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Article ; Online: The effect of massage therapy on pain after surgery

Chunhua Liu / Xiang Chen / Simin Wu

Complementary Therapies in Medicine, Vol 71, Iss , Pp 102892- (2022)

A comprehensive meta-analysis

2022

Abstract: Background: Findings on the usefulness of massage therapy (MT) in postoperative pain management are often inconsistent among studies. Objectives: This study’s aim is to conduct a meta-analysis of randomized controlled trials (RCT) to clarify the effects ... ...

Abstract	Background: Findings on the usefulness of massage therapy (MT) in postoperative pain management are often inconsistent among studies. Objectives: This study’s aim is to conduct a meta-analysis of randomized controlled trials (RCT) to clarify the effects of massage therapy in the treatment of postoperative pain. Methods: Three databases (PubMed, Embase, and Cochrane Central Register of Controlled Trials) were searched for RCTs published from database inception through January 26, 2021. The primary outcome was pain relief. The quality of RCTs was appraised with the Cochrane Collaboration risk of bias tool. The random-effect model was used to calculate the effect sizes and standardized mean difference (SMD) with 95 % confidential intervals (CIs) as a summary effect. The heterogeneity test was conducted through I2. Subgroup and sensitivity analyses were used to explore the source of heterogeneity. Possible publication bias was assessed using visual inspection of funnel plot asymmetry. Results: The analysis included 33 RCTs and showed that MT is effective in reducing postoperative pain (SMD, −1.32; 95 % CI, −2.01 to −0.63; p = 0.0002; I2 = 98.67 %). A similar significant effect was found for both short (immediate assessment) and long terms (assessment performed 4–6 weeks after the MT). Remarkably, we found neither the duration per session nor the dose had an impact on the effect of MT and there seemed to be no difference in the effects of different MT types. In addition, MT seemed to be more effective for adults. Furthermore, MT had better analgesic effects on cesarean section and heart surgery than orthopedic surgery. Limitations: Publication bias is possible due to the inclusion of studies in English only. Additionally, the included studies were extremely heterogeneous. Double-blind research on MT is difficult to implement, and none of the included studies is double-blind. There was some heterogeneity and publication bias in the included studies. In addition, there is no uniform evaluation standard for the ...
Keywords	Postoperative pain ; Massage therapy ; Meta-analysis ; Randomized controlled trials ; Other systems of medicine ; RZ201-999
Subject code	150
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Growth and physiological responses in a submerged clonal aquatic plant and multiple-endpoint assessment under prolonged exposure to ciprofloxacin

Pei Fan / Chunhua Liu / Zhen Ke / Wei Zhou / Zhonghua Wu

Ecotoxicology and Environmental Safety, Vol 239, Iss , Pp 113690- (2022)

2022

Abstract: Ciprofloxacin is ubiquitous and poses a potential threat to aquatic ecosystems. However, the comprehensive effect of prolonged ciprofloxacin exposure on the submerged clonal plant Vallisneria natans (Lour.) Hara remains unknown. Growth and physiological ... ...

Abstract	Ciprofloxacin is ubiquitous and poses a potential threat to aquatic ecosystems. However, the comprehensive effect of prolonged ciprofloxacin exposure on the submerged clonal plant Vallisneria natans (Lour.) Hara remains unknown. Growth and physiological responses in V. natans exposed to ciprofloxacin at concentrations of 0, 0.05, 0.25, 1.25, 2.5, 5 and 10 mg/L were repeatedly evaluated on Days 7, 14, 28, 42 and 56. V. natans maintained good growth properties under 0.05–0.25 mg/L ciprofloxacin treatments, while the inhibition effect on plant growth induced by higher-concentration treatments increased over time. The IC50 values of ciprofloxacin for growth endpoints ranged from 1.6 mg/L to 5.3 mg/L and displayed time-dependent decreases. Pigment contents were significantly stimulated by ciprofloxacin on Day 7 but decreased to varying degrees as the exposure time was extended. Soluble protein and hydrogen peroxide content rose significantly over the first 14 days of treatment with 0.25–10 mg/L ciprofloxacin but decreased under 1.25–10 mg/L ciprofloxacin treatments since Day 28. Antioxidants including superoxide dismutase, catalase, guaiacol peroxidase, ascorbate peroxidase and proline functioned well in mitigating oxidative stress under different ciprofloxacin concentrations, lowering the comprehensive toxic effects of ciprofloxacin on V. natans during the period from Day 14 to Day 42, as evidenced by decreased IBR (integrated biomarker response) values. However, the toxic pressure of ciprofloxacin on V. natans peaked on Day 56. These findings suggest that exposure time can influence the responses of V. natans exposed to ciprofloxacin and that IBR can be employed to evaluate the integrated impacts of prolonged ciprofloxacin contamination in aquatic settings.
Keywords	Antibiotic ; Submerged plant ; Antioxidants ; Time-dependent effects ; Integrated biomarker response ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response of Sea Water Exchange Processes to Monsoons in Jiaozhou Bay, China

Zhenhuan Tian / Jinghao Shi / Yuanyuan Liu / Wei Wang / Chunhua Liu / Fangfang Li / Yanqin Shao

Sustainability, Vol 15, Iss 21, p

2023 Volume 15198

Abstract: The self-purification capacity of semi-closed bays is closely related to the exchange process of open sea water. In recent years, with the enhancement of human development activities, environmental problems such as eutrophication, weak hydrodynamics, and ...

Abstract	The self-purification capacity of semi-closed bays is closely related to the exchange process of open sea water. In recent years, with the enhancement of human development activities, environmental problems such as eutrophication, weak hydrodynamics, and poor water exchange capacity have appeared in the bays. In this paper, the water exchange time and flow field in Jiaozhou Bay (JZB) were investigated using the environmental fluid dynamics code with a coupled dye module. Specifically, Jiaozhou Bay was divided into seven zones to explore the effect mechanism of a monsoon on the water exchange process. A detailed analysis was performed on the current water exchange status in the highly polluted northeastern region of the bay and its influence on the surrounding areas. Based on the definition of the average residence time and considering the effect of the tracer release moment, the distribution of the water exchange time in the bay under three circumstances was obtained. Results showed that the timing of the tracer release exerted minimal influence on the average residence time. The water exchange process was influenced by a combination of astronomical and meteorological factors. The overall exchange capacity of the bay was strongest under the impact of a winter monsoon and tides, followed by a summer monsoon and tides, and the weakest exchange occurred under the influence of tides alone. Moreover, both summer and winter monsoons greatly facilitated water exchange in the heavily polluted northeastern region. However, pollutants from this region had a significant impact on surrounding areas during a summer monsoon. Changes in the structure and intensity of residual flow fields were the primary causes of exchange rate discrepancies.
Keywords	Jiaozhou Bay ; Eulerian dispersion model ; water exchange ; average residence time ; exchange rate discrepancies ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comprehensive analysis of cuproptosis-related lncRNAs in immune infiltration and prognosis in hepatocellular carcinoma

Chunhua Liu / Simin Wu / Liying Lai / Jinyu Liu / Zhaofu Guo / Zegen Ye / Xiang Chen

BMC Bioinformatics, Vol 24, Iss 1, Pp 1-

2023 Volume 22

Abstract: Abstract Background Being among the most common malignancies worldwide, hepatocellular carcinoma (HCC) accounting for the third cause of cancer mortality. The regulation of cell death is the most crucial step in tumor progression and has become a crucial ...

Abstract	Abstract Background Being among the most common malignancies worldwide, hepatocellular carcinoma (HCC) accounting for the third cause of cancer mortality. The regulation of cell death is the most crucial step in tumor progression and has become a crucial target for nearly all therapeutic options. Cuproptosis, a copper-induced cell death, was recently reported in Science. However, its primary function in carcinogenesis is still unclear. Methods Cuproptosis-related lncRNAs significantly associated with overall survival (OS) were screened by stepwise univariate Cox regression. The signature of cuproptosis-related lncRNAs for HCC prognosis was constructed by the LASSO algorithm and multivariate Cox regression. Further Kaplan–Meier analysis, proportional hazards model, and ROC analysis were performed. Functional annotation was performed using gene set enrichment analysis (GSEA). The relationship between prognostic cuproptosis-related lncRNAs and HCC prognosis was further explored by GEPIA( http://gepia.cancer-pku.cn/ ) online analysis tool. Finally, we used the ESTIMATE and XCELL algorithms to estimate stromal and immune cells in tumor tissue and cast each sample to infer the underlying mechanism of cuproptosis-related lncRNAs in the tumor immune microenvironment (TIME) of HCC patients. Results Four cuproptosis-related lncRNAs were used to construct a prognostic lncRNA signature, which was an independent factor in predicting OS in HCC patients. Kaplan–Meier curves showed significant differences in survival rates between risk subgroups (p = 0.002). At the same time, we found that the expression levels of most immune checkpoint genes increased with increasing risk scores. Tumorigenesis and immunological-related pathways were primarily enhanced in the high-risk group, as determined by GSEA. The results of drug sensitivity analysis showed that compared with patients in the high-risk group, the IC50 values of erlotinib and lapatinib were lower in patients in the low-risk group, while the opposite was true for sunitinib, ...
Keywords	Cuproptosis-related lncRNAs ; Hepatocellular carcinoma ; Immune infiltration ; Tumor immune microenvironment ; Drug therapy ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Superhydrophilic and Underwater Superoleophobic Copper Mesh Coated with Bamboo Cellulose Hydrogel for Efficient Oil/Water Separation

Yun Peng / Shuang Zhao / Chuanlin Huang / Feifei Deng / Jie Liu / Chunhua Liu / Yibao Li

Polymers, Vol 16, Iss 1, p

2023 Volume 14

Abstract: Super-wetting interface materials have shown great potential for applications in oil–water separation. Hydrogel-based materials, in particular, have been extensively studied for separating water from oily wastewater due to their unique hydrophilicity and ...

Abstract	Super-wetting interface materials have shown great potential for applications in oil–water separation. Hydrogel-based materials, in particular, have been extensively studied for separating water from oily wastewater due to their unique hydrophilicity and excellent anti-oil effect. In this study, a superhydrophilic and underwater superoleophobic bamboo cellulose hydrogel-coated mesh was fabricated using a feasible and eco-friendly dip-coating method. The process involved dissolving bamboo cellulose in a green alkaline/urea aqueous solvent system, followed by regeneration in ethanol solvent, without the addition of surface modifiers. The resulting membrane exhibited excellent special wettability, with superhydrophilicity and underwater superoleophobicity, enabling oil–water separation through a gravity-driven “water-removing” mode. The super-wetting composite membrane demonstrated a high separation efficiency of higher than 98% and a permeate flux of up to 9168 L·m −2 ·h −1 for numerous oil/water mixtures. It also maintained a separation efficiency of >95% even after 10 cycles of separation, indicating its long-term stability. This study presents a green, simple, cost-effective, and environmentally friendly approach for fabricating superhydrophilic surfaces to achieve oil–water separation. It also highlights the potential of bamboo-based materials in the field of oil–water separation.
Keywords	wetting ; bamboo cellulose ; hydrogel coating ; oil/water separation ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of resource heterogeneity and environmental disturbance on the growth performance and interspecific competition of wetland clonal plants

Nan Shen / Chunhua Liu / Hongwei Yu / Jiuhui Qu

Global Ecology and Conservation, Vol 22, Iss , Pp - (2020)

2020

Abstract: Resource heterogeneity significantly influences the growth, reproduction, and vegetation composition of wetland plants. However, the effect of the interaction of resource heterogeneity and environmental disturbance on growth performance and interspecific ...

Abstract	Resource heterogeneity significantly influences the growth, reproduction, and vegetation composition of wetland plants. However, the effect of the interaction of resource heterogeneity and environmental disturbance on growth performance and interspecific relationships among emergent plants is far from clear. In this study, we used a mesocosm experiment to examine the plasticity in clonal growth responses of Acorus calamus and Schoenoplectus tabernaemontani to different levels of flooding disturbance and soil sediment heterogeneity types. Soil nutrient heterogeneity treatments did not always have a positive effect on the growth of A. calamus and S. tabernaemontani because species-specific characteristics and environmental disturbance can influence the positive effect of environmental heterogeneity on clonal plants. A. calamus exhibited longer root length, behavior advantageous for heterogeneous distributions of nutrients. To adapt to deep water habitats, A. calamus and S. tabernaemontani transform clonal growth in the horizontal direction into the vertical direction. Soil nutrient heterogeneity can cause interspecific competition between A. calamus and S. tabernaemontani. However, with increasing water level, the effects of interspecific competition on S. tabernaemontani and A. calamus decreased gradually. The two wetland species compete for heterogeneously distributed soil nutrients under low water levels. However, an increase in water level results in limited illumination, so vertical growth is employed to compete for light resources. Our results show that S. tabernaemontani and A. calamus used both plasticity strategies to cope with resource heterogeneity and environmental disturbance. These spatial and temporal variations may modify growth and vegetation stability in disturbed environments.
Keywords	Sediment heterogeneity ; Disturbance ; Foraging behavior ; Growth strategy ; Interspecific competition ; Ecology ; QH540-549.5
Subject code	580
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sheng-Mai San extracts attenuate heart injury in chronic intermittent hypoxia via suppressing oxidative damage and regulating glucose metabolism

Chunhua Liu / Yaqian Feng / Dazheng Zhou / Aichun Ju / Junping Kou / Boyang Yu / Jin Qi

Pharmacological Research - Modern Chinese Medicine, Vol 5, Iss , Pp 100194- (2022)

2022

Abstract: Background: Sheng-Mai San extracts (SMSE), derived from a Chinese medicine formula Sheng-Mai San, benefits prevention and treatment of cardiovascular disease. However, it remains unknown how SMSE exerts its effects on chronic intermittent hypoxia (CIH)- ... ...

Abstract	Background: Sheng-Mai San extracts (SMSE), derived from a Chinese medicine formula Sheng-Mai San, benefits prevention and treatment of cardiovascular disease. However, it remains unknown how SMSE exerts its effects on chronic intermittent hypoxia (CIH)-induced heart injury. Objective: This study aims to evaluate the efficacy of SMSE on CIH-induced heart injury by suppressing oxidative damage and promoting glucose energy metabolism. Methods: The CIH-induced model was established through the mice being placed in a hypoxic chamber with 7 to 8% O2. Then, such indexes as cardiac function, histopathological changes, creatine kinase (CK), superoxide dismutase (SOD) and myeloperoxidase (MPO) and malondialdehyde (MDA) were measured. Lastly, the influence on energy metabolism was explored through determining the ratio of ATP/ADP, concentrations of pyruvate and lactic acid, ATPase activities and levels of proteins including pyruvate kinase M2 (PKM2), fructose 6-phosphate kinase (6-FPK) and pyruvate dehydrogenase kinase 4 (PDK4). Results: SMSE could obviously improve cardiac function and histopathological changes of heart tissue; reduce CK and MPO activities as well as MDA and lactic acid contents; increase SOD and ATPase activities, the ratio of ATP/ADP and pyruvate concentration; and regulate the protein expression of PKM2, 6-FPK and PDK4. Conclusion: SMSE could attenuate CIH-induced heart injury via suppressing oxidative damage and regulating glucose metabolism.
Keywords	Sheng-Mai San extracts ; Chronic intermittent hypoxia ; Oxidative stress ; Glucose metabolism ; Cardioprotection ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integratively Genomic Analysis Reveals the Prognostic and Immunological Characteristics of Pyroptosis and Ferroptosis in Pancreatic Cancer for Precision Immunotherapy

Ting Yu / Huaicheng Tan / Chunhua Liu / Wen Nie / Yang Wang / Kexun Zhou / Huashan Shi

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract: The non-apoptotic cell death processes including pyroptosis and ferroptosis have been implicated in the progression and therapeutic responses of pancreatic adenocarcinoma (PAAD). However, the extent to which pyroptosis and ferroptosis influence tumor ... ...

Abstract	The non-apoptotic cell death processes including pyroptosis and ferroptosis have been implicated in the progression and therapeutic responses of pancreatic adenocarcinoma (PAAD). However, the extent to which pyroptosis and ferroptosis influence tumor biology remains ambiguous, especially in PAAD, which is characterized with “cold” immunity. Considering the heterogeneity among different patients, it was more practical to quantify distinct cell death profiles in an individual tumor sample. Herein, we developed a pyroptosis-ferroptosis (P-F) score for PAAD patients in The Cancer Genome Atlas (TCGA) database. A high P-F score was associated with active immune phenotype, decreased genomic alterations, and significantly longer survival. Good accuracy of the P-F score in predicting overall survival (OS) was further confirmed in the TCGA-PAAD, ICGC-PACA-CA, and E-MTAB-6134 cohorts. Besides, one immunotherapy cohort (IMvigor210 dataset) has verified that patients with high P-F scores exhibited significant advantages in therapeutic responses and clinical benefits. The sensitivity to chemotherapeutics was analyzed through the Genomics of Drug Sensitivity in Cancer (GDSC), and patients with low P-F score might be more sensitive to paclitaxel and 5-fluorouracil. Collectively, the P-F score based on the systematic evaluation of cell death profiles could serve as an effective biomarker in predicting the outcomes and responses of PAAD patients to treatments with chemotherapeutic agents or immunotherapies.
Keywords	pyroptosis ; ferroptosis ; pancreatic cancer ; P-F score ; immunity ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Snail communities increase submerged macrophyte growth by grazing epiphytic algae and phytoplankton in a mesocosm experiment

Tian Lv / Xin Guan / Shufeng Fan / Chen Han / Zhongyao Gao / Chunhua Liu

Ecology and Evolution, Vol 12, Iss 2, Pp n/a-n/a (2022)

2022

Abstract: Abstract The relationships between producers (e.g., macrophytes, phytoplankton and epiphytic algae) and snails play an important role in maintaining the function and stability of shallow ecosystems. Complex relationships exist among macrophytes, ... ...

Abstract	Abstract The relationships between producers (e.g., macrophytes, phytoplankton and epiphytic algae) and snails play an important role in maintaining the function and stability of shallow ecosystems. Complex relationships exist among macrophytes, epiphytic algae, phytoplankton, and snails. We studied the effects of snail communities (consisting of Radix swinhoei, Hippeutis cantori, Bellamya aeruginosa, and Parafossarulus striatulus) on the biomass of phytoplankton and epiphytic algae as well as on the growth of three species of submerged macrophytes (Hydrilla verticillata, Vallisneria natans, and one exotic submerged plant, Elodea nuttallii) in a 90‐day outdoor mesocosm experiment conducted on the shore of subtropical Lake Liangzihu, China. A structural equation model showed that the snail communities affected the submerged macrophytes by grazing phytoplankton and epiphytic algae (reduction in phytoplankton Chl‐a and epiphytic algal abundance), enhancing the biomass of submerged macrophytes. Highly branched macrophytes with high surfaces and morphologies and many microhabitats supported the most snails and epiphytic algae (the biomass of the snail communities and epiphytic algae on H. verticillata was greater than that on V. natans), and snails preferred to feed on native plants. Competition drove the snails to change their grazing preferences to achieve coexistence.
Keywords	coexistence ; exotic macrophyte ; grazing preferences ; snail–macrophyte–algae relationship ; Ecology ; QH540-549.5
Subject code	333
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A versatile genetic-encoded reporter for magnetic resonance imaging

Haiyang Yang / Zhengjiang Qian / Chunhua Liu / Changjun Tie / Aoling Cai / Jie Wang / Yao Xing / Jun Xia / Xiang Li

Heliyon, Vol 9, Iss 3, Pp e14054- (2023)

2023

Abstract: It has been a long-cherished wish in biomedicine research to have an imaging tool to visualize gene expression, with good spatiotemporal resolution, in rodent and primate animals noninvasively and longitudinally. To this purpose, we here present a novel ... ...

Abstract	It has been a long-cherished wish in biomedicine research to have an imaging tool to visualize gene expression, with good spatiotemporal resolution, in rodent and primate animals noninvasively and longitudinally. To this purpose, we here present a novel genetic encoded magnetic resonance imaging reporter, i.e., GEM reporter, for noninvasive visualization of cell-specific gene expression. The GEM reporter was developed through codon modification of a bacteria-originated manganese (Mn) binding protein, allowing the sequestration of endogenous Mn in local tissues. When expressed in bacteria, plant and animals, GEM reporter can robustly produce high image contrast in T1-weighted MRI without additional substrates or contrast agents. Importantly, GEM reporter can be tracked inherently by MRI in specific cells and tissues. These findings support GEM reporter as a versatile marker for deciphering gene expression spatiotemporally in living subjects.
Keywords	MRI ; Molecular imaging ; Contrast agent ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	616
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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