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  1. Article ; Online: Pharmacogenetics of aminoglycoside-related ototoxicity: a systematic review.

    Gaafar, D / Baxter, N / Cranswick, N / Christodoulou, J / Gwee, A

    The Journal of antimicrobial chemotherapy

    2024  

    Abstract: Background: Aminoglycosides (AGs) are important antibiotics in the treatment of Gram-negative sepsis. However, they are associated with the risk of irreversible sensorineural hearing loss (SNHL). Several genetic variants have been implicated in the ... ...

    Abstract Background: Aminoglycosides (AGs) are important antibiotics in the treatment of Gram-negative sepsis. However, they are associated with the risk of irreversible sensorineural hearing loss (SNHL). Several genetic variants have been implicated in the development of ototoxicity.
    Objectives: To evaluate the pharmacogenetic determinants of AG-related ototoxicity.
    Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses and was registered on Prospero (CRD42022337769). In Dec 2022, PubMed, Cochrane Library, Embase and MEDLINE were searched. Included studies were those reporting original data on the effect of the AG-exposed patient's genome on the development of ototoxicity.
    Results: Of 10 202 studies, 31 met the inclusion criteria. Twenty-nine studies focused on the mitochondrial genome, while two studied the nuclear genome. One study of neonates found that 30% of those with the m.1555A > G variant failed hearing screening after AG exposure (level 2 evidence). Seventeen additional studies found the m.1555A > G variant was associated with high penetrance (up to 100%) of SNHL after AG exposure (level 3-4 evidence). Nine studies of m.1494C > T found the penetrance of AG-related SNHL to be up to 40%; however, this variant was also identified in those with SNHL without AG exposure (level 3-4 evidence). The variants m.1005T > C and m.1095T > C may be associated with AG-related SNHL; however, further studies are needed.
    Conclusions: This review found that the m.1555A > G and m.1494C > T variants in the MT-RNR1 gene have the strongest evidence in the development of AG-related SNHL, although study quality was limited (level 2-4). These variants were associated with high penetrance of a SNHL phenotype following AG exposure.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae106
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  2. Book ; Conference proceedings: Selected papers / 9th International Conference on Pteridines and Related Biogenic Amines

    Christodoulou, J.

    Port Douglas, Australia, 19th - 24th May, 1996

    1996  

    Event/congress International Conference on Pteridines and Related Biogenic Amines (9, 1996, Douglas)
    Author's details (eds.: J. Christodoulou ...)
    Keywords Pteridines / congresses
    Language English
    Document type Book ; Conference proceedings
    Note In: Pteridines. - ISSN 0933-4807. - 7 (1996),3, S. 87 - 112
    HBZ-ID HT007400698
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 2647 -7- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: The Concurrent and Longitudinal Relationship between Perinatal Sleep Difficulties and Depression in a Large Sample of High-Risk Women in South Africa.

    Asarnow, L D / Norwood, P P / Christodoulou, J / Tomlinson, M / Rotheram-Borus, M J

    Maternal and child health journal

    2023  Volume 28, Issue 4, Page(s) 700–707

    Abstract: Introduction: Perinatal depression and sleep difficulties are common among studies conducted in high income countries (HIC). This study examines the relationship between sleep difficulties and depression during the perinatal period and over an eight- ... ...

    Abstract Introduction: Perinatal depression and sleep difficulties are common among studies conducted in high income countries (HIC). This study examines the relationship between sleep difficulties and depression during the perinatal period and over an eight-year follow-up period in South Africa, a middle income country.
    Method: A population cohort of 1238 pregnant women (mean age = 26.33) in 24 township neighborhoods in South Africa were recruited and reassessed six times over the next 8 years post birth with follow-up rates of 96-83%. The relationship between maternal depressed mood and sleep difficulties was examined over time, as well as the relationship of sleep with other socioeconomic, environmental, and psychiatric risk factors.
    Results: Thirty-five percent of the women reported sleep difficulties during the perinatal period; whereas only 8% reported sleep difficulties at 8-year follow-up. Perinatal sleep difficulties were associated with lower income, lower educational attainment, less access to electricity, more food insecurity, higher rates of interpersonal violence and HIV, alcohol consumption, and depressed mood at 8 years. However, the severity of depressed mood was the strongest predictor of sleep problems longitudinally and cross-sectionally, after accounting for all other risk factors.
    Conclusions: We found that the severity of depressed mood is highly associated with sleep difficulties from pregnancy to 8 years post-birth and in a linear relationship, so that higher depressed mood is associated with more sleep problems.
    Trial registration: ClinicalTrials.gov registration: # NCT00996528.
    MeSH term(s) Female ; Pregnancy ; Humans ; Adult ; Mothers/psychology ; Depression/epidemiology ; Depression/psychology ; South Africa/epidemiology ; Pregnant Women/psychology ; Sleep Initiation and Maintenance Disorders
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-023-03850-x
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  4. Article ; Online: Analysis of conformational exchange processes using methyl-TROSY-based Hahn echo measurements of quadruple-quantum relaxation.

    Waudby, Christopher A / Christodoulou, John

    Magnetic resonance (Gottingen, Germany)

    2021  Volume 2, Issue 2, Page(s) 777–793

    Abstract: Transverse nuclear spin relaxation is a sensitive probe of chemical exchange on timescales on the order of microseconds to milliseconds. Here we present an experiment for the simultaneous measurement of the relaxation rates of two quadruple-quantum ... ...

    Abstract Transverse nuclear spin relaxation is a sensitive probe of chemical exchange on timescales on the order of microseconds to milliseconds. Here we present an experiment for the simultaneous measurement of the relaxation rates of two quadruple-quantum transitions in
    Language English
    Publishing date 2021-11-03
    Publishing country Germany
    Document type Journal Article
    ISSN 2699-0016
    ISSN (online) 2699-0016
    DOI 10.5194/mr-2-777-2021
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  5. Article ; Online: NMR Lineshape Analysis of Intrinsically Disordered Protein Interactions.

    Waudby, Christopher A / Christodoulou, John

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2141, Page(s) 477–504

    Abstract: Interactions of intrinsically disordered proteins are central to their cellular functions, and solution-state NMR spectroscopy provides a powerful tool for characterizing both structural and mechanistic aspects of such interactions. Here we focus on the ... ...

    Abstract Interactions of intrinsically disordered proteins are central to their cellular functions, and solution-state NMR spectroscopy provides a powerful tool for characterizing both structural and mechanistic aspects of such interactions. Here we focus on the analysis of IDP interactions using NMR titration measurements. Changes in resonance lineshapes in two-dimensional NMR spectra upon titration with a ligand contain rich information on structural changes in the protein and the thermodynamics and kinetics of the interaction, as well as on the microscopic association mechanism. Here we present protocols for the optimal design of titration experiments, data acquisition, and data analysis by two-dimensional lineshape fitting using the TITAN software package.
    MeSH term(s) Automation ; Hydrogen ; Intrinsically Disordered Proteins/chemistry ; Kinetics ; Nuclear Magnetic Resonance, Biomolecular/instrumentation ; Nuclear Magnetic Resonance, Biomolecular/methods ; Software ; Thermodynamics
    Chemical Substances Intrinsically Disordered Proteins ; Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0524-0_24
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  6. Article ; Online: Ending HIV/AIDS: Not as close as many would have us believe.

    Rotheram-Borus, M J / Gordon, S / Christodoulou, J / Tomlinson, M

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2020  Volume 110, Issue 2, Page(s) 12848

    MeSH term(s) Acquired Immunodeficiency Syndrome/epidemiology ; Child ; Child, Preschool ; Disease Eradication ; Female ; Global Health ; HIV Infections/epidemiology ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/prevention & control ; Pregnancy Complications, Infectious/virology ; South Africa/epidemiology
    Language English
    Publishing date 2020-01-30
    Publishing country South Africa
    Document type Letter
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0038-2469 ; 0256-9574
    ISSN (online) 2078-5135
    ISSN 0038-2469 ; 0256-9574
    DOI 10.7196/10.7196/SAMJ.2020.v110i2.14526
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    Zs.MO 645: Show issues

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  7. Article ; Online: Any symptom, in any organ, at any age: A case report of multiple genetic diagnoses mimicking mitochondrial disease in an adult with kidney disease.

    Ratnayake, Chathri / Rius, Rocio / Wallis, Mathew / Raj, Rajesh / Christodoulou, John

    Nephrology (Carlton, Vic.)

    2022  Volume 27, Issue 7, Page(s) 640–641

    MeSH term(s) Adult ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/genetics ; Mitochondrial Diseases/diagnosis ; Mitochondrial Diseases/genetics
    Language English
    Publishing date 2022-02-06
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14023
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    Zs.A 4822: Show issues Location:
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  8. Article ; Online: Longitudinal Association Between Intimate Partner Violence and Alcohol Use in a Population Cohort of South African Women.

    Yalch, Matthew M / Christodoulou, Joan / Rotheram-Borus, Mary Jane / Tomlinson, Mark

    Journal of interpersonal violence

    2022  Volume 38, Issue 1-2, Page(s) NP1718–NP1737

    Abstract: Intimate partner violence (IPV) is a common traumatic stressor for women worldwide, especially for women living in low-and-middle-income countries. One of the most common correlates of IPV victimization is alcohol use, but the dynamics of IPV and ... ...

    Abstract Intimate partner violence (IPV) is a common traumatic stressor for women worldwide, especially for women living in low-and-middle-income countries. One of the most common correlates of IPV victimization is alcohol use, but the dynamics of IPV and drinking among women are not well understood. Although some research suggests that women drink in the aftermath of IPV to cope with distress related to the violence they experienced, other studies imply that higher levels of alcohol use among one or both partners in a relationship make violence more likely. In this study, we examine this question in a secondary analysis of a longitudinal study of a population cohort of pregnant women in South Africa (
    MeSH term(s) Female ; Humans ; Pregnancy ; South Africa/epidemiology ; Longitudinal Studies ; Bayes Theorem ; Intimate Partner Violence ; Pregnant Women ; Sexual Partners ; Risk Factors
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2028900-5
    ISSN 1552-6518 ; 0886-2605
    ISSN (online) 1552-6518
    ISSN 0886-2605
    DOI 10.1177/08862605221092068
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  9. Article ; Online: Thermodynamics of co-translational folding and ribosome-nascent chain interactions.

    Waudby, Christopher A / Burridge, Charles / Cabrita, Lisa D / Christodoulou, John

    Current opinion in structural biology

    2022  Volume 74, Page(s) 102357

    Abstract: Proteins can begin the conformational search for their native structure in parallel with biosynthesis on the ribosome, in a process termed co-translational folding. In contrast to the reversible folding of isolated domains, as a nascent chain emerges ... ...

    Abstract Proteins can begin the conformational search for their native structure in parallel with biosynthesis on the ribosome, in a process termed co-translational folding. In contrast to the reversible folding of isolated domains, as a nascent chain emerges from the ribosome exit tunnel during translation the free energy landscape it explores also evolves as a function of chain length. While this presents a substantially more complex measurement problem, this review will outline the progress that has been made recently in understanding, quantitatively, the process by which a nascent chain attains its full native stability, as well as the mechanisms through which interactions with the nearby ribosome surface can perturb or modulate this process.
    MeSH term(s) Entropy ; Protein Biosynthesis ; Protein Folding ; Proteins/chemistry ; Ribosomes/metabolism
    Chemical Substances Proteins
    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2022.102357
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  10. Article ; Online: Storing paediatric genomic data for sequential interrogation across the lifespan.

    Gyngell, Christopher / Lynch, Fiona / Vears, Danya / Bowman-Smart, Hilary / Savulescu, Julian / Christodoulou, John

    Journal of medical ethics

    2023  

    Abstract: Genomic sequencing (GS) is increasingly used in paediatric medicine to aid in screening, research and treatment. Some health systems are trialling GS as a first-line test in newborn screening programmes. Questions about what to do with genomic data after ...

    Abstract Genomic sequencing (GS) is increasingly used in paediatric medicine to aid in screening, research and treatment. Some health systems are trialling GS as a first-line test in newborn screening programmes. Questions about what to do with genomic data after it has been generated are becoming more pertinent. While other research has outlined the ethical reasons for storing deidentified genomic data to be used in research, the ethical case for storing data for future clinical use has not been explicated. In this paper, we examine the ethical case for storing genomic data with the intention of using it as a lifetime health resource. In this model, genomic data would be stored with the intention of reanalysis at certain points through one's life. We argue this could benefit individuals and create an important public resource. However, several ethical challenges must first be met to achieve these benefits. We explore issues related to privacy, consent, justice and equality. We conclude by arguing that health systems should be moving towards futures that allow for the sequential interrogation of genomic data throughout the lifespan.
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/jme-2022-108471
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