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  1. Article ; Online: Assessment of the Anti-inflammatory Effects of NORFLO® ORO in Acute Relapses of HLA-B27-associated Autoimmune Uveitis: A Multicenter, Randomized, Placebo-controlled, Double-blind Clinical Study.

    Allegri, Pia / Cimino, Luca / Davis, Janet L / Tugal-Tutkun, Ilknur

    Ocular immunology and inflammation

    2022  Volume 31, Issue 3, Page(s) 526–535

    Abstract: Background: An effective therapy to reduce the number and severity of HLA-B27-related acute anterior uveitis (AAU) recurrences represents a clinical need. Curcumin is a promising therapeutic option in various inflammatory eye diseases. To enhance its ... ...

    Abstract Background: An effective therapy to reduce the number and severity of HLA-B27-related acute anterior uveitis (AAU) recurrences represents a clinical need. Curcumin is a promising therapeutic option in various inflammatory eye diseases. To enhance its absorption and eye tissue selectivity, a phospholipidic-curcumin complex (PHBC) has been formulated (Iphytoone®, Eye Pharma S.p.A.).
    Aims: This study investigates if PHBC is effective and safe to decrease the number and intensity of HLA-B27-related AAU relapses.
    Methods: HLA-B27-related AAU patients were randomly divided to receive PHBC or placebo for 12 months (NCT03584724).
    Results: Compared with the previous year, the number of relapses decreased in both groups. The proportion of responders was significantly higher in the PBHC group. The severity of attacks was comparable. The study drug was well tolerated.
    Conclusions: A beneficial effect of PHBC treatment is suggested because the proportion of responders was significantly higher in this group of patients.
    MeSH term(s) Humans ; HLA-B27 Antigen ; Curcumin/therapeutic use ; Uveitis/drug therapy ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/drug therapy ; Recurrence ; Acute Disease ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances HLA-B27 Antigen ; Curcumin (IT942ZTH98) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2022.2039210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ocular manifestations of cryoglobulinemia: a reappraisal.

    Dammacco, Rosanna / Cimino, Luca / De Simone, Luca / Alessio, Giovanni / Dammacco, Franco

    Eye (London, England)

    2023  Volume 38, Issue 3, Page(s) 585–593

    Abstract: Background/objectives: To describe frequency and type of ocular manifestations in patients with cryoglobulinemic vasculitis (CV), as well as management approaches and outcomes.: Subjects/methods: This was a retrospective, observational, cohort study ... ...

    Abstract Background/objectives: To describe frequency and type of ocular manifestations in patients with cryoglobulinemic vasculitis (CV), as well as management approaches and outcomes.
    Subjects/methods: This was a retrospective, observational, cohort study of patients who were diagnosed with CV at a single center and regularly underwent a comprehensive ocular assessment.
    Results: Ophthalmologic manifestations were recorded in 16 patients (28%). The diagnoses included dry eye disease and primary Sjögren syndrome in 5 and 2 patients, respectively; peripheral ulcerative keratitis and anterior scleritis in 1 patient each; hyperviscosity syndrome and hypertensive retinopathy in 2 patients each; and Purtscher- like retinopathy in 3 patients. Twelve patients (75%) were anti-HCV/HCV RNA-positive, 11 of whom achieved a sustained virologic response (SVR) following treatment with interferon-α2b plus ribavirin or direct-acting antivirals. All patients were treated with ocular lubricants. Systemic therapeutic measures, including glucocorticoids, immunosuppressive and biologic agents, induced the disappearance or ≥50% reduction of cryoglobulins and major signs of vasculitis in 11 patients (68.7%). In the remaining 5 patients (31.3%), cryoglobulins and CV manifestations remained unchanged or decreased by <50%. The corresponding ophthalmologic assessment showed a variable degree of improvement in the ocular symptoms in all but 2 patients (87.5%). The best corrected visual acuity following treatment improved in 26 eyes, was unchanged in 3 eyes, and worsened in 3 eyes.
    Conclusions: Eye involvement is not a rare event in CV patients. A timely diagnosis and the correct employment of the available therapeutic measures may result in a favorable outcome of the ocular and extra-ocular manifestations.
    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; Cohort Studies ; Cryoglobulinemia/complications ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/drug therapy ; Cryoglobulins/therapeutic use ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Vasculitis/drug therapy ; Retrospective Studies
    Chemical Substances Antiviral Agents ; Cryoglobulins
    Language English
    Publishing date 2023-10-09
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-023-02738-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Serous macular detachment in ocular toxoplasmosis: A review.

    Cirone, Daniele / Pellegrini, Francesco / Cuna, Alessandra / Caruso, Ettore / Cimino, Luca / Leonardi, Francesca

    European journal of ophthalmology

    2023  Volume 34, Issue 1, Page(s) 30–38

    Abstract: Ocular toxoplasmosis, a disease of the eye caused by the protozoan ... ...

    Abstract Ocular toxoplasmosis, a disease of the eye caused by the protozoan parasite
    MeSH term(s) Humans ; Toxoplasmosis, Ocular/complications ; Toxoplasmosis, Ocular/diagnosis ; Toxoplasmosis, Ocular/drug therapy ; Retinal Detachment/diagnosis ; Retinal Detachment/drug therapy ; Retinal Detachment/etiology ; Uveitis, Posterior ; Toxoplasma
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721231168148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differential diagnosis of myopic choroidal neovascularization (mCNV): insights from multimodal imaging and treatment implications.

    Feo, Alessandro / De Simone, Luca / Cimino, Luca / Angi, Martina / Romano, Mario R

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2023  

    Abstract: Purpose: The aim of this article is to conduct a comprehensive systematic review about the current understandings and differential diagnosis of myopic choroidal neovascularization (mCNV) and other several similar diseases, describing their multimodal ... ...

    Abstract Purpose: The aim of this article is to conduct a comprehensive systematic review about the current understandings and differential diagnosis of myopic choroidal neovascularization (mCNV) and other several similar diseases, describing their multimodal imaging analysis, prognostic implications, and current types of management.
    Methods: This systematic review was performed based on a search on the PubMed database of relevant papers regarding mCNV and other entities discussed in the paper, according to our current knowledge.
    Results: Through the integration of a multimodal imaging approach, especially optical coherence tomography (OCT), along with accurate demographic and clinical assessment, it becomes possible to effectively differentiate mCNV from similar yet heterogeneous entities. These conditions include macular hemorrhage due to new lacquer crack (LC) formation, inflammatory diseases such as punctate inner choroidopathy (PIC)/multifocal choroidits (MFC) and epiphenomenon multiple evanescent white dot syndrome (Epi-MEWDS), neovascular age-related macular degeneration (nAMD), idiopathic CNV (ICNV), dome-shaped macula (DSM) with subretinal fluid, retinal pigment epithelium (RPE) humps, angioid streaks (AS), choroidal rupture (CR), and choroidal osteoma (CO). Each one of these entities will be described and discussed in this article.
    Conclusion: Myopic choroidal neovascularization is a common retinal condition, especially among young individuals. Accurate diagnosis and differentiation from similar conditions are crucial for effective treatment. Multimodal imaging, particularly OCT, plays a crucial role in precise assessment. Future research should focus on defining biomarkers and distinguishing features to facilitate prompt treatment.
    Language English
    Publishing date 2023-12-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-023-06320-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: I comportamenti violenti nel sonno REM

    Cimino Luca

    Rivista di Criminologia, Vittimologia e Sicurezza, Vol V, Iss 1, Pp 69-

    aspetti clinici, criminologici e medico-legali / Les comportements violents pendant le sommeil MOR : aspects cliniques, criminologiques et médico-légaux / The Violent Behaviour in REM Sleep-related: Clinical, Criminological and Forensic Aspects

    2011  Volume 80

    Abstract: The violent behaviour of sleep represents a new frontier of forensic interest. After examining the clinical aspects of a particular form of parasomnia related to REM stage of sleep, called REM Behavior Disorder-RBD, the author highlights the ... ...

    Abstract The violent behaviour of sleep represents a new frontier of forensic interest. After examining the clinical aspects of a particular form of parasomnia related to REM stage of sleep, called REM Behavior Disorder-RBD, the author highlights the criminological and forensic implications emphasizing the distinctive features in terms of responsibility and imputability.Les comportements violents pendant le sommeil MOR représentent une nouvelle “frontière” d’intérêt de la psychologie médico-légale. Après avoir examiné les aspects cliniques d’une forme particulière de parasomnie liée à la phase MOR du sommeil (denominata REM Behaviour Disorders-RBD, l’auteur de l’article met en évidence ses implications criminologiques et médico-légales; en outre, il souligne les aspects particuliers de cette parasomnie en matière de responsabilité et d’imputabilité.I comportamenti violenti del sonno rappresentano una nuova “frontiera” di interesse forense. L’autore, dopo aver esaminato gli aspetti clinici di una particolare forma di parasonnia legata alla fase REM del sonno, denominata REM Behaviour Disorders-RBD, ne sottolinea le implicazioni criminologiche e medico-legali sottolineandone gli aspetti peculiari in tema di colpa ed imputabilità.
    Keywords REM-sleep related ; violent behaviour ; Criminal law and procedure ; K5000-5582 ; Comparative law. International uniform law ; K520-5582 ; Law in general. Comparative and uniform law. Jurisprudence ; K1-7720 ; Law ; K ; DOAJ:Law ; DOAJ:Law and Political Science
    Language Italian
    Publishing date 2011-04-01T00:00:00Z
    Publisher Società Italiana di Vittimologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: L'approccio psicoterapeutico alle vittime di violenza

    Cimino Luca

    Rivista di Criminologia, Vittimologia e Sicurezza, Vol V, Iss 3, Pp 85-

    una prospettiva fenomenologica/L'approche psychothérapeutique chez les victimes de violence : une perspective phénoménologique/he Psychoterapeutic Approach to Victims of Violence: a Phenomenological Perspective

    2011  Volume 93

    Abstract: L’autore affronta il problema della psicoterapia della vittima di violenza indicando i principi generali che ne devonoguidare lo svolgimento e proponendo, fra i vari modelli possibili, un paradigma di cura fenomenologicamente fondatoche, per le sue ... ...

    Abstract L’autore affronta il problema della psicoterapia della vittima di violenza indicando i principi generali che ne devonoguidare lo svolgimento e proponendo, fra i vari modelli possibili, un paradigma di cura fenomenologicamente fondatoche, per le sue intrinseche caratteristiche, appare particolarmente idoneo a consentire quell’adattamento umano aglieventi traumatici che rappresenta l’avvio di ogni processo di guarigione.RésuméL’auteur aborde le problème de la psychothérapie chez la victime de violence en indiquant les principes généraux quidoivent guider son déroulement, et en proposant, parmi les différents modèles possibles, un paradigme de traitementphénoménologiquement fondé. Ce dernier paraît, pour ses caractéristiques intrinsèques, particulièrement approprié àl’adaptation des individus après les événements traumatiques, qui représente le début de chaque processus de guérison.AbstractThe author addresses the problem of psychotherapy of victims of violence indicating the general principles that shouldguide its development thus proposing a phenomenological perspective as one of the possible models. Owing to itsintrinsic characteristics, this perspective seems particularly appropriate to allow that sort of human adaptation necessaryto begin a healing process after encountering a traumatic event.
    Keywords victims of violence ; psychoterapeutic approach ; Criminal law and procedure ; K5000-5582 ; Comparative law. International uniform law ; K520-5582 ; Law in general. Comparative and uniform law. Jurisprudence ; K1-7720 ; Law ; K ; DOAJ:Law ; DOAJ:Law and Political Science
    Language Italian
    Publishing date 2011-12-01T00:00:00Z
    Publisher Società Italiana di Vittimologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Recensione / Recension / Book Review

    Cimino Luca

    Rivista di Criminologia, Vittimologia e Sicurezza, Vol V, Iss 1, Pp 125-

    2011  Volume 127

    Abstract: Book review of: Sicurella S., Vittime e istituzioni locali. Quale dialogo?, Clueb, Bologna, ... ...

    Abstract Book review of: Sicurella S., Vittime e istituzioni locali. Quale dialogo?, Clueb, Bologna, 2010
    Keywords victims ; local agencies ; Criminal law and procedure ; K5000-5582 ; Comparative law. International uniform law ; K520-5582 ; Law in general. Comparative and uniform law. Jurisprudence ; K1-7720 ; Law ; K ; DOAJ:Law ; DOAJ:Law and Political Science
    Language Italian
    Publishing date 2011-04-01T00:00:00Z
    Publisher Società Italiana di Vittimologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Ocular Manifestations in an Italian Cohort of Patients with Takayasu Arteritis.

    Dammacco, Rosanna / Cimino, Luca / De Simone, Luca / Alessio, Giovanni / Dammacco, Franco

    Ocular immunology and inflammation

    2022  Volume 31, Issue 5, Page(s) 945–954

    Abstract: Purpose: We describe ophthalmic manifestations, therapy, and outcomes in 16 patients with Takayasu arteritis (TA).: Methods: Takayasu retinopathy was detected in 15 eyes of 9 patients and hypertensive retinopathy in 14 eyes of 7 patients.: Results!# ...

    Abstract Purpose: We describe ophthalmic manifestations, therapy, and outcomes in 16 patients with Takayasu arteritis (TA).
    Methods: Takayasu retinopathy was detected in 15 eyes of 9 patients and hypertensive retinopathy in 14 eyes of 7 patients.
    Results: Visual acuity was normal in 7 eyes, 20/40 to 20/200 in 20 eyes, counting fingers in 2 eyes, hand motion in 2 eyes, and no light perception in 1 eye. Glucocorticoids associated with immunosuppressive agents induced a sustained remission in 13 patients. Three relapsing-refractory patients were given the monoclonal antibody tocilizumab, which led to partial and complete response in 1 and 2 patients respectively. Steroid-induced cataracts developed in 4 patients. Restenosis and the consequent recurrence of visual symptoms were detected in 2 of 9 patients who underwent a patency procedure for their stenotic lesions.
    Conclusions: Ocular manifestations were a common feature (37.2%) in our cohort of TA patients and were frequently responsible for severe visual deterioration.
    Abbreviations: BCVA: best-corrected visual acuity; FFA: fundus fluorescein angiography; GC: glucocorticoids; HR: hypertensive retinopathy; ITAS: Indian Takayasu activity score; OCT: optical coherence tomography; TA: Takayasu arteritis; TR: Takayasu retinopathy.
    MeSH term(s) Humans ; Glucocorticoids/therapeutic use ; Takayasu Arteritis/complications ; Takayasu Arteritis/diagnosis ; Eye ; Retinal Diseases/diagnosis ; Hypertensive Retinopathy/complications
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2022.2072348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Optical Coherence Tomography in Inflammatory and Neoplastic Lesions Deforming the Choroidal Profile.

    Bolletta, Elena / De Simone, Luca / Pellegrini, Marco / Preziosa, Chiara / Mastrofilippo, Valentina / Adani, Chantal / Gentile, Pietro / Gozzi, Fabrizio / Cimino, Luca

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: The choroid is the main part of the uvea, the vascular layer of the eye that lies between the retina and the sclera. The high vascular component of the choroid makes this structure susceptible to inflammation in multisystemic diseases, as well as the ... ...

    Abstract The choroid is the main part of the uvea, the vascular layer of the eye that lies between the retina and the sclera. The high vascular component of the choroid makes this structure susceptible to inflammation in multisystemic diseases, as well as the most common site of metastasis in the eye. Therefore, the choroid is involved in many pathological conditions, from uveitis to intraocular tumors. Differentiating between inflammatory and neoplastic lesions deforming the choroidal profile can sometimes be challenging. In addition, scleral disorders can also deform the choroidal profile. Choroidal imaging includes ophthalmic ultrasonography, indocyanine green angiography, and optical coherence tomography (OCT). Recent advances in choroidal imaging techniques, such as enhanced depth imaging optical coherence tomography (EDI-OCT) and swept-source optical coherence tomography (SS-OCT), have facilitated an in-depth analysis of the choroid. The purpose of this review article is to report on and highlight the most common OCT findings to help in the differential diagnosis between inflammatory and neoplastic lesions deforming the choroidal profile.
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13121991
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  10. Article ; Online: Eosinophilic giant cell arteritis: A different subset of disease?

    Boiardi, Luigi / Marvisi, Chiara / Macchioni, Pierluigi / Cavazza, Alberto / Croci, Stefania / Besutti, Giulia / Spaggiari, Lucia / Giorgi Rossi, Paolo / Cimino, Luca / Pipitone, Nicolò / Ricordi, Caterina / Muratore, Francesco / Salvarani, Carlo

    Seminars in arthritis and rheumatism

    2024  Volume 65, Page(s) 152409

    Abstract: Objectives: To describe the clinical findings, response to therapy and course of patients with transmural eosinophilic infiltration at temporal artery biopsy (TAB).: Methods: The study consisted of a retrospective cohort of 254 consecutive GCA ... ...

    Abstract Objectives: To describe the clinical findings, response to therapy and course of patients with transmural eosinophilic infiltration at temporal artery biopsy (TAB).
    Methods: The study consisted of a retrospective cohort of 254 consecutive GCA patients with evidence of transmural inflammation at TAB seen at the Santa Maria Nuova Hospital over a 28-year period. The findings of the 22 patients with eosinophilic infiltration (≥ 20 eosinophils/hpf) at TAB were compared with those of 232 patients without. Among these 232 patients, we sampled 42 GCA patients matched for age, sex and follow-up duration to the 22 with eosinophilic infiltration, to compare allergic manifestations.
    Results: GCA patients with eosinophilic infiltration compared to those without presented more frequently cranial symptoms (p = 0.052), headaches (p = 0.005), abnormalities of TAs at physical examination (p = 0.045), jaw claudication (p = 0.024), and systemic manifestations (p = 0.016) and had higher CRP levels at diagnosis (p = 0.001). Regarding histological lesions, a severe transmural inflammation, laminar necrosis and intraluminal acute thrombosis were more frequently observed in patients with eosinophilic infiltration (p = 0.066, p < 0.001, and p = 0.010, respectively). Long-term remission and flares were similar in the two groups. When 21 GCA patients with eosinophilic infiltration were compared to 42 without, blood eosinophilic counts at diagnosis were normal and no patients had evidence or developed allergic manifestations and/or clinical findings of systemic necrotizing vasculitis.
    Conclusion: Patients with transmural eosinophilic infiltration represent a subset of GCA with cranial disease and more severe inflammation.
    MeSH term(s) Humans ; Giant Cell Arteritis/drug therapy ; Temporal Arteries/pathology ; Retrospective Studies ; Biopsy ; Inflammation
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2024.152409
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