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  1. Book ; Online: Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations

    Ciarimboli, Giuliano

    2021  

    Keywords Medicine ; transporters ; endogenous metabolism ; functional subgroups ; SLC22 ; remote sensing and signaling ; drug transporters ; gut microbiome ; chronic kidney disease ; solute carrier 22 (SLC22) ; Remote Sensing and Signaling Theory ; interorgan communication ; organic anion transporter ; organic cation transporter ; SLC22A15 ; SLC22A16 ; SLC22A18 ; kidney ; Malpighian tubule ; TCGA ; human pathology atlas ; gene ontology ; organic cations ; transport ; kidneys ; regulation ; Nuclear receptor ; renal excretion ; bile acids ; organic cation transporters ; drug disposition ; genetic polymorphisms ; drug-induced kidney injury ; nephrotoxicity ; RA ; Tofacitinib ; Baricitinib ; MATE1 ; solute carrier (SLC) family ; OCT1 ; SLC22A1 ; species differences ; drugs ; pesticides ; cisplatin nephrotoxicity ; PPAR-alpha ; organic transporters ; serotonin transporter ; plasma membrane monoamine transporter ; ketamine ; isoflurane ; serotonin clearance ; antidepressant-like activity ; chronoamperometry ; tail suspension test ; forced swim test ; hepatotoxicity ; solute carrier ; pulmonary drug delivery ; SLC22A1-5 ; lung epithelium ; drug uptake ; β2-agonists ; chronic lung diseases ; anticholinergics ; trospium ; OCT ; MATE ; drug excretion ; drug transport ; n/a
    Size 1 electronic resource (248 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289958
    ISBN 9783036505633 ; 3036505636
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Overcoming Biological Barriers: Importance of Membrane Transporters in Homeostasis, Disease and Disease Treatment.

    Ciarimboli, Giuliano

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: This editorial summarizes the 22 scientific papers published in the Special Issue "Overcoming Biological Barriers: Importance of Membrane Transporters in Homeostasis, Disease, and Disease Treatment" of the International Journal of Molecular Sciences [ ... ] ...

    Abstract This editorial summarizes the 22 scientific papers published in the Special Issue "Overcoming Biological Barriers: Importance of Membrane Transporters in Homeostasis, Disease, and Disease Treatment" of the International Journal of Molecular Sciences [...].
    MeSH term(s) Membrane Transport Proteins ; Homeostasis
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physiology, Biochemistry and Pharmacology of Transporters for Organic Cations 2.0.

    Ciarimboli, Giuliano

    International journal of molecular sciences

    2022  Volume 23, Issue 11

    Abstract: This editorial summarizes the 12 scientific papers published in the Special Issue "Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 2 [ ... ]. ...

    Abstract This editorial summarizes the 12 scientific papers published in the Special Issue "Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 2 [...].
    MeSH term(s) Biochemistry ; Cations ; Membrane Transport Proteins ; Pharmacology
    Chemical Substances Cations ; Membrane Transport Proteins
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23116328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Organic cation transporters

    Ciarimboli, Giuliano / Gautron, Sophie / Schlatter, Eberhard

    integration of physiology, pathology, and pharmacology

    2016  

    Keywords Molecular biology ; Cytoplasm ; Structural biology ; Cell Membrane ; Genetics
    Language English
    Size XIV, 264 S. : Ill., graph. Darst., 235 mm x 155 mm, 0 g
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018861923
    ISBN 978-3-319-23792-3 ; 978-3-319-23793-0 ; 3-319-23792-6 ; 3-319-23793-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 137 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: Anticancer Platinum Drugs Update.

    Ciarimboli, Giuliano

    Biomolecules

    2021  Volume 11, Issue 11

    Abstract: The discovery of the anticancer properties of platinum derivatives by Rosenberg represents a milestone in the development of chemotherapeutic protocols for tumor treatment [ ... ]. ...

    Abstract The discovery of the anticancer properties of platinum derivatives by Rosenberg represents a milestone in the development of chemotherapeutic protocols for tumor treatment [...].
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Humans ; Immunity/drug effects ; Immunogenic Cell Death/drug effects ; Platinum/pharmacology
    Chemical Substances Antineoplastic Agents ; Platinum (49DFR088MY)
    Language English
    Publishing date 2021-11-04
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11111637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1.

    Ciarimboli, Giuliano

    Frontiers in pharmacology

    2021  Volume 11, Page(s) 607613

    Abstract: The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane. In humans, OCT1 is mainly expressed in the sinusoidal ... ...

    Abstract The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane. In humans, OCT1 is mainly expressed in the sinusoidal membrane of hepatocytes, while in rodents, OCT1 is strongly represented also in the basolateral membrane of renal proximal tubule cells. Considering that organic cations of endogenous origin are important neurotransmitters and that those of exogenous origin are important drugs, these transporters have significant physiological and pharmacological implications. Because of the high expression of OCTs in excretory organs, their activity has the potential to significantly impact not only local but also systemic concentration of their substrates. Even though many aspects governing OCT function, interaction with substrates, and pharmacological role have been extensively investigated, less is known about regulation of OCTs. Possible mechanisms of regulation include genetic and epigenetic modifications, rapid regulation processes induced by kinases, regulation caused by protein-protein interaction, and long-term regulation induced by specific metabolic and pathological situations. In this mini-review, the known regulatory processes of OCT1 expression and function obtained from
    Language English
    Publishing date 2021-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.607613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations.

    Ciarimboli, Giuliano

    International journal of molecular sciences

    2021  Volume 22, Issue 2

    Abstract: This editorial summarizes the 13 scientific papers published in the Special Issue "Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations" of ... ...

    Abstract This editorial summarizes the 13 scientific papers published in the Special Issue "Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations" of the
    MeSH term(s) Cations/chemistry ; Cations/metabolism ; Chemical Phenomena ; Drug Discovery ; Membrane Transport Proteins/chemistry ; Membrane Transport Proteins/physiology
    Chemical Substances Cations ; Membrane Transport Proteins
    Language English
    Publishing date 2021-01-13
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22020732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fishing for protective compounds.

    Ciarimboli, Giuliano

    eLife

    2020  Volume 9

    Abstract: A new zebrafish study identifies compounds that shield ears and kidneys against an anticancer drug. ...

    Abstract A new zebrafish study identifies compounds that shield ears and kidneys against an anticancer drug.
    MeSH term(s) Animals ; Antineoplastic Agents ; Cisplatin ; Kidney ; Protective Agents ; Zebrafish
    Chemical Substances Antineoplastic Agents ; Protective Agents ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2020-09-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.61547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Verwendung von in vitro- und ex-vivo-Modellen zur Charakterisierung des intestinalen und hepatischen Influx- und Effluxtransports von Arzneistoffen

    Keiser, Markus Wolfdiedrich Bernard / Tzvetkov, Madlen V. / Ciarimboli, Giuliano / Hinz, Burkhard

    2018  

    Title variant in vitro-Modellen Influxtransports
    Institution Universität Greifswald
    Author's details vorgelegt von Dr. med. vet.Markus Wolfdiedrich Bernard Keiser ; 1. Gutachter: Prof. Dr. rer. nat. Madlen V. Tzvetkov, 2. Gutachter: Prof. Dr. rer. nat Giuliano Ciarimboli, 3. Gutachter: Prof. Dr. rer. nat. Burkhard Hinz
    Language German ; English
    Size 1 Band (verschiedene Seitenzählungen), Illustrationen, Diagramme
    Publishing place Greifswald
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universitätsmedizin der Universität Greifswald, 2019
    Note Text deutsch, Anhang englisch ; Literaturverzeichnis: Seite 21-26
    HBZ-ID HT020398165
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 E 491 order for loan Magazin

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  10. Article: Editorial: Transporters: a hitchhiker's guide to physiology, toxicology, and pharmacology-TransportDays 2022.

    Ciarimboli, Giuliano / Masereeuw, Rosalinde / Oswald, Stefan

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1365106

    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1365106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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