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  1. AU="Christopher H Chapman"
  2. AU="Odor, Peter M."
  3. AU="Griesdale, Donald E G"
  4. AU="Allicock, Orchid"
  5. AU=Alderton Alexandra
  6. AU=Zhao Guanlan
  7. AU="Seiradake, Elena"
  8. AU="Daqiu Yin"
  9. AU="Ribeiro, Miriam O"
  10. AU="Zhang, Yuanlin"
  11. AU="Conturso, Alaina C"
  12. AU="Wang, Zuyi"
  13. AU="Ambade, Preshit Nemdas"
  14. AU="Sarmah, Deepraj"
  15. AU="Little, James W."
  16. AU="Templin, Zoe"
  17. AU="Levick, Samantha"
  18. AU="Tatakis, Fotis"
  19. AU="de Vries, Florentine R"
  20. AU="Tsai, Y-T" AU="Tsai, Y-T"
  21. AU="Gonakoti, Sriram"
  22. AU="Wulf, J"
  23. AU="Mardsen, D"
  24. AU="James, David B A"
  25. AU="Montabone, Erika"
  26. AU="Susan J. Burke"
  27. AU="Chen, Yuguang"
  28. AU="Zhao, Zhenghuan"
  29. AU="De Chiara, Anna Rosaria"
  30. AU="Savage, Anne"
  31. AU="Salamanca, Albert"
  32. AU="Zhong, Xiao-Song"
  33. AU="Deguchi, Masashi"
  34. AU="Żmuda, J"
  35. AU="Liao, Yanyan"
  36. AU="Zhu, Jin-Wei"
  37. AU="Khan, Azkia"
  38. AU="Folkman, Judah"
  39. AU=Bhatia Rajesh
  40. AU="Thobois, Stéphane"
  41. AU="Lai, Chien-Chih"
  42. AU="Ahn, Bo Young"
  43. AU="Jeje, Olamide"
  44. AU="Fine, Samson W"
  45. AU="Riemann, Burkhard"
  46. AU="Nazir, Ahsan"
  47. AU="Kawakita, Emi"
  48. AU="Wang, Junnian"
  49. AU="Nie, Chong"

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  1. Artikel ; Online: Timing of Urgent Inpatient Palliative Radiation Therapy

    Susan Y. Wu, MD / Emily Yee, NP / Jason W. Chan, MD / Christopher H. Chapman, MD, MS / Lauren Boreta, MD / Steve E. Braunstein, MD, PhD

    Advances in Radiation Oncology, Vol 6, Iss 3, Pp 100670- (2021)

    2021  

    Abstract: Purpose: Urgent indications for palliative radiation therapy (RT) include malignant spinal cord compression, symptomatic brain metastases, pain, airway obstruction, and bleeding. Data on the timing of palliative RT in the inpatient setting are limited. ... ...

    Abstract Purpose: Urgent indications for palliative radiation therapy (RT) include malignant spinal cord compression, symptomatic brain metastases, pain, airway obstruction, and bleeding. Data on the timing of palliative RT in the inpatient setting are limited. We report our experience with inpatient palliative RT at a tertiary academic center and evaluate the effect of a dedicated inpatient palliative RT nurse practitioner (NP) on treatment timelines. Methods and Materials: We performed a retrospective, single-institution review of 219 inpatients consulted for RT to sites of metastatic disease between May 2012 and May 2018. We compared time-to-treatment intervals before and after integrating an NP for palliative RT in August 2017. Results: The median age of the 219 patients receiving RT was 61 years (interquartile range [IQR], 51-69 years). The most frequent indications were symptomatic brain metastases (73 patients [33%]), pain (61 patients [28%]), and cord/cauda compression (48 patients [22%]). The median time from consultation request to consult was 1 day (IQR, 0-2 days), and the median time from consultation request to first RT fraction was 3 days (IQR, 2-6 days). The median time from consultation request to RT was shorter for cord compression (2 [IQR, 1-4] days) than for pain (5 [IQR, 2-7] days) (P = .001) or symptomatic brain metastases (3 [IQR, 1-6] days; P = .037). With an NP, patients were more likely to undergo same-day consultation and simulation (75% vs 60%; P = .045), which was associated with shorter median duration from consultation to initiation of RT (1 [IQR, 0-3] days vs 4 [IQR, 2-7] days; P <.001). After the integration of an NP for palliative RT, patients had a higher median Karnofsky Performance Score (70 [IQR, 60-80] vs 50 [IQR, 40-60]; P < .001) and were more likely to complete their prescribed RT course (93% vs 82%; P = .05) Conclusions: Time from consultation request to RT is necessarily short for urgent inpatient palliative RT. Advanced practice providers may facilitate and potentially ...
    Schlagwörter Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Regional variation in brain white matter diffusion index changes following chemoradiotherapy

    Christopher H Chapman / Mohammad Nazem-Zadeh / Oliver E Lee / Matthew J Schipper / Christina I Tsien / Theodore S Lawrence / Yue Cao

    PLoS ONE, Vol 8, Iss 3, p e

    a prospective study using tract-based spatial statistics.

    2013  Band 57768

    Abstract: There is little known about how brain white matter structures differ in their response to radiation, which may have implications for radiation-induced neurocognitive impairment. We used diffusion tensor imaging (DTI) to examine regional variation in ... ...

    Abstract There is little known about how brain white matter structures differ in their response to radiation, which may have implications for radiation-induced neurocognitive impairment. We used diffusion tensor imaging (DTI) to examine regional variation in white matter changes following chemoradiotherapy.Fourteen patients receiving two or three weeks of whole-brain radiation therapy (RT) ± chemotherapy underwent DTI pre-RT, at end-RT, and one month post-RT. Three diffusion indices were measured: fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). We determined significant individual voxel changes of diffusion indices using tract-based spatial statistics, and mean changes of the indices within fourteen white matter structures of interest.Voxels of significant FA decreases and RD increases were seen in all structures (p<0.05), with the largest changes (20-50%) in the fornix, cingula, and corpus callosum. There were highly significant between-structure differences in pre-RT to end-RT mean FA changes (p<0.001). The inferior cingula had a mean FA decrease from pre-RT to end-RT significantly greater than 11 of the 13 other structures (p<0.00385).Brain white matter structures varied greatly in their response to chemoradiotherapy as measured by DTI changes. Changes in FA and RD related to white matter demyelination were prominent in the cingula and fornix, structures relevant to radiation-induced neurocognitive impairment. Future research should evaluate DTI as a predictive biomarker of brain chemoradiotherapy adverse effects.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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