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  1. Article ; Online: Persistent SARS-CoV-2 infectivity greater than 50 days in a case series of allogeneic peripheral blood stem cell transplant recipients.

    Han, Alice / Rodriguez, Tulio E / Beck, Eric T / Relich, Ryan F / Udeoji, Dioma U / Petrak, Robert / Chundi, Vishnu V

    Current problems in cancer. Case reports

    2021  Volume 3, Page(s) 100057

    Abstract: The coronavirus disease 19 (COVID-19) pandemic has infected tens of millions across the world, but there is a significant gap in our understanding about COVID-19 in the hematopoietic stem transplant (HSCT) recipient population. Prolonged viral shedding ... ...

    Abstract The coronavirus disease 19 (COVID-19) pandemic has infected tens of millions across the world, but there is a significant gap in our understanding about COVID-19 in the hematopoietic stem transplant (HSCT) recipient population. Prolonged viral shedding is frequently observed with severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), but studies suggest viral loads decline 10 days after symptom onset. Current CDC guidance suggests that severely ill and immunocompromised hosts are no longer infectious after 20 days from symptom onset. Cycle threshold (Ct) values are inversely proportional to the viral load and are used to detect SARS-CoV-2 RNA concentration. Specimens with reverse transcriptase PCR (RT-PCR) Ct values > 33-34 have been associated with inability to culture virus, and have been used as a surrogate for diminished infectivity. We report two cases of  allogeneic peripheral blood stem cell transplant (PBSCT) recipients who had prolonged durations of infectivity with SARSCov-2, based on culture positivity and persistently low Ct values for greater than 50 days.
    Language English
    Publishing date 2021-01-16
    Publishing country United States
    Document type Case Reports
    ISSN 2666-6219
    ISSN (online) 2666-6219
    DOI 10.1016/j.cpccr.2021.100057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: SARS-CoV2 and Co-Infections: A Review of Two Cases.

    Sohal, Sumit / Rodriguez-Nava, Guillermo / Khabbaz, Ramzy / Chaudry, Sana / Musurakis, Clio / Chitrakar, Solab / Chundi, Vishnu V / Friedman, Harvey J

    Case reports in infectious diseases

    2020  Volume 2020, Page(s) 8882348

    Abstract: COVID-19 infection caused by SARS-CoV2 virus is an acute respiratory illness which was declared as a pandemic by the World Health Organization. Usually, SARS-CoV2 infects independently and can cause spectrum of disease ranging from mild illness to severe ...

    Abstract COVID-19 infection caused by SARS-CoV2 virus is an acute respiratory illness which was declared as a pandemic by the World Health Organization. Usually, SARS-CoV2 infects independently and can cause spectrum of disease ranging from mild illness to severe progressive pneumonia, multiorgan dysfunction, and death; however, co-infections with other respiratory pathogens have been noted. Here, we present 2 fatal cases with co-infection, one with parainfluenza-4 virus and other co-infection/secondary infection with
    Keywords covid19
    Language English
    Publishing date 2020-09-14
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2020/8882348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Value and Clinical Impact of an Infectious Disease-Supervised Outpatient Parenteral Antibiotic Therapy Program.

    Petrak, Russell M / Skorodin, Nathan C / Fliegelman, Robert M / Hines, David W / Chundi, Vishnu V / Harting, Brian P

    Open forum infectious diseases

    2016  Volume 3, Issue 4, Page(s) ofw193

    Abstract: Background. ...

    Abstract Background.
    Language English
    Publishing date 2016-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofw193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS-CoV-2.

    Petrak, Russell M / Skorodin, Nathan C / Van Hise, Nicholas W / Fliegelman, Robert M / Pinsky, Jonathan / Didwania, Vishal / Anderson, Michael / Diaz, Melina / Shah, Kairav / Chundi, Vishnu V / Hines, David W / Harting, Brian P / Sidwha, Kamo / Yu, Brian / Brune, Paul / Owaisi, Anjum / Beezhold, David / Kent, Joseph / Vais, Dana /
    Han, Alice / Gowda, Neethi / Sahgal, Nishi / Silverman, Jan / Stake, Jonathan / Nepomuceno, Jenie / Heddurshetti, Renuka

    Clinical and translational science

    2021  Volume 14, Issue 6, Page(s) 2146–2151

    Abstract: Tocilizumab is an IL-6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). We evaluated patients treated with tocilizumab for a SARS- ... ...

    Abstract Tocilizumab is an IL-6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). We evaluated patients treated with tocilizumab for a SARS-CoV-2 infection who were admitted between March 13, 2020, and April 16, 2020. This was a multicenter study with data collected by chart review both retrospectively and concurrently. Parameters evaluated included age, sex, race, use of mechanical ventilation (MV), usage of steroids and vasopressors, inflammatory markers, and comorbidities. Early dosing was defined as a tocilizumab dose administered prior to or within 1 day of intubation. Late dosing was defined as a dose administered > 1 day after intubation. In the absence of MV, the timing of the dose was related to the patient's date of admission only. We evaluated 145 patients. The average age was 58.1 years, 64% were men, 68.3% had comorbidities, and 60% received steroid therapy. Disposition of patients was 48.3% discharged and 29.3% died, of which 43.9% were African American. MV was required in 55.9%, of which 34.5% died. Avoidance of MV (P = 0.002) and increased survival (P < 0.001) was statistically associated with early dosing. Tocilizumab therapy was effective at decreasing mortality and should be instituted early in the management of critically ill patients with coronavirus disease 2019) COVID-19).
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/therapy ; COVID-19/virology ; Critical Illness/mortality ; Critical Illness/therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/mortality ; Cytokine Release Syndrome/therapy ; Cytokine Release Syndrome/virology ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2/immunology ; Severity of Illness Index ; Time Factors ; Time-to-Treatment ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.12894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS‐CoV‐2

    Petrak, Russell M. / Skorodin, Nathan C. / Van Hise, Nicholas W. / Fliegelman, Robert M. / Pinsky, Jonathan / Didwania, Vishal / Anderson, Michael / Diaz, Melina / Shah, Kairav / Chundi, Vishnu V. / Hines, David W. / Harting, Brian P. / Sidwha, Kamo / Yu, Brian / Brune, Paul / Owaisi, Anjum / Beezhold, David / Kent, Joseph / Vais, Dana /
    Han, Alice / Gowda, Neethi / Sahgal, Nishi / Silverman, Jan / Stake, Jonathan / Nepomuceno, Jenie / Heddurshetti, Renuka

    Clinical and Translational Science ; ISSN 1752-8054 1752-8062

    2020  

    Keywords General Pharmacology, Toxicology and Pharmaceutics ; General Biochemistry, Genetics and Molecular Biology ; General Neuroscience ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/cts.12894
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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