LIVIVO - Search results -

Search results

Result 1 - 10 of total 57

Search options

Article ; Online: The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis.

Ciccarone, Daniel

2021 Volume 34, Issue 4, Page(s) 344–350

Abstract: Purpose of review: This review provides an update on recently published literature on the rise of illicit fentanyls, risks for overdose, combinations with other substances, e.g. stimulants, consequences, and treatment.: Recent findings: Overdose due ... ...

Abstract	Purpose of review: This review provides an update on recently published literature on the rise of illicit fentanyls, risks for overdose, combinations with other substances, e.g. stimulants, consequences, and treatment. Recent findings: Overdose due to illicit synthetic opioids (e.g. fentanyl and fentanyl analogs) continues to rise in the US both preceding and during the COVID-19 pandemic. Fentanyl-related overdose is rising in new geographic areas e.g. the western USA. Stimulant-related overdose is also increasing nationwide driven by methamphetamine and cocaine. Polysubstance use, e.g. the use of a stimulant along with an opioid is driving stimulant-related overdose. Other medical consequences of injection drug use are rising including HIV and hepatitis C infections. Medication approaches to treating opioid use disorder remain the standard of care and there are new promising pharmacological approaches to treating methamphetamine use disorder. Summary: A 'fourth wave' of high mortality involving methamphetamine and cocaine use has been gathering force in the USA. Availability and use of illicit fentanyls are still the major drivers of overdose deaths and the current rise in stimulant-related deaths appears entwined with the ongoing opioid epidemic.
MeSH term(s)	Analgesics, Opioid/poisoning ; Central Nervous System Stimulants/poisoning ; Cocaine/poisoning ; Cocaine-Related Disorders/epidemiology ; Comorbidity ; Drug Overdose/epidemiology ; Fentanyl/poisoning ; Humans ; Illicit Drugs/poisoning ; Methamphetamine/poisoning ; Opiate Overdose/epidemiology ; Opioid Epidemic/statistics & numerical data
Chemical Substances	Analgesics, Opioid ; Central Nervous System Stimulants ; Illicit Drugs ; Methamphetamine (44RAL3456C) ; Cocaine (I5Y540LHVR) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	645162-7
ISSN	1473-6578 ; 0951-7367
ISSN (online)	1473-6578
ISSN	0951-7367
DOI	10.1097/YCO.0000000000000717
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2532: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Heroin Smoking Is Not Common in the United States.

Ciccarone, Daniel

JAMA neurology

2019 Volume 76, Issue 4, Page(s) 508

MeSH term(s)	Analgesics, Opioid ; Heroin ; Heroin Dependence ; Humans ; Opioid Epidemic ; Smoking ; United States
Chemical Substances	Analgesics, Opioid ; Heroin (70D95007SX)
Language	English
Publishing date	2019-02-26
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2019.0183
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.191: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The influence of transformations in supply on methamphetamine initiation among people injecting opioids in the United States.

Mars, Sarah / Ondocsin, Jeff / Holm, Nicole / Ciccarone, Daniel

Harm reduction journal

2024 Volume 21, Issue 1, Page(s) 57

Abstract: Background: Co-use of methamphetamine (MA) and opioids (pharmaceutical pills, heroin and fentanyls) has increased in the United States and is represented in rising mortality. Although coinciding with the import of low cost, high potency and purity ... ...

Abstract	Background: Co-use of methamphetamine (MA) and opioids (pharmaceutical pills, heroin and fentanyls) has increased in the United States and is represented in rising mortality. Although coinciding with the import of low cost, high potency and purity methamphetamine, the relationship between supply and demand in propelling this polydrug use is not well understood. We consider the influence of macro changes in supply on the uptake of opioid and methamphetamine co-use by injection at the level of individual drug and injection initiation in West Virginia, a state which leads the US in drug overdose mortality. Method: We recruited n = 30 people for semi-structured interviews who self-reported injecting heroin/fentanyl and using methamphetamine by any route at a West Virginia syringe service program and through snowball sampling. Interviews were recorded and transcripts analyzed using a thematic approach. Ethnographic observation was also conducted and recorded in fieldnotes. Sequence of substance and mode of use initiation and use trajectories for opioids and stimulants were charted for each participant. Results: A clear pattern of individual drug initiation emerged that matched each successive supply wave of the US overdose epidemic: 25 participants had initiated opioid use with pills, followed by heroin, often mixed with/replaced by fentanyl, and subsequently added methamphetamine use. For participants, the supply and consumption of opioid analgesics had set in motion a series of steps leading to the addition of stimulant injection to existing opioid injecting repertoires. Unlike other studies that have found a birth cohort effect in patterns of initiation, participants showed the same sequence across age groups. Considerations of economy, availability, dependence, tolerance and the erosion of taboos that marked transitions from opioid pills to heroin injection influenced these subsequent trajectories in novel ways. The form, timing and extent of opioid and stimulant consumption was influenced by four stages of the changing drug supply, which in turn reflected back on demand. Conclusion: Transformations in the social meaning and supply of methamphetamine enabled these transitions while other desired, non-injectable drugs were difficult to obtain. We discuss policy implications of injectable drugs' market dominance at this location and possible interventions.
MeSH term(s)	Humans ; Analgesics, Opioid ; Methamphetamine ; Heroin ; Fentanyl ; West Virginia ; Drug Overdose
Chemical Substances	Analgesics, Opioid ; Methamphetamine (44RAL3456C) ; Heroin (70D95007SX) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2146691-9
ISSN	1477-7517 ; 1477-7517
ISSN (online)	1477-7517
ISSN	1477-7517
DOI	10.1186/s12954-024-00976-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The triple wave epidemic: Supply and demand drivers of the US opioid overdose crisis.

Ciccarone, Daniel

The International journal on drug policy

2019 Volume 71, Page(s) 183–188

MeSH term(s)	Analgesics, Opioid/poisoning ; Analgesics, Opioid/supply & distribution ; Drug Overdose/epidemiology ; Drug Overdose/mortality ; Humans ; Opioid Epidemic/mortality ; Opioid Epidemic/trends ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/mortality ; United States/epidemiology
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2019-02-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2019.01.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Testing the test strips: laboratory performance of fentanyl test strips.

Halifax, John C / Lim, Lilly / Ciccarone, Daniel / Lynch, Kara L

Harm reduction journal

2024 Volume 21, Issue 1, Page(s) 14

Abstract: Background: The overdose crisis driven by synthetic opioids continues to escalate in the USA. We evaluated the efficacy of multiple manufacturing lots of a fentanyl test strip (FTS) to detect fentanyl and fentanyl analogs and assessed cross-reactivity ... ...

Abstract	Background: The overdose crisis driven by synthetic opioids continues to escalate in the USA. We evaluated the efficacy of multiple manufacturing lots of a fentanyl test strip (FTS) to detect fentanyl and fentanyl analogs and assessed cross-reactivity with possible interferences. Methods: Drug standards were dissolved in water in a laboratory setting and serially diluted. Drug dilutions were tested using five different manufacturing lots of BTNX Rapid Response (20 ng/mL cutoff) lateral flow chromatographic immunoassay strips to assess lot-to-lot variability for FTS sensitivity and cross-reactivity for the analytes of interest. Results: All five manufacturing lots cross-reacted with fentanyl and eleven fentanyl analogs. Diphenhydramine, lidocaine, MDMA, and methamphetamine were found to cause false positives with the strips. There was notable lot-to-lot variability in the sensitivity of the strips for fentanyl, fentanyl analogs, and known interferences. Discussion: FTS remains an important overdose prevention tool, but lot-to-lot variability in performance complicates robust instructions that balance the prevention of false positives and false negatives. Continued lot-to-lot performance assessment is recommended to ensure health education for FTS remains accurate. More sophisticated drug checking technologies and services are needed in the community landscape to augment personal FTS use to facilitate informed consumption and overdose risk mitigation.
MeSH term(s)	Humans ; Fentanyl/analysis ; Analgesics, Opioid/analysis ; Drug Overdose/prevention & control
Chemical Substances	Fentanyl (UF599785JZ) ; Analgesics, Opioid
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2146691-9
ISSN	1477-7517 ; 1477-7517
ISSN (online)	1477-7517
ISSN	1477-7517
DOI	10.1186/s12954-023-00921-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Fentanyl in the US heroin supply: A rapidly changing risk environment.

Ciccarone, Daniel

The International journal on drug policy

2017 Volume 46, Page(s) 107–111

MeSH term(s)	Drug Contamination/prevention & control ; Drug Contamination/statistics & numerical data ; Drug Overdose/epidemiology ; Drug Overdose/prevention & control ; Fentanyl/supply & distribution ; Heroin/supply & distribution ; Humans ; Risk Factors ; United States/epidemiology
Chemical Substances	Heroin (70D95007SX) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2017-07-20
Publishing country	Netherlands
Document type	Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2017.06.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Understanding Stimulant Use and Use Disorders in a New Era.

Ciccarone, Daniel / Shoptaw, Steve

The Medical clinics of North America

2021 Volume 106, Issue 1, Page(s) 81–97

Abstract: Extending from the triple wave epidemic of opioid-related overdose deaths, a fourth wave of high mortality involving methamphetamine and cocaine use has been gathering force. This article provides a review of the published literature on stimulants ... ...

Abstract	Extending from the triple wave epidemic of opioid-related overdose deaths, a fourth wave of high mortality involving methamphetamine and cocaine use has been gathering force. This article provides a review of the published literature on stimulants including epidemiology, pharmacology, neurobiology, medical and psychiatric consequences, withdrawal management, and medical and behavioral treatments.
MeSH term(s)	Adrenergic alpha-2 Receptor Antagonists/therapeutic use ; Adult ; Anticonvulsants/therapeutic use ; Behavior Therapy/methods ; Bupropion/therapeutic use ; Central Nervous System Stimulants/adverse effects ; Central Nervous System Stimulants/pharmacology ; Cocaine-Related Disorders/drug therapy ; Cocaine-Related Disorders/epidemiology ; Cocaine-Related Disorders/mortality ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/epidemiology ; Comorbidity ; Dopamine Uptake Inhibitors/therapeutic use ; Female ; Humans ; Illicit Drugs/adverse effects ; Illicit Drugs/pharmacology ; Male ; Mental Disorders/chemically induced ; Mental Disorders/epidemiology ; Methamphetamine/adverse effects ; Methamphetamine/pharmacology ; Mirtazapine/therapeutic use ; Neurobiology ; Neurodegenerative Diseases/chemically induced ; Neurodegenerative Diseases/epidemiology ; Opiate Overdose/epidemiology ; Opiate Overdose/mortality ; Substance Withdrawal Syndrome/therapy ; Topiramate/therapeutic use ; Transgender Persons ; United States/epidemiology
Chemical Substances	Adrenergic alpha-2 Receptor Antagonists ; Anticonvulsants ; Central Nervous System Stimulants ; Dopamine Uptake Inhibitors ; Illicit Drugs ; Bupropion (01ZG3TPX31) ; Topiramate (0H73WJJ391) ; Methamphetamine (44RAL3456C) ; Mirtazapine (A051Q2099Q)
Language	English
Publishing date	2021-11-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215710-x
ISSN	1557-9859 ; 0025-7125
ISSN (online)	1557-9859
ISSN	0025-7125
DOI	10.1016/j.mcna.2021.08.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.158: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: National and regional trends in fentanyl seizures in the United States, 2017-2023.

Palamar, Joseph J / Fitzgerald, Nicole / Carr, Thomas H / Cottler, Linda B / Ciccarone, Daniel

The International journal on drug policy

2024 , Page(s) 104417

Abstract: Background: Rates of synthetic opioid-related deaths over time and across regions have been compared within the US, but other indicator data could help inform prevention and harm reduction as well. We compared regional trends in fentanyl seizures to ... ...

Abstract	Background: Rates of synthetic opioid-related deaths over time and across regions have been compared within the US, but other indicator data could help inform prevention and harm reduction as well. We compared regional trends in fentanyl seizures to examine potential shifts in illicit fentanyl availability. Methods: Annual trends in fentanyl seizures were examined using data from High Intensity Drug Trafficking Areas for the US overall and by region from 2017 through 2023. Multiple measures included the number of seizures, the number of powder seizures, the number of pill seizures, the total weight of seizures, the number of pills seized, and the percentage of the number of pill seizures relative to the number of total seizures. Results: The percentage of seizures in pill form in the US increased from 10.3 % in 2017 to 49.0 % in 2023 (adjusted annual percentage change [AAPC]=25.2, 95 % CI: 17.6, 33.2), with 115.6 million individual pills seized in 2023. Pill weight related to total seizure weight also increased from 0.4 % to 54.5 % (AAPC=112.6, 95 % CI: 78.6, 153.2). In 2023, the plurality of seizures was in the West, in seven out of eight of our measures, with 77.8 % of seizures in the West being in pill form. Although the Midwest had lower prevalence of seizures than the West, there were notable increases in the Midwest in the number of pill seizures (AAPC=142.2, 95 % CI: 91.9, 205.8) and number of pills seized (AAPC=421.0, 95 % CI: 272.7, 628.4). Total weight of fentanyl seized increased the most in the West (AAPC=84.6, 95 % CI: 72.3, 97.8). Conclusions: The number and size of fentanyl seizures is increasing in the US, with the majority of seizures, especially in pill form, in the West. Continued monitoring of regional shifts in the fentanyl supply can help inform targeted prevention and public health response.
Language	English
Publishing date	2024-05-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2010000-0
ISSN	1873-4758 ; 0955-3959
ISSN (online)	1873-4758
ISSN	0955-3959
DOI	10.1016/j.drugpo.2024.104417
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Estimating changes in overdose death rates from increasing methamphetamine supply in Ohio: Evidence from crime lab data.

Rosenblum, Daniel / Ondocsin, Jeffrey / Mars, Sarah G / Cauchon, Dennis / Ciccarone, Daniel

Drug and alcohol dependence reports

2024 Volume 11, Page(s) 100238

Abstract: Background: We investigate the relationship between the supply of methamphetamine and overdose death risk in Ohio. Ohio and the overall US have experienced a marked increase in overdose deaths from methamphetamine combined with fentanyl over the last ... ...

Abstract	Background: We investigate the relationship between the supply of methamphetamine and overdose death risk in Ohio. Ohio and the overall US have experienced a marked increase in overdose deaths from methamphetamine combined with fentanyl over the last decade. The increasing use of methamphetamine may be increasing the risk of overdose death. However, if people are using it to substitute away from more dangerous synthetic opioids, it may reduce the overall risk of overdose death. Methods: Ohio's Bureau of Criminal Investigation's crime lab data include a detailed list of the content of drug samples from law enforcement seizures, which are used as a proxy for drug supply. We use linear regressions to estimate the relationship between the proportion of methamphetamine in lab samples and unintentional drug overdose death rates from January 2015 through September 2021. Results: Relatively more methamphetamine in crime lab data in a county-month has either no statistically significant relationship with overdose death rates (in small and medium population counties) or a negative and statistically significant relationship with overdose death rates (in large population counties). Past overdose death rates do not predict future increases in methamphetamine in crime lab data. Conclusions: The results are consistent with a relatively higher supply of methamphetamine reducing the general risk of overdose death, possibly due to substitution away from more dangerous synthetic opioids. However, the supply of methamphetamine appears unrelated to the past illicit drug risk environment. The non-lethal and yet serious health effects of MA use were not explored and, thus, even if the presence of MA reduces the population-level overdose mortality rate, the rise of other adverse health effects may counteract any public health benefits of fewer deaths.
Language	English
Publishing date	2024-04-27
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-7246
ISSN (online)	2772-7246
DOI	10.1016/j.dadr.2024.100238
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The motives and methods of methamphetamine and 'heroin' co-use in West Virginia.

Ondocsin, Jeff / Holm, Nicole / Mars, Sarah G / Ciccarone, Daniel

Harm reduction journal

2023 Volume 20, Issue 1, Page(s) 88

Abstract: Background: Opioid and methamphetamine co-use is increasing across the USA with overdoses involving these drugs also rising. West Virginia (WV) has led the US in opioid overdose death rates since at least 2013 and rising co-use of methamphetamine with ... ...

Abstract	Background: Opioid and methamphetamine co-use is increasing across the USA with overdoses involving these drugs also rising. West Virginia (WV) has led the US in opioid overdose death rates since at least 2013 and rising co-use of methamphetamine with opioids has played a greater role in deaths over the last 5 years. Methods: This study used rapid ethnography to examine methods and motivations behind opioids and methamphetamine co-use from the viewpoint of their consumers. Participants (n = 30) were people who injected heroin/fentanyl also using methamphetamine who participated in semi-structured interviews. Results: We found multiple methods of co-using opioids and methamphetamine, whether alternately or simultaneously and in varying order. Most prioritized opioids, with motives for using methamphetamine forming three thematic categories: 'intrinsic use', encompassing both inherent pleasure of combined use greater than using both drugs separately or for self-medication of particular conditions; 'opioid assisting use' in which methamphetamine helped people manage their existing heroin/fentanyl use; and 'reluctant or indifferent use' for social participation, reflecting methamphetamine's low cost and easy availability. Conclusions: Methamphetamine serves multiple functions among people using opioids in WV. Beliefs persist that methamphetamine can play a role in preventing and reversing opioid overdose, including some arguments for sequential use being protective of overdose. 'Reluctant' uptake attests to methamphetamine's social use and the influence of supply. The impact on overdose risk of the many varied co-use patterns needs further investigation.
MeSH term(s)	Motivation ; Methamphetamine/administration & dosage ; Methamphetamine/poisoning ; Methamphetamine/supply & distribution ; Heroin/administration & dosage ; Heroin/poisoning ; West Virginia/epidemiology ; Fentanyl/administration & dosage ; Fentanyl/poisoning ; Heroin Dependence/mortality ; Heroin Dependence/psychology ; Interviews as Topic ; Self Medication ; Pleasure ; Social Interaction ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Female ; Adult
Chemical Substances	Methamphetamine (44RAL3456C) ; Heroin (70D95007SX) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2146691-9
ISSN	1477-7517 ; 1477-7517
ISSN (online)	1477-7517
ISSN	1477-7517
DOI	10.1186/s12954-023-00816-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito