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Article ; Online: Risk Stratification of Precursors to Multiple Myeloma in 2020.

Chudasama, Rani / Barth, Peter

Rhode Island medical journal (2013)

2020 Volume 103, Issue 3, Page(s) 46–47

Abstract: With advances in the treatment of plasma cell disorders, there have also been improvements in the risk stratification of these diseases. There are currently no screening recommendations for monoclonal gammopathy of unknown significance (MGUS); however, ... ...

Abstract	With advances in the treatment of plasma cell disorders, there have also been improvements in the risk stratification of these diseases. There are currently no screening recommendations for monoclonal gammopathy of unknown significance (MGUS); however, new studies are analyzing the role of screening for patients age 40-75 who are African American or have a family history of multiple myeloma (MM). Patients with smoldering multiple myeloma (SMM) have an increased risk of progression to MM when compared to MGUS. Data have shown that evaluation of bone marrow biopsy, full body MRI and free light chain ratios can identify high-risk SMM patients. Current investigation into early initiation of treatment for patients with SMM who do not meet criteria for MM showed improvement in time to progression. By continuing to evaluate clinical markers of disease burden, physicians can risk stratify patients to identify those at highest risk for progression to MM.
MeSH term(s)	Disease Progression ; Humans ; Monoclonal Gammopathy of Undetermined Significance/complications ; Monoclonal Gammopathy of Undetermined Significance/diagnosis ; Multiple Myeloma/diagnosis ; Prognosis ; Risk Assessment ; Risk Factors ; Smoldering Multiple Myeloma/diagnosis
Language	English
Publishing date	2020-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	419430-5
ISSN	2327-2228 ; 0363-7913
ISSN (online)	2327-2228
ISSN	0363-7913
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Article: Vaccines in Gastrointestinal Malignancies: From Prevention to Treatment.

Chudasama, Rani / Phung, Quan / Hsu, Andrew / Almhanna, Khaldoun

Vaccines

2021 Volume 9, Issue 6

Abstract: Gastrointestinal (GI) malignancies are some of the most common and devastating malignancies and include colorectal, gastric, esophageal, hepatocellular, and pancreatic carcinomas, among others. Five-year survival rates for many of these malignancies ... ...

Abstract	Gastrointestinal (GI) malignancies are some of the most common and devastating malignancies and include colorectal, gastric, esophageal, hepatocellular, and pancreatic carcinomas, among others. Five-year survival rates for many of these malignancies remain low. The majority presents at an advanced stage with limited treatment options and poor overall survival. Treatment is advancing but not at the same speed as other malignancies. Chemotherapy and radiation treatments are still only partially effective in GI malignancies and cause significant side effects. Thus, there is an urgent need for novel strategies in the treatment of GI malignancies. Recently, immunotherapy and checkpoint inhibitors have entered as potential new therapeutic options for patients, and thus, cancer vaccines may play a major role in the future of treatment for these malignancies. Further advances in understanding the interaction between the tumor and immune system have led to the development of novel agents, such as cancer vaccines.
Language	English
Publishing date	2021-06-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines9060647
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Article: Targeted therapies for gastroesophageal cancers.

Hsu, Andrew / Chudasama, Rani / Almhanna, Khaldoun / Raufi, Alexander

Annals of translational medicine

2020 Volume 8, Issue 17, Page(s) 1104

Abstract: Gastroesophageal cancers are some of the most common malignancies worldwide. A significant portion of patients are diagnosed with advanced or metastatic disease given the insidious nature of gastroesophageal cancers. In the instance where surgical ... ...

Abstract	Gastroesophageal cancers are some of the most common malignancies worldwide. A significant portion of patients are diagnosed with advanced or metastatic disease given the insidious nature of gastroesophageal cancers. In the instance where surgical resection for cure is no longer an option, the prognosis is poor and generally less than a year. Traditionally, standard front-line chemotherapy included two- to three-drug regimens with modest improvements in overall survival. Over the past two decades, with increased understanding of the biology of cancer, targeted therapies have been developed to stop the actions of molecules that are key in the growth and spread of cancer cells and have been successful in a number of cancers. In gastroesophageal cancer, these gains have been more modest with limited approval-trastuzumab being incorporated into front-line use in HER2-positive disease, and ramucirumab alone or in combination with paclitaxel becoming the preferred second-line regimen in progressive disease. However, with increased understanding of the biology of cancer, new and promising targeted therapies have emerged along with novel strategies in combining targeted therapies with traditional chemotherapy and immunotherapy. In this article, we will review the use of targeted therapies in the treatment of gastroesophageal cancer and touch upon future treatment strategies and therapeutics currently under investigation.
Language	English
Publishing date	2020-11-02
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-3265
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Article ; Online: Orbital metastasis in inflammatory breast cancer.

Chudasama, Rani / Hsu, Andrew / Constantinou, Maria

The breast journal

2020 Volume 26, Issue 8, Page(s) 1629–1630

MeSH term(s)	Breast Neoplasms ; Female ; Humans ; Inflammatory Breast Neoplasms/diagnostic imaging ; Orbital Neoplasms/diagnostic imaging
Language	English
Publishing date	2020-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.13839
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Article ; Online: Delayed Diagnosis of Disseminated Cryptococcosis with Associated Meningoencephalitis in an Immunocompetent Septuagenarian Host.

Chan, Isaac S / Chudasama, Rani / Burrows, Adam B

The American journal of medicine

2017 Volume 130, Issue 1, Page(s) e31–e32

Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2016.05.044
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Ua VI Zs.289: Show issues

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Article ; Online: Structure prediction and molecular docking studies of aromatic hydrocarbon sensing proteins TbuT, HbpR and PhnR to detect priority pollutants.

Patel, Rushika / Chudasama, Rajesh / Solanki, Rutujaben / Patel, Priya / Parmar, Krupali / Munshi, Nasreen S

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

2019 Volume 55, Issue 2, Page(s) 126–141

Abstract: On-line detection of aromatic hydrocarbon pollutants in aqueous environments can be achieved by biosensing strains having fusion of gene responsible for pollutant sensing protein with a reporter gene. Regulatory proteins TbuT, HbpR and PhnR are such ... ...

Abstract	On-line detection of aromatic hydrocarbon pollutants in aqueous environments can be achieved by biosensing strains having fusion of gene responsible for pollutant sensing protein with a reporter gene. Regulatory proteins TbuT, HbpR and PhnR are such proteins for recognizing one-, two-and three-ring aromatic hydrocarbon pollutants respectively, for which the structure is not known till date. Aim of the present study was to predict the structure of proteins and to determine their
MeSH term(s)	Amino Acid Sequence ; Bacterial Proteins/chemistry ; Biosensing Techniques/methods ; Computer Simulation ; Environmental Pollutants/analysis ; Hydrocarbons, Aromatic/analysis ; Ligands ; Molecular Docking Simulation ; Molecular Weight ; Protein Stability ; Sensitivity and Specificity
Chemical Substances	Bacterial Proteins ; Environmental Pollutants ; Hydrocarbons, Aromatic ; Ligands
Language	English
Publishing date	2019-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	196584-0
ISSN	1532-4117 ; 0360-1226 ; 1077-1204 ; 1093-4529
ISSN (online)	1532-4117
ISSN	0360-1226 ; 1077-1204 ; 1093-4529
DOI	10.1080/10934529.2019.1672457
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Article ; Online: Atrial fibrillation and heart failure due to reduced versus preserved ejection fraction: A systematic review and meta-analysis of death and adverse outcomes.

Kotecha, Dipak / Chudasama, Rajiv / Lane, Deirdre A / Kirchhof, Paulus / Lip, Gregory Y H

International journal of cardiology

2015 Volume 203, Page(s) 660–666

Abstract: Background: Atrial fibrillation (AF) and heart failure frequently coexist, commonly resulting in serious adverse events. With both conditions increasing in prevalence and justified concerns about treatment efficacy, it is vital to understand how the ... ...

Abstract	Background: Atrial fibrillation (AF) and heart failure frequently coexist, commonly resulting in serious adverse events. With both conditions increasing in prevalence and justified concerns about treatment efficacy, it is vital to understand how the type of heart failure impacts on prognosis. Methods: We performed a systematic review of studies examining cardiovascular outcomes in AF patients with heart failure and reduced ejection fraction (AF-HFrEF) compared to those with preserved ejection fraction (AF-HFpEF). The primary outcome was all-cause mortality, meta-analyzed using a random-effects model. Prospective registration: PROSPERO-CRD42014007305. Results: Thirteen studies were included in the systematic review (n=54,587) with 10 suitable for meta-analysis, including retrospective/prospective cohorts and sub-group analyses of randomized trials. AF-HFrEF was present in 49% and these patients were younger, more often male and with higher NYHA class than AF-HFpEF. Oral anticoagulation use was 55% versus 50% respectively (p<0.001). All-cause mortality was significantly higher in AF-HFrEF; risk ratio (RR) 1.24, 95% CI 1.12-1.36, p<0.001 (n=45,100), with absolute death rates of 24% compared to 18% in AF-HFpEF over 2 years. There were no significant differences in incident stroke (RR 0.85, 95% CI 0.70-1.03, p=0.094; n=33,773) or heart failure hospitalization (RR 1.21, 95% CI 0.96-1.53, p=0.115; n=31,583). The risk of bias was generally low, but heterogeneity was substantial. Conclusions: All-cause mortality is significantly higher in AF patients with HFrEF compared to HFpEF, although stroke risk and heart failure hospitalization are similar. Further studies are needed to address the prevention of adverse outcomes in all AF patients with heart failure, regardless of ejection fraction.
MeSH term(s)	Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Heart Failure/complications ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Humans ; Prognosis ; Stroke Volume/physiology
Language	English
Publishing date	2015-10-28
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2015.10.220
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Article: A Two Wave Analysis of Hospitalizations and Mortality from Seasonal and Pandemic 2009 A (H1N1) Influenza in Saurashtra, India: 2009-2011.

Chudasama, Rk / Patel, Uv / Verma, Pb / Banerjee, A / Buch, P / Patel, P

Annals of medical and health sciences research

2013 Volume 3, Issue 3, Page(s) 334–340

Abstract: Background: During May 2009, India reported the confirmed case of 2009 A (H1N1) influenza reported and in August 2009, Saurashtra region made the first report.: Aim: We describe the clinico-epidemiological characteristics of patients who were ... ...

Abstract	Background: During May 2009, India reported the confirmed case of 2009 A (H1N1) influenza reported and in August 2009, Saurashtra region made the first report. Aim: We describe the clinico-epidemiological characteristics of patients who were hospitalized with 2009 A (H1N1) influenza infection and seasonal influenza in Saurashtra region. Subjects and methods: A total of 1726 patients suffering from A (H1N1) influenza and seasonal influenza were admitted in the different hospitals of Rajkot city of Saurashtra region during September 2009-February 2011. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm the infection. The clinico-epidemiological features of the patients were closely monitored. Data were analyzed by Chi square or Fisher's exact test, using Epi Info software (version 3.5.1) of the Center for Disease Control (CDC). Results: Among the patients hospitalized due to influenza, 29.6% (511/1726) were laboratory confirmed cases of A (H1N1) influenza while the rest 70.4% (1215/1726) were cases of seasonal influenza. A median time of 5 days was observed from the onset of illness to laboratory confirmed diagnosis of A (H1N1) influenza. The median duration of hospital stay of such patients was 2-32 days. All admitted A (H1N1) influenza patients received Oseltamivir drug, but only 14.9% (76/511) received it within 2 days of onset of illness. 24.9% (127/511) of those admitted for A (H1N1) influenza died as compared to 5.3% (65/1215) of those suffering from seasonal influenza. The most common symptoms were cough, fever, sore throat and shortness of breath in both the groups of patients. The prevalence of any coexisting morbidity in those with A (H1N1) influenza was 31.3% (160/511) while in those with seasonal influenza it was 19.4% (236/1215). The common coexisting morbidities were hypertension, diabetes mellitus, chronic pulmonary diseases and pregnancy. Pneumonia was reported in 91% positive patients with chest radiography. Conclusion: Though the clinico-epidemiological pattern of the A (H1N1) influenza patients were comparable to that of those suffering from seasonal influenza, a fivefold higher mortality was noted in A (H1N1) influenza patients. Hypertension, pregnancy, pneumonia on chest X-ray, and receiving antiviral treatment within 2 days of illness onset were mainly reported among A (H1N1) influenza patients.
Language	English
Publishing date	2013-08-01
Publishing country	India
Document type	Journal Article
ZDB-ID	2732886-7
ISSN	2277-9205 ; 2141-9248
ISSN (online)	2277-9205
ISSN	2141-9248
DOI	10.4103/2141-9248.117929
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Article: Role of cationic and anionic peroxidase in browning of multiple shoots of carnation (Dianthus caryophyllus L.) in vitro

Kansagra, M. / Pawar, V. / Bhatt, K. / Chudasama, R. / Thaker, V.

Indian Journal of Plant Physiology (India)

(Jul-Sep 2008) , Issue (3)

Abstract: Multiple shoots were induced from nodal region of carnation (Dianthus caryophyllus L.) in Murashige and Skoog medium containing 1.5 mg 1-1 BAP and 0.5 mg J-l NAA. Induction of the shoots was observed in three weeks, but good amount of tissue turned brown ...

Abstract	Multiple shoots were induced from nodal region of carnation (Dianthus caryophyllus L.) in Murashige and Skoog medium containing 1.5 mg 1-1 BAP and 0.5 mg J-l NAA. Induction of the shoots was observed in three weeks, but good amount of tissue turned brown in sub-cultures. Cationic and anionic peroxidase activities were studied in green and brown multiple shoot culture of carnation. It was observed that anionic protein was more in brown tissue and specific anionic peroxidase activity was also higher. It is concluded that anionic peroxidase plays an important role in browning of the tissue.
Keywords	DIANTHUS CARYOPHYLLUS ; IN VITRO ; SHOOTS
Language	English
Document type	Article
ISSN	0019-5502
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Iodine deficiency disorders in 6-12 years old rural primary school children in Kutch district, Gujarat.

Chudasama, Rajesh / Patel, Umed V / R, Ravikant / Verma, Pramod H

Indian pediatrics

2010 Volume 48, Issue 6, Page(s) 453–456

Abstract: Objective: To compare prevalence of goitre in primary school children; to determine median urinary iodine concentration in children; and, to assess level of salt iodization at retail trader level.: Design: 30 cluster survey study.: Settings: ... ...

Abstract	Objective: To compare prevalence of goitre in primary school children; to determine median urinary iodine concentration in children; and, to assess level of salt iodization at retail trader level. Design: 30 cluster survey study. Settings: Primary schools of Kutch district, Gujarat, India. Methods: Total 70 students including five boys and five girls from 1st to 7th standard, present in class on the day of visit were selected randomly for Goitre examination (n=2100). Urine sample was collected from one boy and one girl from each standard in each cluster. From the community, 28 children, including two boys and two girls from each standard in the same age group were examined, and salt samples were tested from their households. From each village, one retail shop was visited and various salts available were purchased and tested for iodine on the spot with spot kit. Results: Goitre prevalence of 11.2% was found among primary school children (grade 1- 8.6% and grade 2-2.6%). As the age increased, the Goitre prevalence also increased except in age group of 8 years. Median urinary iodine excretion level was 110 µg/L. Iodine level more than 15 ppm was found in 92.3% salts samples tested at the household level. Conclusion: Present study showed mild goitre prevalence in primary school children in Kutch district of Gujarat.
MeSH term(s)	Child ; Cross-Sectional Studies ; Female ; Goiter/epidemiology ; Humans ; India/epidemiology ; Iodine/deficiency ; Male ; Prevalence ; Rural Population ; Students/statistics & numerical data
Chemical Substances	Iodine (9679TC07X4)
Language	English
Publishing date	2010-11-30
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
DOI	10.1007/s13312-011-0077-y
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