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Article ; Online: Combined procedure with radial probe and convex probe endobronchial ultrasound.

Chung, Hyun Sung / Pak, Kyoungjune / Lee, Geewon / Eom, Jung Seop

2022 Volume 13, Issue 20, Page(s) 2837–2843

Abstract: Background: Concurrent bronchoscopy using radial probe and convex endobronchial ultrasound (RP- and CP-EBUS) is used to simultaneously evaluate both peripheral lung lesions for the histological diagnosis of the primary tumor and mediastinal lymph nodes ... ...

Abstract	Background: Concurrent bronchoscopy using radial probe and convex endobronchial ultrasound (RP- and CP-EBUS) is used to simultaneously evaluate both peripheral lung lesions for the histological diagnosis of the primary tumor and mediastinal lymph nodes for mediastinal staging. So far, little is known about the combined procedure with RP- and CP-EBUS. Methods: Between January 2020 and March 2021, the bronchoscopy database was reviewed to identify the clinical outcomes of the combined procedure with RP- and CP-EBUS. Patients who underwent transbronchial biopsy using RP-EBUS alone were classified as the RP-EBUS group, while those who underwent a combined procedure with RP- and CP-EBUS were classified as the combination group. Results: The overall diagnostic yield of the bronchoscopic procedure in the combination group was significantly higher than the RP-EBUS group (90.7% vs. 70.0%, p < 0.001). CP-EBUS increased the diagnostic yield of the bronchoscopic procedure in the combination group by 9.3%. Although the mean procedure time was significantly longer, and the mean doses of midazolam and fentanyl were significantly higher in the combination group (p < 0.001), there were no differences in the overall complication rates between the two study groups (1.4% and 1.0% for the RP-EBUS and combination groups, respectively, p = 0.766). Conclusions: Combined bronchoscopy using RP- and CP-EBUS is feasible and safe. In addition to mediastinal staging, CP-EBUS increased the overall diagnostic yield of the bronchoscopic procedure by 9.3%.
MeSH term(s)	Bronchoscopy/methods ; Endosonography/methods ; Fentanyl ; Humans ; Lung Neoplasms/pathology ; Midazolam
Chemical Substances	Midazolam (R60L0SM5BC) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2022-08-29
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14622
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Zs.A 6921: Show issues

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Article ; Online: Development of the Korean Association for Lung Cancer Clinical Practice Guidelines: Recommendations on Radial Probe Endobronchial Ultrasound for Diagnosing Lung Cancer - An Updated Meta-Analysis.

Kim, Soo Han / Chung, Hyun Sung / Kim, Jinmi / Kim, Mi-Hyun / Lee, Min Ki / Kim, Insu / Eom, Jung Seop

Cancer research and treatment

2023 Volume 56, Issue 2, Page(s) 464–483

Abstract: Purpose: Radial probe endobronchial ultrasound (RP-EBUS) accurately locates peripheral lung lesions (PLLs) during transbronchial biopsy (TBB). We performed an updated meta-analysis of the diagnostic yield of TBB for PLLs using RP-EBUS to generate ... ...

Abstract	Purpose: Radial probe endobronchial ultrasound (RP-EBUS) accurately locates peripheral lung lesions (PLLs) during transbronchial biopsy (TBB). We performed an updated meta-analysis of the diagnostic yield of TBB for PLLs using RP-EBUS to generate recommendations for the development of the Korean Association of Lung Cancer guidelines. Materials and methods: We systematically searched MEDLINE and EMBASE (from January 2013 to December 2022), and performed a meta-analysis using R software. The diagnostic yield was evaluated by dividing the number of successful diagnoses by the total lesion number. Subgroup analysis was performed to identify related factors. Results: Forty-one studies with a total of 13,133 PLLs were included. The pooled diagnostic yield of RP-EBUS was 0.72 (95% confidence interval [CI], 0.70 to 0.75). Significant heterogeneity was observed among studies (χ2=292.38, p < 0.01, I2=86.4%). In a subgroup analysis, there was a significant difference in diagnostic yield based on RP-EBUS findings (within, adjacent to, invisible), with a risk ratio of 1.45 (95% CI, 1.23 to 1.72) between within and adjacent to, 4.20 (95% CI, 1.89 to 9.32) between within and invisible, and 2.59 (95% CI, 1.32 to 5.01) between adjacent to and invisible. There was a significant difference in diagnostic yield based on lesion size, histologic diagnosis, computed tomography (CT) bronchus sign, lesion character, and location from the hilum. The overall complication rate of TBB with RP-EBUS was 6.8% (bleeding, 4.5%; pneumothorax, 1.4%). Conclusion: Our study showed that TBB with RP-EBUS is an accurate diagnostic tool for PLLs with good safety profiles, especially for PLLs with within orientation on RP-EBUS or positive CT bronchus sign.
MeSH term(s)	Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Bronchoscopy/methods ; Retrospective Studies ; Biopsy ; Republic of Korea ; Lung/diagnostic imaging ; Lung/pathology
Language	English
Publishing date	2023-11-29
Publishing country	Korea (South)
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	2133613-1
ISSN	2005-9256 ; 1598-2998
ISSN (online)	2005-9256
ISSN	1598-2998
DOI	10.4143/crt.2023.749
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Article ; Online: Performance of the galactomannan test for the diagnosis of invasive pulmonary aspergillosis using non-invasive proximal airway samples.

Chun, June Young / Jeong, Sahng-Joon / Kim, Sinae / Choi, Soyoung / Lee, Jong Hyuk / Chung, Hyun Sung / Park, Seungman / Lee, Hyewon / Kim, Hyae Young / Hwangbo, Bin / Choi, Young Ju

The Journal of infection

2024 Volume 88, Issue 6, Page(s) 106159

Abstract: Objective: To diagnose invasive pulmonary aspergillosis (IPA), galactomannan (GM) detection in serum or bronchoalveolar lavage fluid (BALF) is widely used. However, the utility of proximal airway GM test (from induced sputum or tracheal aspirate) has ... ...

Abstract	Objective: To diagnose invasive pulmonary aspergillosis (IPA), galactomannan (GM) detection in serum or bronchoalveolar lavage fluid (BALF) is widely used. However, the utility of proximal airway GM test (from induced sputum or tracheal aspirate) has not been well elucidated. Methods: In this retrospective cohort study, we evaluated the diagnostic performance of proximal airway GM in diagnosis of IPA including COVID-19 associated pulmonary aspergillosis (CAPA). Between January 2022 and January 2023, patients who had been tested for GM with clinical suspicion or for surveillance from any specimen (serum, induced sputum, tracheal aspirate, and BALF) were screened. IPA was diagnosed using EORTC/MSGERC criteria, and CAPA was diagnosed following the 2020 ECMM/ISHAM consensus criteria. Results: Of 624 patients with GM results, 70 met the criteria for proven/probable IPA and 427 had no IPA. The others included possible IPA and chronic form of aspergillosis. The sensitivities and specificities of serum, proximal airway, and BALF GM for proven/probable IPA versus no IPA were 78.9% and 70.6%, 93.1% and 78.7%, and 78.6% and 91.0%, respectively. Areas under the receiver operating characteristic curve (AUCs) were 0.742 for serum GM, 0.935 for proximal airway GM, and 0.849 for BALF GM (serum GM vs proximal airway GM, p = 0.014; proximal airway GM vs BALF GM, p = 0.334; serum GM vs BALF GM, p = 0.286). Conclusion: This study demonstrates that the performance of GM test from non-invasive proximal airway samples is comparable or even better than those from serum and distal airway sample (BALF).
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2024.106159
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Unexpected exposure to Mycobacterium tuberculosis during bronchoscopy using radial probe endobronchial ultrasound.

Chung, Hyun Sung / Bae, Soohyun / Kim, Insu / Ahn, Hyo Yeong / Eom, Jung Seop

PloS one

2021 Volume 16, Issue 1, Page(s) e0246371

Abstract: Background: Bronchoscopy using radial probe endobronchial ultrasound (EBUS) is performed when a peripheral lung lesion (PLL) is suspected to be malignant. However, pulmonary tuberculosis is diagnosed in some patients, and healthcare workers could ... ...

Abstract	Background: Bronchoscopy using radial probe endobronchial ultrasound (EBUS) is performed when a peripheral lung lesion (PLL) is suspected to be malignant. However, pulmonary tuberculosis is diagnosed in some patients, and healthcare workers could therefore be exposed to tuberculosis if sufficient precautions are not taken. In this study, we examined the proportion of and factors associated with unexpected exposure to Mycobacterium tuberculosis during bronchoscopy using radial probe EBUS. Methods: This retrospective study included 970 patients who received bronchoscopy using radial probe EBUS between December 2015 and November 2018. Clinical, histological, radiological, and microbiological data were reviewed. Results: Pulmonary tuberculosis was diagnosed in 31 patients (3.2%) during bronchoscopy using radial probe EBUS. Patients with a lower age were significantly more likely to be diagnosed with tuberculosis than elderly patients (odds ratio [OR], 0.951; 95% confidence interval [CI], 0.924-0.978; P = 0.001). Among the various CT findings, a low HUs difference between pre- and post-enhanced CT (OR, 0.976; 95% CI, 0.955-0.996; P = 0.022), the presence of concentric cavitation (OR, 5.211; 95% CI, 1.447-18.759; P = 0.012), and the presence of satellite centrilobular nodules (OR, 22.925; 95% CI, 10.556-49.785; P < 0.001) were independently associated with diagnosis of tuberculosis. Conclusions: The proportion of unexpected exposure to Mycobacterium tuberculosis during bronchoscopy using radial probe EBUS was 3.2%. A higher risk was independently associated with a younger age and CT findings of a small difference in HUs between pre- and post-enhancement images, concentric cavitation, and the presence of a satellite centrilobular nodule.
MeSH term(s)	Age Factors ; Aged ; Bronchoscopy/adverse effects ; Endosonography/adverse effects ; Female ; Follow-Up Studies ; Humans ; Lung/diagnostic imaging ; Lung/microbiology ; Lung Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Mycobacterium tuberculosis ; Retrospective Studies ; Risk Factors ; Tuberculosis, Pulmonary/diagnostic imaging ; Tuberculosis, Pulmonary/etiology ; Tuberculosis, Pulmonary/genetics
Language	English
Publishing date	2021-01-28
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0246371
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Article ; Online: Linezolid-induced black hairy tongue in a patient with multidrug-resistant tuberculosis: A case report.

Lee, Jaemin / Chung, Hyun Sung / Roh, Jiyeon / Oh, Yeseul / Mok, Jeongha

Science progress

2021 Volume 104, Issue 3, Page(s) 368504211042982

Abstract: The revised World Health Organization guidelines on multidrug-resistant tuberculosis include linezolid in the core drugs group. Consequently, the use of linezolid for patients with multidrug-resistant tuberculosis is increasing. Common adverse events of ... ...

Abstract	The revised World Health Organization guidelines on multidrug-resistant tuberculosis include linezolid in the core drugs group. Consequently, the use of linezolid for patients with multidrug-resistant tuberculosis is increasing. Common adverse events of long-term linezolid use include bone marrow suppression and neuropathies. However, there is limited information on a rare adverse event, black hairy tongue. Here, we report a case of linezolid-induced black hairy tongue in a patient with multidrug-resistant tuberculosis. The etiology, pathogenesis, diagnosis, and treatment of black hairy tongue are also discussed.
MeSH term(s)	Humans ; Linezolid/adverse effects ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy ; Tongue, Hairy/chemically induced ; Tongue, Hairy/drug therapy ; Tuberculosis, Multidrug-Resistant/drug therapy
Chemical Substances	Linezolid (ISQ9I6J12J)
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	128412-5
ISSN	2047-7163 ; 0036-8504 ; 0302-1785
ISSN (online)	2047-7163
ISSN	0036-8504 ; 0302-1785
DOI	10.1177/00368504211042982
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Article ; Online: Localization Technique Using Mixture of Indigo Carmine and Lipiodol of Pulmonary Nodule via Bronchoscopic Navigation.

Lee, Na-Hyeon / Chung, Hyun-Sung / Cho, Jeong-Su / Kim, Yeong-Dae / Eom, Jung-Seop / Ahn, Hyo-Yeong

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 9

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Carmine ; Ethiodized Oil ; Humans ; Indigo Carmine/adverse effects ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Solitary Pulmonary Nodule/chemically induced ; Solitary Pulmonary Nodule/diagnostic imaging ; Solitary Pulmonary Nodule/surgery
Chemical Substances	Ethiodized Oil (8008-53-5) ; Carmine (CID8Z8N95N) ; Indigo Carmine (D3741U8K7L)
Language	English
Publishing date	2022-09-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58091235
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Article ; Online: Appropriate amounts proportions of lidocaine gel, indigo carmine and lipiodol mixture for preoperative marking in video-assisted thoracic surgery.

Seol, Hee Yun / Ahn, Hyo Yeong / Chung, Hyun Sung / Eom, Jung Seop

General thoracic and cardiovascular surgery

2019 Volume 68, Issue 1, Page(s) 87–90

Abstract: Preoperative marking is necessary in thoracoscopic wedge resections of lung nodules expected to be invisible or nonpalpable during surgery. Recently, lidocaine gel was added to a dye solution containing indigo carmine and lipiodol to promote micelle ... ...

Abstract	Preoperative marking is necessary in thoracoscopic wedge resections of lung nodules expected to be invisible or nonpalpable during surgery. Recently, lidocaine gel was added to a dye solution containing indigo carmine and lipiodol to promote micelle formation, but the optimal mixing ratio was not determined. Thus, an in vitro experiment was performed to identify the optimal mixing ratio of lidocaine gel, indigo carmine and lipiodol. To fixed volumes of indigo carmine and lipiodol of 0.5 ml each, 0.1, 0.2, 0.3, 0.4 and 0.5 ml of lidocaine gel was added. Changes were examined every 2 h. No changes were seen in the mixtures containing 0.1 and 0.2 ml of lidocaine gel, whereas those with 0.3, 0.4 and 0.5 ml had clearly separated after 2 h. Our findings suggest that the ideal proportion of indigo carmine, lipiodol and lidocaine gel for use in preoperative marking is 5:5:2.
MeSH term(s)	Administration, Cutaneous ; Coloring Agents ; Ethiodized Oil/administration & dosage ; Gels ; Humans ; Indigo Carmine/administration & dosage ; Lidocaine/administration & dosage ; Preoperative Care ; Thoracic Surgery, Video-Assisted/methods
Chemical Substances	Coloring Agents ; Gels ; Ethiodized Oil (8008-53-5) ; Lidocaine (98PI200987) ; Indigo Carmine (D3741U8K7L)
Language	English
Publishing date	2019-11-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2376888-5
ISSN	1863-6713 ; 1863-6705
ISSN (online)	1863-6713
ISSN	1863-6705
DOI	10.1007/s11748-019-01257-6
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Article ; Online: Sequential Organ Failure Assessment score as a predictor of mortality in ventilated patients with multidrug-resistant bacteremia.

Oh, Yeseul / Roh, Jiyeon / Lee, Jaemin / Chung, Hyun Sung / Lee, Kwangha / Lee, Min Ki

Acute and critical care

2020 Volume 35, Issue 3, Page(s) 169–178

Abstract: Background: The occurrence of multidrug-resistant (MDR) bacteremia in ventilated patients may be associated with a high mortality rate. We evaluated whether Sequential Organ Failure Assessment (SOFA) score on the day of bacteremia could predict 90-day ... ...

Abstract	Background: The occurrence of multidrug-resistant (MDR) bacteremia in ventilated patients may be associated with a high mortality rate. We evaluated whether Sequential Organ Failure Assessment (SOFA) score on the day of bacteremia could predict 90-day mortality in these patients. Methods: Data were obtained retrospectively from 202 patients (male, 60.4%; median age, 64 years) hospitalized at a single university-affiliated tertiary care hospital. All adult patients who had were ventilated and had one of the following six MDR bacteremias between March 2011 and February 2018 were enrolled: methicillin-resistant Staphylococcus aureus, extended-spectrum β-lactamase-producing Gram-negative bacteria (Escherichia coli and Klebsiella pneumonia), carbapenem-resistant Gram-negative rods (Acinetobacter baumannii and Pseudomonas aeruginosa), or vancomycin-resistant Enterococcus faecium. Results: The overall 90-day mortality rate after the day of bacteremia was 59.9%. The areas under the receiver operating characteristic curves for the SOFA and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were 0.732 (95% confidence interval [CI], 0.666 to 0.792; P<0.001) and 0.662 (95% CI, 0.593 to 0.727; P<0.001), respectively, with no difference between the two (P=0.059). Also, the cutoff value of the SOFA score was 9 (based on Youden's index). Multivariate Cox regression analysis showed that this cut-off value was significantly associated with higher mortality rate (hazard ratio, 2.886; 95% CI, 1.946 to 4.221; P<0.001). Conclusions: SOFA score measured on the day of bacteremia may be a useful prognostic indicator of 90-day mortality in ventilated patients with MDR bacteremia.
Language	English
Publishing date	2020-08-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3003021-3
ISSN	2586-6060 ; 2586-6052
ISSN (online)	2586-6060
ISSN	2586-6052
DOI	10.4266/acc.2020.00143
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Article ; Online: Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions.

Eom, Jung Seop / Lee, Geewon / Roh, Jiyeon / Chung, Hyun Sung / Jeong, Yeon Joo

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 9

Abstract: Background and ... ...

Abstract	Background and objectives
MeSH term(s)	Bronchoscopy ; Feasibility Studies ; Humans ; Lung/diagnostic imaging ; Radiation Dosage ; Retrospective Studies ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-09-19
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56090479
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Article ; Online: Prediction Models for Mediastinal Metastasis and Its Detection by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Potentially Operable Non-Small Cell Lung Cancer: A Prospective Study.

Chung, Hyun Sung / Yoon, Ho Il / Hwangbo, Bin / Park, Eun Young / Choi, Chang-Min / Park, Young Sik / Lee, Kyungjong / Ji, Wonjun / Park, Sohee / Lee, Geon Kook / Kim, Tae Sung / Kim, Hyae Young / Kim, Moon Soo / Lee, Jong Mog

Chest

2023 Volume 164, Issue 3, Page(s) 770–784

Abstract: Background: Prediction models for mediastinal metastasis and its detection by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) have not been developed using a prospective cohort of potentially operable patients with non-small ...

Abstract	Background: Prediction models for mediastinal metastasis and its detection by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) have not been developed using a prospective cohort of potentially operable patients with non-small cell lung cancer (NSCLC). Research question: Can mediastinal metastasis and its detection by EBUS-TBNA be predicted with prediction models in NSCLC? Study design and methods: For the prospective development cohort, 589 potentially operable patients with NSCLC were evaluated (July 2016-June 2019) from five Korean teaching hospitals. Mediastinal staging was performed using EBUS-TBNA (with or without the transesophageal approach). Surgery was performed for patients without clinical N (cN) 2-3 disease by endoscopic staging. The prediction model for lung cancer staging-mediastinal metastasis (PLUS-M) and a model for mediastinal metastasis detection by EBUS-TBNA (PLUS-E) were developed using multivariable logistic regression analyses. Validation was performed using a retrospective cohort (n = 309) from a different period (June 2019-August 2021). Results: The prevalence of mediastinal metastasis diagnosed by EBUS-TBNA or surgery and the sensitivity of EBUS-TBNA in the development cohort were 35.3% and 87.0%, respectively. In PLUS-M, younger age (< 60 years and 60-70 years compared with ≥ 70 years), nonsquamous histology (adenocarcinoma and others), central tumor location, tumor size (> 3-5 cm), cN1 or cN2-3 stage by CT, and cN1 or cN2-3 stage by PET-CT were significant risk factors for N2-3 disease. Areas under the receiver operating characteristic curve (AUCs) for PLUS-M and PLUS-E were 0.876 (95% CI, 0.845-0.906) and 0.889 (95% CI, 0.859-0.918), respectively. Model fit was good (PLUS-M: Hosmer-Lemeshow P = .658, Brier score = 0.129; PLUS-E: Hosmer-Lemeshow P = .569, Brier score = 0.118). In the validation cohort, PLUS-M (AUC, 0.859 [95% CI, 0.817-0.902], Hosmer-Lemeshow P = .609, Brier score = 0.144) and PLUS-E (AUC, 0.900 [95% CI, 0.865-0.936], Hosmer-Lemeshow P = .361, Brier score = 0.112) showed good discrimination ability and calibration. Interpretation: PLUS-M and PLUS-E can be used effectively for decision-making for invasive mediastinal staging in NSCLC. Trial registry: ClinicalTrials.gov; No.: NCT02991924; URL: www. Clinicaltrials: gov.
MeSH term(s)	Humans ; Middle Aged ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Lung Neoplasms/pathology ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Mediastinal Neoplasms/pathology ; Mediastinum/pathology ; Neoplasm Staging ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Aged
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.03.041
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