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  1. AU="Christopher C. Ward"
  2. AU="Chavez, Luis Fernando(Universidade Federal do Rio Grande do Sul PPG Ciência do Solo)" AU="Chavez, Luis Fernando(Universidade Federal do Rio Grande do Sul PPG Ciência do Solo)"

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Artikel ; Online: ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants

Jeffrey Seow / Carl Graham / Sadie R. Hallett / Thomas Lechmere / Thomas J.A. Maguire / Isabella Huettner / Daniel Cox / Hataf Khan / Suzanne Pickering / Rebekah Roberts / Anele Waters / Christopher C. Ward / Christine Mant / Michael J. Pitcher / Jo Spencer / Julie Fox / Michael H. Malim / Katie J. Doores

Cell Reports, Vol 39, Iss 5, Pp 110757- (2022)

2022  

Abstract: Summary: Although the antibody response to COVID-19 vaccination has been studied extensively at the polyclonal level using immune sera, little has been reported on the antibody response at the monoclonal level. Here, we isolate a panel of 44 anti-SARS- ... ...

Abstract Summary: Although the antibody response to COVID-19 vaccination has been studied extensively at the polyclonal level using immune sera, little has been reported on the antibody response at the monoclonal level. Here, we isolate a panel of 44 anti-SARS-CoV-2 monoclonal antibodies (mAbs) from an individual who received two doses of the ChAdOx1 nCoV-19 (AZD1222) vaccine at a 12-week interval. We show that, despite a relatively low serum neutralization titer, Spike-reactive IgG+ B cells are still detectable 9 months post-boost. Furthermore, mAbs with potent neutralizing activity against the current SARS-CoV-2 variants of concern (Alpha, Gamma, Beta, Delta, and Omicron) are present. The vaccine-elicited neutralizing mAbs form eight distinct competition groups and bind epitopes overlapping with neutralizing mAbs elicited following SARS-CoV-2 infection. AZD1222-elicited mAbs are more mutated than mAbs isolated from convalescent donors 1–2 months post-infection. These findings provide molecular insights into the AZD1222 vaccine-elicited antibody response.
Schlagwörter CP: Immunology ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code) 570
Sprache Englisch
Erscheinungsdatum 2022-05-01T00:00:00Z
Verlag Elsevier
Dokumenttyp Artikel ; Online
Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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