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  1. AU="Chun-Lin Yang"
  2. AU="Romine, Kyle A"
  3. AU="Cunsolo, Vincenzo"
  4. AU="Ba, Aboubacar"
  5. AU="Prisca, Mirandolina"
  6. AU="Perez, Tate"
  7. AU="Bakkaloglu, Sevan"
  8. AU="Guernieri, Rebecca L"
  9. AU="Xing, Z Y"
  10. AU="Yu-Heng Cheng"
  11. AU=Freeman Richard B Jr
  12. AU="Wang, Qi-En"
  13. AU="Mallamaci, M"
  14. AU="Turk, Yael R"
  15. AU="Tinto, Monica"
  16. AU="Selvendiran, Karuppaiyah" AU="Selvendiran, Karuppaiyah"
  17. AU="Enns, Murray W"
  18. AU="Yaohua Yang" AU="Yaohua Yang"

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  1. Artikel ; Online: Altered serum levels of cytokines in patients with myasthenia gravis

    Shu-Li Wei / Chun-Lin Yang / Wei-Yue Si / Jing Dong / Xue-Lu Zhao / Peng Zhang / Heng Li / Cong-Cong Wang / Min Zhang / Xiao-Li Li / Rui-Sheng Duan

    Heliyon, Vol 10, Iss 1, Pp e23745- (2024)

    1481  

    Abstract: Background: Myasthenia gravis (MG) is an autoimmune disease characterized by generalized skeletal muscle contraction weakness due to autoantibodies targeting neural-muscular junctions. Here, we investigated the relationship between key cytokines and MG ... ...

    Abstract Background: Myasthenia gravis (MG) is an autoimmune disease characterized by generalized skeletal muscle contraction weakness due to autoantibodies targeting neural-muscular junctions. Here, we investigated the relationship between key cytokines and MG type, disease course, antibodies, and comorbidities. Method: Cytokine levels in serum samples collected from MG (n = 45) and healthy control (HC, n = 38) patients from January 2020 to June 2022 were quantified via flow cytometry. Results: Levels of IL-6 were higher in the MG group versus healthy individuals (p = 0.026) and in patients with generalized versus ocular MG (p = 0.019). IL-6 levels were positively correlated with QMG score. In patients with MG with both AChR and Titin antibodies, serum levels of sFas and granulysin were higher than in those with AChR alone (p = 0.036, and p = 0.028, respectively). LOMG had a reduction in serum levels of IL-2 compared to EOMG (p = 0.036). LOMG patients with diabetes had lower serum levels of IL-2, IL-4, and IFN-γ (p = 0.044, p = 0.038, and p = 0.047, respectively) versus those without diabetes. sFas in the MG with Abnormal thymus were reduced compared to those in MG with Normal thymus (p = 0.008). Conclusions: This study revealed a positive correlation between IL-6 level and MG status. Serum cytokine levels of the AChR + Titin MG group differed from those of the AChR group. LOMG had a lower IL-2 level. Comorbidities affect some cytokines in peripheral blood in MG serum.
    Schlagwörter Myasthenia gravis ; Cytokine ; Titin ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Insight into the Systematics of Novel Entomopathogenic Fungi Associated with Armored Scale Insect, Kuwanaspis howardi (Hemiptera

    Xiu-Lan Xu / Qian Zeng / Yi-Cong Lv / Rajesh Jeewon / Sajeewa S. N. Maharachchikumbura / Dhanushka N. Wanasinghe / Kevin D. Hyde / Qian-Gang Xiao / Ying-Gao Liu / Chun-Lin Yang

    Journal of Fungi, Vol 7, Iss 628, p

    Diaspididae) in China

    2021  Band 628

    Abstract: This study led to the discovery of three entomopathogenic fungi associated with Kuwanaspis howardi , a scale insect on Phyllostachys heteroclada (fishscale bamboo) and Pleioblastus amarus (bitter bamboo) in China. Two of these species belong to ... ...

    Abstract This study led to the discovery of three entomopathogenic fungi associated with Kuwanaspis howardi , a scale insect on Phyllostachys heteroclada (fishscale bamboo) and Pleioblastus amarus (bitter bamboo) in China. Two of these species belong to Podonectria : P. kuwanaspidis X.L. Xu & C.L. Yang sp. nov. and P . novae-zelandiae Dingley. The new species P. kuwanaspidis has wider and thicker setae, longer and wider asci, longer ascospores, and more septa as compared with similar Podonectria species. The morphs of extant species P. novae-zelandiae is confirmed based on sexual and asexual morphologies. Maximum likelihood and Bayesian inference analyses of ITS, LSU, SSU, tef1-α , and rpb2 sequence data provide further evidence for the validity of the two species and their placement in Podonectriaceae (Pleosporales). The second new species, Microcera kuwanaspidis X.L. Xu & C.L. Yang sp. nov., is established based on DNA sequence data from ITS, LSU, SSU, tef1-α , rpb1 , rpb2 , acl1 , act , cmdA , and his3 gene regions, and it is characterized by morphological differences in septum numbers and single conidial mass.
    Schlagwörter 2 new taxa ; bamboo ; entomopathogens ; Nectriaceae ; Podonectriaceae ; scale insect ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 590
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Toll-like receptor 9 antagonist suppresses humoral immunity in experimental autoimmune myasthenia gravis

    Zhang, Peng / Chun-lin Yang / Ru-tao Liu / Heng Li / Min Zhang / Na Zhang / Long-tao Yue / Cong-cong Wang / Ying-chun Dou / Rui-sheng Duan

    Molecular immunology. 2018 Feb., v. 94

    2018  

    Abstract: Recent studies have demonstrated the important role of toll-like receptor 9 (TLR9) signalling in autoimmune diseases, but its role in myasthenia gravis (MG) has not been fully established. We show herein that blocking TLR9 signalling via the suppressive ... ...

    Abstract Recent studies have demonstrated the important role of toll-like receptor 9 (TLR9) signalling in autoimmune diseases, but its role in myasthenia gravis (MG) has not been fully established. We show herein that blocking TLR9 signalling via the suppressive oligodeoxynucleotide (ODN) H154 alleviated the symptoms of experimental autoimmune myasthenia gravis (EAMG). With the downregulation of dendritic cells (DCs), TLR9 interruption reduced follicular helper T cells (Tfh) and germinal centre (GC) B cells, leading to decreased antibody production. In addition, TLR9⁺ B cells as well as total B cells in the spleen were inhibited by H154. These findings highlight the critical role of TLR9 in EAMG and suggest that the inhibition of the TLR9 pathway might be a potential pharmacological strategy for the treatment of myasthenia gravis.
    Schlagwörter B-lymphocytes ; Toll-like receptor 9 ; antagonists ; antibody formation ; dendritic cells ; humoral immunity ; myasthenia gravis ; oligodeoxyribonucleotides ; spleen
    Sprache Englisch
    Erscheinungsverlauf 2018-02
    Umfang p. 200-208.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2018.01.005
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  4. Artikel: Macroevolutionary trends of atomic composition and related functional group proportion in eukaryotic and prokaryotic proteins

    Zhang, Yu-Juan / Bin Chen / Chun-Lin Yang / Jian-Fan Wen / Ying Li / You-Jin Hao

    Gene. 2014 Jan. 25, v. 534

    2014  

    Abstract: To fully explore the trends of atomic composition during the macroevolution from prokaryote to eukaryote, five atoms (oxygen, sulfur, nitrogen, carbon, hydrogen) and related functional groups in prokaryotic and eukaryotic proteins were surveyed and ... ...

    Abstract To fully explore the trends of atomic composition during the macroevolution from prokaryote to eukaryote, five atoms (oxygen, sulfur, nitrogen, carbon, hydrogen) and related functional groups in prokaryotic and eukaryotic proteins were surveyed and compared. Genome-wide analysis showed that eukaryotic proteins have more oxygen, sulfur and nitrogen atoms than prokaryotes do. Clusters of Orthologous Groups (COG) analysis revealed that oxygen, sulfur, carbon and hydrogen frequencies are higher in eukaryotic proteins than in their prokaryotic orthologs. Furthermore, functional group analysis demonstrated that eukaryotic proteins tend to have higher proportions of sulfhydryl, hydroxyl and acylamino, but lower of sulfide and carboxyl. Taken together, an apparent trend of increase was observed for oxygen and sulfur atoms in the macroevolution; the variation of oxygen and sulfur compositions and their related functional groups in macroevolution made eukaryotic proteins carry more useful functional groups. These results will be helpful for better understanding the functional significances of atomic composition evolution.
    Schlagwörter carbon ; eukaryotic cells ; hydrogen ; nitrogen ; oxygen ; prokaryotic cells ; proteins ; sulfides ; sulfur
    Sprache Englisch
    Erscheinungsverlauf 2014-0125
    Umfang p. 163-168.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2013.10.070
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  5. Artikel: The Thellungiella salsuginea Tonoplast Aquaporin TsTIP1;2 Functions in Protection Against Multiple Abiotic Stresses

    Wang, Li-Li / An-Ping Chen / Chun-Lin Yang / Fang Wang / Gui-Xian Xia / Michael F. Romero / Nai-Qin Zhong / Ning Liu / Xiao-Min Wu

    Plant & cell physiology. 2014 Jan., v. 55, no. 1

    2014  

    Abstract: Examination of aquaporin (AQP) membrane channels in extremophile plants may increase our understanding of plant tolerance to high salt, drought or other conditions. Here, we cloned a tonoplast AQP gene (TsTIP1;2) from the halophyte Thellungiella ... ...

    Abstract Examination of aquaporin (AQP) membrane channels in extremophile plants may increase our understanding of plant tolerance to high salt, drought or other conditions. Here, we cloned a tonoplast AQP gene (TsTIP1;2) from the halophyte Thellungiella salsuginea and characterized its biological functions. TsTIP1;2 transcripts accumulate to high levels in several organs, increasing in response to multiple external stimuli . Ectopic overexpression of TsTIP1;2 in Arabidopsis significantly increased plant tolerance to drought, salt and oxidative stresses. TsTIP1;2 had water channel activity when expressed in Xenopus oocytes. TsTIP1;2 was also able to conduct H ₂O ₂ molecules into yeast cells in response to oxidative stress. TsTIP1;2 was not permeable to Na ⁺ in Xenopus oocytes, but it could facilitate the entry of Na ⁺ ions into plant cell vacuoles by an indirect process under high-salinity conditions. Collectively, these data showed that TsTIP1;2 could mediate the conduction of both H ₂O and H ₂O ₂ across membranes, and may act as a multifunctional contributor to survival of T . salsuginea in highly stressful habitats.
    Schlagwörter abiotic stress ; aquaporins ; Arabidopsis ; drought ; drought tolerance ; Eutrema salsugineum ; extremophiles ; genes ; habitats ; halophytes ; hydrogen peroxide ; ions ; oocytes ; oxidative stress ; salt tolerance ; sodium ; tonoplast ; vacuoles ; Xenopus ; yeasts
    Sprache Englisch
    Erscheinungsverlauf 2014-01
    Umfang p. 148-161.
    Erscheinungsort Japanese Society of Plant Physiologists.
    Dokumenttyp Artikel
    ZDB-ID 208907-5
    ISSN 1471-9053 ; 0032-0781
    ISSN (online) 1471-9053
    ISSN 0032-0781
    DOI 10.1093/pcp/pct166
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  6. Artikel ; Online: Low-Power Built-In Self-Test Techniques for Embedded SRAMs

    Shyue-Kung Lu / Yuang-Cheng Hsiao / Chia-Hsiu Liu / Chun-Lin Yang

    VLSI Design, Vol

    2007  Band 2007

    Abstract: The severity of power consumption during parallel BIST of embedded memory cores is growing significantly. In order to alleviate this problem, a row bank-based precharge technique based on the divided wordline (DWL) architecture is proposed for low-power ... ...

    Abstract The severity of power consumption during parallel BIST of embedded memory cores is growing significantly. In order to alleviate this problem, a row bank-based precharge technique based on the divided wordline (DWL) architecture is proposed for low-power testing of embedded SRAMs. The memory cell array is first divided into row banks. The effectiveness of the row bank-based precharge technique is due to the predictable address sequence during test. In low-power test mode, instead of precharging the entire memory array, only the current accessed row bank is precharged. This will result in significant power saving for the precharge circuitry. The precharge power can be reduced to 1/b of that of the traditional precharge techniques, where b denotes the number of row banks in the memory array. With simple transmission gates and inverters, the modified precharge control circuitry was also designed. The hardware overhead for implementing the low-power technique is almost negligible. Moreover, the corresponding BIST design to implement the low-power technique is almost the same as the conventional BIST designs. It is also notable that the inherent low-power characteristics of the DWL architecture can be preserved. According to experimental results, 48.9% power reduction can be achieved for a 256 × 256 bit-oriented SRAM. The memory is divided into 8 row banks. Moreover, if the number of row banks increases, the power saving will also increase.
    Schlagwörter Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 600
    Sprache Englisch
    Erscheinungsdatum 2007-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: The Cotton Transcription Factor TCP14 Functions in Auxin-Mediated Epidermal Cell Differentiation and Elongation

    Wang, Miao-Ying / Chun-Lin Yang / Gui-Xian Xia / Hai-Yun Wang / Huan-Qing Cheng / Jian-Ru Zuo / Li-Bo Han / Nai-Qin Zhong / Peng Gao / Pi-Ming Zhao / Xiao-Min Wu

    Plant physiology. 2013 July, v. 162, no. 3

    2013  

    Abstract: GhTCP14 is a dual-function transcription factor able to positively or negatively regulate expression of auxin response and transporter genes, and it may act as a crucial regulator in auxin-mediated differentiation and elongation of cotton fiber cells. ...

    Abstract GhTCP14 is a dual-function transcription factor able to positively or negatively regulate expression of auxin response and transporter genes, and it may act as a crucial regulator in auxin-mediated differentiation and elongation of cotton fiber cells.
    Schlagwörter auxins ; cell differentiation ; fiber cells ; genes ; lint cotton ; transcription (genetics) ; transcription factors
    Sprache Englisch
    Erscheinungsverlauf 2013-07
    Umfang p. 1669-1680.
    Erscheinungsort American Society of Plant Biologists
    Dokumenttyp Artikel
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.113.215673
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