER was significantly associated with low LC3 expression in tumor and ANT tissues, HCC tissues only and ANT tissues only (6.54/2.934-15.81, 3.26/1.034-10.27, and 2.09/1.313-3.321) and macrovascular and microvascular invasion (2.65/1.306-5.343 and 2.55/1.177-5.504). LR was significantly associated with low LC3 expression in tumor and ANT tissues, HCC tissues only and ANT tissues only (5.02/1.372-18.83, 3.19/1.13-12.09, and 1.66/1.051-2.620) and cirrhosis (1.66/1.049-2.631). Patients with low and high LC3 expression in tumor and ANT tissues showed a 5-year cumulative recurrence of 94.3% and 41.7%, respectively (p < 0.001).
    Conclusions: The high LC3 expression in the tumor and liver microenvironments is significantly associated with lower HCC recurrence. Furthermore, tumor characteristics and liver microenvironment were also significantly associated with ER and LR, respectively.
    Translational impact: The analysis for LC3 expression in both the HCC and ANT tissues could identify patients at risk of HCC recurrence.
    Mesh-Begriff(e) Aged ; Autophagy/genetics ; Beclin-1/analysis ; Beclin-1/genetics ; Biomarkers ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Female ; Follow-Up Studies ; Gene Expression ; Hepatectomy ; Humans ; Liver/chemistry ; Liver/pathology ; Liver/surgery ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Microtubule-Associated Proteins/analysis ; Microtubule-Associated Proteins/genetics ; Middle Aged ; Neoplasm Recurrence, Local ; Prognosis ; RNA-Binding Proteins/analysis ; RNA-Binding Proteins/genetics ; Retrospective Studies ; Tumor Microenvironment/genetics
    Chemische Substanzen Beclin-1 ; Biomarkers ; MAP1LC3A protein, human ; Microtubule-Associated Proteins ; P62 protein, human ; RNA-Binding Proteins
    Sprache Englisch
    Erscheinungsdatum 2018-07-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.1038/s41424-018-0033-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Development of laparoscopic donor nephrectomy: a strategy to increase living kidney donation incentive and maintain equivalent donor/recipient outcome.

    Hung, Chung-Jye / Lin, Yih-Jyh / Chang, Shen-Shin / Chou, Tsung-Ching / Lee, Po-Chang

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2009  Band 108, Heft 2, Seite(n) 135–145

    Abstract: Background/purpose: Laparoscopic donor nephrectomy (LDN) has emerged as the preferred technique worldwide, and has contributed to a dramatic increase in living kidney donation during the past decade. We adopted LDN in 2002 with the intention of ... ...

    Abstract Background/purpose: Laparoscopic donor nephrectomy (LDN) has emerged as the preferred technique worldwide, and has contributed to a dramatic increase in living kidney donation during the past decade. We adopted LDN in 2002 with the intention of increasing living kidney donation incentive and maintaining equivalent donor/recipient outcome.
    Methods: Forty-five LDNs were performed between September 2002 and November 2007. Donor demographics, operative characteristics, perioperative complications and donor/recipient outcome were reviewed retrospectively. The LDN series was divided into earlier and later groups for comparison. To confirm the safety and efficacy of LDN, we compared the results with those of previous series and our open donor nephrectomy (ODN) series.
    Results: All 45 LDN kidneys were procured and transplanted successfully. Mean donor operation time was 327.7+/-10.2 minutes, blood loss was 286.0+/-48.3 mL, and warm ischemia time was 233.9+/-19.6 seconds. Two (4.4%) open conversions happened in the earlier group. There was a significant decrease in warm ischemia time and donor intraoperative complications in the later group. There was no donor mortality and there were no repeat surgical procedures. Delayed graft function occurred in 8.9% of cases and three (6.7%) recipients developed ureteral complications. All but one recipient was discharged with adequate renal function. Graft function continued in 41 of the 43 harvested kidneys (95.3%). Compared with ODN, there was a significant decrease in donor postoperative stay in the LDN series (p=0.00). There was no difference between the series with regard to donor safety, donor outcome, and immediate and long-term recipient outcome.
    Conclusion: The number of living kidney donations increased significantly after adopting LDN in our series. The equivalent donor/recipient outcome of the LDN series compared with that of previous and ODN series was achieved with increasing experience.
    Mesh-Begriff(e) Adult ; Female ; Graft Survival ; Humans ; Kidney Transplantation/methods ; Laparoscopy ; Length of Stay ; Living Donors ; Male ; Nephrectomy/methods ; Tissue and Organ Harvesting/methods ; Tissue and Organ Procurement/methods ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2009-02
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/S0929-6646(09)60044-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 1041: Hefte anzeigen Standort:
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