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  1. Article ; Online: Hospitalisation due to acute cardiovascular conditions: is screening for recreational drug use justified?

    Choudry, Fizzah A / Jones, Daniel A / Archbold, R Andrew

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 21, Page(s) 1582–1583

    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Editorial
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-322808
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 112: Show issues

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  2. Article ; Online: Editorial commentary: Understanding thrombosis in COVID-19 - A long way to go.

    Choudry, Fizzah A / Mathur, Anthony / Jones, Daniel A

    Trends in cardiovascular medicine

    2020  Volume 31, Issue 3, Page(s) 161–162

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Thrombosis/epidemiology
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2020.12.006
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    Zs.A 3419: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Long-Term Outcomes of COVID-19-Associated ST-Elevation Myocardial Infarction Treated With Primary PCI.

    Choudry, Fizzah A / Rathod, Krishnaraj S / Baumbach, Andreas / Mathur, Anthony / Jones, Daniel A

    Cardiovascular revascularization medicine : including molecular interventions

    2022  Volume 43, Page(s) 133–135

    MeSH term(s) COVID-19 ; Coronary Angiography ; Humans ; Myocardial Infarction/therapy ; Percutaneous Coronary Intervention/adverse effects ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/therapy ; Treatment Outcome
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Letter
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2022.05.029
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  4. Article ; Online: Reply: Pitfalls of Unfractionated Heparin Use During ST-Segment Elevation Myocardial Infarction in Patients With COVID-19 Infection.

    Choudry, Fizzah A / Rathod, Krishnaraj S / Baumbach, Andreas / Mathur, Anthony / Jones, Daniel A

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 1, Page(s) 105–106

    MeSH term(s) COVID-19 ; Heparin/adverse effects ; Hirudins ; Humans ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/diagnosis
    Chemical Substances Hirudins ; Heparin (9005-49-6)
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.11.004
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    Zs.MO 196: Show issues

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  5. Article ; Online: Thrombus Embolisation: Prevention is Better than Cure.

    Choudry, Fizzah A / Weerackody, Roshan P / Jones, Daniel A / Mathur, Anthony

    Interventional cardiology (London, England)

    2019  Volume 14, Issue 2, Page(s) 95–101

    Abstract: Thrombus embolisation complicating primary percutaneous coronary intervention in ST-elevation myocardial infarction is associated with an increase in adverse outcomes. However, there are currently no proven recommendations for intervention in the setting ...

    Abstract Thrombus embolisation complicating primary percutaneous coronary intervention in ST-elevation myocardial infarction is associated with an increase in adverse outcomes. However, there are currently no proven recommendations for intervention in the setting of large thrombus burden. In this review, we discuss the clinical implications of thrombus embolisation and angiographic predictors of embolisation, and provide an update of current evidence for some preventative strategies, both pharmacological and mechanical, in this setting.
    Keywords covid19
    Language English
    Publishing date 2019-05-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2813989-6
    ISSN 1756-1485 ; 1756-1477
    ISSN (online) 1756-1485
    ISSN 1756-1477
    DOI 10.15420/icr.2019.11
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  6. Article ; Online: Intravascular ultrasound-guided management of ST-elevation myocardial infarction in a patient with lung cancer and myocardial metastasis.

    Ramasamy, Anantharaman / Bajaj, Retesh / Choudry, Fizzah A / Pugliese, Francesca / Baumbach, Andreas / Bourantas, Christos V

    European heart journal

    2020  Volume 41, Issue 33, Page(s) 3201

    MeSH term(s) Coronary Angiography ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/therapy ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/therapy ; Treatment Outcome ; Ultrasonography, Interventional
    Language English
    Publishing date 2020-03-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa004
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    Zs.MO 640: Show issues

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  7. Article: The safety of deferred coronary angiography in COVID-19 patients with acute coronary syndrome: the Barts COVID recovered pathway.

    Teoh, Zhi / Rathod, Krishnaraj S / Comer, Katrina / Tyrlis, Angelos / Choudry, Fizzah A / Ozkor, Mick / Archbold, R Andrew / Guttmann, Oliver / Wragg, Andrew / Baumbach, Andreas / Jain, Ajay K / Mathur, Anthony / Jones, Daniel A

    American journal of cardiovascular disease

    2023  Volume 13, Issue 3, Page(s) 168–176

    Abstract: Objective: To assess the safety and effectiveness of a novel pathway of deferrred invasive angiography in low-risk NSTEMI patients with concurrent COVID-19 infections; contrary to current UK guidelines recommending invasive coronary angiography in ... ...

    Abstract Objective: To assess the safety and effectiveness of a novel pathway of deferrred invasive angiography in low-risk NSTEMI patients with concurrent COVID-19 infections; contrary to current UK guidelines recommending invasive coronary angiography in NSTEMI patients within 72 hours.
    Methods: This was a single-centre, observational study of all NSTEMI patients referred for inpatient coronary angiography at Barts Heart Centre, between March 2020 and June 2022. Demographic, procedural and outcome data were collected as part of a national cardiac audit.
    Results: 201 COVID positive NSTEMI patients were referred for angiography at Barts Heart Centre. 10 patients died from COVID related respiratory complications prior to angiography. Therefore, 191 patients underwent deferred angiography (median time 16 days from COVID diagnosis). The median GRACE score was 128 (IQR 86-153). Troponin levels were significantly elevated on initial COVID diagnosis compared to time of their procedure. 73% patients had a culprit lesion identified. 61.2% receiving PCI. Patients were followed-up for a median of 363 days (IQR 120-485 days) with MACE rates of 7.3%. This is comparable to the MACE event for NSTEMI patients (n=4529) without COVID at our institution treated during the same time-period (8.1%).
    Conclusion: This study demonstrates the safety and effectiveness of deferred coronary angiography on a COVID-Recovered pathway after a period of medical management for patients presenting with NSTEMI and concurrent COVID-19 infection. There was no adverse signal associated with the wait for angiography with similar MACE rates to the non-deferred NSTEMI cohort without COVID-19.
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616844-3
    ISSN 2160-200X
    ISSN 2160-200X
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  8. Article ; Online: Thrombus Burden and Outcomes in Patients With COVID-19 Presenting With STEMI Across the Pandemic.

    Rathod, Krishnaraj S / Teoh, Zhi / Tyrlis, Angelos / Choudry, Fizzah A / Hamshere, Stephen M / Comer, Katrina / Guttmann, Oliver / Jain, Ajay K / Ozkor, Muhiddin A / Wragg, Andrew / Archbold, R Andrew / Baumbach, Andreas / Mathur, Anthony / Jones, Daniel A

    Journal of the American College of Cardiology

    2023  Volume 81, Issue 25, Page(s) 2406–2416

    Abstract: Background: It has been previously reported during the first COVID-19 outbreak that patients presenting with ST-segment elevation myocardial infarction (STEMI) and concurrent COVID-19 infection have increased thrombus burden and poorer outcomes. To date, ...

    Abstract Background: It has been previously reported during the first COVID-19 outbreak that patients presenting with ST-segment elevation myocardial infarction (STEMI) and concurrent COVID-19 infection have increased thrombus burden and poorer outcomes. To date, there have been no reports comparing the outcomes of COVID-19-positive STEMI patients across all waves of the pandemic.
    Objectives: This study compared the baseline demographic, procedural, and angiographic characteristics alongside the clinical outcomes of patients presenting with STEMI and concurrent COVID-19 infection across the COVID-19 pandemic in the United Kingdom.
    Methods: This was a single-center, observational study of 1,269 consecutive patients admitted with confirmed STEMI treated with percutaneous coronary intervention (between January 3, 2020 and October 3, 2022). COVID-19-positive patients were split into 3 groups based upon the time course of the pandemic, and a comparison was made between waves.
    Results: A total of 154 COVID-19-positive patients with STEMI were included in the present analysis and were compared with 1,115 COVID-19-negative patients. Early during the pandemic (wave 1), STEMI patients presenting with concurrent COVID-19 infection had high rates of cardiac arrest, evidence of increased thrombus burden, bigger infarcts, and worse outcomes. However, by wave 3, no differences existed in outcomes between COVID-19-positive and -negative patients, with significant differences compared with earlier COVID-19-positive patients. Poor outcomes later in the study period were predominantly in unvaccinated individuals.
    Conclusions: Significant changes have occurred in the clinical characteristics, angiographic features, and outcomes of STEMI patients with COVID-19 infection treated by primary percutaneous coronary intervention during the course of the pandemic. Importantly, outcomes of recent waves and in vaccinated individuals are no different to a non-COVID-19 population.
    MeSH term(s) Humans ; COVID-19/epidemiology ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/epidemiology ; ST Elevation Myocardial Infarction/therapy ; Pandemics ; Thrombosis/diagnostic imaging ; Thrombosis/epidemiology ; Thrombosis/etiology ; United Kingdom/epidemiology ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.04.029
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    Zs.MO 196: Show issues

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  9. Article ; Online: An Observational Study Assessing the Predictors of Procedural Failure From the Radial Approach: Is Right Radial Access Always the Best?

    Jones, Johanna / Rathod, Krishnaraj S / Beirne, Anne-Marie / Hamshere, Stephen M / Choudry, Fizzah A / O'Mahony, Constantinos / Guttmann, Oliver P / Knight, Charles J / Amersey, Rajiv / Wragg, Andrew / Baumbach, Andreas / Mathur, Anthony / Jones, Daniel A

    Cardiovascular revascularization medicine : including molecular interventions

    2022  Volume 42, Page(s) 86–91

    Abstract: Objective: The study aimed to determine the predictors of procedural failure (coronary cannulation) in patients undergoing coronary angiography ± percutaneous coronary intervention (PCI) from the transradial (TR) approach.: Methods: We conducted an ... ...

    Abstract Objective: The study aimed to determine the predictors of procedural failure (coronary cannulation) in patients undergoing coronary angiography ± percutaneous coronary intervention (PCI) from the transradial (TR) approach.
    Methods: We conducted an observational study of 20,315 consecutive patients undergoing TR angiography between 2016 and 2020. TR failure was described as inability to cannulate the coronary arteries. Univariate and multivariate analyses were performed to determine independent predictors of TR failure.
    Results: Out of the study population, TR failure was observed in 365 (1.8%) patients, out of which 281 (77%) crossed over successfully to the transfemoral (TF) route and 84 (23%) to left radial access (LRA). Unsuccessful procedures were most likely seen in patients who were elderly, female, BAME background, short stature or with a history of hypertension, diabetes, and renal disease. On regression analysis, age (OR: 1.024; 95% Cl: 1.014-1.035), female gender (OR: 0.729; 95% Cl: 0.555-0.957), BAME (OR: 0.786; 95% Cl: 0.612-0.959), height (OR: 0.988; 95% Cl: 0.977-0.999), hypertension (OR: 1.510; 95% Cl: 1.147-1.987) and RRA (OR: 1.977; 95% Cl: 1.105-3.538) were independent predictors of TR failure. On further analysis, these predictors of failure were not seen from the LRA approach.
    Conclusion: This study identifies that rates of TR failure are low and that predictors of failure differ between the RRA and LRA. The difference in predictors between the 2 routes suggests that in patients when coronary cannulation is unsuccessful via the RRA then the LRA could be considered as a second access site. Further study is needed to see if in selected patient groups the LRA could be used as the first-choice access route.
    MeSH term(s) Aged ; Coronary Angiography/adverse effects ; Coronary Angiography/methods ; Female ; Femoral Artery ; Humans ; Hypertension ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Radial Artery/diagnostic imaging
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2022.03.004
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    Zs.A 5562: Show issues Location:
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  10. Article ; Online: Therapeutic Implications of COVID-19 for the Interventional Cardiologist.

    Kelham, Matthew / Choudry, Fizzah A / Hamshere, Stephen / Beirne, Anne-Marie / Rathod, Krishnaraj S / Baumbach, Andreas / Ahluwalia, Amrita / Mathur, Anthony / Jones, Daniel A

    Journal of cardiovascular pharmacology and therapeutics

    2020  Volume 26, Issue 3, Page(s) 203–216

    Abstract: Although COVID-19 is viewed primarily as a respiratory disease, cardiovascular risk factors and disease are prevalent among infected patients and are associated with worse outcomes. In addition, among multiple extra-pulmonary manifestations, there has ... ...

    Abstract Although COVID-19 is viewed primarily as a respiratory disease, cardiovascular risk factors and disease are prevalent among infected patients and are associated with worse outcomes. In addition, among multiple extra-pulmonary manifestations, there has been an increasing recognition of specific cardiovascular complications of COVID-19. Despite this, in the initial stages of the pandemic there was evidence of a reduction in patients presenting to acute cardiovascular services. In this masterclass review, with the aid of 2 exemplar cases, we will focus on the important therapeutic implications of COVID-19 for interventional cardiologists. We summarize the existing evidence base regarding the varied cardiovascular presentations seen in COVID-19 positive patients and the prognostic importance and potential mechanisms of acute myocardial injury in this setting. Importantly, through the use of a systematic review of the literature, we focus our discussion on the observed higher rates of coronary thrombus burden in patients with COVID-19 and acute coronary syndromes.
    MeSH term(s) COVID-19/physiopathology ; Coronary Thrombosis ; Fibrinolytic Agents/administration & dosage ; Humans ; Inflammation Mediators/metabolism ; Pandemics ; Percutaneous Coronary Intervention/methods ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/pathology ; Thrombosis/pathology ; Troponin/biosynthesis
    Chemical Substances Fibrinolytic Agents ; Inflammation Mediators ; Troponin
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1329372-2
    ISSN 1940-4034 ; 1074-2484
    ISSN (online) 1940-4034
    ISSN 1074-2484
    DOI 10.1177/1074248420982736
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