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  1. Article ; Online: A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy.

    Jex, Nicholas / Chowdhary, Amrit / Thirunavukarasu, Sharmaine / Levelt, Eylem

    European heart journal. Case reports

    2022  Volume 6, Issue 8, Page(s) ytac347

    Abstract: Background: Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion.: Case ...

    Abstract Background: Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion.
    Case summary: A 59-year-old patient with concomitant T2D and an apical phenotype of HCM was seen over a 11-year period with a significant burden of anginal chest pain. Chest pain was refractory to anti-anginal medical therapy and persisted at on-going follow-up. Multi-modality imaging demonstrated significant deterioration in coronary microvascular function and increased myocardial scar burden despite unobstructed epicardial coronary arteries.
    Discussion: Comorbidity with T2D and apical HCM resulted in a significant increase in myocardial fibrosis and deterioration in coronary microvascular function.
    Language English
    Publishing date 2022-08-16
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac347
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  2. Article ; Online: Global microvascular ischaemia following Takotsubo cardiomyopathy with left ventricular function recovery.

    Chowdhary, Amrit / Thirunavukarasu, Sharmaine / Jex, Nick / Levelt, Eylem

    European heart journal. Case reports

    2021  Volume 5, Issue 3, Page(s) ytab093

    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A rare case of all-trans retinoic acid induced myocarditis.

    Ul Hassan, Imtiaz / Chowdhary, Amrit / Kidambi, Ananth

    European heart journal. Cardiovascular Imaging

    2021  Volume 22, Issue 8, Page(s) e131

    MeSH term(s) Humans ; Myocarditis/chemically induced ; Myocarditis/diagnostic imaging ; Tretinoin/adverse effects
    Chemical Substances Tretinoin (5688UTC01R)
    Language English
    Publishing date 2021-05-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeab082
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    Zs.A 5614: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: British Cardiovascular Society/British Heart Foundation/British Atherosclerosis Society/British Society for Cardiovascular Research Young Investigator Award 2023.

    Sau, Arunashis / Amoiradaki, Konstantina / Ardissino, Maddalena / Chowdhary, Amrit / Rathod, Krishnaraj / Hudson, Sarah

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 20, Page(s) 1571–1573

    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-323063
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    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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  5. Article ; Online: Multisystem inflammatory syndrome in an adult with SARS-CoV-2 infection.

    Chowdhary, Amrit / Joy, Eleanor / Plein, Sven / Abdel-Rahman, Saif-El-Dean

    European heart journal. Cardiovascular Imaging

    2020  Volume 22, Issue 5, Page(s) e17

    MeSH term(s) Adult ; COVID-19 ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeaa232
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  6. Article ; Online: Cardiovascular magnetic resonance imaging: emerging techniques and applications.

    Chowdhary, Amrit / Garg, Pankaj / Das, Arka / Nazir, Muhummad Sohaib / Plein, Sven

    Heart (British Cardiac Society)

    2021  Volume 107, Issue 9, Page(s) 697–704

    Abstract: This review gives examples of emerging cardiovascular magnetic resonance (CMR) techniques and applications that have the potential to transition from research to clinical application in the near future. Four-dimensional flow CMR (4D-flow CMR) allows time- ...

    Abstract This review gives examples of emerging cardiovascular magnetic resonance (CMR) techniques and applications that have the potential to transition from research to clinical application in the near future. Four-dimensional flow CMR (4D-flow CMR) allows time-resolved three-directional, three-dimensional (3D) velocity-encoded phase-contrast imaging for 3D visualisation and quantification of valvular or intracavity flow. Acquisition times of under 10 min are achievable for a whole heart multidirectional data set and commercial software packages are now available for data analysis, making 4D-flow CMR feasible for inclusion in clinical imaging protocols. Diffusion tensor imaging (DTI) is based on the measurement of molecular water diffusion and uses contrasting behaviour in the presence and absence of boundaries to infer tissue structure. Cardiac DTI is capable of non-invasively phenotyping the 3D micro-architecture within a few minutes, facilitating transition of the method to clinical protocols. Hybrid positron emission tomography-magnetic resonance (PET-MR) provides quantitative PET measures of biological and pathological processes of the heart combined with anatomical, morphological and functional CMR imaging. Cardiac PET-MR offers opportunities in ischaemic, inflammatory and infiltrative heart disease.
    MeSH term(s) Blood Flow Velocity/physiology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/physiopathology ; Coronary Circulation/physiology ; Humans ; Image Interpretation, Computer-Assisted/methods ; Magnetic Resonance Imaging, Cine/methods ; Predictive Value of Tests
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2019-315669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 112: Show issues

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  7. Article: A case of multiple cardiac calcified amorphous tumours.

    Chowdhary, Amrit / Walpole, Sarah Catherine / Gupta, Sanjay

    Indian heart journal

    2017  Volume 69, Issue 3, Page(s) 349–350

    Abstract: Cardiac calcified amorphous tumours of the heart are rare non-neoplastic cardiac masses that can present like a malignant mass or an intra-cardiac thrombus. We report an extremely unusual case of a 73year old man who presented to hospital with dyspnoea ... ...

    Abstract Cardiac calcified amorphous tumours of the heart are rare non-neoplastic cardiac masses that can present like a malignant mass or an intra-cardiac thrombus. We report an extremely unusual case of a 73year old man who presented to hospital with dyspnoea and subsequent investigations revealed multiple cardiac CATs.
    Language English
    Publishing date 2017-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 604366-5
    ISSN 0019-4832
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2016.12.001
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    Zs.A 616: Show issues Location:
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  8. Article ; Online: A 30-Year-Old Man With Primary Cardiac Angiosarcoma.

    Jex, Nicholas / Farley, Jonathan / Thirunavukarasu, Sharmaine / Chowdhary, Amrit / Sengupta, Anshuman / Greenwood, John / Schlosshan, Dominik / Plein, Sven / Levelt, Eylem

    JACC. Case reports

    2021  Volume 3, Issue 6, Page(s) 944–949

    Abstract: A previously fit and well 30-year-old man presented with palpitations, fever, and pleuritic chest pain. Multimodality imaging and histopathology confirmed the diagnosis of primary cardiac angiosarcoma. We present the details of the presentation, ... ...

    Abstract A previously fit and well 30-year-old man presented with palpitations, fever, and pleuritic chest pain. Multimodality imaging and histopathology confirmed the diagnosis of primary cardiac angiosarcoma. We present the details of the presentation, diagnostic process using multimodality imaging, and clinical management. (
    Language English
    Publishing date 2021-05-12
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2021.03.009
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  9. Article ; Online: Rationale and design of the randomised controlled cross-over trial: Cardiovascular effects of empaglifozin in diabetes mellitus.

    Thirunavukarasu, Sharmaine / Brown, Louise Ae / Chowdhary, Amrit / Jex, Nicholas / Swoboda, Peter / Greenwood, John P / Plein, Sven / Levelt, Eylem

    Diabetes & vascular disease research

    2021  Volume 18, Issue 3, Page(s) 14791641211021585

    Abstract: Background: Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular (CV) disease. In patients with T2D and established CV disease, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2) have been shown to decrease CV and all- ...

    Abstract Background: Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular (CV) disease. In patients with T2D and established CV disease, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2) have been shown to decrease CV and all-cause mortality, and heart failure (HF) admissions. Utilising CV magnetic resonance imaging (CMR) and continuous glucose monitoring (CGM) by FreeStyle Libre Pro Sensor, we aim to explore the mechanisms of action which give Empagliflozin, an SGLT2 inhibitor, its beneficial CV effects and compare these to the effects of dipeptidyl peptidase-4 inhibitor Sitagliptin.
    Methods: This is a single centre, open-label, cross-over trial conducted at the Leeds Teaching Hospitals NHS Trust. Participants are randomised for the order of treatment and receive 3 months therapy with Empagliflozin, and 3 months therapy with Sitagliptin sequentially. Twenty-eight eligible T2D patients with established ischaemic heart disease will be recruited. Patients undergo serial CMR scans on three visits.
    Discussion: The primary outcome measure is the myocardial perfusion reserve in remote myocardium. We hypothesise that Empaglifozin treatment is associated with improvements in myocardial blood flow and reductions in myocardial interstitial fibrosis, independent of CGM measured glycemic control in patients with T2D and established CV disease.
    Trial registration: This study has full research ethics committee approval (REC: 18/YH/0190) and data collection is anticipated to finish in December 2021. This study was retrospectively registered at https://doi.org/10.1186/ISRCTN82391603 and monitored by the University of Leeds. The study results will be submitted for publication within 6 months of completion.
    MeSH term(s) Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/therapeutic use ; Coronary Circulation/drug effects ; Cross-Over Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; England ; Fibrosis ; Glucosides/adverse effects ; Glucosides/therapeutic use ; Glycemic Control/adverse effects ; Humans ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/physiopathology ; Myocardium/pathology ; Randomized Controlled Trials as Topic ; Sitagliptin Phosphate/adverse effects ; Sitagliptin Phosphate/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Time Factors ; Treatment Outcome
    Chemical Substances Benzhydryl Compounds ; Dipeptidyl-Peptidase IV Inhibitors ; Glucosides ; Sodium-Glucose Transporter 2 Inhibitors ; empagliflozin (HDC1R2M35U) ; Sitagliptin Phosphate (TS63EW8X6F)
    Language English
    Publishing date 2021-06-25
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250793-0
    ISSN 1752-8984 ; 1479-1641
    ISSN (online) 1752-8984
    ISSN 1479-1641
    DOI 10.1177/14791641211021585
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  10. Article: Multisystem inflammatory syndrome in an adult with SARS-CoV-2 infection

    Chowdhary, Amrit / Joy, Eleanor / Plein, Sven / Abdel-Rahman, Saif-El-Dean

    European heart journal. Cardiovascular imaging

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #744509
    Database COVID19

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