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  1. Article: Repeatability of [

    Christensen, Nana Louise / Sørensen, Jens / Bouchelouche, Kirsten / Madsen, Michael Alle / Buhl, Christian Selmer / Tolbod, Lars Poulsen

    EJNMMI research

    2024  Volume 14, Issue 1, Page(s) 11

    Abstract: Background: [: Results: Resting perfusion values in the muscle groups of the lower legs ranged from 1.18 to 5.38 mL/min/100 mL (ARG method). In the muscle groups of the feet, perfusion values ranged from 0.41 to 3.41 mL/min/100 mL (ARG method). Test- ... ...

    Abstract Background: [
    Results: Resting perfusion values in the muscle groups of the lower legs ranged from 1.18 to 5.38 mL/min/100 mL (ARG method). In the muscle groups of the feet, perfusion values ranged from 0.41 to 3.41 mL/min/100 mL (ARG method). Test-retest scans demonstrated a strong correlation and good repeatability for skeletal muscle perfusion with an intraclass correlation coefficient (ICC) of 0.88 and 0.87 and a repeatability coefficient of 34% and 53% for lower legs and feet, respectively. An excellent correlation was demonstrated when comparing volume-of-interest-based methods (1TCM and ARG) (lower legs: ICC = 0.96, feet: ICC = 0.99). Parametric images were in excellent agreement with the volume-of-interest-based ARG method (lower legs: ICC = 0.97, feet: ICC = 0.98).
    Conclusion: Parametric images and volume-of-interest-based methods demonstrated comparable resting perfusion values in the lower legs and feet of healthy individuals. The largest variation was seen between individuals, whereas a smaller variation was seen between muscle groups. Repeated measurements of resting blood flow yielded a strong overall correlation for all methods.
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-024-01073-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complete somatostatin-induced insulin suppression combined with heparin loading does not significantly suppress myocardial 18F-FDG uptake in patients with suspected cardiac sarcoidosis.

    Gormsen, Lars C / Christensen, Nana Louise / Bendstrup, Elisabeth / Tolbod, Lars Poulsen / Nielsen, Søren Steen

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2013  Volume 20, Issue 6, Page(s) 1108–1115

    Abstract: Background: Cardiac 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography preceded by extended fasting is used to demonstrate active cardiac sarcoidosis. However, physiological insulin-dependent myocardial 18F-FDG uptake often obscures 18F-FDG ... ...

    Abstract Background: Cardiac 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography preceded by extended fasting is used to demonstrate active cardiac sarcoidosis. However, physiological insulin-dependent myocardial 18F-FDG uptake often obscures 18F-FDG uptake in sarcoid lesions. We therefore aimed to completely suppress physiological myocardial 18F-FDG uptake by pharmaceutically blocking endogenous insulin secretion while elevating free fatty acids (FFAs).
    Methods and results: Six patients with suspected cardiac sarcoidosis were studied in a randomized cross-over design: (1) 12 hours fasting followed by 2 hours saline infusion (SALINE), and (2) 12 hours fasting followed by 2 hour infusions of somatostatin (300 μg/hour) and heparin (70 mIE/kg/minutes) (SOMA). 18F-FDG PET scans were performed post-infusion. Glucose, insulin, and FFA levels were measured and left ventricle SUV-values were recorded. During the SALINE infusion, insulin, glucose, and FFAs remained stable. By design, the SOMA infusions rapidly (<60 minutes) suppressed insulin completely, while FFA levels peaked at 1.13 ± 0.23 mM. However, SOMA infusions only suppressed cardiac 18F-FDG uptake insignificantly globally [SUVmean (g/mL): 4.0 ± 3.3 (SALINE) vs 2.4 ± 1.2 (SOMA), P = .15] and regionally.
    Conclusions: Complete insulin suppression combined with markedly increased circulating FFAs does not completely suppress physiological myocardial 18F-FDG uptake and thus conveys no extra diagnostic value compared with extended fasting.
    MeSH term(s) Adult ; Aged ; Cardiomyopathies/diagnostic imaging ; Cross-Over Studies ; Fatty Acids, Nonesterified/blood ; Female ; Fluorodeoxyglucose F18 ; Heparin/pharmacology ; Humans ; Insulin/blood ; Male ; Middle Aged ; Radionuclide Imaging ; Radiopharmaceuticals ; Sarcoidosis/diagnostic imaging ; Somatostatin/pharmacology
    Chemical Substances Fatty Acids, Nonesterified ; Insulin ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Somatostatin (51110-01-1) ; Heparin (9005-49-6)
    Language English
    Publishing date 2013-10-17
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-013-9798-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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