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  1. Book ; Online ; E-Book: RNA Therapeutics Part A

    Chu, Dinh-Toi / Than, Van Thai

    2024  

    MeSH term(s) RNA/therapeutic use ; RNA, Neoplasm.
    Language English
    Size 1 online resource (328 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-22315-7 ; 9780443223143 ; 978-0-443-22315-0 ; 0443223149
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: An introduction to RNA therapeutics and their potentials.

    Bui, Nhat-Le / Chu, Dinh-Toi

    Progress in molecular biology and translational science

    2024  Volume 203, Page(s) 1–12

    Abstract: RNA therapeutics is a biological term regarding the usage of RNA-based molecules for medical purposes. Thanks to the success of mRNA-vaccine production against COVID-19, RNA therapeutics has gained more and more attention and investigation from worldwide ...

    Abstract RNA therapeutics is a biological term regarding the usage of RNA-based molecules for medical purposes. Thanks to the success of mRNA-vaccine production against COVID-19, RNA therapeutics has gained more and more attention and investigation from worldwide scientists. It is considered as one of the promising alternatives for conventional drugs. In this first chapter, we presented an overview of the history and perspectives of RNA therapeutics' development. This chapter also explained the underlying mechanisms of different RNA-based molecules, including antisense oligonucleotide, interfering RNA (iRNA), aptamer, and mRNA, from degrading mRNA to inactivating targeted protein. Although there are many advantages of RNA therapeutics, its challenges in designing RNA chemical structure and the delivery vehicle need to be discussed. We described advanced technologies in the development of drug delivery systems that are positively correlated to the efficacy of the drug. Our aim is to provide a general background of RNA therapeutics to the audience before introducing plenty of more detailed parts, including clinical applications in certain diseases in the following chapters of the "RNA therapeutics" book.
    MeSH term(s) Humans ; RNA, Small Interfering ; Oligonucleotides, Antisense ; Drug Delivery Systems ; RNA, Messenger/genetics ; RNA, Messenger/therapeutic use
    Chemical Substances RNA, Small Interfering ; Oligonucleotides, Antisense ; RNA, Messenger
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.12.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Frizzled receptors and SFRP5 in lipid metabolism: Current findings and potential applications.

    Chu, Dinh-Toi / Nguyen, Thanh-Lam

    Progress in molecular biology and translational science

    2022  Volume 194, Page(s) 377–393

    Abstract: Lipid metabolism plays a very important role as the central metabolic process of the body. Lipid metabolism interruptions may cause many chronic diseases, for example, non-alcoholic fatty liver disease (NAFLD), diabetes, and obesity. Secreted Frizzled ... ...

    Abstract Lipid metabolism plays a very important role as the central metabolic process of the body. Lipid metabolism interruptions may cause many chronic diseases, for example, non-alcoholic fatty liver disease (NAFLD), diabetes, and obesity. Secreted Frizzled Related Protein 5 (SFRP5) and Frizzled receptors (FZD) are two newly discovered adipokines that are involved in lipid metabolism as well as lipogenesis. Both of these adipokines affect lipid metabolism and adipogenesis through three WNT signaling pathways (WNTSP): WNT/β-catenin, WNT/Ca
    MeSH term(s) Humans ; Adaptor Proteins, Signal Transducing/metabolism ; Adipokines/metabolism ; Antigens, Ly/metabolism ; Frizzled Receptors/metabolism ; Lipid Metabolism ; Obesity ; Urokinase-Type Plasminogen Activator/metabolism ; Wnt Signaling Pathway
    Chemical Substances Adaptor Proteins, Signal Transducing ; Adipokines ; Antigens, Ly ; Frizzled Receptors ; SFRP5 protein, human ; SLURP1 protein, human ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2022-07-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2022.06.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: RNA therapeutics: Molecular mechanisms, and potential clinical translations.

    Nguyen, Tiep Tien / Nguyen Thi, Yen Vi / Chu, Dinh-Toi

    Progress in molecular biology and translational science

    2024  Volume 203, Page(s) 65–82

    Abstract: RNA therapies involve the utilization of natural and artificial RNA molecules to control the expression and function of cellular genes and proteins. Initializing from 1990s, RNA therapies now show the rapid growth in the development and application of ... ...

    Abstract RNA therapies involve the utilization of natural and artificial RNA molecules to control the expression and function of cellular genes and proteins. Initializing from 1990s, RNA therapies now show the rapid growth in the development and application of RNA therapeutics for treating various conditions, especially for undruggable diseases. The outstanding success of recent mRNA vaccines against COVID-19 infection again highlighted the important role of RNA therapies in future medicine. In this review, we will first briefly provide the crucial investigations on RNA therapy, from the first pieces of discovery on RNA molecules to clinical applications of RNA therapeutics. We will then classify the mechanisms of RNA therapeutics from various classes in the treatment of diseases. To emphasize the huge potential of RNA therapies, we also provide the key RNA products that have been on clinical trials or already FDA-approved. With comprehensive knowledge on RNA biology, and the advances in analysis, technology and computer-aid science, RNA therapies can bring a promise to be more expanding to the market in the future.
    MeSH term(s) Humans ; RNA/genetics ; COVID-19 Vaccines ; RNA Interference
    Chemical Substances RNA (63231-63-0) ; COVID-19 Vaccines
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: RNA therapeutics for disorders of excretory system.

    Vu, Thuy-Duong / Nguyen, Mai Anh / Jurgoński, Adam / Chu, Dinh-Toi

    Progress in molecular biology and translational science

    2024  Volume 203, Page(s) 245–256

    Abstract: The excretory system is responsible for removing wastes from the human body, which plays a crucial role in our lives. Current treatments for diseases related to this system have shown several limitations; therefore, there is a rising need for novel ... ...

    Abstract The excretory system is responsible for removing wastes from the human body, which plays a crucial role in our lives. Current treatments for diseases related to this system have shown several limitations; therefore, there is a rising need for novel methods. In this circumstance, RNA-based therapeutics have rapidly emerged as new and promising candidates. In fact, to date, a handful of potential drugs have passed the development step and entered the clinical pipeline. Among them, one drug received FDA approval to enter the global market, which is Oxlumo (Lumasiran) for the treatment of primary hyperoxaluria type 1. For other excretory diseases, such as paroxysmal nocturnal hemoglobinuria, urothelial cancer or renal cancer, RNA-based candidates are also being tested under clinical trials. Currently, the most potential types of RNA therapeutics to treat disorders of the excretory system are those based on small interfering RNA (siRNA), antisense oligonucleotides (ASO) and messenger RNA (mRNA), Among them, siRNA therapeutics seem to be the most promising, including Oxlumo and two other developing drug candidates. This chapter will provide a general overview on the application of RNA therapeutics in disorders of the excretory system.
    MeSH term(s) Humans ; RNA, Small Interfering/therapeutic use ; Oligonucleotides, Antisense/therapeutic use ; RNA, Messenger
    Chemical Substances RNA, Small Interfering ; Oligonucleotides, Antisense ; RNA, Messenger
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: RNA therapeutics for the treatment of blood disorders.

    Ngo, Anh Dao / Nguyen, Hoang Lam / Caglayan, Safak / Chu, Dinh-Toi

    Progress in molecular biology and translational science

    2024  Volume 203, Page(s) 273–286

    Abstract: Blood disorders are defined as diseases related to the structure, function, and formation of blood cells. These diseases lead to increased years of life loss, reduced quality of life, and increased financial burden for social security systems around the ... ...

    Abstract Blood disorders are defined as diseases related to the structure, function, and formation of blood cells. These diseases lead to increased years of life loss, reduced quality of life, and increased financial burden for social security systems around the world. Common blood disorder treatments such as using chemical drugs, organ transplants, or stem cell therapy have not yet approached the best goals, and treatment costs are also very high. RNA with a research history dating back several decades has emerged as a potential method to treat hematological diseases. A number of clinical trials have been conducted to pave the way for the use of RNA molecules to cure blood disorders. This novel approach takes advantage of regulatory mechanisms and the versatility of RNA-based oligonucleotides to target genes and cellular pathways involved in the pathogenesis of specific diseases. Despite positive results, currently, there is no RNA drug to treat blood-related diseases approved or marketed. Before the clinical adoption of RNA-based therapies, challenges such as safe delivery of RNA molecules to the target site and off-target effects of injected RNA in the body need to be addressed. In brief, RNA-based therapies open novel avenues for the treatment of hematological diseases, and clinical trials for approval and practical use of RNA-targeted are crucial.
    MeSH term(s) Humans ; RNA/therapeutic use ; Quality of Life ; Drug Delivery Systems/methods ; Hematologic Diseases/genetics ; Hematologic Diseases/therapy
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: RNA therapeutics for metabolic disorders.

    Vu, Thuy-Duong / Lin, Sheng-Che / Wu, Chia-Ching / Chu, Dinh-Toi

    Progress in molecular biology and translational science

    2024  Volume 203, Page(s) 181–196

    Abstract: The prevalence of metabolic disorders is increasing exponentially and has recently reached epidemic levels. Over the decades, a large number of therapeutic options have been proposed to manage these diseases but still show several limitations. In this ... ...

    Abstract The prevalence of metabolic disorders is increasing exponentially and has recently reached epidemic levels. Over the decades, a large number of therapeutic options have been proposed to manage these diseases but still show several limitations. In this circumstance, RNA therapeutics have rapidly emerged as a new hope for patients with metabolic diseases. 57 years have elapsed from the discovery of mRNA, a large number of RNA-based drug candidates have been evaluated for their therapeutic effectiveness and clinical safety under clinical studies. To date, there are seven RNA drugs for treating metabolic disorders receiving official approval and entering the global market. Their targets include hereditary transthyretin-mediated amyloidosis (hATTR), familial chylomicronemia syndrome, acute hepatic porphyria, primary hyperoxaluria type 1 and hypercholesterolemia, which are all related to liver proteins. All of these seven RNA drugs are antisense oligonucleotides (ASO) and small interfering RNA (siRNA). These two types of treatment are both based on oligonucleotides complementary to target RNA through Watson-Crick base-pairing, but their mechanisms of action include different nucleases. Such treatments show greatest potential among all types of RNA therapeutics due to consecutive achievements in chemical modifications. Another method, mRNA therapeutics also promise a brighter future for patients with a handful of drug candidates currently under development.
    MeSH term(s) Humans ; Oligonucleotides/therapeutic use ; Oligonucleotides, Antisense/therapeutic use ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use ; RNA, Messenger ; Amyloid Neuropathies, Familial
    Chemical Substances Oligonucleotides ; Oligonucleotides, Antisense ; RNA, Small Interfering ; RNA, Messenger
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Epigenetics in cancer development, diagnosis and therapy.

    Chu, Dinh-Toi / Ngo, Anh-Dao / Wu, Chia-Ching

    Progress in molecular biology and translational science

    2023  Volume 198, Page(s) 73–92

    Abstract: Cancer is a dangerous disease and one of the leading causes of death in the world. In 2020, there were nearly 10 million cancer deaths and approximately 20 million new cases. New cases and deaths from cancer are expected to increase further in the coming ...

    Abstract Cancer is a dangerous disease and one of the leading causes of death in the world. In 2020, there were nearly 10 million cancer deaths and approximately 20 million new cases. New cases and deaths from cancer are expected to increase further in the coming years. To have a deeper insight into the mechanism of carcinogenesis, epigenetics studies have been published and received much attention from scientists, doctors, and patients. Among alterations in epigenetics, DNA methylation and histone modification are studied by many scientists. They have been reported to be a major contributor in tumor formation and are involved in metastasis. From the understanding of DNA methylation and histone modification, effective, accurate and cost-effective methods for diagnosis and screening of cancer patients have been introduced. Furthermore, therapeutic approaches and drugs targeting altered epigenetics have also been clinically studied and have shown positive results in combating tumor progression. Several cancer drugs that rely on DNA methylation inactivation or histone modification have been approved by the FDA for the treatment of cancer patients. In summary, epigenetics changes such as DNA methylation or histone modification are take part in tumor growth, and they also have great prospect to study diagnostic and therapeutic methods of this dangerous disease.
    MeSH term(s) Humans ; Carcinogenesis/genetics ; DNA Methylation/genetics ; Epigenesis, Genetic ; Epigenomics ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; Histones/metabolism
    Chemical Substances Histones
    Language English
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Obesity and hypertension in Asia: Current status and challenges.

    Chu, Dinh-Toi / Singh, Vijai

    The Lancet regional health. Western Pacific

    2021  Volume 15, Page(s) 100243

    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2021.100243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Application of data science and bioinformatics in RNA therapeutics.

    Thi, Hue Vu / Hoang, Thanh-Nhat / Le, Nguyen Quoc Khanh / Chu, Dinh-Toi

    Progress in molecular biology and translational science

    2024  Volume 203, Page(s) 83–97

    Abstract: Nowadays, information technology (IT) has been holding a significant role in daily life worldwide. The trajectory of data science and bioinformatics promises pioneering personalized therapies, reshaping medical landscapes and patient care. For RNA ... ...

    Abstract Nowadays, information technology (IT) has been holding a significant role in daily life worldwide. The trajectory of data science and bioinformatics promises pioneering personalized therapies, reshaping medical landscapes and patient care. For RNA therapy to reach more patients, a comprehensive understanding of the application of data science and bioinformatics to this therapy is essential. Thus, this chapter has summarized the application of data science and bioinformatics in RNA therapeutics. Data science applications in RNA therapy, such as data integration and analytics, machine learning, and drug development, have been discussed. In addition, aspects of bioinformatics such as RNA design and evaluation, drug delivery system simulation, and databases for personalized medicine have also been covered in this chapter. These insights have shed light on existing evidence and opened potential future directions. From there, scientists can elevate RNA-based therapeutics into an era of tailored treatments and revolutionary healthcare.
    MeSH term(s) Humans ; Data Science ; Computational Biology ; Precision Medicine
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2023.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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