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  1. Article: Towards telemedicine in pulmonary hypertension: Assessing the feasibility of remote quality of life and exercise capacity assessment.

    Stubbs, Harrison / Brewis, Melanie / Church, Colin / Johnson, Martin

    Pulmonary circulation

    2022  Volume 12, Issue 4, Page(s) e12144

    Abstract: Patients with pulmonary hypertension (PH) are happy to perform simple exercise capacity tests at home and believe this is feasible. A proportion of patients are able to use an electronic form to complete quality of life questionnaires. These findings are ...

    Abstract Patients with pulmonary hypertension (PH) are happy to perform simple exercise capacity tests at home and believe this is feasible. A proportion of patients are able to use an electronic form to complete quality of life questionnaires. These findings are being used to build a telemedicine strategy for PH patients.
    Language English
    Publishing date 2022-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COMPERA 2.0 risk stratification in medically managed chronic thromboembolic pulmonary hypertension.

    Stubbs, Harrison / Lua, Stephanie / Brewis, Melanie / Johnson, Martin / Church, Colin

    The European respiratory journal

    2022  Volume 60, Issue 3

    MeSH term(s) Chronic Disease ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/therapy ; Pulmonary Artery ; Pulmonary Embolism/complications ; Pulmonary Embolism/therapy ; Risk Assessment
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00313-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
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  3. Article: Impairment of skeletal muscle oxygen extraction and cardiac output are matched in precapillary pulmonary hypertension.

    Stubbs, Harrison / Church, Colin / Johnson, Martin / Thomson, Stephen

    ERJ open research

    2021  Volume 7, Issue 3

    Abstract: In precapillary pulmonary hypertension, exercising muscles extract oxygen to a similar level seen in healthy individuals. Exercise limitation is a result of impaired oxygen delivery, which is matched to any impairment in skeletal muscle oxygen extraction. ...

    Abstract In precapillary pulmonary hypertension, exercising muscles extract oxygen to a similar level seen in healthy individuals. Exercise limitation is a result of impaired oxygen delivery, which is matched to any impairment in skeletal muscle oxygen extraction.
    Language English
    Publishing date 2021-08-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00449-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The MRC Dyspnoea Scale and mortality risk prediction in pulmonary arterial hypertension: A retrospective longitudinal cohort study.

    Arogundade, Folawemimo / Jani, Bhautesh / Church, Colin / Brewis, Melanie / Johnson, Martin / Stubbs, Harrison

    Pulmonary circulation

    2023  Volume 13, Issue 3, Page(s) e12257

    Abstract: Risk stratification models in pulmonary arterial hypertension (PAH) rely on World Health Organisation Functional Class (WHO FC). A high proportion of patients are classified as WHO FC III, a heterogenous group which limits the stratification abilities of ...

    Abstract Risk stratification models in pulmonary arterial hypertension (PAH) rely on World Health Organisation Functional Class (WHO FC). A high proportion of patients are classified as WHO FC III, a heterogenous group which limits the stratification abilities of risk models. The Medical Research Council (MRC) Dyspnoea Scale may allow a more precise assessment of functional status and improve current risk models. We investigated the ability of the MRC Dyspnoea Scale to assess survival in PAH and compared performance to WHO FC and the COMPERA 2.0 models. Patients with Idiopathic, Hereditary or Drug-induced PAH who were diagnosed between 2010 and 2021 were included. The MRC Dyspnoea Scale was retrospectively applied as derived from a combination of patient notes, 6MWD tests results and WHO functional status using a purpose-designed algorithm. Survival was assessed using Kaplan-Meier analyses, log rank testing and Cox proportional hazard ratios. Model performance was compared with Harrell's C Statistic. Data from 216 patients were retrospectively analyzed. At baseline, of 120 patients classified as WHO FC III, 8% were MRC Dyspnoea Scale 2, 12% Scale 3, 71% Scale 4 and 10% Scale 5. The MRC Dyspnoea Scale performed well compared to the WHO FC and COMPERA models at follow up (respectively, C-statistic 0.74 vs. 0.69 vs. 0.75). It was possible to use the MRC Dyspnoea Scale to subdivide patients in WHO FC III into groups which had distinct survival estimates. We conclude that at follow-up, the MRC Dyspnoea Scale may be a valid tool for the assessment of risk stratification in pulmonary arterial hypertension.
    Language English
    Publishing date 2023-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12257
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  5. Article ; Online: The right ventricle under pressure: Anatomy and imaging in sickness and health.

    Stubbs, Harrison / MacLellan, Alexander / Lua, Stephanie / Dormand, Helen / Church, Colin

    Journal of anatomy

    2022  Volume 242, Issue 1, Page(s) 17–28

    Abstract: The right ventricle (RV) is an important structure which serves a multitude of vital physiological functions in health. For many years, the left ventricle has dominated the focus of understanding in both biology and pathophysiology and the RV was felt to ...

    Abstract The right ventricle (RV) is an important structure which serves a multitude of vital physiological functions in health. For many years, the left ventricle has dominated the focus of understanding in both biology and pathophysiology and the RV was felt to be more of a passive structure which rarely had an effect on disease states. However, it is increasingly recognised that the RV is essential to the homoeostasis of normal physiology and disturbances in RV structure and function have a substantial effect on patient outcomes. Indeed, the prognosis of diseases of lung diseases affecting the pulmonary vasculature and left heart disease is intimately linked to the function of the right ventricle. This review sets out to describe the developmental and anatomical complexities of the right ventricle while exploring the modern techniques employed to image and understand its function from a clinical perspective.
    MeSH term(s) Humans ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/anatomy & histology
    Language English
    Publishing date 2022-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2955-5
    ISSN 1469-7580 ; 0021-8782
    ISSN (online) 1469-7580
    ISSN 0021-8782
    DOI 10.1111/joa.13654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Remote exercise testing in pulmonary hypertension (PHRET).

    Stubbs, Harrison / Lua, Stephanie / Ingram, Jamie / Jani, Bhautesh D / Brewis, Melanie / Church, Colin / Johnson, Martin

    Pulmonary circulation

    2023  Volume 13, Issue 4, Page(s) e12325

    Abstract: Remote exercise tests for patients with pulmonary hypertension (PH) would improve the telemedicine strategies in this disease. The PHRET study assessed the validity and feasibility of four remote exercise tests performed by PH patients at home. ... ...

    Abstract Remote exercise tests for patients with pulmonary hypertension (PH) would improve the telemedicine strategies in this disease. The PHRET study assessed the validity and feasibility of four remote exercise tests performed by PH patients at home. Participants undergoing diagnostic assessment for PH were included. At baseline, patients completed a 6MWT followed by a range of study tests including a Timed Up and Go (TUG) test, a Sit-to-Stand (STS), a Step Test (ST), and a tele-6MWT (T6MWT) performed outside using a GPS-enabled smartphone. Patients performed these tests at home following discharge and at first follow-up. Analysis focused on comparing the results of study tests to the standard 6MWT. The discontinuation rate was 15%. Ninety-seven percent of patients were able to complete a TUG, 92% a STS, 73% a ST, and 49% a T6MWT. At baseline, correlation between the standard 6MWT and study tests, respectively, was T6MWT 0.93, ST 0.78, STS 0.71, and TUG -0.76 (
    Language English
    Publishing date 2023-12-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12325
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  7. Article: Pulmonary hypertension and severe right heart failure following lumbar spinal surgery.

    Jayasekera, Geeshath / Johnson, Martin / Hussey, Keith / Church, Colin

    SAGE open medical case reports

    2019  Volume 7, Page(s) 2050313X19847805

    Abstract: Pulmonary hypertension is a disease process affecting the pulmonary circulation and is defined by an increase in pulmonary artery pressure subsequently causing right ventricular failure. Vascular complications, including arteriovenous fistulae, are ... ...

    Abstract Pulmonary hypertension is a disease process affecting the pulmonary circulation and is defined by an increase in pulmonary artery pressure subsequently causing right ventricular failure. Vascular complications, including arteriovenous fistulae, are recognised, but are uncommon complications of spinal surgery. Arteriovenous fistulae increase venous return to the right heart and can induce a high-output cardiac state, mimicking pulmonary arterial hypertension and right heart failure. We present a 47-year-old man with a 1 year history of worsening dyspnoea, exertional pre-syncope and leg swelling presenting with severe right heart failure. The previous year, he had complex spinal surgery, which included discectomy, laminectomy and bilateral nerve reconstruction at L5-S1 level. Initial non-invasive investigations including echocardiography and chest imaging raised the possibility of right heart failure presumed secondary to pulmonary vascular disease. Clinical examination and right heart catheterisation were in keeping with a high cardiac output state, and invasive saturation monitoring was suggestive of a sub-diaphragmatic shunt. Subsequent imaging confirmed the presence of an iatrogenic ilio-iliac arteriovenous fistula. The patient underwent urgent endovascular repair, which resulted in resolution of his symptoms and haemodynamics. We describe the case and present a review of the relevant literature.
    Language English
    Publishing date 2019-05-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X19847805
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  8. Article: Predicting Group II pulmonary hypertension: diagnostic accuracy of the H2FPEF and OPTICS scores in Scotland.

    Stubbs, Harrison / MacLellan, Alexander / McGettrick, Michael / Jani, Bhautesh / Brewis, Melanie / Church, Colin / Johnson, Martin

    Open heart

    2022  Volume 9, Issue 1

    Abstract: Objective: Group II pulmonary hypertension (PH) can be challenging to distinguish from Group I PH without proceeding to right heart catheterisation (RHC). The diagnostic accuracy of the H2FPEF and OPTICS scores was investigated in Scotland.: Methods: ...

    Abstract Objective: Group II pulmonary hypertension (PH) can be challenging to distinguish from Group I PH without proceeding to right heart catheterisation (RHC). The diagnostic accuracy of the H2FPEF and OPTICS scores was investigated in Scotland.
    Methods: Patients were included in the study if they were referred to the Scottish Pulmonary Vascular Unit between 2016 and 2020 and subsequently diagnosed with Group II PH or Group I PH which was either idiopathic, heritable or pulmonary veno-occlusive disease. The established cut offs for the H2FPEF and for the OPTICS scores were applied retrospectively to predict the presence of Group II PH. The diagnosis from the scores were compared with the MDT consensus diagnosis following RHC.
    Results: 107 patients with Group I PH and 86 patients with Group II PH were included. Retrospective application of the OPTICS score demonstrated that pretest scoring would detect 28% of cases with Group II PH yet at the cost of misdiagnosing 4% of patients with Group I as Group II PH (specificity 0.96). The H2FPEF score had a far greater sensitivity (0.70) yet reduced specificity (0.91), leading to misdiagnosis of 9% of Group I PH cases.
    Conclusion: While the specificity of these scores was high, the lack of perfect specificity limits their utility as it results in missed patients with Group I PH. As a consequence, they cannot replace RHC as the means of diagnosing the aetiology of PH in their current form. The scores may still be used to support clinical judgement or to indicate the advisability for further provocative testing at RHC.
    MeSH term(s) Cardiac Catheterization ; Humans ; Hypertension, Pulmonary/diagnosis ; Predictive Value of Tests ; Retrospective Studies ; Scotland
    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2022-002023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Establishing expert consensus for the optimal approach to holistic risk-management in pulmonary arterial hypertension: a Delphi process and narrative review.

    Church, Colin / Gin-Sing, Wendy / Grady, Duncan / Johnson, Martin / Kiely, David G / Lordan, Jim / Turner, Nadine / Wort, S John / Condliffe, Robin

    Expert review of respiratory medicine

    2021  Volume 15, Issue 11, Page(s) 1493–1503

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Consensus ; Delphi Technique ; Humans ; Pulmonary Arterial Hypertension ; Surveys and Questionnaires
    Language English
    Publishing date 2021-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2021.1931129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6963: Show issues Location:
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  10. Article: Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry

    Denver, Nina / Khan, Shazia / Stasinopoulos, Ioannis / Church, Colin / Homer, Natalie Z.M. / MacLean, Margaret R. / Andrew, Ruth

    Data in Brief. 2019 Apr., v. 23

    2019  

    Abstract: Analysis of catechol estrogens (2 & 4 hydroxy-estrone and estradiol) has proven troublesome by liquid chromatography tandem mass spectrometry due to their low concentrations, short half-lives and temperature-labile nature. Derivatization to methyl ... ...

    Abstract Analysis of catechol estrogens (2 & 4 hydroxy-estrone and estradiol) has proven troublesome by liquid chromatography tandem mass spectrometry due to their low concentrations, short half-lives and temperature-labile nature. Derivatization to methyl piperazine analogues has been reported for a panel of 9 estrogens in, “Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry” (Denver et al., 2019). Data show alteration of the base catalyst in this method was required to allow detection of catechol estrogens to low levels. Data also highlight the challenges faced in chromatographic separation of isomers and isotopologues, which were partially overcome by employing an extended column length and reduced oven temperature. In addition, data analysis displayed significant matrix effects during quantitation in plasma, following solid-phase extraction, despite efficient recoveries.
    Keywords catalysts ; catechol ; derivatization ; estradiol ; half life ; humans ; liquid chromatography ; metabolites ; ovens ; piperazine ; solid phase extraction ; tandem mass spectrometry ; temperature
    Language English
    Dates of publication 2019-04
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2019.103740
    Database NAL-Catalogue (AGRICOLA)

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