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  1. AU="Ciebiera, Małgorzata"
  2. AU="Granich, R"
  3. AU="Koh, Lian Chye Winston"
  4. AU="Meredith M. White"
  5. AU="Aft, Rebecca"
  6. AU="Urban, Gerald A"
  7. AU="Jeong, Jae-Hyun"
  8. AU="Patsch, Wolfgang"
  9. AU="Garwood, Sarah K"
  10. AU="Pilon, Dominic"
  11. AU="Ignacio Cerro, C"
  12. AU=Jethani Bipin AU=Jethani Bipin

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  1. Artikel: Monitoring of treatment with L-asparaginase in children with acute lymphoblastic leukaemia, with a focus on silent inactivation and its influence on the treatment outcome.

    Czogala, Malgorzata / Rogatko, Iwona / Pawińska-Wąsikowska, Katarzyna / Czogała, Wojciech / Bal, Wioletta / Ciebiera, Małgorzata / Chaber, Radosław / Chodała-Grzywacz, Agnieszka / Karolczyk, Grażyna / Sztefko, Krystyna / Balwierz, Walentyna / Skoczeń, Szymon

    Contemporary oncology (Poznan, Poland)

    2022  Band 26, Heft 4, Seite(n) 282–288

    Abstract: Introduction: The aim of the study was to analyse the frequency of silent inactivation and allergic reaction to asparaginase (ASP) and its impact on treatment results in patients with lymphoblastic leukaemia.: Material and methods: Seventy patients ... ...

    Abstract Introduction: The aim of the study was to analyse the frequency of silent inactivation and allergic reaction to asparaginase (ASP) and its impact on treatment results in patients with lymphoblastic leukaemia.
    Material and methods: Seventy patients with acute lymphoblastic leukaemia treated with ASP were enrolled in the study. Asparaginase activity was monitored. The patients were switched to another ASP formulation after allergy or inactivation. The treatment results were analysed.
    Results: Silent inactivation of native
    Conclusions: Monitoring of ASP activity is crucial to recognize silent inactivation and to guarantee treatment effectiveness by switching to other ASP preparations.
    Sprache Englisch
    Erscheinungsdatum 2022-12-30
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ISSN 1428-2526
    ISSN 1428-2526
    DOI 10.5114/wo.2023.124972
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Characteristics and treatment results of refractory and relapsed acute myeloid leukaemia in paediatric patients treated in Polish Paediatric Leukaemia/Lymphoma Study Group institutions according to the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012 and a review of novel treatment possibilities in paediatric acute myeloid leukaemia.

    Samborska, Magdalena / Skalska-Sadowska, Jolanta / Achkar, Robert / Wachowiak, Jacek / Derwich, Katarzyna / Czogała, Małgorzata / Balwierz, Walentyna / Skoczeń, Szymon / Dobaczewski, Grzegorz / Chybicka, Alicja / Kałwak, Krzysztof / Krawczuk-Rybak, Maryna / Muszyńska-Rosłan, Katarzyna / Adamkiewicz-Drożyńska, Elżbieta / Maciejka-Kapuscińska, Lucyna / Irga-Jaworska, Ninela / Pohorecka, Joanna / Chodała-Grzywacz, Agnieszka / Karolczyk, Grażyna /
    Wójcik, Beata / Kowalczyk, Jerzy R / Drabko, Katarzyna / Zawitkowska, Joanna / Mycko, Katarzyna / Badowska, Wanda / Ociepa, Tomasz / Urasiński, Tomasz / Sikorska-Fic, Barbara / Matysiak, Michał / Laguna, Paweł / Dąbrowska-Pawliszyn, Anna / Tomaszewska, Renata / Szczepański, Tomasz / Sobol, Grażyna / Mizia-Malarz, Agnieszka / Ciebiera, Małgorzata / Chaber, Radosław / Kołtan, Sylwia / Wysocki, Mariusz / Styczyński, Jan / Woszczyk, Mariola / Wieczorek, Maria / Karpińska-Derda, Irena / Urbańska-Rakus, Justyna / Bobeff, Katarzyna / Trelińska, Joanna / Młynarski, Wojciech

    Contemporary oncology (Poznan, Poland)

    2024  Band 27, Heft 4, Seite(n) 249–254

    Abstract: Introduction: This study aimed to present the clinical features and results of treatment of patients diagnosed with refractory or relapsed acute myeloid leukaemia (AML) in Polish Paediatric Leukaemia/Lymphoma Study Group (PPL/LSG) institutions, treated ... ...

    Abstract Introduction: This study aimed to present the clinical features and results of treatment of patients diagnosed with refractory or relapsed acute myeloid leukaemia (AML) in Polish Paediatric Leukaemia/Lymphoma Study Group (PPL/LSG) institutions, treated in accordance with the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012, as their first-line therapy.
    Material and methods: The outcome data of 10 patients with refractory AML (median age 9.5 years) and 30 with relapsed AML (median age 12 years) were analysed retrospectively. Re-induction was usually based on idarubicin, fludarabine, and cytarabine along with allogeneic haematopoietic stem cell transplant (allo-HSCT) in 5 patients with refractory AML and 7 relapsed AML children.
    Results: 37.5% (3/8) of refractory AML patients achieved second complete remission second complete remission (CRII). One of ten patients (1/10; 10%) was alive and stayed in complete remission for 34 months after the allo-HSCT. The probability of 3-year event-free survival (pEFS) in this group was 0.125 ±0.11. In the group of relapsed AML patients, the CRII was achieved in 9 patients (34%), and the probability of survival was: pEFS = 0.24 ±0.08; probability overall survival (pOS) = 0.34 ±0.09, with significantly better results achieved in patients who underwent allo-HSCT (pOS = 0.54 ±0.14 vs. 0.08 ±0.08,
    Conclusions: The prognosis of refractory AML and the first AML recurrence in children who were first-line treated in PPL/LSG centres according to Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012 is poor. Failures of re-induction treatment particularly result from difficulties in achieving remission. Allogeneic HSCT improves prognosis in children with refractory and first recurrent AML, under the condition it is performed in complete remission. Novel therapeutic approaches are needed to increase the remission rate and improve the outcomes.
    Sprache Englisch
    Erscheinungsdatum 2024-02-12
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ISSN 1428-2526
    ISSN 1428-2526
    DOI 10.5114/wo.2023.135327
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Treatment Outcomes of Adolescents Compared to Younger Pediatric Patients with Acute Myeloid Leukemia: Do They Need a Special Approach?

    Pawińska-Wąsikowska, Katarzyna / Czogała, Małgorzata / Bukowska-Strakova, Karolina / Surman, Marta / Rygielska, Monika / Książek, Teofila / Sadowska, Beata / Pac, Agnieszka / Skalska-Sadowska, Jolanta / Samborska, Magdalena / Wachowiak, Jacek / Ciebiera, Małgorzata / Chaber, Radosław / Tomaszewska, Renata / Szczepański, Tomasz / Zielezińska, Karolina / Urasiński, Tomasz / Moj-Hackemer, Małgorzata / Kałwak, Krzysztof /
    Kozłowska, Marta / Irga-Jaworska, Ninela / Sikorska-Fic, Barbara / Łaguna, Paweł / Muszyńska-Rosłan, Katarzyna / Krawczuk-Rybak, Maryna / Fałkowska, Anna / Drabko, Katarzyna / Bobeff, Katarzyna / Młynarski, Wojciech / Chodała-Grzywacz, Agnieszka / Karolczyk, Grażyna / Mycko, Katarzyna / Badowska, Wanda / Bartoszewicz, Natalia / Styczyński, Jan / Machnik, Katarzyna / Mizia-Malarz, Agnieszka / Balwierz, Walentyna / Skoczeń, Szymon

    Cancers

    2024  Band 16, Heft 6

    Abstract: Background: The reports of studies that compare the survival of adolescents and young adults with younger children with acute myeloid leukemia (AML) are contradictory.: Patients and methods: We retrospectively analyzed 220 AML patients aged 0-18 ... ...

    Abstract Background: The reports of studies that compare the survival of adolescents and young adults with younger children with acute myeloid leukemia (AML) are contradictory.
    Patients and methods: We retrospectively analyzed 220 AML patients aged 0-18 years treated in pediatric oncologic centers in Poland from 2015 to 2022. The evaluated group included 31 infants (below 1 year), 91 younger children (1-9.9 years), 59 older children (10-14.9 years), and 39 adolescents (15-18 years).
    Results: A 5-year overall survival for adolescents was not significantly inferior compared to younger and older children (74.3 ± 7.6% vs. 80.5 ± 4.4% vs. 77.9 ± 5.1,
    Conclusions: Although we have not found that age over 15 years is an unfavorable factor for overall survival, the optimal approach to therapy in adolescents, as in other age groups, is to adjust the intensity of therapy to individual genetic risk and introduce targeted therapies when indicated.
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061145
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Characteristics and Outcome of FLT3-ITD-Positive Pediatric Acute Myeloid Leukemia-Experience of Polish Pediatric Leukemia and Lymphoma Study Group from 2005 to 2022.

    Czogała, Małgorzata / Czogała, Wojciech / Pawińska-Wąsikowska, Katarzyna / Książek, Teofila / Bukowska-Strakova, Karolina / Sikorska-Fic, Barbara / Łaguna, Paweł / Fałkowska, Anna / Drabko, Katarzyna / Muszyńska-Rosłan, Katarzyna / Krawczuk-Rybak, Maryna / Kozłowska, Marta / Irga-Jaworska, Ninela / Zielezińska, Karolina / Urasiński, Tomasz / Bartoszewicz, Natalia / Styczyński, Jan / Skalska-Sadowska, Jolanta / Wachowiak, Jacek /
    Rodziewicz-Konarska, Anna / Kałwak, Krzysztof / Ciebiera, Małgorzata / Chaber, Radosław / Mizia-Malarz, Agnieszka / Chodała-Grzywacz, Agnieszka / Karolczyk, Grażyna / Bobeff, Katarzyna / Młynarski, Wojciech / Mycko, Katarzyna / Badowska, Wanda / Tomaszewska, Renata / Szczepański, Tomasz / Machnik, Katarzyna / Zamorska, Natalia / Balwierz, Walentyna / Skoczeń, Szymon

    Cancers

    2023  Band 15, Heft 18

    Abstract: Background: The FMS-like tyrosine kinase 3 (FLT3) gene mutated in 10-15% of pediatric acute myeloid leukemia (AML) is associated with an inferior outcome. The aim of the study was to analyze the outcome and characteristics of FLT3-ITD-positive pediatric ...

    Abstract Background: The FMS-like tyrosine kinase 3 (FLT3) gene mutated in 10-15% of pediatric acute myeloid leukemia (AML) is associated with an inferior outcome. The aim of the study was to analyze the outcome and characteristics of FLT3-ITD-positive pediatric AML.
    Methods: We retrospectively analyzed the nationwide pediatric AML database from between 2005 and 2022. FLT3-ITD was found in 54/497 (10.7%) patients with available analysis. Three consecutive treatment protocols were used (AML-BFM 2004 Interim, AML-BFM 2012 Registry, AML-BFM 2019 recommendations).
    Results: Probabilities of 5-year overall (OS), event-free (EFS) and relapse-free survival were significantly lower in the FLT3-ITD-positive patients compared to FLT3-ITD-negative (0.54 vs. 0.71,
    Conclusions: It seems that SCT and FLT3 inhibitors have a beneficial impact on the prognosis. Additional genetic alterations, like the WT1 and NPM1 mutations, significantly influence the outcome.
    Sprache Englisch
    Erscheinungsdatum 2023-09-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15184557
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Retrospective Analysis of the Treatment Outcome in Myeloid Leukemia of Down Syndrome in Polish Pediatric Leukemia and Lymphoma Study Group From 2005 to 2019.

    Czogala, Malgorzata / Pawinska-Wasikowska, Katarzyna / Ksiazek, Teofila / Sikorska-Fic, Barbara / Matysiak, Michal / Skalska-Sadowska, Jolanta / Wachowiak, Jacek / Rodziewicz-Konarska, Anna / Chybicka, Alicja / Myszynska-Roslan, Katarzyna / Krawczuk-Rybak, Maryna / Grabowski, Dominik / Kowalczyk, Jerzy / Maciejka-Kemblowska, Lucyna / Adamkiewicz-Drozynska, Elzbieta / Bobeff, Katarzyna / Mlynarski, Wojciech / Tomaszewska, Renata / Szczepanski, Tomasz /
    Pohorecka, Joanna / Chodala-Grzywacz, Agnieszka / Karolczyk, Grazyna / Mizia-Malarz, Agnieszka / Mycko, Katarzyna / Badowska, Wanda / Zielezinska, Karolina / Urasinski, Tomasz / Nykiel, Magdalena / Woszczyk, Mariola / Ciebiera, Malgorzata / Chaber, Radosław / Skoczen, Szymon / Balwierz, Walentyna

    Frontiers in pediatrics

    2020  Band 8, Seite(n) 277

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2020-06-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00277
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: High Frequency of Fusion Gene Transcript Resulting From t(10;11)(p12;q23) Translocation in Pediatric Acute Myeloid Leukemia in Poland.

    Ksiazek, Teofila / Czogala, Malgorzata / Kaczowka, Przemyslaw / Sadowska, Beata / Pawinska-Wasikowska, Katarzyna / Bik-Multanowski, Mirosław / Sikorska-Fic, Barbara / Matysiak, Michał / Skalska-Sadowska, Jolanta / Wachowiak, Jacek / Rodziewicz-Konarska, Anna / Chybicka, Alicja / Muszynska-Rosłan, Katarzyna / Krawczuk-Rybak, Maryna / Grabowski, Dominik / Kowalczyk, Jerzy / Maciejka-Kemblowska, Lucyna / Adamkiewicz-Drozynska, Elzbieta / Mlynarski, Wojciech /
    Tomaszewska, Renata / Szczepanski, Tomasz / Pohorecka, Joanna / Karolczyk, Grazyna / Mizia-Malarz, Agnieszka / Mycko, Katarzyna / Badowska, Wanda / Zielezinska, Karolina / Urasinski, Tomasz / Karpinska-Derda, Irena / Woszczyk, Mariola / Ciebiera, Małgorzata / Lejman, Monika / Skoczen, Szymon / Balwierz, Walentyna

    Frontiers in pediatrics

    2020  Band 8, Seite(n) 278

    Abstract: 11q23/ ...

    Abstract 11q23/
    Sprache Englisch
    Erscheinungsdatum 2020-07-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00278
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Advances in the First Line Treatment of Pediatric Acute Myeloid Leukemia in the Polish Pediatric Leukemia and Lymphoma Study Group from 1983 to 2019.

    Czogała, Małgorzata / Balwierz, Walentyna / Pawińska-Wąsikowska, Katarzyna / Książek, Teofila / Bukowska-Strakova, Karolina / Czogała, Wojciech / Sikorska-Fic, Barbara / Matysiak, Michał / Skalska-Sadowska, Jolanta / Wachowiak, Jacek / Moj-Hackemer, Małgorzata / Kałwak, Krzysztof / Muszyńska-Rosłan, Katarzyna / Krawczuk-Rybak, Maryna / Grabowski, Dominik / Kowalczyk, Jerzy / Maciejka-Kembłowska, Lucyna / Irga-Jaworska, Ninela / Bobeff, Katarzyna /
    Młynarski, Wojciech / Tomaszewska, Renata / Szczepański, Tomasz / Chodała-Grzywacz, Agnieszka / Karolczyk, Grażyna / Mizia-Malarz, Agnieszka / Mycko, Katarzyna / Badowska, Wanda / Zielezińska, Karolina / Urasiński, Tomasz / Urbańska-Rakus, Justyna / Ciebiera, Małgorzata / Chaber, Radosław / Bartoszewicz, Natalia / Wysocki, Mariusz / Skoczeń, Szymon

    Cancers

    2021  Band 13, Heft 18

    Abstract: Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed the results of pediatric AML treatment in Poland from 1983 to ... ...

    Abstract Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed the results of pediatric AML treatment in Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML).
    Methods: The study included 899 children suffering from AML treated with the following: AML-PPPLBC 83 (1983-1993,
    Results: The probability of three-year overall survival was 0.34 ± 0.03, 0.37 ± 0.05, 0.54 ± 0.04, 0.67 ± 0.03, and 0.75 ± 0.05; event-free survival was 0.31 ± 0.03, 0.34 ± 0.05, 0.44 ± 0.04, 0.53 ± 0.03, and 0.67 ± 0.05; and relapse-free survival was 0.52 ± 0.03, 0.65 ± 0.05, 0.58 ± 0.04, 0.66 ± 0.03, and 0.78 ± 0.05, respectively, in the subsequent periods. A systematic reduction of early deaths and deaths in remission was achieved, while the percentage of relapses decreased only in the last therapeutic period. Surprisingly good results were obtained in the group of patients treated with AML-BFM 2012 with unfavorable genetic abnormalities like KMT2A-MLLT10/t(10;11)(p12;q23) and DEK-NUP214/t(6;9)(p23;q24), while unsatisfactory outcomes were found in the patients with FLT3-ITD.
    Conclusions: The use of standardized, systematically modified therapeutic protocols, with the successive consideration of genetic prognostic factors, and advances in supportive care led to a significant improvement in AML treatment outcomes over the last 40 years.
    Sprache Englisch
    Erscheinungsdatum 2021-09-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13184536
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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