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  1. Article ; Online: The COPD Foundation's COPD360Net Initiative Approach to Patient-Centric Drug Development

    Ruth Tal-Singer PhD / Bruce E Miller PhD / Jean M Rommes PhD / Mark A Luttmann BS / Christophe Demaison PhD / M Bradley Drummond MD / Cara B Pasquale MPH

    Journal of Patient Experience, Vol

    A Case Study in Using Patient Surveys to Inform New Treatments for Viral Respiratory Infections

    2023  Volume 10

    Abstract: Patient-centric drug development is crucial to creating treatments that address unmet patient needs but is often ignored. The COPD Foundation's COPD360Net ® includes a multistakeholder approach for operationalizing patient-centric development of ... ...

    Abstract Patient-centric drug development is crucial to creating treatments that address unmet patient needs but is often ignored. The COPD Foundation's COPD360Net ® includes a multistakeholder approach for operationalizing patient-centric development of treatments where patients, caregivers, scientists, and clinicians review opportunities based on scientific merit, potential to address an unmet need, and feasibility of adoption. COPD360Net deploys large-scale online community surveys to review profiles of potential therapies based on those criteria. This approach was implemented to inform the development of an intranasal spray to prevent viral respiratory infections (VRIs), a major cause of exacerbations in people with chronic lung diseases. Insights included: Of the 376 respondents with COPD surveyed, frequent exacerbators reported strong interest in a new type of antiviral nasal spray to prevent VRI. Patient survey and advisory committee insights demonstrated that a pan antiviral nasal spray has potential high value to both clinicians and patients and informed the COPD360Net decision to partner on its development. Including patient perspectives from the outset can be conducted efficiently by mobilizing an engaged online patient community.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

    Georgia Deliyannis / Chinn Yi Wong / Hayley A. McQuilten / Annabell Bachem / Michele Clarke / Xiaoxiao Jia / Kylie Horrocks / Weiguang Zeng / Jason Girkin / Nichollas E. Scott / Sarah L. Londrigan / Patrick C. Reading / Nathan W. Bartlett / Katherine Kedzierska / Lorena E. Brown / Francesca Mercuri / Christophe Demaison / David C. Jackson / Brendon Y. Chua

    JCI Insight, Vol 6, Iss

    2021  Volume 5

    Abstract: The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections pose an equal and ongoing risk of severe disease. Moreover, vaccines and antiviral drugs are not always effective or available ...

    Abstract The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections pose an equal and ongoing risk of severe disease. Moreover, vaccines and antiviral drugs are not always effective or available for many respiratory viruses. We investigated how induction of effective and appropriate antigen-independent innate immunity in the upper airways can prevent the spread of respiratory virus infection to the vulnerable lower airways. Activation of TLR2, when restricted to the nasal turbinates, resulted in prompt induction of innate immune–driven antiviral responses through action of cytokines, chemokines, and cellular activity in the upper but not the lower airways. We have defined how nasal epithelial cells and recruitment of macrophages work in concert and play pivotal roles to limit progression of influenza virus to the lungs and sustain protection for up to 7 days. These results reveal underlying mechanisms of how control of viral infection in the upper airways can occur and support the implementation of strategies that can activate TLR2 in nasal passages to provide rapid protection, especially for at-risk populations, against severe respiratory infection when vaccines and antiviral drugs are not always effective or available.
    Keywords Infectious disease ; Therapeutics ; Medicine ; R
    Subject code 610 ; 570
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

    Pamela C. Proud / Daphne Tsitoura / Robert J. Watson / Brendon Y. Chua / Marilyn J. Aram / Kevin R. Bewley / Breeze E. Cavell / Rebecca Cobb / Stuart Dowall / Susan A. Fotheringham / Catherine M.K. Ho / Vanessa Lucas / Didier Ngabo / Emma Rayner / Kathryn A. Ryan / Gillian S. Slack / Stephen Thomas / Nadina I. Wand / Paul Yeates /
    Christophe Demaison / Weiguang Zeng / Ian Holmes / David C. Jackson / Nathan W. Bartlett / Francesca Mercuri / Miles W. Carroll

    EBioMedicine, Vol 63, Iss , Pp 103153- (2021)

    2021  

    Abstract: Background: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in the upper respiratory tract (URT). Infected individuals are often asymptomatic, ...

    Abstract Background: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in the upper respiratory tract (URT). Infected individuals are often asymptomatic, yet highly infectious and readily transmit virus. A therapy that restricts initial replication in the URT has the potential to prevent progression of severe lower respiratory tract disease as well as limiting person-to-person transmission. Methods: SARS-CoV-2 Victoria/01/2020 was passaged in Vero/hSLAM cells and virus titre determined by plaque assay. Challenge virus was delivered by intranasal instillation to female ferrets at 5.0 × 106 pfu/ml. Treatment groups received intranasal INNA-051, developed by Ena Respiratory. SARS-CoV-2 RNA was detected using the 2019-nCoV CDC RUO Kit and QuantStudio™ 7 Flex Real-Time PCR System. Histopathological analysis was performed using cut tissues stained with haematoxylin and eosin (H&E). Findings: We show that prophylactic intra-nasal administration of the TLR2/6 agonist INNA-051 in a SARS-CoV-2 ferret infection model effectively reduces levels of viral RNA in the nose and throat. After 5 days post-exposure to SARS-CoV-2, INNA-051 significantly reduced virus in throat swabs (p=<0.0001) by up to a 24 fold (96% reduction) and in nasal wash (p=0.0107) up to a 15 fold (93% reduction) in comparison to untreated animals. Interpretation: The results of our study support clinical development of a therapy based on prophylactic TLR2/6 innate immune activation in the URT, to reduce SARS-CoV-2 transmission and provide protection against COVID-19. Funding: This work was funded by Ena Respiratory, Melbourne, Australia.
    Keywords Ferret ; COVID-19 ; SARS-CoV-2 ; Viral shedding ; TLR-2 ; INNA-051 ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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