LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 188

Search options

  1. Article: Urine and Saliva: Relevant Specimens for Malaria Diagnosis?

    Chai, Hwa Chia / Chua, Kek Heng

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: Blood remains the specimen of preference for malaria diagnosis, whether it is for microscopic, nucleic acid-based or biomarker detection ... ...

    Abstract Blood remains the specimen of preference for malaria diagnosis, whether it is for microscopic, nucleic acid-based or biomarker detection of
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12122989
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: The Potential Use of Volatile Biomarkers for Malaria Diagnosis.

    Chai, Hwa Chia / Chua, Kek Heng

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: Pathogens may change the odor and odor-related biting behavior of the vector and host to enhance pathogen transmission. In recent years, volatile biomarker investigations have emerged to identify odors that are differentially and specifically released by ...

    Abstract Pathogens may change the odor and odor-related biting behavior of the vector and host to enhance pathogen transmission. In recent years, volatile biomarker investigations have emerged to identify odors that are differentially and specifically released by pathogens and plants, or the pathogen-infected or even cancer patients. Several studies have reported odors or volatile biomarkers specifically detected from the breath and skin of malaria-infected individuals. This review will discuss the potential use of these odors or volatile biomarkers for the diagnosis of malaria. This approach not only allows for the non-invasive mean of sample collection but also opens up the opportunity to develop a biosensor for malaria diagnosis in low-resource settings.
    Language English
    Publishing date 2021-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11122244
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Virulence Profiles among Gastrointestinal and Extraintestinal Clinical Isolates of Plesiomonas shigelloides.

    Puah, Suat Moi / Puthucheary, Savithri Devi Ampalam / Chua, Kek Heng

    Japanese journal of infectious diseases

    2022  Volume 75, Issue 4, Page(s) 407–410

    Abstract: The genus Plesiomonas, represented by a single species, Plesiomonas shigelloides, is a gram-negative bacillus associated with gastrointestinal and extraintestinal diseases in humans. In this study, 44 clinical isolates (gastrointestinal, n = 41; ... ...

    Abstract The genus Plesiomonas, represented by a single species, Plesiomonas shigelloides, is a gram-negative bacillus associated with gastrointestinal and extraintestinal diseases in humans. In this study, 44 clinical isolates (gastrointestinal, n = 41; extraintestinal, n = 3) were genetically confirmed to be P. shigelloides using the hug gene. All 20 virulence genes were detected in the gastrointestinal isolates, ranging from 7.7% to 100%; however, only 12 genes were detected in the extra-gastrointestinal isolates, ranging from 33.3% to 100%. The phlA gene was significantly associated with the gastrointestinal isolates (P = 0.0216). The results of this study suggest that phlA may play a role in gastrointestinal infections. However, pilF, tolC, and fur were detected in both gastrointestinal and extraintestinal clinical isolates, and further investigations are warranted to elucidate their role in the pathogenesis of P. shigelloides.
    MeSH term(s) Gram-Negative Bacterial Infections ; Humans ; Plesiomonas/genetics ; Virulence/genetics
    Language English
    Publishing date 2022-01-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1478383-6
    ISSN 1884-2836 ; 1344-6304
    ISSN (online) 1884-2836
    ISSN 1344-6304
    DOI 10.7883/yoken.JJID.2021.477
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The Medicinal Mushroom Ganoderma neo-japonicum (Agaricomycetes) Polysaccharide Extract Prevents Obesity-Induced Diabetes in C57BL/6J Mice.

    Subramaniam, Sarasvathy / Ong, Kien Chai / Sabaratnam, Vikineswary / Chua, Kek Heng / Kuppusamy, Umah Rani

    International journal of medicinal mushrooms

    2023  Volume 25, Issue 4, Page(s) 27–42

    Abstract: Ganoderma neo-japonicum Imazeki is a medicinal mushroom consumed by the indigenous people in Malaysia as a remedy for diabetes. This study aims to validate the efficacy of G. neo-japonicum polysaccharides (GNJP) on obesity-induced type 2 diabetes ... ...

    Abstract Ganoderma neo-japonicum Imazeki is a medicinal mushroom consumed by the indigenous people in Malaysia as a remedy for diabetes. This study aims to validate the efficacy of G. neo-japonicum polysaccharides (GNJP) on obesity-induced type 2 diabetes mellitus (T2DM) in C57BL/6J mice. Mice were divided into seven groups; normal diet (ND)-control, high-fat-diet (HFD)-control, HFDGNJP-treated (50, 100, 200 mg/kg b.w.), HFDMET (metformin 50 mg/kg; positive-control) and ND-GNJP (200 mg/kg b.w.). Mice were administered GNJP or metformin orally for 10 weeks (thrice/week) and sacrificed after an oral glucose tolerance test. Body weight, serum biochemicals, liver histology, adipocyte gene expressions, glucose and insulin levels were measured. HFD caused obesity, dyslipidemia, and diabetes in the untreated groups. GNJP (50 mg/kg b.w.) supplementation prevented weight gain and liver steatosis, improved serum lipid profile and glucose tolerance and attenuated hyperglycemia and hyperinsulinemia more effectively when compared with the other treatment groups. The prevention of obesity and lipid dysregulation is plausibly attributed to the increased hormone-sensitive lipase and reduced Akt-1 and Ppary gene expressions while the up-regulation of AdipoQ (adiponectin), Prkag2 and Slc2a4 genes served to sensitize insulin and improve glucose uptake. Thus, supplementation with an appropriate dose of GNJP has promising efficacies in preventing HFD aka obesity-induced T2DM and associated metabolic abnormalities.
    MeSH term(s) Animals ; Mice ; Insulin Resistance ; Diabetes Mellitus, Type 2/prevention & control ; Agaricales/metabolism ; Mice, Inbred C57BL ; Blood Glucose/metabolism ; Obesity/complications ; Obesity/prevention & control ; Insulin/metabolism ; Polysaccharides ; Diet, High-Fat/adverse effects ; Metformin/therapeutic use ; Basidiomycota/metabolism ; Lipids
    Chemical Substances Blood Glucose ; Insulin ; Polysaccharides ; Metformin (9100L32L2N) ; Lipids
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108803-2
    ISSN 1940-4344 ; 1521-9437
    ISSN (online) 1940-4344
    ISSN 1521-9437
    DOI 10.1615/IntJMedMushrooms.2023047595
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7482: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Comparative Transcriptomic Profiling of Pellicle and Planktonic Cells from Carbapenem-Resistant

    Ng, Heng Kang / Puah, Suat Moi / Teh, Cindy Shuan Ju / Idris, Nuryana / Chua, Kek Heng

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: Acinetobacter ... ...

    Abstract Acinetobacter baumannii
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12071185
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Characterisation of pellicle-forming ability in clinical carbapenem-resistant

    Ng, Heng Kang / Puah, Suat Moi / Teh, Cindy Shuan Ju / Idris, Nuryana / Chua, Kek Heng

    PeerJ

    2023  Volume 11, Page(s) e15304

    Abstract: Background: Acinetobacter baumannii: Methods: The : Results: All 96 clinical CRAB isolates carried the : Conclusion: These four pellicle-forming clinical CRAB isolates could be potentially more virulent, therefore further investigation is ... ...

    Abstract Background: Acinetobacter baumannii
    Methods: The
    Results: All 96 clinical CRAB isolates carried the
    Conclusion: These four pellicle-forming clinical CRAB isolates could be potentially more virulent, therefore further investigation is warranted to provide insights into their pathogenic mechanisms.
    MeSH term(s) Humans ; Bacterial Proteins/genetics ; beta-Lactamases/genetics ; Acinetobacter baumannii/genetics ; Microbial Sensitivity Tests ; Carbapenems/pharmacology
    Chemical Substances Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; Carbapenems
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15304
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Emerging Strategies to Improve the Stability and Bioavailability of Insulin: An Update on Formulations and Delivery Approaches.

    Tan, Pak Kheong / Kuppusamy, Umah Rani / Chua, Kek Heng / Arumugam, Bavani

    Current drug delivery

    2022  Volume 20, Issue 8, Page(s) 1141–1162

    Abstract: One of the primary goals of diabetes management is to maintain blood glucose levels within a normal range, and insulin plays a vital role in achieving this. All Type 1 DM patients and advanced Type 2 DM patients require insulin. Insulin is administered ... ...

    Abstract One of the primary goals of diabetes management is to maintain blood glucose levels within a normal range, and insulin plays a vital role in achieving this. All Type 1 DM patients and advanced Type 2 DM patients require insulin. Insulin is administered subcutaneously, which may cause patient discomfort from the use of needles. Therefore, developing alternative routes of insulin administration has always been a major focus of diabetes research. This review aims to provide an update on the insulin formulations and delivery routes as well as strategies used to improve its stability and bioavailability for the treatment of diabetes.
    MeSH term(s) Humans ; Insulin/therapeutic use ; Biological Availability ; Drug Delivery Systems ; Diabetes Mellitus/drug therapy ; Hypoglycemic Agents/therapeutic use
    Chemical Substances Insulin ; Hypoglycemic Agents
    Language English
    Publishing date 2022-10-31
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2185284-4
    ISSN 1875-5704 ; 1567-2018
    ISSN (online) 1875-5704
    ISSN 1567-2018
    DOI 10.2174/1567201820666221102094433
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6415: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Genetic variations of penicillin-binding protein 1A: insights into the current status of amoxicillin-based regimens for

    Ng, Heng Kang / Chua, Kek Heng / Kee, Boon Pin / Chuah, Kee Huat / Por, Lip Yee / Puah, Suat Moi

    Journal of medical microbiology

    2024  Volume 73, Issue 5

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Amoxicillin/pharmacology ; Humans ; Helicobacter pylori/genetics ; Helicobacter pylori/drug effects ; Malaysia ; Helicobacter Infections/drug therapy ; Helicobacter Infections/microbiology ; Penicillin-Binding Proteins/genetics ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Genetic Variation ; Phylogeny ; Mutation ; Male ; Adult ; Microbial Sensitivity Tests ; Proton Pump Inhibitors/therapeutic use ; Female ; Middle Aged ; Drug Therapy, Combination ; Bacterial Proteins/genetics
    Chemical Substances Amoxicillin (804826J2HU) ; Penicillin-Binding Proteins ; Anti-Bacterial Agents ; Proton Pump Inhibitors ; Bacterial Proteins
    Language English
    Publishing date 2024-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001832
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: In vitro Anti-colorectal Cancer Potential of the Medicinal Mushroom Ganoderma neo-japonicum Imazeki in Hyperglycemic Condition: Impact on Oxidative Stress, Cell Cycle and Apoptosis

    Lau, Meng-Fei / Chua, Kek-Heng / Sabaratnam, Vikineswary / Kuppusamy, Umah Rani

    Nutrition and cancer. 2022 Mar. 24, v. 74, no. 3

    2022  

    Abstract: Clinical efficacy of chemotherapy is often compromised by diabetogenic glucose on colorectal cancer (CRC). High glucose has been shown to diminish the cytotoxicity of anticancer drugs. The issue can potentially be addressed with natural products. ... ...

    Abstract Clinical efficacy of chemotherapy is often compromised by diabetogenic glucose on colorectal cancer (CRC). High glucose has been shown to diminish the cytotoxicity of anticancer drugs. The issue can potentially be addressed with natural products. Recently, we revealed that Ganoderma neo-japonicum exhibits inhibitory activities against human colonic carcinoma cells. In this study, the impacts of hexane fraction (Hex, sterol-enriched) and chloroform fraction (Chl, terpenoid-enriched) were further elucidated. The cellular responses, including oxidative stress, cell cycle, and apoptosis were compared between the presence of normal glucose (NG, 5.5 mM) and high glucose (HG, 25 mM). HG promoted cell viability with concomitant elevation of GSH level. Both Hex and Chl fractions stimulated NO production, in addition, induced cell cycle arrest. The apoptotic effect of Hex fraction was glucose-dependent, but Chl fraction triggered apoptosis with an equivalent extent in NG and HG conditions. Overall, the active fractions from G. neo-japonicum show therapeutic potential in managing hyperglycemia-associated CRC.
    Keywords Ganoderma ; apoptosis ; carcinoma ; cell cycle checkpoints ; cell viability ; chloroform ; colorectal neoplasms ; cytotoxicity ; drug therapy ; glucose ; hexane ; humans ; medicinal fungi ; nutrition ; oxidative stress
    Language English
    Dates of publication 2022-0324
    Size p. 978-995.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2021.1931701
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Current status of

    Puah, Suat Moi / Goh, Khean Lee / Ng, Heng Kang / Chua, Kek Heng

    PeerJ

    2021  Volume 9, Page(s) e11518

    Abstract: Background: Resistance to clarithromycin and levofloxacin in : Materials and methods: Gastric biopsy samples were obtained from treatment-naïve patients. Bacterial genomic DNA was extracted using a commercial kit and continued with DNA amplification ... ...

    Abstract Background: Resistance to clarithromycin and levofloxacin in
    Materials and methods: Gastric biopsy samples were obtained from treatment-naïve patients. Bacterial genomic DNA was extracted using a commercial kit and continued with DNA amplification using polymerase chain reaction (PCR) with specific primers. The PCR amplicons were subjected to sequencing on 23S rRNA gene targeting nucleotide positions at 2,146, 2,147, 2,186 and amino acids at
    Results: Sixty-one urease-positive gastric biopsy samples were studied. The findings revealed the primary resistance rates to clarithromycin was 14.8% and to levofloxacin was 3.3% in our current scenario based on detection of reported resistance-related mutations of A2147G and D91N in 23S rRNA and
    Conclusion: The primary resistance rate of
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.11518
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top