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  1. Book: Cilia

    Satir, Peter / Christensen, Søren T.

    methods and protocols

    (Methods in molecular biology ; 1454 ; Springer protocols)

    2016  

    Author's details edited by Peter Satir, Søren Tvorup Christensen
    Series title Methods in molecular biology ; 1454
    Springer protocols
    Collection
    Keywords Drosophila ; Xenopus ; cell organelle ; ciliates ; flagellate algae ; motile cilia ; nematodes ; planaria ; sensory cilia ; zebrafish
    Language English
    Size XIV, 259 Seiten, Illustrationen, Diagramme, 25.4 cm x 17.8 cm, 0 g
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT019075297
    ISBN 978-1-4939-3787-5 ; 1-4939-3787-1 ; 9781493937899 ; 1493937898
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1454- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Global N

    Christensen, Søren / Rousk, Kathrin

    iScience

    2024  Volume 27, Issue 2, Page(s) 109042

    Abstract: In some places, ... ...

    Abstract In some places, N
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides.

    Christensen, Søren Brøgger

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 17

    Abstract: During a screening performed by the National Cancer Institute in the 1960s, the terpenoid paclitaxel was discovered. Paclitaxel expanded the treatment options for breast, lung, prostate and ovarian cancer. Paclitaxel is only present in minute amounts in ... ...

    Abstract During a screening performed by the National Cancer Institute in the 1960s, the terpenoid paclitaxel was discovered. Paclitaxel expanded the treatment options for breast, lung, prostate and ovarian cancer. Paclitaxel is only present in minute amounts in the bark of
    MeSH term(s) Docetaxel/pharmacology ; Female ; Humans ; Macrolides/pharmacology ; Male ; Microtubules ; Ovarian Neoplasms/drug therapy ; Paclitaxel/pharmacology ; Peptides/pharmacology
    Chemical Substances Macrolides ; Peptides ; Docetaxel (15H5577CQD) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-09-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27175648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is Learning in Biological Neural Networks Based on Stochastic Gradient Descent? An Analysis Using Stochastic Processes.

    Christensen, Sören / Kallsen, Jan

    Neural computation

    2024  , Page(s) 1–9

    Abstract: In recent years, there has been an intense debate about how learning in biological neural networks (BNNs) differs from learning in artificial neural networks. It is often argued that the updating of connections in the brain relies only on local ... ...

    Abstract In recent years, there has been an intense debate about how learning in biological neural networks (BNNs) differs from learning in artificial neural networks. It is often argued that the updating of connections in the brain relies only on local information, and therefore a stochastic gradient-descent type optimization method cannot be used. In this article, we study a stochastic model for supervised learning in BNNs. We show that a (continuous) gradient step occurs approximately when each learning opportunity is processed by many local updates. This result suggests that stochastic gradient descent may indeed play a role in optimizing BNNs.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025692-1
    ISSN 1530-888X ; 0899-7667
    ISSN (online) 1530-888X
    ISSN 0899-7667
    DOI 10.1162/neco_a_01668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2914: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Natural Products That Changed Society.

    Christensen, Søren Brøgger

    Biomedicines

    2021  Volume 9, Issue 5

    Abstract: Until the end of the 19th century all drugs were natural products or minerals. During the 19th century chemists succeeded in isolating pure natural products such as quinine, morphine, codeine and other compounds with beneficial effects. Pure compounds ... ...

    Abstract Until the end of the 19th century all drugs were natural products or minerals. During the 19th century chemists succeeded in isolating pure natural products such as quinine, morphine, codeine and other compounds with beneficial effects. Pure compounds enabled accurate dosing to achieve serum levels within the pharmacological window and reproducible clinical effects. During the 20th and the 21st century synthetic compounds became the major source of drugs. In spite of the impressive results achieved within the art of synthetic chemistry, natural products or modified natural products still constitute almost half of drugs used for treatment of cancer and diseases like malaria, onchocerciasis and lymphatic filariasis caused by parasites. A turning point in the fight against the devastating burden of malaria was obtained in the 17th century by the discovery that bark from trees belonging to the genus
    Language English
    Publishing date 2021-04-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9050472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams.

    Christensen, Søren Brøgger

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 19

    Abstract: The appearance of antibiotic drugs revolutionized the possibilities for treatment of diseases with high mortality such as pneumonia, sepsis, plaque, diphtheria, tetanus, typhoid fever, and tuberculosis. Today fewer than 1% of mortalities in high income ... ...

    Abstract The appearance of antibiotic drugs revolutionized the possibilities for treatment of diseases with high mortality such as pneumonia, sepsis, plaque, diphtheria, tetanus, typhoid fever, and tuberculosis. Today fewer than 1% of mortalities in high income countries are caused by diseases caused by bacteria. However, it should be recalled that the antibiotics were introduced in parallel with sanitation including sewerage, piped drinking water, high standard of living and improved understanding of the connection between food and health. Development of salvarsan, sulfonamides, and β-lactams into efficient drugs is described. The effects on life expectancy and life quality of these new drugs are indicated.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Arsphenamine/pharmacology ; Bacterial Infections/drug therapy ; Drug Development ; Drug Discovery ; Humans ; Quality of Life ; Sulfonamides/pharmacology ; beta-Lactams/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Sulfonamides ; beta-Lactams ; Arsphenamine (139-93-5)
    Language English
    Publishing date 2021-10-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26196057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article: Editorial: Signaling by primary cilia in development and disease.

    Kim, Sung-Eun / Nechipurenko, Inna / Christensen, Søren Tvorup

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1186367

    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1186367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Primary cilia as dynamic and diverse signalling hubs in development and disease.

    Mill, Pleasantine / Christensen, Søren T / Pedersen, Lotte B

    Nature reviews. Genetics

    2023  Volume 24, Issue 7, Page(s) 421–441

    Abstract: Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate cell types, are essential for regulating signalling pathways during development and adult homeostasis. Mutations in genes affecting cilia cause an overlapping ... ...

    Abstract Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate cell types, are essential for regulating signalling pathways during development and adult homeostasis. Mutations in genes affecting cilia cause an overlapping spectrum of >30 human diseases and syndromes, the ciliopathies. Given the immense structural and functional diversity of the mammalian cilia repertoire, there is a growing disconnect between patient genotype and associated phenotypes, with variable severity and expressivity characteristic of the ciliopathies as a group. Recent technological developments are rapidly advancing our understanding of the complex mechanisms that control biogenesis and function of primary cilia across a range of cell types and are starting to tackle this diversity. Here, we examine the structural and functional diversity of primary cilia, their dynamic regulation in different cellular and developmental contexts and their disruption in disease.
    MeSH term(s) Adult ; Animals ; Humans ; Cilia/genetics ; Cilia/metabolism ; Signal Transduction ; Ciliopathies/genetics ; Ciliopathies/metabolism ; Mammals
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-023-00587-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5474: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 40: Show issues

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  9. Article ; Online: Targeting Toxins toward Tumors.

    Franzyk, Henrik / Christensen, Søren Brøgger

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 5

    Abstract: Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states. In slowly developing cancer diseases only a minor part ... ...

    Abstract Many cancer diseases, e.g., prostate cancer and lung cancer, develop very slowly. Common chemotherapeutics like vincristine, vinblastine and taxol target cancer cells in their proliferating states. In slowly developing cancer diseases only a minor part of the malignant cells will be in a proliferative state, and consequently these drugs will exert a concomitant damage on rapidly proliferating benign tissue as well. A number of toxins possess an ability to kill cells in all states independently of whether they are benign or malignant. Such toxins can only be used as chemotherapeutics if they can be targeted selectively against the tumors. Examples of such toxins are mertansine, calicheamicins and thapsigargins, which all kill cells at low micromolar or nanomolar concentrations. Advanced prodrug concepts enabling targeting of these toxins to cancer tissue comprise antibody-directed enzyme prodrug therapy (ADEPT), gene-directed enzyme prodrug therapy (GDEPT), lectin-directed enzyme-activated prodrug therapy (LEAPT), and antibody-drug conjugated therapy (ADC), which will be discussed in the present review. The review also includes recent examples of protease-targeting chimera (PROTAC) for knockdown of receptors essential for development of tumors. In addition, targeting of toxins relying on tumor-overexpressed enzymes with unique substrate specificity will be mentioned.
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Calicheamicins/pharmacology ; Cell Proliferation/drug effects ; Delayed-Action Preparations/chemistry ; Drug Carriers/chemistry ; Drug Design ; Drug Liberation ; Enzyme Therapy ; Gene Knockdown Techniques ; Humans ; Lung Neoplasms/drug therapy ; Male ; Maytansine/pharmacology ; Molecular Targeted Therapy ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Prostatic Neoplasms/drug therapy ; Thapsigargin/pharmacology ; Toxins, Biological/chemistry ; Toxins, Biological/pharmacology
    Chemical Substances Antineoplastic Agents ; Calicheamicins ; Delayed-Action Preparations ; Drug Carriers ; Prodrugs ; Toxins, Biological ; Maytansine (14083FR882) ; Thapsigargin (67526-95-8) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2021-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26051292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article: Survey of Danish Head and Neck Cancer Patients' Positions on Personalized Medicine, Gene Tests, and Personalized Follow-Up.

    Danstrup, Christian Sander / Andersen, Maria / Lundbye-Christensen, Søren / Sommer, Mia / Lyhne, Nina Munk

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: The field of personalized medicine (PM) has grown rapidly because of the "omics revolution", but PM may be difficult for patients to comprehend. This study sought to explore head and neck cancer (HNC) patients' positions and knowledge of PM, gene tests, ... ...

    Abstract The field of personalized medicine (PM) has grown rapidly because of the "omics revolution", but PM may be difficult for patients to comprehend. This study sought to explore head and neck cancer (HNC) patients' positions and knowledge of PM, gene tests, and follow-up and to compare HNC patients' positions to a sample from a national Danish questionnaire. To do this, patients with prior HNC were invited to participate in a questionnaire. Initial interviews revealed a heterogenic understanding of PM between patients. A total of 226 patients were included in the survey and 177 patients with complete data were included for analysis. Most patients were more positive than negative towards gene tests and gene research (83% and 93%, respectively), but 72% had little or no knowledge of the subject. Almost all patients, 98%, were satisfied with their follow-up. Significantly more patients with HNC were positive towards gene research compared to a sample from a national Danish questionnaire (
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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