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Article ; Online: Targeting Mesothelin in Solid Tumours: Anti-mesothelin Antibody and Drug Conjugates.

Chu, Quincy

2023 Volume 25, Issue 4, Page(s) 309–323

Abstract: Purpose of review: This review aims to summarise the pathobiological role of mesothelin and the current data on therapeutic antibodies targeting mesothelin in solid tumours.: Recent findings: High mesothelin expression is restricted to the ... ...

Abstract	Purpose of review: This review aims to summarise the pathobiological role of mesothelin and the current data on therapeutic antibodies targeting mesothelin in solid tumours. Recent findings: High mesothelin expression is restricted to the pericardium, pleura, peritoneum and tunica vaginalis. Mesothelin does not seem to have any normal biological function in adult normal tissues. Mesothelin is highly expressed in mesothelioma, serous ovarian cancer, pancreatic cancer and some gastric cancer and adenocarcinoma of the lung and is responsible for tumour proliferation, metastasis, resistance to chemotherapy or radiation and evasion of immune system. To date, antibody, antibody drug conjugates and bispecific antibodies with immune checkpoints have been investigated in mesothelin expressing malignancies. After a couple of decades of clinical investigation in antibody targeting mesothelin, the therapeutic benefit is relatively modest. Novel delivery of mesothelin targeting agents, more potent payload in antibody drug conjugates and immune checkpoint inhibitor, may improve therapeutic benefit.
MeSH term(s)	Humans ; Adenocarcinoma/drug therapy ; GPI-Linked Proteins/metabolism ; GPI-Linked Proteins/therapeutic use ; Immunoconjugates/therapeutic use ; Pharmaceutical Preparations ; Mesothelin/immunology
Chemical Substances	GPI-Linked Proteins ; Immunoconjugates ; Pharmaceutical Preparations ; Mesothelin (J27WDC343N)
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-023-01367-8
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Zs.A 5521: Show issues

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Article ; Online: The use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may relate to the survival and walking ability in geriatric patients with hip fractures: a 1-year follow-up study.

Chu, Qining / Wang, Liqiang / Chu, Qingbo

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 236

Abstract: Background: Many elder patients with hip fractures also suffered from hypertension. This study aims to explore the relationship between the use of ACEI or ARB and the outcomes of geriatric hip fractures.: Methods: All the patients were divided into ... ...

Abstract	Background: Many elder patients with hip fractures also suffered from hypertension. This study aims to explore the relationship between the use of ACEI or ARB and the outcomes of geriatric hip fractures. Methods: All the patients were divided into four groups: non-users without hypertension, non-users with hypertension, ACEI users, and ARB users. The outcomes of patients in different groups were compared. LASSO regression and univariable Cox analysis were used for variable screening. Then Cox models and Logistics models were established to identify the relationships between the use of RAAS inhibitors and outcomes. Results: ACER users (p = 0.016) and ARB users (p = 0.027) had a significantly lower survival probability than the non-users with hypertension. Non-users without hypertension, ACEI users, and ARB users may face lower 6-month and 1-year mortalities and higher 6-month and 1-year free walking rates compared with non-users with hypertension. Conclusion: Patients with the use of ACEI or ARB may face a better prognosis of hip fractures.
MeSH term(s)	Aged ; Humans ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Follow-Up Studies ; Hypertension/complications ; Hypertension/drug therapy ; Retrospective Studies ; Receptors, Angiotensin
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; ACE protein, human (EC 3.4.15.1) ; Receptors, Angiotensin
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06362-5
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Article: miR-942-5p Regulates Proliferation, Invasion and EMT of Trophoblast Cells in Gestational Diabetes by Targeting the CEBPA.

Chu, Qiaoxiang / Zhong, Xiaorong / Lu, Yuemei / Xu, Yunzhao

Alternative therapies in health and medicine

2024

Abstract: Objective: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder caused by abnormal glucose metabolism during pregnancy. Trophoblast dysfunction induced by hyperglycemia during pregnancy is the main factor leading to the development of ... ...

Abstract	Objective: Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder caused by abnormal glucose metabolism during pregnancy. Trophoblast dysfunction induced by hyperglycemia during pregnancy is the main factor leading to the development of GDM. In this study, we evaluated the expression of miR-942-5p in the placenta of patients with GDM and its regulation of trophoblast cell biological function. Methods: HTR-8/SVneo trophoblast cells were incubated with glucose to establish in vitro models, and miR-942-5p mimics transfected cells were added. The expression levels of miR-942-5p, CCAAT-enhancer-binding protein alpha (CEBPA) and N-cadherin in tissues and cells were detected by reverse-transcription quantitative polymerase chain reaction (RT-qPCR), protein blotting and immunohistochemistry (IHC). MTT, flow cytometry and Transwell assays were used to determine changes in cell proliferation, apoptosis and invasion. Dual-luciferase reporter assay and Pearson analysis were used to confirm the association between miR-942-5p and CEBPA. Results: miR-942-5p and N-cadherin were decreased in placental tissue and in human placental trophoblast cells (HTR-8/SVneo) exposed to high glucose (HG) conditions, while CEBPA was increased in placental tissue and HTR-8/SVneo exposed to HG conditions. Elevated levels of miR-942-5p suppressed apoptosis induced by HG and facilitated the proliferative and invasive capacities of HTR-8/SVneo. Mechanistically, we confirmed that miR-942-5p overexpression directly targeted CEBPA and suppressed CEBPA expression, while upregulating N-cadherin expression, which is involved in the EMT process of trophoblast cells and alleviated the dysfunction of trophoblast cells induced by HG in GDM. Conclusion: Overexpression of miR-942-5p promotes proliferation, invasion and EMT of trophoblast cells by targeting and negatively regulating CEBPA. These findings offer novel understanding regarding the treatment of GDM.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Zs.A 4504: Show issues

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Article ; Online: Predicting the enthalpy of formation of energetic molecules

Zhang, Di / Chu, Qingzhao / Chen, Dongping

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 8, Page(s) 7029–7041

Abstract: Machine learning (ML) provides a promising method for efficiently and accurately predicting molecular properties. Using ML models to predict the enthalpy of formation of energetic molecules helps in fast screening of potential high-energy molecules, ... ...

Abstract	Machine learning (ML) provides a promising method for efficiently and accurately predicting molecular properties. Using ML models to predict the enthalpy of formation of energetic molecules helps in fast screening of potential high-energy molecules, thereby accelerating the design of energetic materials. A persistent challenge is to determine the optimal featurization methods for molecular representation and use an appropriate ML model. Thus, in our study, we evaluate various featurization methods (CDS, ECFP, SOAP, GNF) and ML models (RF, MLP, GCN, MPNN), dividing them into two groups: conventional ML models and GNN models, to predict the enthalpy of formation of potential high-energy molecules. Our results demonstrate that CDS and SOAP have advantages over the ECFP, while the GNFs in GCN and MPNN models perform better. Furthermore, the MPNN model performs best among all models with a root mean square error (RMSE) as low as 8.42 kcal mol
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp05490j
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Article ; Online: Comparative transcriptome analysis reveals potential regulatory mechanisms of genes and immune pathways following Vibrio harveyi infection in red drum (Sciaenops ocellatus).

Zhou, Jiale / Yu, Jingyao / Chu, Qing

Fish & shellfish immunology

2024 Volume 146, Page(s) 109386

Abstract: Red drum (Sciaenops ocellatus), as an important economical marine fish, has been affected by various bacterial diseases in recent years. Vibrio harveyi cause fatal vibriosis in S. ocellatus, leading to massive mortality and causing significant setbacks ... ...

Abstract	Red drum (Sciaenops ocellatus), as an important economical marine fish, has been affected by various bacterial diseases in recent years. Vibrio harveyi cause fatal vibriosis in S. ocellatus, leading to massive mortality and causing significant setbacks in aquaculture. However, the regulatory mechanisms of S. ocellatus response to V. harveyi infection are poorly understood. In this regard, we performed transcriptomic analysis with head kidney tissues of S. ocellatus after V. harveyi infection from 12 h to 48 h to reveal genes, gene expression profiles, and pathways involved in immune and inflammation responses. Specifically, a total of 9,599, 5,728, and 7144 differentially expressed genes (DEGs) were identified after V. harveyi infection at 12 h, 24 h, and 48 h, respectively, and 1,848 shared DEGs have been identified from the above three comparison groups. Subsequent pathway analysis revealed that the shared DEGs following V. harveyi were involved in complement and coagulation cascades (C1R, C1QC, C3, C4, C5, C7, C8A, C8B, C8G, C9, CFB, CFH, and CFI), MAPK signaling pathway, chemokine signaling pathway (CCL19, CXCL8, CXCL12, CXCL14, CCR4, CCR7, and CXCR2), PPAR signaling pathway (PPAR-α, PPAR-γ and PPAR-β), and TNF signaling pathway. Finally, the expression patterns of DEGs in head kidney tissues and S. ocellatus macrophages were validated by qRT-PCR, suggesting the reliability of RNA sequencing for gene expression analysis. This dynamic transcriptome analyses provided insights into gene expression regulation and immune related pathways involved in S. ocellatus after V. harveyi infection, and provides useful information for further study on the immune defense mechanisms in S. ocellatus as well as other teleost species.
MeSH term(s)	Animals ; Transcriptome ; Peroxisome Proliferator-Activated Receptors/genetics ; Reproducibility of Results ; Vibrio/physiology ; Vibrio Infections ; Gene Expression Profiling/veterinary ; Perciformes/genetics ; Fish Diseases
Chemical Substances	Peroxisome Proliferator-Activated Receptors
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2024.109386
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Z 5917: Show issues

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Article ; Online: Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer.

Jia, JunJun / Zhou, Xuelian / Chu, Qingfei

Molecular and cellular biochemistry

2024

Abstract: Liver cancer (LC) poses a significant global health challenge due to its high incidence and poor prognosis. Current systemic treatment options, such as surgery, chemotherapy, radiofrequency ablation, and immunotherapy, have shown limited effectiveness ... ...

Abstract	Liver cancer (LC) poses a significant global health challenge due to its high incidence and poor prognosis. Current systemic treatment options, such as surgery, chemotherapy, radiofrequency ablation, and immunotherapy, have shown limited effectiveness for advanced LC patients. Moreover, owing to the heterogeneous nature of LC, it is crucial to uncover more in-depth pathogenic mechanisms and develop effective treatments to address the limitations of the existing therapeutic modalities. Increasing evidence has revealed the crucial role of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway in the pathogenesis of LC. The specific mechanisms driving the JAK-STAT pathway activation in LC, participate in a variety of malignant biological processes, including cell differentiation, evasion, anti-apoptosis, immune escape, and treatment resistance. Both preclinical and clinical investigations on the JAK-STAT pathway inhibitors have exhibited potential in LC treatment, thereby opening up avenues for the development of more targeted therapeutic strategies for LC. In this study, we provide an overview of the JAK-STAT pathway, delving into the composition, activation, and dynamic interplay within the pathway. Additionally, we focus on the molecular mechanisms driving the aberrant activation of the JAK-STAT pathway in LC. Furthermore, we summarize the latest advancements in targeting the JAK-STAT pathway for LC treatment. The insights presented in this review aim to underscore the necessity of research into the JAK-STAT signaling pathway as a promising avenue for LC therapy.
Language	English
Publishing date	2024-03-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-024-04983-5
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Zs.A 892: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Structural characterization of a novel polysaccharide from Tremella fuciformis and its interaction with gut microbiota.

Song, Haizhao / Lu, Jing / Chu, Qiang / Deng, Rou / Shen, Xinchun

Journal of the science of food and agriculture

2024

Abstract: Background: Because of their diverse biological activities, polysaccharides derived from Tremella fuciformis have received growing attention. This study aimed to investigate the structural characterization of a purified polysaccharide (designated as PTP- ...

Abstract	Background: Because of their diverse biological activities, polysaccharides derived from Tremella fuciformis have received growing attention. This study aimed to investigate the structural characterization of a purified polysaccharide (designated as PTP-3a) derived from T. fuciformis and explore its interaction with gut microbiota in vitro. Results: The findings revealed that PTP-3a had a molecular weight of 1.22 × 10 Conclusion: These findings suggested that PTP-3a has potential as a prebiotic for modulating the gut microbiota. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.13479
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Zs.B 808: Show issues

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Article ; Online: Alterations in white matter fiber tracts and their correlation with flying cadet behavior.

Chen, Xi / Chu, Qi / Meng, Qingbin / Xu, Peiran / Zhang, Shicong

Cerebral cortex (New York, N.Y. : 1991)

2024 Volume 34, Issue 2

Abstract: An increasing number of studies have shown that flight training alters the human brain structure; however, most studies have focused on gray matter, and the exploration of white matter structure has been largely neglected. This study aimed to investigate ...

Abstract	An increasing number of studies have shown that flight training alters the human brain structure; however, most studies have focused on gray matter, and the exploration of white matter structure has been largely neglected. This study aimed to investigate the changes in white matter structure induced by flight training and estimate the correlation between such changes and psychomotor and flight performance. Diffusion tensor imaging data were obtained from 25 flying cadets and 24 general college students. Data were collected in 2019 and 2022 and analyzed using automated fiber quantification. This study found no significant changes in the flight group in 2019. However, in 2022, the flight group exhibited significant alterations in the diffusion tensor imaging of the right anterior thalamic radiation, left cingulum cingulate, bilateral superior longitudinal fasciculus, and left arcuate fasciculus. These changes occurred within local nodes of the fiber tracts. In addition, we found that changes in fiber tracts in the 2022 flight group were correlated with the reaction time of the psychomotor test task and flight duration. These findings may help improve flight training programs and provide new ideas for the selection of excellent pilots.
MeSH term(s)	Humans ; White Matter/diagnostic imaging ; Diffusion Tensor Imaging/methods ; Brain/diagnostic imaging ; Gray Matter ; Nerve Fibers ; Anisotropy
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad548
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Zs.A 3235: Show issues

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Article ; Online: Determining the mechanical and decomposition properties of high energetic materials (α-RDX, β-HMX, and ε-CL-20) using a neural network potential.

Wen, Mingjie / Chang, Xiaoya / Xu, Yabei / Chen, Dongping / Chu, Qingzhao

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 13, Page(s) 9984–9997

Abstract: Molecular simulations of high energetic materials (HEMs) are limited by efficiency and accuracy. Recently, neural network potential (NNP) models have achieved molecular simulations of millions of atoms while maintaining the accuracy of density functional ...

Abstract	Molecular simulations of high energetic materials (HEMs) are limited by efficiency and accuracy. Recently, neural network potential (NNP) models have achieved molecular simulations of millions of atoms while maintaining the accuracy of density functional theory (DFT) levels. Herein, an NNP model covering typical HEMs containing C, H, N, and O elements is developed. The mechanical and decomposition properties of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), hexahydro-1,3,5-trinitro-1,3,5-triazine (HMX), and 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL-20) are determined by employing the molecular dynamics (MD) simulations based on the NNP model. The calculated results show that the mechanical properties of α-RDX, β-HMX, and ε-CL-20 agree with previous experiments and theoretical results, including cell parameters, equations of state, and elastic constants. In the thermal decomposition simulations, it is also found that the initial decomposition reactions of the three crystals are N-NO
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d4cp00017j
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Article ; Online: Ab Initio Driven Exploration on the Thermal Properties of Al-Li Alloy.

Chang, Xiaoya / Wu, Yongchao / Chu, Qingzhao / Zhang, Gang / Chen, Dongping

ACS applied materials & interfaces

2024 Volume 16, Issue 12, Page(s) 14954–14964

Abstract: Al-Li alloys are feasible and promising additives in advanced energy and propellant systems due to the significantly enhanced heat release and increased specific impulse. The thermal properties of Al-Li alloys directly determine the manufacturing, ... ...

Abstract	Al-Li alloys are feasible and promising additives in advanced energy and propellant systems due to the significantly enhanced heat release and increased specific impulse. The thermal properties of Al-Li alloys directly determine the manufacturing, storage safety, and ignition delay of propellants. In this study, a neural network potential (NNP) is developed to investigate the thermal behaviors of Al-Li alloys from an atomistic perspective. The novel NNP demonstrates an excellent predictive ability for energy, atomic force, mechanical behaviors, phonon vibrations, and dynamic evolutions. A series of NNP-based molecular dynamics simulations are performed to investigate the effect of Li doping on the thermal properties of Al-Li alloys. All calculated results for Al-Li alloys are consistent with experimental values for Al, ensuring their validity in predicting Al-Li interactions. The simulation results suggest that a minor increment in the Li content results in a slight change in the melting point, thermal expansion, and radical distribution functions. These three properties are associated with the lattice characteristics; nonetheless, it causes a substantial reduction in thermal conductivity, which is related to the physical properties of the elements. The lower thermal conductivity allows heat accumulation on the particle surface, thereby speeding up the surface premelt and ignition. This provides an alternative atomic explanation for the improved combustion performance of Al-Li alloys. These findings integrate insights from the field of alloy material science into crucial combustion applications, serving as an atomistic guide for developing manufacturing techniques.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c01480
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