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  1. AU="Chunlei Yu"
  2. AU="Nagao, Asuteka"
  3. AU="Derwael, Céline" AU="Derwael, Céline"
  4. AU="Yao, Yang"
  5. AU=Strutz Frank
  6. AU="Won-Sang Lee"
  7. AU="the ICHseq Investigators" AU="the ICHseq Investigators"
  8. AU="Green, J G"
  9. AU="Xinguang Yang"
  10. AU="Masamed, Rinat"
  11. AU="Flores-Estrada, Diana"
  12. AU="Castellanos, Jason A"
  13. AU="Kiberd, Bryce A"
  14. AU="Kaushal, Deepak"
  15. AU="Rouzaire, Paul"
  16. AU="Mohammed A. S. Abourehab"
  17. AU="Basa, S."
  18. AU="Rohner, Eliane"
  19. AU="Abu-Mahfouz, Adnan M"
  20. AU="Falanti, Andrea"
  21. AU="Yujing Dang"
  22. AU="Clare Duncan"
  23. AU="Calvo Soto, Andrea Patricia"
  24. AU="Joanna I. Olszewska"
  25. AU="Francesco Cavallieri"
  26. AU="Betaieb, Ehssen"
  27. AU="Fan, Xiaoyu"
  28. AU="Riveros-Magaña, Alma Rocío"
  29. AU="Zhang, Wei-Fen"
  30. AU="Ciuca, Catrinel"
  31. AU="Friend, James R"
  32. AU="Colin R. Jackson"
  33. AU="Messina, Claudia"
  34. AU="Faircloth, Chelsey"
  35. AU="Md. Zabirul Islam" AU="Md. Zabirul Islam"
  36. AU="Butcher, Xochitl"
  37. AU="Espay, Alberto J."

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  1. Artikel ; Online: A review and update for registered clinical studies of stem cells for non-tumorous and non-hematological diseases

    Jianhua Chen / Lijun Luo / Ruimin Tian / Chunlei Yu

    Regenerative Therapy, Vol 18, Iss , Pp 355-

    2021  Band 362

    Abstract: Objective: To provide consultative information on selecting potential indications of stem cells in the treatment of non-tumorous and non-hematopoietic system conditions, we screened the clinical trials on website: http://www.clinicaltrials.gov. Methods: ... ...

    Abstract Objective: To provide consultative information on selecting potential indications of stem cells in the treatment of non-tumorous and non-hematopoietic system conditions, we screened the clinical trials on website: http://www.clinicaltrials.gov. Methods: A literature search was conducted using the National Institute of Health (NIH) website (http://www.clinicaltrials.gov) from May 10th, 2012 to Oct 13th, 2020 with stem cells as an intervention in human trials for non-tumorous and non-hematological conditions. There was no restriction for language, research location, and research race. Results and conclusion: Search terms initially found a total of 3576 articles. Firstly, 138 terminated or suspended studies were excluded and further 24 repeated studies were excluded. Secondly, 987 tumorous and hematopoietic conditions-related studies were excluded. Lastly, 1218 studies were excluded without stem cell therapy as their primary purpose. A total of 1209 research studies were entered into the analysis and reviewed. The top 4 diseases were about motor system diseases 229 (19.28%). In addition, 206 (17.34%) studies were related to central nervous system (CNS) diseases. 140 (11.78%) were autoimmune diseases or graft-versus-host disease (GVHD) after organ transplantation. 129 (10.86%) were about respiratory system diseases, among them, 44.19% projects were about new coronary pneumonia (NCP). The main cell types used in various diseases are Mesenchymal Stem Cells (MSCs), bone marrow stem cells (BM-SCs), peripheral blood stem cells (PBSCs), hematopoietic stem cells (HSCs), adipose stem cell (ASCs) and precursor cells.
    Schlagwörter Stem cell ; Clinical trial ; Indications ; Medicine (General) ; R5-920 ; Cytology ; QH573-671
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Nanocrystalline Yb:YAG-Doped Silica Glass with Good Transmittance and Significant Spectral Performance Enhancements

    Hehe Dong / Yinggang Chen / Yan Jiao / Qinling Zhou / Yue Cheng / Hui Zhang / Yujie Lu / Shikai Wang / Chunlei Yu / Lili Hu

    Nanomaterials, Vol 12, Iss 8, p

    2022  Band 1263

    Abstract: In this study, Yb:YAG-nanocrystal-doped silica glass with high transmission and excellent spectral properties was successfully prepared using a modified sol–gel method. The X-ray diffraction (XRD), micro-Raman spectroscopy, electron paramagnetic ... ...

    Abstract In this study, Yb:YAG-nanocrystal-doped silica glass with high transmission and excellent spectral properties was successfully prepared using a modified sol–gel method. The X-ray diffraction (XRD), micro-Raman spectroscopy, electron paramagnetic resonance (EPR), transmission electron microscopy (TEM), and high-resolution TEM (HR-TEM) analyses confirmed that the Yb:YAG nanocrystals, with their low content, homogeneous distribution, and small crystal size, directly crystallized into the silica glass network without annealing treatment. In contrast with conventional microcrystalline glass having large particles (>0.1 μm) and a large particle content, nanocrystalline glass with a homogeneous distribution and sizes of ~22 nm had higher optical transmittance and better spectral properties. Compared with Yb 3+ doped silica glass without nanocrystals, the Yb:YAG-nanocrystal-doped silica glass had a 28% increase in absorption cross-section at 975 nm and a 172% enhanced emission cross-section at 1030 nm without any changes in the spectral pattern of the Yb 3+ ions in the silica glass. Meanwhile, the Yb:YAG-doped silica glass with large size and high optical quality was easily prepared. Therefore, the Yb:YAG-nanocrystal-doped silica glass is expected to be a promising near-infrared laser material.
    Schlagwörter Yb:YAG nanocrystals ; silica glass ; microstructure ; spectral properties ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression

    Na Li / Yanhong Wang / Anqing Wang / Jing Zhang / Chaoran Jia / Chunlei Yu / Zhenbo Song / Shuyue Wang / Lei Liu / Jingwen Yi / Yongli Bao / Yanxin Huang / Luguo Sun

    International Journal of Molecular Sciences, Vol 24, Iss 2987, p

    2023  Band 2987

    Abstract: STS1 and STS2, as the protein phosphatases that dephosphorylate FLT3 and cKIT, negatively regulate the self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs). To obtain the small molecule inhibitors of STS1/STS2 phosphatase ... ...

    Abstract STS1 and STS2, as the protein phosphatases that dephosphorylate FLT3 and cKIT, negatively regulate the self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs). To obtain the small molecule inhibitors of STS1/STS2 phosphatase activity used to expand HSPCs both in vitro and in vivo, we establish an in vitro phosphatase assay using the recombinant proteins of the STS1/STS2 histidine phosphatase (HP) domain, by which we screened out baicalein (BC) as one of the effective inhibitors targeting STS1 and STS2. Then, we further demonstrate the direct binding of BC with STS1/STS2 using molecular docking and capillary electrophoresis and verify that BC can restore the phosphorylation of FLT3 and cKIT from STS1/STS2 inhibition. In a short-term in vitro culture, BC promotes profound expansion and enhances the colony-forming capacity of both human and mouse HSPCs along with the elevation of phospho-FLT3 and phospho-cKIT levels. Likewise, in vivo administration with BC significantly increases the proportions of short-term hematopoietic stem cells (ST-HSCs), multipotent progenitors (MPPs) and especially long-term HSCs (LT-HSCs) in healthy mouse bone marrow and increases the numbers of colony-forming units (CFU) formed by HSPCs as well. More importantly, pre-administration of BC significantly enhances the survival of mice with lethal 5-fluorouracil (5-FU) injection due to the alleviation of 5-FU-induced myelosuppression, as evidenced by the recovery of bone marrow histologic injury, the increased proportions of LT-HSCs, ST-HSCs and MPPs, and enhanced colony-forming capacity. Collectively, our study not only suggests BC as one of the small molecule candidates to stimulate HSPC expansion both in vitro and in vivo when needed in either physiologic or pathologic conditions, but also supports STS1/STS2 as potential therapeutic drug targets for HSPC expansion and hematopoietic injury recovery.
    Schlagwörter STS1 ; STS2 ; baicalein ; hematopoietic and progenitor stem cells ; chemotherapy-induced myelosuppression ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Mass spectrometry identification of the liquor contained in the plum vase excavated from Jurou Li’s Grave of the Jin Dynasty (1115–1234 CE) in Xi’an, Shannxi, China

    Zhanyun Zhu / Chunlei Yu / Yifei Miao / Zhiyong Lu / Junchang Yang

    Heritage Science, Vol 6, Iss 1, Pp 1-

    2018  Band 6

    Abstract: Abstract In order to accurately identify the ancient liquid contained in the plum vase excavated from Jurou Li’s Grave of the Jin Dynasty (1115–1234 CE) in Xi’an, mass spectrometry was applied to determine the amino acid sequences of the residual ... ...

    Abstract Abstract In order to accurately identify the ancient liquid contained in the plum vase excavated from Jurou Li’s Grave of the Jin Dynasty (1115–1234 CE) in Xi’an, mass spectrometry was applied to determine the amino acid sequences of the residual proteins extracted from the liquid sample. The sequences were searched against a standard protein sequence database. The proteins extracted was identified as glycosyltransferase from Sorghum bicolor, calcium-dependent protein kinase 2 from Wickerhamomyces ciferrii, and cytochrome b-c1 complex subunit Rieske from Nadsonia fulvescens. These findings indicate that the extremely degraded liquid in the plum vase was made from the cereal of sorghum by alcoholic fermentation of Wickerhamomyces ciferrii and Nadsonia fulvescens, providing direct evidence for liquor in the Jin Dynasty.
    Schlagwörter Archaeological chemistry ; Mass spectrometry ; Fermented beverage ; Plum vase ; Jin Dynasty ; Fine Arts ; N ; Analytical chemistry ; QD71-142
    Thema/Rubrik (Code) 930
    Sprache Englisch
    Erscheinungsdatum 2018-07-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Fault recognition method of smart grid data acquisition system based on FNN and sequential DS fusion

    Hanzhe Qiao / Quanbo Ge / Haoyu Jiang / Ziyi Li / Zilong You / Jianmin Zhang / Fengjuan Bi / Chunlei Yu

    Cognitive Computation and Systems, Vol 3, Iss 1, Pp 28-

    2021  Band 36

    Abstract: Abstract It is of significant practical importance to ensure the operational safety of the smart grid, which requires real‐time fault diagnosis and identifying what causes it based on an enormous amount of data. This article further studies the ... ...

    Abstract Abstract It is of significant practical importance to ensure the operational safety of the smart grid, which requires real‐time fault diagnosis and identifying what causes it based on an enormous amount of data. This article further studies the intelligent fault‐identification method based on the combination of multi‐machine learning methods on the bases of researching on Fault Diagnosis of Smart Grid Data Acquisition System. Firstly, we should apply statistical analysis and feature extraction for fault data. Then, we can use fuzzy neural network (FNN) to calculate the probability of fault prediction of power distribution stations, manufacturers and operation businesses, and use the membership function to calculate the corresponding fault membership and uncertainty. Secondly, it makes use of Dempster/Shafer (DS) evidence sequential fusion method to realize fault membership fusion, and gives the corresponding decision criteria for failure causes. Thirdly, a fault‐identification method of smart grid data‐acquisition system is established based on FNN and DS Evidence Fusion. Finally, the experimental results based on the actual operation data of smart grid show that the new method has a very good application effect at fault cause identification.
    Schlagwörter statistical analysis ; fuzzy neural nets ; feature extraction ; smart power grids ; condition monitoring ; fault diagnosis ; Computer engineering. Computer hardware ; TK7885-7895 ; Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage

    Lei Qi / Tonghe Pan / Liling Ou / Zhiqiang Ye / Chunlei Yu / Bijun Bao / Zixia Wu / Dayong Cao / Liming Dai

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Band 12

    Abstract: Qi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They ... ...

    Abstract Qi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They can suppress growth of cancer cells by selectively inducing DNA damage.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer

    Aizhu Duan / Lingmei Kong / Tao An / Hongyu Zhou / Chunlei Yu / Yan Li

    Biology Open, Vol 8, Iss

    2019  Band 11

    Abstract: Tumor protein D52 (TPD52) is an oncogene amplified and overexpressed in various cancers. Tumor-suppressive microRNA-449a and microRNA-34a (miR-449a/34a) were recently reported to inhibit breast cancer cell migration and invasion via targeting TPD52. ... ...

    Abstract Tumor protein D52 (TPD52) is an oncogene amplified and overexpressed in various cancers. Tumor-suppressive microRNA-449a and microRNA-34a (miR-449a/34a) were recently reported to inhibit breast cancer cell migration and invasion via targeting TPD52. However, the upstream events are not clearly defined. Star-PAP is a non-canonical poly (A) polymerase which could regulate the expression of many miRNAs and mRNAs, but its biological functions are not well elucidated. The present study aimed to explore the regulative roles of Star-PAP in miR-449a/34a and TPD52 expression in breast cancer. We observed a negative correlation between the expression of TPD52 and Star-PAP in breast cancer. Overexpression of Star-PAP inhibited TPD52 expression, while endogenous Star-PAP knockdown led to increased TPD52. Furthermore, RNA immunoprecipitation assay suggested that Star-PAP could not bind to TPD52, independent of the 3′-end processing. RNA pull-down assay showed that Star-PAP could bind to 3′region of miR-449a. In line with these results, blunted cell proliferation or cell apoptosis caused by Star-PAP was rescued by overexpression of TPD52 or downregulation of miR-449a/34a. Our findings identified that Star-PAP regulates TPD52 by modulating miR-449a/34a, which may be an important molecular mechanism underlying the tumorigenesis of breast cancer and provide a rational therapeutic target for breast cancer treatment.
    Schlagwörter star-pap ; tpd52 ; mir-449a ; mir-34a ; breast cancer ; Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2019-11-01T00:00:00Z
    Verlag The Company of Biologists
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3

    Yanhong Wang / Na Li / Yanping Zheng / Anqing Wang / Chunlei Yu / Zhenbo Song / Shuyue Wang / Ying Sun / Lihua Zheng / Guannan Wang / Lei Liu / Jingwen Yi / Yanxin Huang / Muqing Zhang / Yongli Bao / Luguo Sun

    International Journal of Molecular Sciences, Vol 23, Iss 104, p

    2022  Band 104

    Abstract: The survival and prognosis of hepatocellular carcinoma (HCC) are poor, mainly due to metastasis. Therefore, insights into the molecular mechanisms underlying HCC invasion and metastasis are urgently needed to develop a more effective antimetastatic ... ...

    Abstract The survival and prognosis of hepatocellular carcinoma (HCC) are poor, mainly due to metastasis. Therefore, insights into the molecular mechanisms underlying HCC invasion and metastasis are urgently needed to develop a more effective antimetastatic therapy. Here, we report that KIAA1217, a functionally unknown macromolecular protein, plays a crucial role in HCC metastasis. KIAA1217 expression was frequently upregulated in HCC cell lines and tissues, and high KIAA1217 expression was closely associated with shorter survival of patients with HCC. Overexpression and knockdown experiments revealed that KIAA1217 significantly promoted cell migration and invasion by inducing epithelial-mesenchymal transition (EMT) in vitro. Consistently, HCC cells overexpressing KIAA1217 exhibited markedly enhanced lung metastasis in vivo. Mechanistically, KIAA1217 enhanced EMT and accordingly promoted HCC metastasis by interacting with and activating JAK1/2 and STAT3. Interestingly, KIAA1217-activated p-STAT3 was retained in the cytoplasm instead of translocating into the nucleus, where p-STAT3 subsequently activated the Notch and Wnt/β-catenin pathways to facilitate EMT induction and HCC metastasis. Collectively, KIAA1217 may function as an adaptor protein or scaffold protein in the cytoplasm and coordinate multiple pathways to promote EMT-induced HCC metastasis, indicating its potential as a therapeutic target for curbing HCC metastasis.
    Schlagwörter KIAA1217 ; hepatocellular carcinoma ; epithelial-mesenchymal transition ; metastasis ; STAT3 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling

    Lin Liu / Guangyu Wang / Liguo Wang / Chunlei Yu / Mengwei Li / Shuhui Song / Lili Hao / Lina Ma / Zhang Zhang

    Biology Direct, Vol 15, Iss 1, Pp 1-

    2020  Band 14

    Abstract: Abstract Background Glioma is one of the most common malignant brain tumors and exhibits low resection rate and high recurrence risk. Although a large number of glioma studies powered by high-throughput sequencing technologies have led to massive multi- ... ...

    Abstract Abstract Background Glioma is one of the most common malignant brain tumors and exhibits low resection rate and high recurrence risk. Although a large number of glioma studies powered by high-throughput sequencing technologies have led to massive multi-omics datasets, there lacks of comprehensive integration of glioma datasets for uncovering candidate biomarker genes. Results In this study, we collected a large-scale assemble of multi-omics multi-cohort datasets from worldwide public resources, involving a total of 16,939 samples across 19 independent studies. Through comprehensive molecular profiling across different datasets, we revealed that PRKCG (Protein Kinase C Gamma), a brain-specific gene detectable in cerebrospinal fluid, is closely associated with glioma. Specifically, it presents lower expression and higher methylation in glioma samples compared with normal samples. PRKCG expression/methylation change from high to low is indicative of glioma progression from low-grade to high-grade and high RNA expression is suggestive of good survival. Importantly, PRKCG in combination with MGMT is effective to predict survival outcomes in a more precise manner. Conclusions PRKCG bears the great potential for glioma diagnosis, prognosis and therapy, and PRKCG-like genes may represent a set of important genes associated with different molecular mechanisms in glioma tumorigenesis. Our study indicates the importance of computational integrative multi-omics data analysis and represents a data-driven scheme toward precision tumor subtyping and accurate personalized healthcare.
    Schlagwörter Glioma ; Multi-omics ; PRKCG ; Biomarker ; Cerebrospinal fluid ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Konferenzbeitrag: The proceedings of brain metastases from lung cancer

    Zhao, Hang / Guijie Li / Chunlei Yu / Zhe An

    Open life sciences. 2016 Jan. 1, v. 11, no. 1

    2016  

    Abstract: Brain tumors include primary tumors of various intracranial tissue and secondary intracranial tumors that transferred from other parts of the body. Secondary intracranial tumors are especially prevalent in patients with lung cancer. The mechanisms of ... ...

    Abstract Brain tumors include primary tumors of various intracranial tissue and secondary intracranial tumors that transferred from other parts of the body. Secondary intracranial tumors are especially prevalent in patients with lung cancer. The mechanisms of lung cancer with brain metastases are complicated, they are affected by a variety of factors. Thus, identifying the mechanisms of lung cancer with brain metastases will have far-reaching meanings both for clinic pharmacy research and for a better quality of life for patients; Brain metastases from lung cancer represent a prevalent and challenging clinical dilemma, and some research suggests that the outcomes and characteristics of brain metastases that result from lung cancer primary sites are perhaps different than those from other primary sites, therefore increasing the difficulty of clinical treatment. Despite steady research developments during recent years, the survival rates remain poor. The mechanisms and therapeutic options for treating brain metastases arising from lung cancer are review in this article.
    Schlagwörter brain ; brain neoplasms ; lung neoplasms ; metastasis ; patients ; quality of life ; survival rate
    Sprache Englisch
    Erscheinungsverlauf 2016-0101
    Umfang p. 116-121.
    Erscheinungsort De Gruyter Open
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 2817958-4
    ISSN 2391-5412
    ISSN 2391-5412
    DOI 10.1515/biol-2016-0016
    Datenquelle NAL Katalog (AGRICOLA)

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