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  1. Article ; Conference proceedings: Proceedings of the 43rd Italian Transplantation Society Congress

    Cillo, Umberto

    Transplantation proceedings vol. 52, no. 5 (June 2020), Seite [1521]-1626

    November 21-23, 2019, Rome, Italy

    2020  

    Event/congress Società italiana trapianti d'organo e di tessuti (43., 2019, Rom, Congresso nazionale)
    Author's details guest editor Umberto Cillo, Salvatore Agnes
    Collection Transplantation proceedings
    Language English
    Size Illustrationen, Diagramme
    Publishing place New York, NY, [2020]
    Publishing country United States
    Document type Article ; Conference proceedings
    HBZ-ID HT020615202
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Zs A 835 -52-

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  2. Article ; Conference proceedings: Proceedings of the 41st Congress of the Italian Transplantation Society

    Cillo, Umberto

    Transplantation proceedings vol. 51, no. 1 (Jan/Feb 2019), Seite 95-241

    November 9-11, 2017, Cagliari, Italy

    2019  

    Event/congress Società italiana trapianti d'organo (41., 2017, Cagliari, Congresso nazionale)
    Author's details guest editor Umberto Cillo
    Collection Transplantation proceedings
    Language English
    Size Illustrationen, Diagramme
    Publishing place New York, NY, [2019]
    Publishing country United States
    Document type Article ; Conference proceedings
    HBZ-ID HT020047279
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Zs A 835 -51-

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  3. Article ; Online: Liver focal nodular hyperplasia next to giant haemangioma.

    Rugge, Massimo / Cillo, Umberto

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 6, Page(s) 823

    MeSH term(s) Humans ; Focal Nodular Hyperplasia/diagnostic imaging ; Focal Nodular Hyperplasia/pathology ; Liver/diagnostic imaging ; Liver/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Hemangioma/diagnostic imaging ; Hemangioma, Cavernous ; Hyperplasia/pathology
    Language English
    Publishing date 2023-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1134: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: ormothermic Perfusion of a Human Tumoral Liver for 17 Days with concomitant extracorporeal blood purification therapy: case description.

    Cillo, Umberto / Nalesso, Federico / Bertacco, Alessandra / Indraccolo, Stefano / Gringeri, Enrico

    Journal of hepatology

    2024  

    Language English
    Publishing date 2024-05-02
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.04.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
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  5. Article: Risk Factors for Recurrence of Primary Sclerosing Cholangitis after Liver Transplantation: Single-Center Data.

    Catanzaro, Elisa / Gringeri, Enrico / Cazzagon, Nora / Floreani, Annarosa / Cillo, Umberto / Burra, Patrizia / Gambato, Martina

    Journal of personalized medicine

    2024  Volume 14, Issue 3

    Abstract: Background: Primary sclerosing cholangitis (PSC), comprising 5-15% of European liver transplantation (LT) cases, poses a significant challenge due to the risk of post-transplant disease recurrence (rPSC). This single-center study aimed to determine the ... ...

    Abstract Background: Primary sclerosing cholangitis (PSC), comprising 5-15% of European liver transplantation (LT) cases, poses a significant challenge due to the risk of post-transplant disease recurrence (rPSC). This single-center study aimed to determine the rPSC rate and long-term post-LT outcomes in PSC patients and to identify potentially modifiable risk factors of rPSC.
    Methods: All PSC patients receiving LT at Padua Hospital from 1993 to 2021 were included. Recipient data were collected pre-LT, at LT, and during the follow-up. Donor and LT features were recorded. The rPSC rate was assessed according to Mayo Clinic criteria. Patient and graft survival were reported.
    Results: Thirty-three patients were included. The main indication of LT was decompensated cirrhosis (70%). Nine patients (27%) developed rPSC during a median follow-up of 59 months (45-72). A longer cold ischemia time (
    Conclusion: Specific donor and surgical features might increase the risk of rPSC. Identifying predictive factors for rPSC to prevent graft loss is challenging but could lead to a more personalized organ allocation and follow-up in PSC transplanted patients. IBD reactivation might have a pathogenic role in rPSC. In our single-center experience, rPSC did not affect patient and graft survival.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14030222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Liver resection versus radiofrequency ablation or trans-arterial chemoembolization for early-stage (BCLC A) oligo-nodular hepatocellular carcinoma: meta-analysis.

    Romano, Pierluigi / Busti, Marco / Billato, Ilaria / D'Amico, Francesco / Marchegiani, Giovanni / Pelizzaro, Filippo / Vitale, Alessandro / Cillo, Umberto

    BJS open

    2024  Volume 8, Issue 1

    Abstract: Background: The 2022 Barcelona Clinic Liver Cancer (BCLC) algorithm does not recommend liver resection (LR) in BCLC A patients with oligo-nodular (two or three nodules ≤3 cm) hepatocellular carcinoma (HCC). This sharply contrasts with the therapeutic ... ...

    Abstract Background: The 2022 Barcelona Clinic Liver Cancer (BCLC) algorithm does not recommend liver resection (LR) in BCLC A patients with oligo-nodular (two or three nodules ≤3 cm) hepatocellular carcinoma (HCC). This sharply contrasts with the therapeutic hierarchy concept, implying a precise treatment order exists within each BCLC stage. This study aimed to compare the outcomes of LR versus radiofrequency ablation (RFA) or trans-arterial chemoembolization (TACE) in BCLC A patients.
    Methods: A meta-analysis adhering to PRISMA guidelines and the Cochrane Handbook was performed. All RCT, cohort and case-control studies that compared LR versus RFA or TACE in oligo-nodular BCLC A HCC published between January 2000 and October 2023 were comprehensively searched on PubMed, Embase, the Cochrane Library and China Biology Medicine databases. Primary outcomes were overall survival (OS) and disease-free survival (DFS) at 3 and 5 years. Risk ratio (RR) was computed as a measure of treatment effect (OS and DFS benefit) to calculate common and random effects estimates for meta-analyses with binary outcome data.
    Results: 2601 patients from 14 included studies were analysed (LR = 1227, RFA = 686, TACE = 688). There was a significant 3- and 5-year OS benefit of LR over TACE (RR = 0.55, 95% c.i. 0.44 to 0.69, P < 0.001 and RR 0.57, 95% c.i. 0.36 to 0.90, P = 0.030, respectively), while there was no significant 3- and 5-year OS benefit of LR over RFA (RR = 0.78, 95% c.i. 0.37 to 1.62, P = 0.452 and RR 0.74, 95% c.i. 0.50 to 1.09, P = 0.103, respectively). However, a significant 3- and 5-year DFS benefit of LR over RFA was found (RR = 0.70, 95% c.i. 0.54 to 0.93, P = 0.020 and RR 0.82, 95% c.i. 0.72 to 0.95, P = 0.015, respectively). A single study comparing LR and TACE regarding DFS showed a significant superiority of LR. The Newcastle-Ottawa Scale quality of studies was high in eight (57%) and moderate in six (43%).
    Conclusions: In BCLC A oligo-nodular HCC patients, LR should be preferred to RFA or TACE (therapeutic hierarchy concept). Additional comparative cohort studies are urgently needed to increase the certainty of this evidence.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Radiofrequency Ablation ; Disease-Free Survival
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad158
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  7. Article ; Online: Preface.

    Cillo, Umberto / Piredda, Gianni

    Transplantation proceedings

    2019  Volume 51, Issue 1, Page(s) 95

    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2019.01.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 835: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Society of Organ and Tissue Transplantation 2018.

    Cillo, Umberto / Faenza, Stefano

    Transplantation proceedings

    2019  Volume 51, Issue 9, Page(s) 2855

    Language English
    Publishing date 2019-11-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2019.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 835: Show issues Location:
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  9. Article ; Online: Merits and boundaries of the BCLC staging and treatment algorithm: Learning from the past to improve the future with a novel proposal.

    Trevisani, Franco / Vitale, Alessandro / Kudo, Masatoshi / Kulik, Laura / Park, Joon-Won / Pinato, David J / Cillo, Umberto

    Journal of hepatology

    2024  Volume 80, Issue 4, Page(s) 661–669

    Abstract: In this Expert Opinion, we thoroughly analyse the Barcelona Clinic Liver Cancer (BCLC) staging and treatment algorithm for hepatocellular carcinoma (HCC) that, since 1999, has standardised HCC management, offering a structured approach for the prognostic ...

    Abstract In this Expert Opinion, we thoroughly analyse the Barcelona Clinic Liver Cancer (BCLC) staging and treatment algorithm for hepatocellular carcinoma (HCC) that, since 1999, has standardised HCC management, offering a structured approach for the prognostic evaluation and treatment of patients with HCC. The first part of the article presents the strengths and evolutionary improvements of the BCLC staging system. Nevertheless, both patient characteristics and available treatments have changed in the last two decades, limiting the role of the BCLC criteria for treatment allocation in a growing number of patients. As therapeutic options expand and become more effective, the stage-linked treatment decision-making algorithm may lead to undertreatment and suboptimal outcomes for patients with disease beyond early-stage HCC. Consequently, strict adherence to BCLC criteria is limited in expert centres, particularly for patients diagnosed beyond early-stage HCC. Although the BCLC system remains the benchmark against which other therapeutic frameworks must be judged, the era of precision medicine calls for patient-tailored therapeutic decision-making (by a multidisciplinary tumour board) rather than stage-dictated treatment allocation. Acknowledging this conceptual difference in clinical management, the second part of the article describes a novel "multiparametric therapeutic hierarchy", which integrates a comprehensive assessment of clinical factors, biomarkers, technical feasibility, and resource availability. Lastly, considering the increasing efficacy of locoregional and systemic treatments, the concept of "converse therapeutic hierarchy" is introduced. These treatments can increase the feasibility (conversion approach) and effectiveness (adjuvant approach of systemic therapy) of potentially curative approaches to greatly improve clinical outcomes.
    MeSH term(s) Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/therapy ; Liver Neoplasms/pathology ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/pathology ; Neoplasm Staging ; Prognosis ; Algorithms ; Retrospective Studies
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Reply to: "Outcome of in situ split liver transplantation in Italy over the last 25 years: An alternative analysis and personal view".

    Lauterio, Andrea / Cillo, Umberto / De Carlis, Riccardo / Bernasconi, Davide / De Carlis, Luciano / Colledan, Michele / Andorno, Enzo

    Journal of hepatology

    2024  Volume 80, Issue 5, Page(s) e214–e215

    MeSH term(s) Humans ; Liver Transplantation ; Tissue and Organ Procurement ; Treatment Outcome ; Italy ; Tissue Donors ; Graft Survival
    Language English
    Publishing date 2024-01-26
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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