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  1. Book ; Online ; E-Book: Dementia

    Christopher, Gary

    current perspectives in research and treatment

    2023  

    Abstract: This book explores how our conception of dementia has changed since its initial discovery, taking in advancements in knowledge that translate into better ways to manage the condition. ...

    Author's details Gary Christopher
    Abstract This book explores how our conception of dementia has changed since its initial discovery, taking in advancements in knowledge that translate into better ways to manage the condition.
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (viii, 248 Seiten)
    Publisher Routledge, Taylor & Francis Group
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030021678
    ISBN 978-1-317-40060-8 ; 978-1-315-68158-0 ; 9781138904101 ; 9781138904118 ; 1-317-40060-7 ; 1-315-68158-7 ; 1138904104 ; 1138904112
    DOI 10.4324/9781315681580
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Depression

    Christopher, Gary

    Current Perspectives in Research and Treatment

    2018  

    Abstract: Depression, now recognized as a significant source of disability across the globe, is something many of us will be familiar with. This book explores the way people have discussed depression and examines how scientific understanding has led to ways to ... ...

    Author's details Gary Christopher, PhD, is a gerontologist working in the Centre for Innovative Ageing at Swansea University. His research focuses on memory and emotion regulation within the context of older adult mental health. He is particularly interested in dementia as an existential threat and ways to mitigate the impact
    Abstract Depression, now recognized as a significant source of disability across the globe, is something many of us will be familiar with. This book explores the way people have discussed depression and examines how scientific understanding has led to ways to better appreciate and treat the condition. -- Through evaluations of contemporary research and literature, this book examines how depression has been depicted throughout history and presents an up-to-date account of how a diagnosis is made. Offe...
    Keywords Clinical Psychology ; cognitive neuropsychology ; Depression ; MERS ; Progressive Disease ; Social Jetlag ; Anorexia Nervosa ; Treatment Resistant Depression ; Light Therapy ; Significant Executive Dysfunction ; Premenstrual Dysphoric Disorder ; Thyroid Function ; Deep Brain Stimulation ; White Blood Cells ; Trait EI ; White Matter Hyperintensities Lesions ; White Cell ; VNS ; Default Mode Network ; Vulnerability Stress Models ; Melatonergic Antidepressants ; Reminiscence Therapy ; Late Onset Depression ; Salivary Gland Hypofunction ; Low Social Status Groups ; St John's Wort ; Instrumental Conditioning ; Safer Toxicity Profile
    Language English
    Size 200 p.
    Edition 1
    Publisher Taylor & Francis Ltd
    Document type Book
    Note PDA Manuell_22
    Format 234 x 154 x 14
    ISBN 9781138904149 ; 1138904147
    Database PDA

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  3. Book ; Online: The Immunobiology of HLA-Haploidentical Hematopoietic Cell Transplantation

    Mancusi, Antonella / Pierini, Antonio / Kanakry, Christopher G.

    2020  

    Keywords Medicine ; Immunology ; haploidentical transplantation ; T-cell depleted grafts ; T-cell-replete grafts ; post-transplantation cyclophosphamide ; immune reconstitution ; adoptive cell therapy ; regulatory T cells ; immune evasion
    Size 1 electronic resource (153 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230211
    ISBN 9782889638246 ; 2889638243
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Papillary Renal Cell Carcinoma: Evolving Classification by Combined Morphologic and Molecular Means.

    Przybycin, Christopher G

    Advances in anatomic pathology

    2024  Volume 31, Issue 3, Page(s) 147–156

    Abstract: Papillary renal cell carcinoma classification has evolved as a result of attentive morphologic observations by pathologists coupled with specific immunohistochemical, molecular, and clinical data. Refinement of this relatively common diagnostic category ... ...

    Abstract Papillary renal cell carcinoma classification has evolved as a result of attentive morphologic observations by pathologists coupled with specific immunohistochemical, molecular, and clinical data. Refinement of this relatively common diagnostic category of renal neoplasia has resulted in the parsing out of specific renal cell carcinoma subtypes that no longer belong in the papillary renal cell carcinoma category and can have distinct familial and prognostic implications (eg, fumarate hydratase (FH)-deficient renal cell carcinomas). In addition, evolving classification has enabled more accurate diagnosis by surgical pathologists (through the description of recognizable morphologic variants). In many cases, molecular findings have aided and confirmed morphologic categorization. The combination of morphologic and molecular findings continues to provide important prognostic information for patients and their clinicians.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Fumarate Hydratase ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Prognosis
    Chemical Substances Fumarate Hydratase (EC 4.2.1.2)
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212493-x
    ISSN 1533-4031 ; 1072-4109
    ISSN (online) 1533-4031
    ISSN 1072-4109
    DOI 10.1097/PAP.0000000000000434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4118: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: State Medical Board Reform: A Patient Safety Imperative.

    Roy, Christopher G

    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

    2024  Volume 51, Issue 4, Page(s) 954–955

    MeSH term(s) Humans ; United States ; Patient Safety
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1168812-9
    ISSN 1748-720X ; 1073-1105 ; 0277-8459
    ISSN (online) 1748-720X
    ISSN 1073-1105 ; 0277-8459
    DOI 10.1017/jme.2024.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2075: Show issues Location:
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  6. Article ; Online: Epigenomic insights into common human disease pathology.

    Bell, Christopher G

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 178

    Abstract: The epigenome-the chemical modifications and chromatin-related packaging of the genome-enables the same genetic template to be activated or repressed in different cellular settings. This multi-layered mechanism facilitates cell-type specific function by ... ...

    Abstract The epigenome-the chemical modifications and chromatin-related packaging of the genome-enables the same genetic template to be activated or repressed in different cellular settings. This multi-layered mechanism facilitates cell-type specific function by setting the local sequence and 3D interactive activity level. Gene transcription is further modulated through the interplay with transcription factors and co-regulators. The human body requires this epigenomic apparatus to be precisely installed throughout development and then adequately maintained during the lifespan. The causal role of the epigenome in human pathology, beyond imprinting disorders and specific tumour suppressor genes, was further brought into the spotlight by large-scale sequencing projects identifying that mutations in epigenomic machinery genes could be critical drivers in both cancer and developmental disorders. Abrogation of this cellular mechanism is providing new molecular insights into pathogenesis. However, deciphering the full breadth and implications of these epigenomic changes remains challenging. Knowledge is accruing regarding disease mechanisms and clinical biomarkers, through pathogenically relevant and surrogate tissue analyses, respectively. Advances include consortia generated cell-type specific reference epigenomes, high-throughput DNA methylome association studies, as well as insights into ageing-related diseases from biological 'clocks' constructed by machine learning algorithms. Also, 3rd-generation sequencing is beginning to disentangle the complexity of genetic and DNA modification haplotypes. Cell-free DNA methylation as a cancer biomarker has clear clinical utility and further potential to assess organ damage across many disorders. Finally, molecular understanding of disease aetiology brings with it the opportunity for exact therapeutic alteration of the epigenome through CRISPR-activation or inhibition.
    MeSH term(s) Humans ; Epigenomics ; Algorithms ; Biological Clocks ; Biomarkers, Tumor ; Cell-Free Nucleic Acids
    Chemical Substances Biomarkers, Tumor ; Cell-Free Nucleic Acids
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05206-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
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  7. Book: Practical radiation oncology for surgeons

    Willett, Christopher G.

    (Surgical oncology clinics of North America ; 22,3)

    2013  

    Author's details ed. Christopher G. Willett
    Series title Surgical oncology clinics of North America ; 22,3
    Collection
    Language English
    Size XVI S., S. 406 - 628 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT017680415
    ISBN 978-1-4557-7614-6 ; 1-4557-7614-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1339 -22,3- verfügbar in Königswinter Königswinter

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  8. Article ; Online: Respiration: The circuit for hypoxia-induced sighs.

    Wilson, Christopher G

    Current biology : CB

    2023  Volume 33, Issue 9, Page(s) R371–R374

    Abstract: Sighs are a response to hypoxia, altered lung volume, and emotional state. A recent study employing in vivo physiology, optogenetics, chemoablation, and genetic silencing shows the importance of gastrin releasing peptide-expressing neurons in mediating ... ...

    Abstract Sighs are a response to hypoxia, altered lung volume, and emotional state. A recent study employing in vivo physiology, optogenetics, chemoablation, and genetic silencing shows the importance of gastrin releasing peptide-expressing neurons in mediating sighs.
    MeSH term(s) Humans ; Respiration ; Emotions ; Gastrin-Releasing Peptide ; Gene Silencing ; Hypoxia
    Chemical Substances Gastrin-Releasing Peptide (80043-53-4)
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.03.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3208: Show issues Location:
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  9. Article ; Online: Understanding and explaining depression: From Karl Jaspers to Karl Friston.

    Davey, Christopher G

    The Australian and New Zealand journal of psychiatry

    2023  Volume 58, Issue 1, Page(s) 5–9

    MeSH term(s) Humans ; Depression/drug therapy ; Mental Disorders ; Psychopathology ; Germany
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Editorial
    ZDB-ID 221140-3
    ISSN 1440-1614 ; 0004-8674
    ISSN (online) 1440-1614
    ISSN 0004-8674
    DOI 10.1177/00048674231219178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 856: Show issues Location:
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  10. Article ; Online: There ain't no such thing as a free lunch - especially in physiology software development.

    Wilson, Christopher G

    The Journal of physiology

    2023  Volume 601, Issue 21, Page(s) 4649–4650

    MeSH term(s) Software ; Physiology
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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