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  1. Article: A systematic review of vitamin D status in southern European countries

    Manios, Yannis / Alexandra Karachaliou / Christina Breidenassel / Christina-Paulina Lambrinou / George Moschonis / Kevin D. Cashman / Konstantina Tsoutsoulopoulou / Mairead Kiely / Marcela Gonzalez-Gross / Panagiota Binou

    European journal of nutrition. 2018 Sept., v. 57, no. 6

    2018  

    Abstract: PURPOSE: Despite an acknowledged dearth of data on serum 25-hydroxyvitamin D (25(OH)D) concentrations from Southern European countries, inter-country comparison is hampered by inconsistent data reporting. The purpose of the current study was to conduct a ...

    Abstract PURPOSE: Despite an acknowledged dearth of data on serum 25-hydroxyvitamin D (25(OH)D) concentrations from Southern European countries, inter-country comparison is hampered by inconsistent data reporting. The purpose of the current study was to conduct a systematic literature review of available data on serum 25(OH)D concentrations and estimate vitamin D status in Southern European and Eastern Mediterranean countries, both at a population level and within key population subgroups, stratified by age, sex, season and country. METHODS: A systematic review of the literature was conducted to identify and retrieve scientific articles reporting data on serum 25(OH)D concentration and/or vitamin D status following standard procedures. RESULTS: Data were extracted from 107 studies, stratified by sex and age group, representing 630,093 individuals. More than one-third of the studies reported mean 25(OH)D concentrations below 50 nmol/L and ~ 10% reported mean serum 25(OH)D concentrations below 25 nmol/L. Overall, females, neonates/ infants and adolescents had the higher prevalence of poor vitamin D status. As expected, there was considerable variability between studies. Specifically, mean 25(OH)D ranged from 6.0 (in Italian centenarians) to 158 nmol/L (in elderly Turkish men); the prevalence of serum 25(OH)D < 50 nmol/L ranged from 6.8 to 97.9% (in Italian neonates). CONCLUSIONS: Contrary to expectations, there was a high prevalence of low vitamin D status in the Southern Europe and the Eastern Mediterranean regions, despite abundant sunshine. These data further emphasize the need for strategies, such as fortification of foods with vitamin D and/or vitamin D supplementation, which will be tailored to the needs of specific population groups with higher risk of insufficiency or deficiency, to efficiently tackle the pandemic of hypovitaminosis D in Europe.
    Keywords adolescents ; blood serum ; elderly ; females ; foods ; men ; neonates ; nutrition risk assessment ; pandemic ; solar radiation ; systematic review ; vitamin D ; vitamin D deficiency ; vitamin status ; Europe ; Mediterranean region ; Southern European region
    Language English
    Dates of publication 2018-09
    Size p. 2001-2036.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-017-1564-2
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Foods contributing to vitamin B6, folate, and vitamin B12 intakes and biomarkers status in European adolescents: The HELENA study

    Iglesia, Iris / Theodora Mouratidou / Marcela González-Gross / Inge Huybrechts / Christina Breidenassel / Javier Santabárbara / Ligia-Esperanza Díaz / Lena Hällström / Stefaan De Henauw / Frédéric Gottrand / Anthony Kafatos / Kurt Widhalm / Yannis Manios / Denes Molnar / Peter Stehle / Luis A. Moreno

    European journal of nutrition. 2017 June, v. 56, no. 4

    2017  

    Abstract: PURPOSE: To examine the association between food groups consumption and vitamin B₆, folate and B₁₂ intakes and biomarkers in adolescents. METHODS: In total 2189 individuals participating in the cross-sectional Healthy Lifestyle in Europe by ... ...

    Institution on the behalf of HELENA study group
    Abstract PURPOSE: To examine the association between food groups consumption and vitamin B₆, folate and B₁₂ intakes and biomarkers in adolescents. METHODS: In total 2189 individuals participating in the cross-sectional Healthy Lifestyle in Europe by Nutrition in Adolescence study met the eligibility criteria for analysis of dietary intakes (46 % males) and 632 for biomarker analysis (47 % males). Food intakes were assessed by two non-consecutive 24-h recalls. Biomarkers were measured by chromatography and immunoassay. Food groups which best discriminated participants in the extreme tertiles of the distribution of vitamins were identified by discriminant analyses. Food groups with standardised canonical coefficients higher or equal to 0.3 were selected as valid discriminators of vitamins intake and biomarkers extreme tertiles. Linear mixed model elucidated the association between food groups and vitamins intakes and biomarkers. RESULTS: Vitamin B₆ intakes and biomarkers were best discriminated by meat (males and females), margarine and mixed origin lipids only in males and breakfast cereals (females). Breakfast cereals (males), and fruits, margarine and mixed origin lipids, vegetables excluding potatoes, breakfast cereals, and soups/bouillon (females) determined the most folate intakes and biomarkers. Considering vitamin B₁₂ intakes and biomarkers, meat, and white and butter milk (males and females), snacks (males), and dairy products (females) best discriminated individual in the extremes of the distribution. Fewer associations were obtained with mixed model for biomarkers than for vitamins intakes with food groups. CONCLUSIONS: Whereas B-vitamin intakes were associated with their food sources, biomarkers did with overall food consumption. Low-nutrient-density foods may compromise adolescents’ vitamin status.
    Keywords adolescence ; adolescents ; biomarkers ; breakfast cereals ; buttermilk ; chromatography ; females ; folic acid ; food groups ; food intake ; fruits ; immunoassays ; lifestyle ; lipids ; males ; margarine ; meat ; potatoes ; pyridoxine ; snacks ; soups ; statistical models ; vitamin B12 ; vitamin status ; Europe
    Language English
    Dates of publication 2017-06
    Size p. 1767-1782.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-016-1221-1
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Fragmentation of daily rhythms associates with obesity and cardiorespiratory fitness in adolescents: The HELENA study

    Garaulet, Marta / Antonio Martinez-Nicolas / Jonatan R. Ruiz / Kenn Konstabel / Idoia Labayen / Marcela González-Gross / Ascensión Marcos / Dénes Molnar / Kurt Widhalm / Jose Antonio Casajús / Stefaan De Henauw / Anthony Kafatos / Christina Breidenassel / Michael Sjöström / Manuel J. Castillo / Luis A. Moreno / Juan A. Madrid / Francisco B. Ortega

    Clinical nutrition. 2017 Dec., v. 36

    2017  

    Abstract: Chronobiology studies periodic changes in living organisms and it has been proposed as a promising approach to investigate obesity. We analyze the association of the characteristics of the rest-activity rhythms with obesity, cardiorespiratory fitness and ...

    Abstract Chronobiology studies periodic changes in living organisms and it has been proposed as a promising approach to investigate obesity. We analyze the association of the characteristics of the rest-activity rhythms with obesity, cardiorespiratory fitness and metabolic risk in adolescents from nine European countries.1044 adolescents (12.5–17.5 y) were studied. Circadian health was evaluated by actigraphy with accelerometers (Actigraph GT1M). Characteristics of the daytime activity such as fragmentation (intradaily variability), estimated acrophase, and 10 h mean daytime activity index were obtained. Body composition was assessed using Bioelectrical-Impedance-Analysis, skinfold thickness, air-displacement-plethysmography and Dual-energy-X-ray-Absorptiometry. Cardiorespiratory fitness (VO2max) and metabolic risk were studied.Highly fragmented activity rhythms were associated with obesity and central adiposity (P < 0.05). Obese adolescents had ∼3 times higher odds of having a high fragmentation of daytime activity compared to normal weight adolescents OR (95% CI) = 2.8 (1.170, 6.443). A highly fragmented rhythm was also related to lower cardiorespiratory fitness and higher metabolic risk (P < 0.05) so those adolescents classified as low fitness showed a significantly higher fragmentation of daytime activity than those included in the high fitness group (P < 0.0001). Other characteristics of the rhythms such as smaller 10 h daytime mean activity index and delayed estimated acrophase were also related to obesity and metabolic risk (P < 0.05).Our results indicate that the daily organization of the rest-activity cycle is more fragmented in obese and less fit adolescents and correlates with higher metabolic risk. This fact reinforces our hypothesis that disturbances in daily rhythms can be considered as sensitive markers of poorer adolescent's health.
    Keywords accelerometers ; actigraphy ; adiposity ; adolescents ; cardiorespiratory fitness ; dual-energy X-ray absorptiometry ; obesity ; risk ; skinfold thickness
    Language English
    Dates of publication 2017-12
    Size p. 1558-1566.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2016.09.026
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: 25-hydroxyvitamin D is differentially associated with calcium intakes of Northern, Central, and Southern European adolescents: Results from the HELENA study

    Julian, Cristina / Alejandro de la O / Anthony Kafatos / Christina Breidenassel / Dénes Molnár / Frederic Gottrand / Germán Vicente-Rodriguez / Inge Huybrechts / Kurt Widhalm / Luis A. Moreno / Luis Gracia-Marco / Marc J. Gunter / Marcela González-Gross / Marika Ferrari / Mathilde Kersting / Stefaan De Henauw / Theodora Mouratidou / Yannis Manios

    Nutrition. 2017 Apr., v. 36

    2017  

    Abstract: Adolescents in the European Union (EU) exhibit a higher prevalence of vitamin D (VitD) deficiency than other age groups. The degree to which sunlight exposure 25-hydroxyvitamin D [25(OH)D] concentrations depends on a variety of factors, including diet. ... ...

    Abstract Adolescents in the European Union (EU) exhibit a higher prevalence of vitamin D (VitD) deficiency than other age groups. The degree to which sunlight exposure 25-hydroxyvitamin D [25(OH)D] concentrations depends on a variety of factors, including diet. Nevertheless, the relationship between calcium and VitD intake and 25(OH)D concentrations has not been previously studied among adolescents living in different EU countries and consequently in different latitudes. Therefore, the aim of this study was to examine whether calcium and VitD intakes are differentially associated with 25(OH)D in adolescents from northern, central and southern EU countries.The present analysis included 178 adolescents from northern EU countries, 251 from central EU countries, and 212 from southern EU countries (ages 12.5–17.5 y). Mixed model linear regression analyses stratified by geographic location were used to verify associations between calcium and VitD intake and 25(OH)D concentrations. Age, Tanner stage, seasonality, energy intake, and supplement use were entered as covariates.Only the calcium intake of central EU adolescents was positively associated with 25(OH)D (α = 0.005; 95% confidence interval, 0.007–0.028).Further longitudinal studies should confirm these observations, as this could be important for future public health interventions aiming to increase 25(OH)D concentrations in adolescents.
    Keywords adolescents ; calcium ; confidence interval ; diet ; energy intake ; European Union ; latitude ; longitudinal studies ; public health ; regression analysis ; solar radiation ; statistical models ; vitamin D
    Language English
    Dates of publication 2017-04
    Size p. 22-25.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2016.08.015
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Vitamins and iron blood biomarkers are associated with blood pressure levels in European adolescents. The HELENA study

    de Moraes, Augusto César Ferreira / Anthony Kafatos / Christina Breidenassel / Dénes Molnar / Frederic Gottrand / Heráclito Barbosa Carvalho / Iris Iglesia / Kurt Widhalm / Luis A. Moreno / Luis Gracia-Marco / Magdalena Cuenca-García / Marcela González-Gross / Marika Ferrari / Michael Sjöström / Odysseas Androutsos / Sonia Gómez-Martínez

    Nutrition. 2014 Nov., Dec., v. 30, no. 11-12

    2014  

    Abstract: Previous research showed that low concentration of biomarkers in the blood during adolescence (i.e., iron status; retinol; and vitamins B6, B12, C, and D) may be involved in the early stages of development of many chronic diseases, such as hypertension. ... ...

    Abstract Previous research showed that low concentration of biomarkers in the blood during adolescence (i.e., iron status; retinol; and vitamins B6, B12, C, and D) may be involved in the early stages of development of many chronic diseases, such as hypertension. The aim was to evaluate if iron biomarkers and vitamins in the blood are associated with blood pressure in European adolescents.Participants from the Healthy Lifestyle in Europe by Nutrition in Adolescence cross-sectional study (N = 1089; 12.5–17.5 y; 580 girls) were selected by complex sampling. Multilevel linear regression models examined the associations between iron biomarkers and vitamins in the blood and blood pressure; the analyses were stratified by sex and adjusted for contextual and individual potential confounders.A positive association was found in girls between RBC folate concentration and systolic blood pressure (SBP) (β = 3.19; 95% confidence interval [CI], 0.61–5.77), although no association between the vitamin serum biomarkers concentrations and diastolic blood pressure (DBP) was found. In boys, retinol was positively associated with DBP (β = 3.84; 95% CI, 0.51–7.17) and vitamin B6 was positively associated with SBP (β = 3.82; 95% CI, 1.46–6.18). In contrast, holotranscobalamin was inversely associated with SBP (β = −3.74; 95% CI, −7.28 to −0.21).Levels of RBC folate and vitamin B6 in blood may affect BP in adolescents. In this context, programs aimed at avoiding high BP levels should promote healthy eating behavior by focusing on the promotion of vegetable proteins and foods rich in vitamin B12 (i.e., white meat and eggs), which may help to achieve BP blood control in adolescents.
    Keywords adolescence ; adolescents ; biomarkers ; blood serum ; boys ; chronic diseases ; confidence interval ; cross-sectional studies ; diastolic blood pressure ; eating habits ; eggs ; erythrocytes ; folic acid ; girls ; healthy diet ; hypertension ; iron ; lifestyle ; meat ; pyridoxine ; regression analysis ; systolic blood pressure ; vegetable protein ; vitamin A ; vitamin B12 ; Europe
    Language English
    Dates of publication 2014-11
    Size p. 1294-1300.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2014.03.010
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Socioeconomic factors are associated with folate and vitamin B12 intakes and related biomarkers concentrations in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence study

    Iglesia, Iris / Adrienne E.J.M. Cavelaars / Anouk Geelen / Anthony Kafatos / Christina Breidenassel / David Jiménez-Pavón / Denes Molnar / Fátima Pérez de Heredia / Frédéric Gottrand / Inge Huybrechts / Kurt Widhalm / Lorenza Mistura / Luis A. Moreno / Marcela González-Gross / Mirjana Gurinovic / Peter Stehle / Pieter Van't Veer / Romana Novakovic / Stefaan De Henauw /
    Theodora Mouratidou / Yanis Manios

    Nutrition research. 2014 Mar., v. 34, no. 3

    2014  

    Abstract: Because socioeconomic factors (SEFs) may influence dietary quality and vitamin intakes, this study aimed to examine associations between socioeconomic factors and folate and vitamin B12 intakes as well as their related biomarkers in the Healthy Lifestyle ...

    Abstract Because socioeconomic factors (SEFs) may influence dietary quality and vitamin intakes, this study aimed to examine associations between socioeconomic factors and folate and vitamin B12 intakes as well as their related biomarkers in the Healthy Lifestyle in Europe by Nutrition in Adolescence study. Vitamin intakes were obtained from two 24-hour recalls in 2253 participants (47% males). Vitamin B biomarkers were assessed in a subsample of 977 participants (46% males). Socioeconomic factors were assessed by questionnaire, and 1-way analysis of covariance and linear regression analysis were applied. For males and females, mean intakes of folate were 211.19 and 177.18μg/d, and for vitamin B12, 5.98 and 4.54μg/d, respectively. Levels of plasma folate, red blood cell folate, serum B12, and holotranscobalamin were 18.74, 807.19, 330.64, and 63.04nmol/L in males, respectively, and 19.13, 770.16, 377.9, and 65.63nmol/L in females, respectively. Lower folate intakes were associated with several SEFs, including maternal and paternal education in both sexes. Regarding folate biomarkers, lower plasma folate intakes were associated with single/shared care in males and with lower paternal occupation in females. Lower vitamin B12 intakes were associated with almost all the studied SEFs, except paternal occupation in both sexes. In females, when considering vitamin B12 biomarkers, lower plasma vitamin B12 was associated with lower maternal education and occupation, and lower holotranscobalamin was associated with lower maternal education and lower paternal occupation. In conclusion, from the set of socioeconomic determinants studied in a sample of European adolescents, maternal education and paternal occupation were more consistently associated with folate and vitamin B12 intakes and biomarkers concentrations.
    Keywords adolescence ; adolescents ; analysis of covariance ; biomarkers ; blood serum ; education ; erythrocytes ; females ; folic acid ; lifestyle ; males ; nutritional adequacy ; questionnaires ; regression analysis ; socioeconomic factors ; vitamin B12 ; Europe
    Language English
    Dates of publication 2014-03
    Size p. 199-209.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 582432-1
    ISSN 1879-0739 ; 0271-5317
    ISSN (online) 1879-0739
    ISSN 0271-5317
    DOI 10.1016/j.nutres.2014.01.006
    Database NAL-Catalogue (AGRICOLA)

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