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Article ; Online: Case-Finding for Sarcopenia in Community-Dwelling Older Adults: Comparison of Mini Sarcopenia Risk Assessment with SARC-F and SARC-CalF.

Chua, Shiyun / Chia, Jia Qian / Lim, Jun Pei / Chew, Justin / Lim, Wee Shiong

Annals of geriatric medicine and research

2024 Volume 28, Issue 1, Page(s) 57–64

Abstract: Background: We compared the diagnostic performance of the short five-item and full seven-item Mini Sarcopenia Risk Assessment Questionnaire (MSRA-5 and MSRA-7) against the Strength, Assistance walking, Rise from a chair, Climb stairs, and Falls (SARC-F) ...

Abstract	Background: We compared the diagnostic performance of the short five-item and full seven-item Mini Sarcopenia Risk Assessment Questionnaire (MSRA-5 and MSRA-7) against the Strength, Assistance walking, Rise from a chair, Climb stairs, and Falls (SARC-F) and SARC-F with calf circumference (SARC-CalF) scales for sarcopenia in healthy community-dwelling older adults. Methods: We conducted a post-hoc cross-sectional secondary data analysis of a prospective cohort study, using data from 230 older adults (mean age 67.2±7.4 years, 92% Chinese, and 73% female) from the "Longitudinal Assessment of Biomarkers for characterization of early Sarcopenia and Osteosarcopenic Obesity in predicting frailty and functional decline in community-dwelling Asian older adults Study" (GeriLABS-2) conducted between December 2017 and March 2019 in Singapore. We performed receiver operating characteristic curve analysis to ascertain the area under the curve (AUC) for sarcopenia diagnosis using the Asian Working Group for Sarcopenia 2019 consensus criteria. We applied the Delong method to compare the AUCs of the four instruments. Results: The MSRA-5 and MSRA-7 demonstrated poor diagnostic performance (AUC of 0.511, 95% confidence interval [CI] 0.433-0.589 and AUC of 0.526, 95% CI 0.445-0.606, respectively), compared to that in SARC-CalF (AUC of 0.739, 95% CI 0.671-0.808) and SARC-F (AUC of 0.564, 95% CI 0.591-0.636). The SARC-CalF demonstrated significantly superior discriminatory ability compared to that in the SARC-F, MSRA-5, and MSRA-7 (all p<0.01). The MSRA-5 demonstrated lower sensitivity (0.464) and specificity (0.597) than in the SARC-CalF (0.661 and 0.738, respectively), whereas the MSRA-7 had higher specificity (0.887) and lower sensitivity (0.145). Conclusion: Conclusions: The poor diagnostic performances of the MSRA-5 and MSRA-7 in our study suggest limitations of self-reported questionnaires for assessing general and dietary risk factors for sarcopenia in healthy and culturally diverse community-dwelling older adults. Studies in different populations are needed to ascertain the utility of the MSRA for the community detection of sarcopenia.
Language	English
Publishing date	2024-01-12
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3035056-6
ISSN	2508-4909 ; 2508-4798
ISSN (online)	2508-4909
ISSN	2508-4798
DOI	10.4235/agmr.23.0190
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Textual Analysis of Tweets Associated with Domestic Violence.

Chua, Stephanie / Sabang, Janice Allison / Chew, Keng Sheng / Nohuddin, Puteri Nor Ellyza

Iranian journal of public health

2023 Volume 52, Issue 11, Page(s) 2402–2411

Abstract: Background: Domestic violence is a global public health concern as stated by World Health Organization. We aimed to conduct a textual analysis of tweets associated with domestic violence through keyword identification, word trends and word collocations. ...

Abstract	Background: Domestic violence is a global public health concern as stated by World Health Organization. We aimed to conduct a textual analysis of tweets associated with domestic violence through keyword identification, word trends and word collocations. The data was obtained from Twitter, focusing on publicly available tweets written in English. The objectives are to find out if the identified keywords, word trends and word collocations can help differentiate between domestic violence-related tweets and non-domestic violence-related tweets, as well as, to analyze the textual characteristics of domestic violence-related tweets and non-domestic violence-related tweets. Methods: Overall, 11,041 tweets were collected using a few keywords over a period of 15 days from 22 March 2021 to 5 April 2021. A text analysis approach was used to discover the most frequent keywords used, the word trends of those keywords and the word collocations of the keywords in differentiating between domestic violence-related or non-domestic violence-related tweets. Results: Domestic violence-related tweets and non-domestic violence-related tweets had differentiating characteristics, despite sharing several main keywords. In particular, keywords like "domestic", "violence" and "suicide" featured prominently in domestic-violence related tweets but not in non-domestic violence-related tweets. Significant differences could also be seen in the frequency of keywords and the word trends in the collection of the tweets. Conclusion: These findings are significant in helping to automate the flagging of domestic-violence related tweets and alert the authorities so that they can take proactive steps such as assisting the victims in getting medical, police and legal help as needed.
Language	English
Publishing date	2023-12-01
Publishing country	Iran
Document type	Journal Article
ISSN	2251-6093 ; 0304-4556
ISSN (online)	2251-6093
ISSN	0304-4556
DOI	10.18502/ijph.v52i11.14039
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Conference proceedings ; Online: Glacial Isostatic Adjustment and sea-level change in Singapore and Southeast Asia

Li, T. / Shaw, T. / Kim, H. / Chua, S. / Wu, P. / Horton, B.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

Implications from past to future

2023

Abstract: Over 400 million people in Southeast Asia live in low elevation coastal zones and are susceptible to future relative sea-level (RSL) rise. Projections of future RSL rely on an accurate understanding of sea-level driving processes such as Glacial ... ...

Abstract	Over 400 million people in Southeast Asia live in low elevation coastal zones and are susceptible to future relative sea-level (RSL) rise. Projections of future RSL rely on an accurate understanding of sea-level driving processes such as Glacial Isostatic Adjustment (GIA). Here we apply GIA models, paleo RSL records and instrumental data to demonstrate the evolution of RSL changes in Singapore and Southeast Asia and the associated impacts. We reconstructed RSL since the Last Glacial Maximum (LGM) to quantify magnitudes and rates of RSL changes through time and used GIA model to assess paleotopography changes and impacts to human populations. We applied the Intergovernmental Panel on Climate Change (IPCC) RSL projections and used the geological past to provide probability perspectives when IPCC future projections were last exceeded in Singapore. Future projections under a moderate emissions scenario show RSL rising 0.95 m at a rate of 7.3 mm/yr by 2150 which was only exceeded (> 99% probability) during rapid ice melting events (MWPs) ~14.5 and ~9 ka BP. We inferred the human population history using 763 high-coverage whole-genome datasets. Integrated paleotopographic and population genomic analysis demonstrates the earliest documented instance of forced human migration driven by rapid sea-level rise (e.g., WMPs). We investigated the mid-Holocene highstand sensitivity revealing that Earth model variation affects the magnitude and ice model variation changes both the timing and magnitude of the highstand. Lastly, we produced a highstand “treasure map” to guide future highstand data collection efforts as the highstand is poorly constrained currently.
Subject code	910
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Corrigendum to "'Prediction of delirium using data mining: A systematic review" [J. Clin. Neurosci. 91C (2021) 288-298].

Chua, S J / Wrigley, S / Hair, C / Sahathevan, R

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2022 Volume 106, Page(s) 243

Language	English
Publishing date	2022-08-15
Publishing country	Scotland
Document type	Published Erratum
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2022.07.027
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Article ; Online: No selective integration required: A race model explains responses to audiovisual motion-in-depth.

Chua, S F Andrew / Liu, Yue / Harris, Julie M / Otto, Thomas U

Cognition

2022 Volume 227, Page(s) 105204

Abstract: Looming motion is an ecologically salient signal that often signifies danger. In both audition and vision, humans show behavioral biases in response to perceiving looming motion, which is suggested to indicate an adaptation for survival. However, it is ... ...

Abstract	Looming motion is an ecologically salient signal that often signifies danger. In both audition and vision, humans show behavioral biases in response to perceiving looming motion, which is suggested to indicate an adaptation for survival. However, it is an open question whether such biases occur also in the combined processing of multisensory signals. Towards this aim, Cappe, Thut, Romei, and Murraya (2009) found that responses to audiovisual signals were faster for congruent looming motion compared to receding motion or incongruent combinations. They considered this as evidence for selective integration of multisensory looming signals. To test this proposal, here, we successfully replicate the behavioral results by Cappe et al. (2009). We then show that the redundant signals effect (RSE - a speedup of multisensory compared to unisensory responses) is not distinct for congruent looming motion. Instead, as predicted by a simple probability summation rule, the RSE is primarily modulated by the looming bias in audition, which suggests that multisensory processing inherits a unisensory effect. Finally, we compare a large set of so-called race models that implement probability summation, but that allow for interference between auditory and visual processing. The best-fitting model, selected by the Akaike Information Criterion (AIC), virtually perfectly explained the RSE across conditions with interference parameters that were either constant or varied only with auditory motion. In the absence of effects jointly caused by auditory and visual motion, we conclude that selective integration is not required to explain the behavioral benefits that occur with audiovisual looming motion.
MeSH term(s)	Acoustic Stimulation/methods ; Auditory Perception/physiology ; Humans ; Photic Stimulation/methods ; Reaction Time/physiology ; Visual Perception/physiology
Language	English
Publishing date	2022-06-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1499940-7
ISSN	1873-7838 ; 0010-0277
ISSN (online)	1873-7838
ISSN	0010-0277
DOI	10.1016/j.cognition.2022.105204
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: One-year outcome of selective caries removal versus pulpotomy treatment of deep caries: A pilot randomized controlled trial.

Chua, S K X / Sim, Y F / Wang, W C / Mok, B Y Y / Yu, V S H

International endodontic journal

2023 Volume 56, Issue 12, Page(s) 1459–1474

Abstract: Aim: This study aimed to compare the outcome of SCR and Pulpotomy in teeth with deep caries extending at least 75% into dentine.: Methodology: This two-armed, parallel-group, randomized, superiority trial included vital mature permanent teeth with ... ...

Abstract	Aim: This study aimed to compare the outcome of SCR and Pulpotomy in teeth with deep caries extending at least 75% into dentine. Methodology: This two-armed, parallel-group, randomized, superiority trial included vital mature permanent teeth with deep primary or secondary caries diagnosed radiographically as being at least 75% into the thickness of dentine, without clinical signs of symptomatic irreversible pulpitis or radiographic evidence of a periapical lesion. Carious teeth were blindly allocated to receive either SCR or Pulpotomy using computer-generated randomized patient codes concealed in opaque envelopes. All teeth were reviewed clinically and radiographically at 6 months and 1 year post-treatment. Using a significance level of p < .05, the log rank test and Cox proportional hazards regression were used to compare the outcome of SCR and Pulpotomy and to identify potential prognostic factors, respectively. Results: In all, 58 teeth in the SCR group and 55 teeth in the pulpotomy group completed treatment, after excluding 6 teeth because they did not complete the allocated treatment and another due to severe periodontal disease. At one year, 57/58 (98.3%) teeth from the SCR group and 48/55 (87.3%) teeth from the Pulpotomy group were available for analysis. One tooth in the Pulpotomy group (2.1%) and eight teeth in the SCR group (14.0%) required the further intervention of root canal treatment (p < .05). There were no other significant prognostic factors for survival. Overall, 91.4% of teeth treated with either SCR or Pulpotomy survived without requiring further intervention over a period of one year. No other adverse events occurred over the review period. Conclusion: Within the limitations of this study, Pulpotomy fares better than SCR in preserving the remaining pulp and periapical health. As a treatment modality, Pulpotomy carries greater cost outlay to patient and takes a longer time to complete treatment than SCR. Long-term follow-up is needed to study the pulpal and restorative outcomes of Pulpotomy and SCR.
MeSH term(s)	Humans ; Pulpotomy ; Dental Caries Susceptibility ; Pilot Projects ; Calcium Compounds/therapeutic use ; Treatment Outcome ; Pulpitis/surgery ; Pulpitis/drug therapy ; Dental Caries/diagnostic imaging ; Dental Caries/surgery ; Silicates/therapeutic use
Chemical Substances	Calcium Compounds ; Silicates
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	603734-3
ISSN	1365-2591 ; 0143-2885
ISSN (online)	1365-2591
ISSN	0143-2885
DOI	10.1111/iej.13978
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Polypropylene anterior-apical single-incision UPHOLD-LITE mesh surgery in women with severe pelvic organ prolapse: Outcome at 53 months follow up.

Lo, Tsia-Shu / Harun, Fazlin / Chua, Sandy / Shen, Yu-Hua / Tan, Yiap Loong / Hsieh, Wu-Chiao

Journal of the Formosan Medical Association = Taiwan yi zhi

2023 Volume 123, Issue 3, Page(s) 331–339

Abstract: Background and purpose: We present this current study to complement with mesh inlays plausible benefits (UPHOLD-LITE System) on available long-term study amidst FDA's concern on mesh complications. This study aims to assess the medium-term outcomes of ... ...

Abstract	Background and purpose: We present this current study to complement with mesh inlays plausible benefits (UPHOLD-LITE System) on available long-term study amidst FDA's concern on mesh complications. This study aims to assess the medium-term outcomes of UPHOLD-LITE system for treatment of advanced pelvic organ prolapse (POP) and its complications, and lower urinary tract symptoms. Methods: This is a retrospective case series of 53 months follow-up of 123 consecutive patients who underwent UPHOLD-LITE system. Objective outcome measures the anatomical correction of prolapse with POP-Q ≤ Stage 1. Subjective outcome was patient's feedback to questions 2 and 3 of POPDI-6. Secondary outcome measures the quality of life, presence of lower urinary tract symptoms and complications. Quality of life is assessed by validated questionnaires on Urogenital Distress Inventory 6 (UDI-6), Incontinence Impact Questionnaire 7 (IIQ-7), Pelvic Organ Prolapse Distress Inventory 6 (POPDI-6), and Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire 12 (PISQ-12) at 1 and 3 years post-operatively. Results: Objective outcome at 1 and 3 years was at 96.7 % and 95.4 % respectively. The subjective cure was 95.1 % and 91.6 %. Five-year cumulative cure rate maintained at 87.2 %. Secondary outcomes observed improvement on UDI-6, IIQ-7, POPDI-6 and PISQ-12 postoperatively. Bladder outlet obstruction improved while de novo urodynamic stress incontinence (USI) increased slightly post surgically. Mesh erosion rate was 0.8 %. Conclusion: The UPHOLD-LITE system demonstrated good medium term anatomical correction of apical and anterior prolapse, with good subjective cure and improved quality of life. Whilst complication rate was low, slight increase in de novo USI was observed.
MeSH term(s)	Humans ; Female ; Follow-Up Studies ; Treatment Outcome ; Polypropylenes ; Retrospective Studies ; Quality of Life ; Surgical Mesh ; Pelvic Organ Prolapse/surgery ; Urinary Incontinence/surgery ; Urinary Incontinence, Stress ; Surveys and Questionnaires
Chemical Substances	Polypropylenes
Language	English
Publishing date	2023-11-22
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2023.11.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prediction of delirium using data mining: A systematic review.

Chua, S J / Wrigley, S / Hair, C / Sahathevan, R

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2021 Volume 91, Page(s) 288–298

Abstract: Delirium remains a significant cause of morbidity, mortality and economic burden to society. "Big data" refers to data of significantly large volume, obtained from a variety of resources, which is created and processed at high velocity. We conducted a ... ...

Abstract	Delirium remains a significant cause of morbidity, mortality and economic burden to society. "Big data" refers to data of significantly large volume, obtained from a variety of resources, which is created and processed at high velocity. We conducted a systematic review and meta-analysis exploring whether big data could predict the incidence of delirium of patients in the inpatient setting. Medline, Embase, the Cochrane Library, Web of Science, CINAHL, clinicaltrials.gov, who.int and IEEE Xplore were searched using MeSH terms "big data", "data mining", "delirium" and "confusion" up to 30th September 2019. We included both randomised and observational studies. The primary outcome of interest was development of delirium and the secondary outcomes of interest were type of statistical methods used, variables included in the mining algorithms and clinically important outcomes such as mortality and length of hospital stay. The quality of studies was graded using the CHARMs checklist. Six retrospective single centre observational studies were included (n = 178,091), of which 17, 574 participants developed delirium. Studies were of generally of low to moderate quality. The most commonly studied method was random forest, followed by support vector machine and artificial neural networks. The model with best performance for delirium prediction was random forest, with area under receiver operating curve (AUROC) ranging from 0.78 to 0.91. Sensitivity ranged from 0.59 to 0.81 and specificity ranged from 0.73 to 0.92. Our systematic review suggests that machine-learning techniques can be utilised to predict delirium.
MeSH term(s)	Area Under Curve ; Data Mining ; Delirium/diagnosis ; Delirium/epidemiology ; Humans ; Length of Stay ; Retrospective Studies
Language	English
Publishing date	2021-07-26
Publishing country	Scotland
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2021.07.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Relation Extraction in Biomedical Texts Based on Multi-Head Attention Model With Syntactic Dependency Feature: Modeling Study.

Li, Yongbin / Hui, Linhu / Zou, Liping / Li, Huyang / Xu, Luo / Wang, Xiaohua / Chua, Stephanie

JMIR medical informatics

2022 Volume 10, Issue 10, Page(s) e41136

Abstract: Background: With the rapid expansion of biomedical literature, biomedical information extraction has attracted increasing attention from researchers. In particular, relation extraction between 2 entities is a long-term research topic.: Objective: ... ...

Abstract	Background: With the rapid expansion of biomedical literature, biomedical information extraction has attracted increasing attention from researchers. In particular, relation extraction between 2 entities is a long-term research topic. Objective: This study aimed to perform 2 multiclass relation extraction tasks of Biomedical Natural Language Processing Workshop 2019 Open Shared Tasks: relation extraction of Bacteria-Biotope (BB-rel) task and binary relation extraction of plant seed development (SeeDev-binary) task. In essence, these 2 tasks are aimed at extracting the relation between annotated entity pairs from biomedical texts, which is a challenging problem. Methods: Traditional research methods adopted feature- or kernel-based methods and achieved good performance. For these tasks, we propose a deep learning model based on a combination of several distributed features, such as domain-specific word embedding, part-of-speech embedding, entity-type embedding, distance embedding, and position embedding. The multi-head attention mechanism is used to extract the global semantic features of an entire sentence. Meanwhile, we introduced a dependency-type feature and the shortest dependency path connecting 2 candidate entities in the syntactic dependency graph to enrich the feature representation. Results: Experiments show that our proposed model has excellent performance in biomedical relation extraction, achieving F Conclusions: We demonstrated that the multi-head attention mechanism can learn relevant syntactic and semantic features in different representation subspaces and different positions to extract comprehensive feature representation. Moreover, syntactic dependency features can improve the performance of the model by learning dependency relation between the entities in biomedical texts.
Language	English
Publishing date	2022-10-20
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2798261-0
ISSN	2291-9694
ISSN	2291-9694
DOI	10.2196/41136
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Article ; Online: Effects of the COVID-19 Pandemic on the Use of Telehealth for Antenatal Care.

Trinh, Lieu Thi Thuy / Achat, Helen / Chua, Seng / Gidaszewski, Beata / Stubbs, Joanne M / Guevarra, Veth

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2022

Abstract: Aims: ...

Abstract	Aims:
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2021.0631
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