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  1. Article ; Online: Detours increase local knowledge-Exploring the hidden benefits of self-control failure.

    Christian Dirk Wiesner / Jennifer Meyer / Christoph Lindner

    PLoS ONE, Vol 16, Iss 10, p e

    2021  Volume 0257717

    Abstract: Self-control enables people to override momentary thoughts, emotions, or impulses in order to pursue long-term goals. Good self-control is a predictor for health, success, and subjective well-being, as bad self-control is for the opposite. Therefore, the ...

    Abstract Self-control enables people to override momentary thoughts, emotions, or impulses in order to pursue long-term goals. Good self-control is a predictor for health, success, and subjective well-being, as bad self-control is for the opposite. Therefore, the question arises why evolution has not endowed us with perfect self-control. In this article, we draw some attention to the hidden benefits of self-control failure and present a new experimental paradigm that captures both costs and benefits of self-control failure. In an experiment, participants worked on three consecutive tasks: 1) In a transcription task, we manipulated how much effortful self-control two groups of participants had to exert. 2) In a number-comparison task, participants of both groups were asked to compare numbers and ignore distracting neutral versus reward-related pictures. 3) After a pause for recreation, participants were confronted with an unannounced recognition task measuring whether they had incidentally encoded the distracting pictures during the previous number-comparison task. The results showed that participants who exerted a high amount of effortful self-control during the first task shifted their priorities and attention toward the distractors during the second self-control demanding task: The cost of self-control failure was reflected in worse performance in the number-comparison task. Moreover, the group which had exerted a high amount of self-control during the first task and showed self-control failure during the second task was better in the unannounced third task. The benefit of self-control failure during number comparison was reflected in better performance during the recognition task. However, costs and benefits were not specific for reward-related distractors but also occurred with neutral pictures. We propose that the hidden benefit of self-control failure lies in the exploration of distractors present during goal pursuit, i.e. the collection of information about the environment and the potential discovery of new ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Increased Risk Perception, Distress Intolerance and Health Anxiety in Stricter Lockdowns

    Christoph Lindner / Ibolya Kotta / Eszter Eniko Marschalko / Kinga Szabo / Kinga Kalcza-Janosi / Jan Retelsdorf

    International Journal of Environmental Research and Public Health, Vol 19, Iss 5098, p

    Self-Control as a Key Protective Factor in Early Response to the COVID-19 Pandemic

    2022  Volume 5098

    Abstract: Studies provide evidence that distress, (health) anxiety, and depressive symptoms were high during the first weeks of COVID-19 lockdown restrictions, decreasing over time (possibly due to individuals’ protective psychological factors). Relations between ... ...

    Abstract Studies provide evidence that distress, (health) anxiety, and depressive symptoms were high during the first weeks of COVID-19 lockdown restrictions, decreasing over time (possibly due to individuals’ protective psychological factors). Relations between different lockdown restrictions, mental health issues, and protective factors need to be explored, since even small lockdown effects might increase the risk of future mental health issues. We merged objective lockdown stringency data with individual data ( N = 1001) to examine differences in lockdown effects in strict lockdown (Romania) and mild lockdown (Hungary) conditions between March and May 2020 on stressors and mental health symptoms, taking protective factors into account. The stricter lockdown in Romania revealed higher levels of perceived risk of infection, distress intolerance, and COVID-19 health anxiety. Protective psychological factors were not affected by the lockdown measures. Surpassing psychological flexibility and resilient coping, self-control proved to be the most promising protective factor. It is recommended that future research merge objective data with study data to investigate the effects of different COVID-19 lockdown measures on mental health and protective factors. Policy decisions should consider lockdown-dependent consequences of mental health issues. Intervention programs are suggested to mitigate mental health issues and to strengthen peoples’ protective psychological factors.
    Keywords COVID-19 ; lockdown stringency ; mental health ; self-control ; Hungary ; Romania ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Weakening self-control biases the emotional evaluation of appetitive cues.

    Christian Dirk Wiesner / Christoph Lindner

    PLoS ONE, Vol 12, Iss 1, p e

    2017  Volume 0170245

    Abstract: Exerting self-control in a first task weakens self-control in a second completely unrelated task (ego-depletion). It has been proposed that ego-depletion increases approach motivation which would amplify positive emotions to appetitive cues. Here we ... ...

    Abstract Exerting self-control in a first task weakens self-control in a second completely unrelated task (ego-depletion). It has been proposed that ego-depletion increases approach motivation which would amplify positive emotions to appetitive cues. Here we investigated the effect of the depletion of cognitive self-control on the subsequent emotional evaluation of appetitive cues. Participants of the depletion group copied a text omitting frequent letters and thereby exerting self-control to inhibit automated writing habits. Participants of the control group just copied the text. In a subsequent task participants had to rate valence and arousal of their responses to neutral vs. positive pictures of humans, animals, food, or sceneries. Ego-depletion caused more positive valence ratings of neutral pictures and lower arousal ratings of positive pictures. The findings do not support the notion that ego-depletion increases approach motivation in general. Rather they suggest that-without a specific motivational context-depletion of cognitive self-control differentially alters the immediate emotional evaluation of appetitive cues.
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A new perspective on the interplay between self-control and cognitive performance

    Christoph Lindner / Gabriel Nagy / Wolfgang Andreas Ramos Arhuis / Jan Retelsdorf

    PLoS ONE, Vol 12, Iss 6, p e

    Modeling progressive depletion patterns.

    2017  Volume 0180149

    Abstract: Exerting self-control in a first task weakens self-control performance in a subsequent unrelated task (ego depletion). In self-control research new strategies are required to investigate the ego-depletion effect, which has recently been shown to be more ... ...

    Abstract Exerting self-control in a first task weakens self-control performance in a subsequent unrelated task (ego depletion). In self-control research new strategies are required to investigate the ego-depletion effect, which has recently been shown to be more fragile than previously assumed. Moreover, the relation between ego depletion and trait self-control is still unclear, as various studies have reported heterogeneous findings concerning the interplay of both variables. We addressed these lacunas by drawing on a sample of N = 120 students, who participated in two test sessions. In the first test session, we assessed trait self-control and several control variables. The second test session followed an experimental design and tested the effects of ego depletion on invested effort and cognitive performance trajectories in an ecologically valid computer-based assessment setting (i.e., a 30-minute mathematical problem-solving and reasoning test). Trait self-control was then used as a moderator of the ego-depletion effect. Combining an established ego-depletion paradigm (i.e., the sequential-task paradigm) with multilevel modeling of time-on-task and performance changes, our results indicate (1) that trait self-control predicted the motivation to solve cognitive tasks, (2) that ego depletion led to a progressive performance decrease, and (3) that the negative effect of ego depletion on performance was stronger for students with high trait self-control. Additional analyses revealed that our results could not be alternatively explained by fatigue effects. All effects were robust even after controlling for the students' cognitive abilities, which are known to be closely related to mathematical performance. Our results provide evidence that the self-control invested in order to keep performance at a consistently high level wanes over time. By modeling progressive ego-depletion effects while considering trait self-control, we provide an alternative approach that may help future researchers to investigate the underlying ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Cation affinity numbers of Lewis bases

    Christoph Lindner / Raman Tandon / Boris Maryasin / Evgeny Larionov / Hendrik Zipse

    Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1406-

    2012  Volume 1442

    Abstract: Using selected theoretical methods the affinity of a large range of Lewis bases towards model cations has been quantified. The range of model cations includes the methyl cation as the smallest carbon-centered electrophile, the benzhydryl and trityl ... ...

    Abstract Using selected theoretical methods the affinity of a large range of Lewis bases towards model cations has been quantified. The range of model cations includes the methyl cation as the smallest carbon-centered electrophile, the benzhydryl and trityl cations as models for electrophilic substrates encountered in Lewis base-catalyzed synthetic procedures, and the acetyl cation as a substrate model for acyl-transfer reactions. Affinities towards these cationic electrophiles are complemented by data for Lewis-base addition to Michael acceptors as prototypical neutral electrophiles.
    Keywords ab initio ; cation affinity ; Lewis basicity ; organocatalysis ; proton affinity ; Science ; Q ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2012-08-01T00:00:00Z
    Publisher Beilstein-Institut
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice.

    Ilona Hauber / Helga Hofmann-Sieber / Jan Chemnitz / Danilo Dubrau / Janet Chusainow / Rolf Stucka / Philip Hartjen / Axel Schambach / Patrick Ziegler / Karl Hackmann / Evelin Schröck / Udo Schumacher / Christoph Lindner / Adam Grundhoff / Christopher Baum / Markus G Manz / Frank Buchholz / Joachim Hauber

    PLoS Pathogens, Vol 9, Iss 9, p e

    2013  Volume 1003587

    Abstract: Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. However, ... ...

    Abstract Stable integration of HIV proviral DNA into host cell chromosomes, a hallmark and essential feature of the retroviral life cycle, establishes the infection permanently. Current antiretroviral combination drug therapy cannot cure HIV infection. However, expressing an engineered HIV-1 long terminal repeat (LTR) site-specific recombinase (Tre), shown to excise integrated proviral DNA in vitro, may provide a novel and highly promising antiviral strategy. We report here the conditional expression of Tre-recombinase from an advanced lentiviral self-inactivation (SIN) vector in HIV-infected cells. We demonstrate faithful transgene expression, resulting in accurate provirus excision in the absence of cytopathic effects. Moreover, pronounced Tre-mediated antiviral effects are demonstrated in vivo, particularly in humanized Rag2⁻/⁻γc⁻/⁻ mice engrafted with either Tre-transduced primary CD4⁺ T cells, or Tre-transduced CD34⁺ hematopoietic stem and progenitor cells (HSC). Taken together, our data support the use of Tre-recombinase in novel therapy strategies aiming to provide a cure for HIV.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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