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  1. Article ; Online: Serplulimab With Chemotherapy in Extensive-Stage SCLC.

    Choudhury, Noura J / Riely, Gregory J

    JAMA

    2022  Volume 328, Issue 12, Page(s) 1205–1207

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Lung Neoplasms/drug therapy ; Small Cell Lung Carcinoma/drug therapy
    Chemical Substances Antineoplastic Agents ; Antineoplastic Agents, Immunological
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.16442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Decade in review: a new era for RET-rearranged lung cancers.

    Choudhury, Noura J / Drilon, Alexander

    Translational lung cancer research

    2021  Volume 9, Issue 6, Page(s) 2571–2580

    Abstract: Targeted therapy has become the standard of care for non-small cell lung cancers with a range of targetable alterations, ... ...

    Abstract Targeted therapy has become the standard of care for non-small cell lung cancers with a range of targetable alterations, including
    Language English
    Publishing date 2021-01-07
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-20-346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Training Oncologists in the Time of COVID-19.

    Choudhury, Noura / Shoushtari, Alexander

    The oncologist

    2020  Volume 25, Issue 7, Page(s) 546–547

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Oncologists ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; United States
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2020-0373
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    Zs.A 4845: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 494: Show issues

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  4. Article ; Online: Training Oncologists in the Time of COVID ‐19

    Choudhury, Noura / Shoushtari, Alexander

    The Oncologist

    2020  Volume 25, Issue 7, Page(s) 546–547

    Keywords Cancer Research ; Oncology ; covid19
    Language English
    Publisher Alphamed Press
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1409038-7
    ISSN 1083-7159
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2020-0373
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 4845: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 494: Show issues

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  5. Article ; Online: Training Oncologists in the Time of COVID ‐19

    Choudhury, Noura / Shoushtari, Alexander

    The Oncologist

    2020  Volume 25, Issue 7, Page(s) 546–547

    Keywords Cancer Research ; Oncology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1409038-7
    ISSN 1083-7159
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2020-0373
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 494: Show issues

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  7. Article ; Online: Translating inspiration from COVID-19 vaccine trials to innovations in clinical cancer research.

    Choudhury, Noura J / Riely, Gregory J / Sabbatini, Paul J / Hellmann, Matthew D

    Cancer cell

    2021  Volume 39, Issue 7, Page(s) 897–899

    MeSH term(s) Access to Information ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Clinical Trials as Topic ; Drug Development ; Humans ; Neoplasms/therapy ; Standard of Care ; Translational Medical Research
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2021.05.001
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    Zs.A 5650: Show issues Location:
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    Zs.MG 104: Show issues

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  8. Article ; Online: Importance of immunopharmacogenomics in cancer treatment: Patient selection and monitoring for immune checkpoint antibodies.

    Choudhury, Noura / Nakamura, Yusuke

    Cancer science

    2015  Volume 107, Issue 2, Page(s) 107–115

    Abstract: In the last 5 years, immune checkpoint antibodies have become established as anticancer agents for various types of cancer. These antibody drugs, namely cytotoxic T-lymphocyte-associated antigen, programmed death-1, and programmed death ligand-1 ... ...

    Abstract In the last 5 years, immune checkpoint antibodies have become established as anticancer agents for various types of cancer. These antibody drugs, namely cytotoxic T-lymphocyte-associated antigen, programmed death-1, and programmed death ligand-1 antibodies, have revealed relatively high response rates, the ability to induce durable responses, and clinical efficacy in malignancies not previously thought to be susceptible to immune-based strategies. However, because of its unique mechanisms of activating the host immune system against cancer as well as expensive cost, immune checkpoint blockade faces novel challenges in selecting appropriate patient populations, monitoring clinical responses, and predicting immune adverse events. The development of objective criteria for selecting patient populations that are likely to have benefit from these therapies has been vigorously investigated but still remains unclear. In this review, we describe immune checkpoint inhibition-specific challenges with patient selection and monitoring, and focus on approaches to remedy these challenges. We also discuss applications of the emerging field of immunopharmacogenomics for guiding selection and monitoring for anti-immune checkpoint treatment.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/therapeutic use ; Humans ; Immunotherapy/methods ; Ipilimumab ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/immunology ; Nivolumab ; Patient Selection ; Pharmacogenetics
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; Ipilimumab ; Nivolumab (31YO63LBSN) ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2015-12-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.12862
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  9. Article ; Online: Genomic Characterization of a RET Inhibitor-Resistant

    Choudhury, Noura J / Yang, Soo-Ryum / Arcila, Maria / Mohanty, Abhinita S / Boire, Adrienne / Drilon, Alexander

    JCO precision oncology

    2020  Volume 4

    Language English
    Publishing date 2020-11-16
    Publishing country United States
    Document type Case Reports
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.20.00188
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  10. Article ; Online: Lorlatinib Tolerability and Association With Clinical Outcomes in Patients With Advanced

    Thummalapalli, Rohit / Choudhury, Noura J / Ehrich, Fiona / Beardslee, Tyler / Brazel, Danielle / Zhang, Shannon S / Merchant, Shelby / Chen, Monica F / Heller, Glenn / Ramalingam, Suresh S / Ou, Sai-Hong Ignatius / Mileham, Kathryn F / Riely, Gregory J

    JTO clinical and research reports

    2023  Volume 4, Issue 8, Page(s) 100546

    Abstract: Introduction: Treatment with lorlatinib for patients with advanced : Methods: We reviewed the course of 144 patients with advanced : Results: A total of 58 patients (40%) had TRAE-related dose reductions, most (59%) owing to neurocognitive AEs or ... ...

    Abstract Introduction: Treatment with lorlatinib for patients with advanced
    Methods: We reviewed the course of 144 patients with advanced
    Results: A total of 58 patients (40%) had TRAE-related dose reductions, most (59%) owing to neurocognitive AEs or neuropathy. Among all patients, the median PFS was 8.1 months (95% confidence interval [CI]: 6.4-11.8); the median OS was 20.7 months (95% CI: 16.3-30.5). Among patients who were started on lorlatinib 100 mg/d (n = 122), a Cox regression model with the occurrence of a dose reduction as a time-dependent covariate indicated no association between dose reduction and PFS (hazard ratio = 0.86, 95% CI: 0.54-1.39) or OS (hazard ratio = 0.78, 95% CI: 0.47-1.30).
    Conclusions: Lorlatinib dose reductions were not associated with inferior clinical outcomes in this multicenter analysis. Prompt identification of lorlatinib TRAEs and implementation of dose reductions may help maximize tolerability without compromising outcomes.
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2023.100546
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