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  1. AU="Christopher J. Bailey"
  2. AU="Nasif, Abdullah"
  3. AU=Oberman Lindsay M.
  4. AU="de Oliveira, Guilherme Xavier Lyra Malcher" AU="de Oliveira, Guilherme Xavier Lyra Malcher"
  5. AU="Afaneh, Hasheemah"
  6. AU="Galicia-Hernández, Victoria"
  7. AU="Daniel A. Haber"
  8. AU=Bu Fangfang
  9. AU="Fox, Kevin J"
  10. AU="Nawazish Naqvi"
  11. AU="Marquardt, Viktoria"
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  13. AU="Caballero, Susana J"
  14. AU="van Dijk, J Hessel M"
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  16. AU="Zhilich V.N."
  17. AU="George, Darren"
  18. AU=Lin Xiukun
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  20. AU="Christian Young"
  21. AU=Takeuchi Kaoru
  22. AU="Wiślicki, W."
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  1. Article ; Online: Functional connectivity of spoken language processing in early-stage Parkinson’s disease

    Rasha Hyder / Mads Jensen / Andreas Højlund / Lilli Kimppa / Christopher J. Bailey / Jeppe L. Schaldemose / Martin B. Kinnerup / Karen Østergaard / Yury Shtyrov

    NeuroImage: Clinical, Vol 32, Iss , Pp 102718- (2021)

    An MEG study

    2021  

    Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder, well-known for its motor symptoms; however, it also adversely affects cognitive functions, including language, a highly important human ability. PD pathology is associated, even in the early stage ...

    Abstract Parkinson’s disease (PD) is a neurodegenerative disorder, well-known for its motor symptoms; however, it also adversely affects cognitive functions, including language, a highly important human ability. PD pathology is associated, even in the early stage of the disease, with alterations in the functional connectivity within cortico-subcortical circuitry of the basal ganglia as well as within cortical networks. Here, we investigated functional cortical connectivity related to spoken language processing in early-stage PD patients. We employed a patient-friendly passive attention-free paradigm to probe neurophysiological correlates of language processing in PD patients without confounds related to active attention and overt motor responses. MEG data were recorded from a group of newly diagnosed PD patients and age-matched healthy controls who were passively presented with spoken word stimuli (action and abstract verbs, as well as grammatically correct and incorrect inflectional forms) while focussing on watching a silent movie. For each of the examined linguistic aspects, a logistic regression classifier was used to classify participants as either PD patients or healthy controls based on functional connectivity within the temporo-fronto-parietal cortical language networks. Classification was successful for action verbs (accuracy = 0.781, p-value = 0.003) and, with lower accuracy, for abstract verbs (accuracy = 0.688, p-value = 0.041) and incorrectly inflected forms (accuracy = 0.648, p-value = 0.021), but not for correctly inflected forms (accuracy = 0.523, p-value = 0.384). Our findings point to quantifiable differences in functional connectivity within the cortical systems underpinning language processing in newly diagnosed PD patients compared to healthy controls, which arise early, in the absence of clinical evidence of deficits in cognitive or general language functions. The techniques presented here may aid future work on establishing neurolinguistic markers to objectively and noninvasively identify ...
    Keywords Parkinson’s disease (PD) ; Magnetoencephalography (MEG) ; Functional connectivity ; Classification ; Action verb ; Morphosyntax ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 150
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Experience Drives Synchronization

    Karen Johanne Pallesen / Christopher J Bailey / Elvira Brattico / Albert Gjedde / J Matias Palva / Satu Palva

    PLoS ONE, Vol 10, Iss 8, p e

    The phase and Amplitude Dynamics of Neural Oscillations to Musical Chords Are Differentially Modulated by Musical Expertise.

    2015  Volume 0134211

    Abstract: Musical expertise is associated with structural and functional changes in the brain that underlie facilitated auditory perception. We investigated whether the phase locking (PL) and amplitude modulations (AM) of neuronal oscillations in response to ... ...

    Abstract Musical expertise is associated with structural and functional changes in the brain that underlie facilitated auditory perception. We investigated whether the phase locking (PL) and amplitude modulations (AM) of neuronal oscillations in response to musical chords are correlated with musical expertise and whether they reflect the prototypicality of chords in Western tonal music. To this aim, we recorded magnetoencephalography (MEG) while musicians and non-musicians were presented with common prototypical major and minor chords, and with uncommon, non-prototypical dissonant and mistuned chords, while watching a silenced movie. We then analyzed the PL and AM of ongoing oscillations in the theta (4-8 Hz) alpha (8-14 Hz), beta- (14-30 Hz) and gamma- (30-80 Hz) bands to these chords. We found that musical expertise was associated with strengthened PL of ongoing oscillations to chords over a wide frequency range during the first 300 ms from stimulus onset, as opposed to increased alpha-band AM to chords over temporal MEG channels. In musicians, the gamma-band PL was strongest to non-prototypical compared to other chords, while in non-musicians PL was strongest to minor chords. In both musicians and non-musicians the long-latency (> 200 ms) gamma-band PL was also sensitive to chord identity, and particularly to the amplitude modulations (beats) of the dissonant chord. These findings suggest that musical expertise modulates oscillation PL to musical chords and that the strength of these modulations is dependent on chord prototypicality.
    Keywords Medicine ; R ; Science ; Q
    Subject code 780
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Cognitive control in auditory working memory is enhanced in musicians.

    Karen Johanne Pallesen / Elvira Brattico / Christopher J Bailey / Antti Korvenoja / Juha Koivisto / Albert Gjedde / Synnöve Carlson

    PLoS ONE, Vol 5, Iss 6, p e

    2010  Volume 11120

    Abstract: Musical competence may confer cognitive advantages that extend beyond processing of familiar musical sounds. Behavioural evidence indicates a general enhancement of both working memory and attention in musicians. It is possible that musicians, due to ... ...

    Abstract Musical competence may confer cognitive advantages that extend beyond processing of familiar musical sounds. Behavioural evidence indicates a general enhancement of both working memory and attention in musicians. It is possible that musicians, due to their training, are better able to maintain focus on task-relevant stimuli, a skill which is crucial to working memory. We measured the blood oxygenation-level dependent (BOLD) activation signal in musicians and non-musicians during working memory of musical sounds to determine the relation among performance, musical competence and generally enhanced cognition. All participants easily distinguished the stimuli. We tested the hypothesis that musicians nonetheless would perform better, and that differential brain activity would mainly be present in cortical areas involved in cognitive control such as the lateral prefrontal cortex. The musicians performed better as reflected in reaction times and error rates. Musicians also had larger BOLD responses than non-musicians in neuronal networks that sustain attention and cognitive control, including regions of the lateral prefrontal cortex, lateral parietal cortex, insula, and putamen in the right hemisphere, and bilaterally in the posterior dorsal prefrontal cortex and anterior cingulate gyrus. The relationship between the task performance and the magnitude of the BOLD response was more positive in musicians than in non-musicians, particularly during the most difficult working memory task. The results confirm previous findings that neural activity increases during enhanced working memory performance. The results also suggest that superior working memory task performance in musicians rely on an enhanced ability to exert sustained cognitive control. This cognitive benefit in musicians may be a consequence of focused musical training.
    Keywords Medicine ; R ; Science ; Q
    Subject code 780
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Scenario Planning to Address Critical Uncertainties for Robust and Resilient Water–Wastewater Infrastructures under Conditions of Water Scarcity and Rapid Development

    Christopher A. Scott / Christopher J. Bailey / Ralph P. Marra / Gwendolyn J. Woods / Kerri Jean Ormerod / Kevin Lansey

    Abstract: Ensuring water availability for multiple needs represents a sustainable development challenge globally. Rigid planning for fixed water supply and reuse targets with estimated demand growth and static assumptions of water availability can prove inflexible ...

    Abstract Ensuring water availability for multiple needs represents a sustainable development challenge globally. Rigid planning for fixed water supply and reuse targets with estimated demand growth and static assumptions of water availability can prove inflexible in responding to changing conditions. Formal methods to adaptively respond to these challenges are needed, particularly in regions with limited natural resources and/or where multiple uncertain forces can influence water-resource availability and supply reliability. This paper assesses the application of Scenario Planning in one such region—Tucson, Arizona, USA—over the coming 40 years, and highlights broader lessons for addressing complex interrelationships of water management, infrastructure development, and population growth. Planners from multiple jurisdictions and researchers identified ten key forces and prioritized three with the greatest uncertainty and the greatest impact for water and development planning: (1) changing demands based on potential future density, layout, and per capita water use/reuse; (2) adequacy of current water supplies to meet future demands; and (3) evolving public perceptions of water reuse including potential options to supplement potable water supplies. Detailed scenario modeling using GIS and infrastructure cost optimization is under development and is now beginning to produce results, to be discussed in future publications. The process has clearly demonstrated the value of Scenario Planning as a tool for bringing stakeholders into agreement over highly complex and historically divisive problems, and for prioritizing amongst diverse uncertainties. The paper concludes by characterizing possible outcomes for this case and draws lessons for other water scarce regions experiencing rapid development.
    Language English
    Document type Article
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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