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  1. AU="Christian Molnár"
  2. AU="Montarello, Natalie"
  3. AU="Phan Nu Dieu Hong"
  4. AU="Polliack, Michael"
  5. AU="Ye, Tianai"
  6. AU="Galenson, Walter"
  7. AU="Nisar, Muhammad K"
  8. AU="Keshavarzi, Nahid"
  9. AU="Gabig, Theodore G"
  10. AU="Nixon, Ian J"
  11. AU="Huang Xiaoting"
  12. AU="Colturato, Virgílio Antônio Rensi"
  13. AU="Mahfouz, Amira Y"
  14. AU="Ayyappan, Sabarish"
  15. AU=Wang Kevin L-C
  16. AU="Lukas T. Hirschwald"
  17. AU="Morley-Davies, A"
  18. AU="Felsberg, Gary J"
  19. AU="Bogen, Oliver"
  20. AU="de Portu, Simona"
  21. AU="Janssens, Rick"

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  1. Artikel ; Online: Influenza-A mediated pre-existing immunity levels to SARS-CoV-2 could predict early COVID-19 outbreak dynamics

    Nerea Martín Almazán / Afsar Rahbar / Marcus Carlsson / Tove Hoffman / Linda Kolstad / Bengt Rönnberg / Mattia Russel Pantalone / Ilona Lewensohn Fuchs / Anna Nauclér / Mats Ohlin / Mariusz Sacharczuk / Piotr Religa / Stefan Amér / Christian Molnár / Åke Lundkvist / Andres Susrud / Birger Sörensen / Cecilia Söderberg-Nauclér

    iScience, Vol 26, Iss 12, Pp 108441- (2023)

    2023  

    Abstract: Summary: Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is highly variable and could be mediated by a cross-protective pre-immunity. We identified 14 cross-reactive peptides between SARS-CoV-2 and influenza A ... ...

    Abstract Summary: Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is highly variable and could be mediated by a cross-protective pre-immunity. We identified 14 cross-reactive peptides between SARS-CoV-2 and influenza A H1N1, H3N2, and human herpesvirus (HHV)-6A/B with potential relevance. The H1N1 peptide NGVEGF was identical to a peptide in the most critical receptor binding motif in SARS-CoV-2 spike protein that interacts with the angiotensin converting enzyme 2 receptor. About 62%–73% of COVID-19-negative blood donors in Stockholm had antibodies to this peptide in the early pre-vaccination phase of the pandemic. Seasonal flu vaccination enhanced neutralizing capacity to SARS-CoV-2 and T cell immunity to this peptide. Mathematical modeling taking the estimated pre-immunity levels to flu into account could fully predict pre-Omicron SARS-CoV-2 outbreaks in Stockholm and India. This cross-immunity provides mechanistic explanations to the epidemiological observation that influenza vaccination protected people against early SARS-CoV-2 infections and implies that flu-mediated cross-protective immunity significantly dampened the first SARS-CoV-2 outbreaks.
    Schlagwörter Immunology ; Immune response ; Virology ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: High seroprevalence of SARS-CoV-2 in elderly care employees in Sweden

    Johanna F. Lindahl / Tove Hoffman / Mouna Esmaeilzadeh / Björn Olsen / Reidar Winter / Stefan Amer / Christian Molnár / Ann Svalberg / Åke Lundkvist

    Infection Ecology & Epidemiology, Vol 10, Iss

    2020  Band 1

    Abstract: The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their ...

    Abstract The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their personnel to secure the safety of the elderly and to avoid unnecessary quarantine of potentially immune employees. Secondary data from a screening with a COVID-19 rapid test for detection of SARS-CoV-2-specific IgM and IgG of 1,005 employees in 22 elderly care homes in Stockholm, Sweden, were analyzed. Seropositive employees were found in 21 out of the 22 care homes. In total, 23% (231/1,005) of the employees tested positive for antibodies against SARS-CoV-2, and 14.3% (144/1,005) were found positive for IgM (either alone or combined with IgG), indicating recent or present infection. Of those that tested seropositive, 46.5% did not report any clinical symptoms, indicating pre- or asymptomatic infections. Reported symptoms with the highest correlation with seropositivity were fever and loss of smell and taste. These results suggest that antibody testing of employees in elderly care homes is valuable for surveillance of disease development and a crucial screening tool in the effort to decrease the death toll in this pandemic.
    Schlagwörter covid-19 ; sars-cov-2 ; rapid test ; igm ; igg ; employees ; elderly care homes ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Thema/Rubrik (Code) 650
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Islet Engraftment and Revascularization in Clinical and Experimental Transplantation

    Christian Molnár / Magnus Essand / Lars Wennberg / Christian Berne / Erik Larsson / Gunnar Tufveson / Olle Korsgren

    Cell Transplantation, Vol

    2013  Band 22

    Abstract: Proper revascularization after transplantation is assumed to be crucial for appropriate islet graft function. We developed a novel noninvasive imaging method, based on adenoviral transduction of islets with a hypoxia responsive reporter gene, for ... ...

    Abstract Proper revascularization after transplantation is assumed to be crucial for appropriate islet graft function. We developed a novel noninvasive imaging method, based on adenoviral transduction of islets with a hypoxia responsive reporter gene, for continuous in vivo monitoring of hypoxia in islet grafts in a mouse model. In addition, morphological data were obtained from a deceased patient previously subject to intraportal transplantation. We detected only transient hypoxia in a minority of the animals transplanted. Importantly, a clear response to hypoxia was observed in vitro after removal of the islet grafts on day 28 after transplantation. Also, the morphological data from the deceased patient demonstrated an extensive revascularization of the transplanted islets. In fact, no differences could be seen between native islets, in pancreas biopsies taken prior to islet isolation, and transplanted islets regarding the number, distribution, and shape of the blood vessels. However, fewer small islets (diameter <39 μm) were found in the liver compared to those found in native pancreases. Notably, an absolute majority of the transplanted islets were found remaining within the venous lumen, in direct contact with the vessel wall. In conclusion, the results presented show less pronounced islet graft hypoxia after subcapsular transplantation than previously reported using more invasive methods. Also, formation of an extensive intraislet capillary network, similar to that seen in native islets in the pancreas, was seen after clinical islet transplantation.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2013-02-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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