Article ; Online: Assessment of the Anti-inflammatory Effects of NORFLO® ORO in Acute Relapses of HLA-B27-associated Autoimmune Uveitis: A Multicenter, Randomized, Placebo-controlled, Double-blind Clinical Study.
Ocular immunology and inflammation
2022 Volume 31, Issue 3, Page(s) 526–535
Abstract: Background: An effective therapy to reduce the number and severity of HLA-B27-related acute anterior uveitis (AAU) recurrences represents a clinical need. Curcumin is a promising therapeutic option in various inflammatory eye diseases. To enhance its ... ...
Abstract | Background: An effective therapy to reduce the number and severity of HLA-B27-related acute anterior uveitis (AAU) recurrences represents a clinical need. Curcumin is a promising therapeutic option in various inflammatory eye diseases. To enhance its absorption and eye tissue selectivity, a phospholipidic-curcumin complex (PHBC) has been formulated (Iphytoone®, Eye Pharma S.p.A.). Aims: This study investigates if PHBC is effective and safe to decrease the number and intensity of HLA-B27-related AAU relapses. Methods: HLA-B27-related AAU patients were randomly divided to receive PHBC or placebo for 12 months (NCT03584724). Results: Compared with the previous year, the number of relapses decreased in both groups. The proportion of responders was significantly higher in the PBHC group. The severity of attacks was comparable. The study drug was well tolerated. Conclusions: A beneficial effect of PHBC treatment is suggested because the proportion of responders was significantly higher in this group of patients. |
---|---|
MeSH term(s) | Humans ; HLA-B27 Antigen ; Curcumin/therapeutic use ; Uveitis/drug therapy ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/drug therapy ; Recurrence ; Acute Disease ; Anti-Inflammatory Agents/therapeutic use |
Chemical Substances | HLA-B27 Antigen ; Curcumin (IT942ZTH98) ; Anti-Inflammatory Agents |
Language | English |
Publishing date | 2022-03-30 |
Publishing country | England |
Document type | Randomized Controlled Trial ; Multicenter Study ; Journal Article |
ZDB-ID | 1193873-0 |
ISSN | 1744-5078 ; 0927-3948 |
ISSN (online) | 1744-5078 |
ISSN | 0927-3948 |
DOI | 10.1080/09273948.2022.2039210 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 4004: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.