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  1. Article ; Online: Dual-specificity tyrosine phosphorylation-regulated kinase 1A promotes the inclusion of amyloid precursor protein exon 7.

    Chu, Dandan / Lei, Leyi / Gu, Shu / Liu, Fei / Wu, Feng

    Biochemical pharmacology

    2024  Volume 224, Page(s) 116233

    Abstract: Extracellular amyloid plaques made of Amyloid-β (Aβ) derived from amyloid precursor protein (APP) is one of the major neuropathological hallmarks of Alzheimer's disease (AD). There are three major isoforms of APP, ... ...

    Abstract Extracellular amyloid plaques made of Amyloid-β (Aβ) derived from amyloid precursor protein (APP) is one of the major neuropathological hallmarks of Alzheimer's disease (AD). There are three major isoforms of APP, APP
    MeSH term(s) Dyrk Kinases ; Amyloid beta-Protein Precursor/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Humans ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Mice, Transgenic ; Protein-Tyrosine Kinases/metabolism ; Protein-Tyrosine Kinases/genetics ; Mice ; Exons ; Alternative Splicing ; HEK293 Cells ; Alzheimer Disease/metabolism ; Alzheimer Disease/genetics
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116233
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Defect Surface Engineering of Hollow NiCo

    Lang, Xiaomin / Chu, Dandan / Wang, Yan / Ge, Danhua / Chen, Xiaojun

    Biosensors

    2022  Volume 12, Issue 10

    Abstract: Transition metal sulfides have been explored as electrode materials for non-enzymatic detection. In this work, we investigated the effects of phosphorus doping on the electrochemical performances of ... ...

    Abstract Transition metal sulfides have been explored as electrode materials for non-enzymatic detection. In this work, we investigated the effects of phosphorus doping on the electrochemical performances of NiCo
    MeSH term(s) Glucose/chemistry ; Electrochemical Techniques ; Nickel/chemistry ; Sulfides ; Phosphorus
    Chemical Substances Glucose (IY9XDZ35W2) ; Nickel (7OV03QG267) ; Sulfides ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2022-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12100823
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  3. Article ; Online: A dicyanoisophorone-based ICT fluorescent probe for the detection of Hg

    Li, Xiangqian / Chu, Dandan / Wang, Juan / Qi, Yueheng / Yuan, Weiwei / Li, Jingguo / Zhou, Zhan

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2023  Volume 295, Page(s) 122628

    Abstract: Mercury ions are notoriously difficult to biodegradable, and its abnormal bioaccumulation in the human body through the food chain can cause various diseases. Therefore, the quantitative and real-time detection of ... ...

    Abstract Mercury ions are notoriously difficult to biodegradable, and its abnormal bioaccumulation in the human body through the food chain can cause various diseases. Therefore, the quantitative and real-time detection of Hg
    MeSH term(s) Humans ; Diagnostic Imaging ; Fluorescent Dyes/analysis ; Mercury/analysis ; Spectrometry, Fluorescence ; Water ; Food Analysis
    Chemical Substances Fluorescent Dyes ; Mercury (FXS1BY2PGL) ; Water (059QF0KO0R) ; isophorone (2BR99VR6WA)
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2023.122628
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    In stock of ZB MED Bonn / Germany

    Z 51/98: Show issues
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    924/340: Show issues

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  4. Article ; Online: Neuronal aerobic glycolysis exacerbates synapse loss in aging mice.

    Zhou, Wenhui / Yang, Xingyue / Wang, Huixia / Yao, Wenjuan / Chu, Dandan / Wu, Feng

    Experimental neurology

    2023  Volume 371, Page(s) 114590

    Abstract: Brain consumes nearly 20% supply of energy from glucose metabolism by oxidative phosphorylation and aerobic glycolysis. Less active state of glycolytic enzymes results in a limited capacity of glycolysis in the neurons of adult brain. Here we identified ... ...

    Abstract Brain consumes nearly 20% supply of energy from glucose metabolism by oxidative phosphorylation and aerobic glycolysis. Less active state of glycolytic enzymes results in a limited capacity of glycolysis in the neurons of adult brain. Here we identified that Warburg effect is enhanced in hippocampal neurons during aging. As hippocampal neurons age, lactate levels progressively increase. Notably, we observed upregulated protein levels of PFKFB3 in the hippocampus of 20-month-old mice compared to young mice, and this higher PFKFB3 expression correlated with declining memory performance in aging mice. Remarkably, in aging mice, knocking down Pfkfb3 in hippocampal neurons rescued cognitive decline and synapse loss. Conversely, Pfkfb3 overexpression in hippocampal neurons led to cognitive impairment and synapse elimination, associated with heightened glycolysis. In vitro experiments with cultured primary neurons confirmed that Pfkfb3 overexpression increased glycolysis and that glycolytic inhibition could prevent apoptotic competency in neurons. These findings underscore that glycolysis in hippocampal neurons could potentially be targeted as a therapeutic avenue to mitigate cognitive decline and preserve synaptic integrity during aging.
    MeSH term(s) Mice ; Animals ; Phosphofructokinase-2/metabolism ; Glycolysis ; Neurons/metabolism ; Aging ; Synapses/metabolism
    Chemical Substances Phosphofructokinase-2 (EC 2.7.1.105)
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114590
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: M2 macrophages promote subconjunctival fibrosis through YAP/TAZ signalling.

    Wang, Yiwei / Geng, Xingchen / Guo, Zhihua / Chu, Dandan / Liu, Ruixing / Cheng, Boyuan / Cui, Haohao / Li, Chengcheng / Li, Jingguo / Li, Zhanrong

    Annals of medicine

    2024  Volume 56, Issue 1, Page(s) 2313680

    Abstract: Purpose: To evaluate the role of M2 macrophages in subconjunctival fibrosis after silicone implantation (SI) and investigate the underlying mechanisms.: Materials and methods: A model of subconjunctival fibrosis was established by SI surgery in ... ...

    Abstract Purpose: To evaluate the role of M2 macrophages in subconjunctival fibrosis after silicone implantation (SI) and investigate the underlying mechanisms.
    Materials and methods: A model of subconjunctival fibrosis was established by SI surgery in rabbit eyes. M2 distribution and collagen deposition were evaluated by histopathology. The effects of M2 cells on the migration (using wound-scratch assay) and activation (by immunofluorescence and western blotting) of human Tenon's fibroblasts (HTFs) were investigated.
    Results: There were more M2 macrophages (CD68+/CD206+ cells) occurring in tissue samples around silicone implant at 2 weeks postoperatively. Dense collagen deposition was observed at 8 weeks after SI.
    Conclusions: TGF-β1/Smad2/3-YAP/TAZ signalling may be involved in M2-induced fibrotic activities in HTFs. M2 plays a key role in promoting subconjunctival fibrosis and can serve as an attractive target for anti-fibrotic therapeutics.
    MeSH term(s) Animals ; Humans ; Rabbits ; Collagen ; Culture Media, Conditioned ; Fibrosis ; Macrophages/metabolism ; Silicones ; Transforming Growth Factor beta1/metabolism ; YAP-Signaling Proteins/metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins/metabolism
    Chemical Substances Collagen (9007-34-5) ; Culture Media, Conditioned ; Silicones ; Transforming Growth Factor beta1 ; YAP-Signaling Proteins ; Transcriptional Coactivator with PDZ-Binding Motif Proteins
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2024.2313680
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 680: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease.

    Zhang, Wei / Zhao, Mengyang / Chu, Dandan / Chen, Huiying / Cui, Bingbing / Ning, Qingyun / Wang, Xing / Li, Zhanrong / Cao, Shaokui / Li, Jingguo

    Journal of nanobiotechnology

    2024  Volume 22, Issue 1, Page(s) 229

    Abstract: Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED). The currently available eye drops for DED treatment are ... ...

    Abstract Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED). The currently available eye drops for DED treatment are palliative, short-lived and frequently administered due to the short precorneal residence time. Here, we developed nanozyme-based eye drops for DED by exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) and poly(vinyl alcohol) (PVA) to overcome these problems. The resultant formulation (PBnZ), which has dual-ROS scavenging abilities and prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect to alleviate DED. In vitro and in vivo experiments revealed that PBnZ could eliminate excess ROS through both its multienzyme-like activity and the ROS-scavenging activity of borate bonds. The positively charged nanozyme-based eye drops displayed a longer precorneal residence time due to physical adhesion and the dynamic borate bonds between phenyboronic acid and PVA or o-diol with mucin. The in vivo results showed that eye drops could effectively alleviate DED. These dual-function PBnZ nanozyme-based eye drops can provide insights into the development of novel treatment strategies for DED and other ROS-mediated inflammatory diseases and a rationale for the application of nanomaterials in clinical settings.
    MeSH term(s) Ophthalmic Solutions/chemistry ; Ophthalmic Solutions/pharmacology ; Dry Eye Syndromes/drug therapy ; Animals ; Reactive Oxygen Species/metabolism ; Mice ; Oxidative Stress/drug effects ; Cornea/drug effects ; Cornea/metabolism ; Polyvinyl Alcohol/chemistry ; Humans ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/pharmacology ; Borates/chemistry ; Nanoparticles/chemistry ; Male
    Chemical Substances Ophthalmic Solutions ; Reactive Oxygen Species ; Polyvinyl Alcohol (9002-89-5) ; Free Radical Scavengers ; Borates
    Language English
    Publishing date 2024-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-024-02499-0
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  7. Article ; Online: Pathological Changes of Tau Related to Alzheimer's Disease.

    Chu, Dandan / Liu, Fei

    ACS chemical neuroscience

    2018  Volume 10, Issue 2, Page(s) 931–944

    Abstract: Alzheimer's disease (AD), the most common form of dementia, is characterized by extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs), which are considered as major targets for AD therapies. However, no effective therapy is ... ...

    Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs), which are considered as major targets for AD therapies. However, no effective therapy is available to cure or prevent the progression of AD up until now. Accumulation of NFTs, which consist of abnormally hyperphosphorylated tau, is directly correlated with the degree of dementia in AD patients. Emerging evidence indicates that the prion-like seeding and spreading of tau pathology may be the key driver of AD. In the past decades, greater understanding of tau pathway reveals new targets for the development of specific therapies. Here, we review the recent research progress in the mechanism underlying tau pathology in AD and briefly introduce tau-based therapeutics.
    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Humans ; Neurofibrillary Tangles/metabolism ; Neurofibrillary Tangles/pathology ; Phosphorylation/physiology ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/pathology ; tau Proteins/metabolism
    Chemical Substances tau Proteins
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.8b00457
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  8. Article: Synergistic Effect of the Photothermal Performance and Osteogenic Properties of MXene and Hydroxyapatite Nanoparticle Composite Nanofibers for Osteogenic Application.

    Li, Chengcheng / Chu, Dandan / Jin, Lin / Tan, Guanxuan / Li, Zhanrong

    Journal of biomedical nanotechnology

    2021  Volume 17, Issue 10, Page(s) 2014–2020

    Abstract: MXene has attracted tremendous attention due to its outstanding photothermal properties and biocompatibility. Hydroxyapatite (HA) contains Ca, Mg and P elements, which play important roles in promoting osteogenic differentiation of mesenchymal stem cells ...

    Abstract MXene has attracted tremendous attention due to its outstanding photothermal properties and biocompatibility. Hydroxyapatite (HA) contains Ca, Mg and P elements, which play important roles in promoting osteogenic differentiation of mesenchymal stem cells (MSCs). In this study, a class of composite nanofibers consisting of MXene nanosheets and HA nanoparticles (M-@HA NFs) are developed based on the synergistic effect of photothermal performance and osteogenic properties. The obtained composite nanofibers demonstrated excellent photothermal properties, and the temperature reached 44 °C under NIR exposure (808 nm). In addition, the composite nanofibers also displayed good biocompatibility and promote the growth and osteogenic differentiation of bone mesenchymal stem cells (BMSCs). More importantly, under NIR exposure, BMSCs on the composite nanofibers achieved much better osteogenic differentiation than those without NIR exposure due to the accelerated release of Ca, Mg and P elements. Therefore, we considered the unique photothermal and osteogenic differentiation to indicate that this new class of MXene composite nanofibers has tremendous application potential in bone tissue engineering.
    MeSH term(s) Cell Differentiation ; Cells, Cultured ; Durapatite ; Nanofibers ; Nanoparticles ; Osteogenesis ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 1550-7033
    ISSN 1550-7033
    DOI 10.1166/jbn.2021.3166
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  9. Article ; Online: Metal-Organic Cages with Missing Linker Defects.

    Tang, Xianhui / Chu, Dandan / Gong, Wei / Cui, Yong / Liu, Yan

    Angewandte Chemie (International ed. in English)

    2021  Volume 60, Issue 16, Page(s) 9099–9105

    Abstract: We present here the controlled synthesis of defective coordination cages by employing steric hindrance of organic linkers to manipulate coordination modes of the assembled metal ions. Three chiral 1,1'-bi-2-naphthol (BINOL) derived bis-tridentate ligands ...

    Abstract We present here the controlled synthesis of defective coordination cages by employing steric hindrance of organic linkers to manipulate coordination modes of the assembled metal ions. Three chiral 1,1'-bi-2-naphthol (BINOL) derived bis-tridentate ligands L
    Language English
    Publishing date 2021-03-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202017244
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  10. Article ; Online: Prism-like bimetallic (Ni-Co) alkaline carboxylate-based non-enzymatic sensor capable of exceptionally high catalytic activity towards glucose.

    Chu, Dandan / Wang, Yan / Li, Dong / Chu, Xue-Qiang / Ge, Danhua / Chen, Xiaojun

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 40, Page(s) 15354–15360

    Abstract: In this study, we fabricated a novel non-enzymatic glucose sensor based on prism-like bimetallic alkaline carboxylate (CoNi-MIM). The morphology and structure of CoNi-MIM were carefully investigated by scanning electron microscopy (SEM), transmission ... ...

    Abstract In this study, we fabricated a novel non-enzymatic glucose sensor based on prism-like bimetallic alkaline carboxylate (CoNi-MIM). The morphology and structure of CoNi-MIM were carefully investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The electrochemical glucose oxidation of the synthesized sensor was then explored by cyclic voltammetry (CV) and chronoamperometry in alkaline medium. It was found that CoNi-MIM is the optimal choice with a remarkably high sensitivity of 5024.4 μA mM
    MeSH term(s) Catalysis ; Electrochemical Techniques/methods ; Electrodes ; Glucose/chemistry ; Photoelectron Spectroscopy ; Powders ; X-Ray Diffraction
    Chemical Substances Powders ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt02424a
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