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  1. AU="Cimino, R."
  2. AU="Judith R. Stabel"
  3. AU="Takeuchi, Kazuto"
  4. AU="Mirzaei, Samira"
  5. AU="Carolina Salgado"
  6. AU="Mate, Sebastian"
  7. AU="Hou, Tian-Yang Liu"
  8. AU=Nino Gustavo
  9. AU="Lydon, Myra"
  10. AU="Jain, Nibha"
  11. AU="David A Schwartz"
  12. AU="Swart, Jonathan"
  13. AU="Karol, Agnieszka"
  14. AU="Reilly, Brittni"
  15. AU="Arfaatabar, Maryam"
  16. AU="Kumar Pandey, Anand"

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  1. Artikel ; Online: Albendazole metabolites excretion in human saliva as a biomarker to assess treatment compliance in mass drug administration (MDA) anthelmintic programs.

    Nieves, E / Cimino, R / Krolewiecki, A / Juarez, M / Lanusse, C / Alvarez, L / Ceballos, L

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 6271

    Abstract: Soil-transmitted-helminth (STH) infections continue to be a persistent global public health problem. Control strategies for STH have been based on the use of mass drug administration (MDA). Coverage and compliance assessment is critical to understanding ... ...

    Abstract Soil-transmitted-helminth (STH) infections continue to be a persistent global public health problem. Control strategies for STH have been based on the use of mass drug administration (MDA). Coverage and compliance assessment is critical to understanding the true effectiveness of albendazole (ABZ) in those MDA programs. The aims of this work were to characterize the pattern of albendazole and metabolites excretion in human saliva, and to develop a saliva-based biomarker (HPLC drug/metabolite detection) useful to accurately estimate the coverage/compliance in MDA campaigns. The study subjects were 12 healthy volunteers treated with a single oral dose of ABZ (400 mg). Saliva and blood (dried blood spot, DBS) samples were taken previously and between 2 and 72 h post-treatment. The samples were analyzed by HPLC with UV detection, C
    Mesh-Begriff(e) Humans ; Albendazole/therapeutic use ; Saliva/metabolism ; Mass Drug Administration ; Anthelmintics ; Patient Compliance
    Chemische Substanzen Albendazole (F4216019LN) ; Anthelmintics
    Sprache Englisch
    Erscheinungsdatum 2024-03-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56804-w
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  2. Artikel ; Online: Influence of individual or group housing of newborn calves on rotavirus and coronavirus infection during the first 2 months of life.

    Bertoni, E A / Bok, M / Vega, C / Martinez, G M / Cimino, R / Parreño, V

    Tropical animal health and production

    2021  Band 53, Heft 1, Seite(n) 62

    Abstract: Bovine rotavirus A (RVA) and bovine coronavirus (CoV) are the two main viral enteropathogens associated with neonatal calf diarrhea. The aim of the present work was to study the impact of group and individual housing systems in the epidemiology of RVA ... ...

    Abstract Bovine rotavirus A (RVA) and bovine coronavirus (CoV) are the two main viral enteropathogens associated with neonatal calf diarrhea. The aim of the present work was to study the impact of group and individual housing systems in the epidemiology of RVA and CoV infection. Eleven calves reared in individual housing (FA) and nine calves in group housing (FB) were monitored during the first 7 weeks of life. Stool and serum samples were screened for RVA and CoV antigens by ELISA. IgG1 antibodies (Ab) to both antigens were also measured. From the 160 fecal samples collected, the proportion of positive samples to RVA and CoV was significantly higher in FB (23.6%) than in FA (9%) (p = 0.03). The geometric mean of colostral IgG1 Ab titers to CoV and RVA in FA (IgG1 anti-CoV 1024 and anti-RVA 1782.9) was lower than in FB (IgG1 anti-CoV 10,321.2 and anti-RVA 4096) at birth. Calves less than 2 weeks of life from FB had a higher risk of being infected by RVA (OR = 4.9; p = 0.01) and CoV (OR = 17.15; p = 0.01) than calves from FA. The obtained results showed that there was higher RVA and CoV shedding in group-housed calves than in individual-housed animals.
    Mesh-Begriff(e) Animals ; Animals, Newborn ; Argentina ; Cattle ; Cattle Diseases/epidemiology ; Cattle Diseases/virology ; Colostrum/immunology ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Coronavirus, Bovine ; Dairying ; Diarrhea/veterinary ; Enzyme-Linked Immunosorbent Assay/veterinary ; Feces/virology ; Female ; Housing, Animal ; Immunoglobulin G/immunology ; Longitudinal Studies ; Pregnancy ; Rotavirus ; Rotavirus Infections/veterinary ; Rotavirus Infections/virology ; Virus Shedding
    Chemische Substanzen Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2021-01-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-020-02540-y
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  3. Buch ; Konferenzbeitrag ; Online: Proceedings / ECLOUD '12: Joint INFN-CERN-EuCARD-AccNet Workshop on Electron-Cloud Effects

    Cimino, R

    (CERN ; 2013,2)

    2013  

    Körperschaft ECLOUD
    Veranstaltung/Kongress ECLOUD '12 (2012.06.05-09, LaBiodolaIsolad'ElbaItaly) ; Joint INFN-CERN-EuCARD-AccNet Workshop on Electron-Cloud Effects (2012.06.05-09, LaBiodolaIsolad'ElbaItaly)
    Verfasserangabe ed.: R. Cimino
    Serientitel CERN ; 2013,2
    Sprache Englisch
    Umfang Online-Ressource (PDF-Datei: XII, 274 S., 139 MB)
    Verlag CERN
    Erscheinungsort Geneva
    Dokumenttyp Buch ; Konferenzbeitrag ; Online
    ISBN 9789290833864 ; 9290833866
    DOI 10.5170/CERN-2013-002
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  4. Artikel ; Online: Short-term Effects of a First-Line Treatment Including Counseling and Self-Management Strategies on Chronic TMD Muscle Pain and Awake Bruxism in Women.

    Donnarumma, Valeria / Michelotti, Ambra / Cimino, Roberta / Vollaro, Stefano / Cioffi, Iacopo

    Journal of oral & facial pain and headache

    2022  Band 36, Heft 1, Seite(n) 36–48

    Abstract: Aims: To evaluate the short-term effects of a standardized first-line noninvasive approach (FL-A) including counseling and self-management strategies on pain, masticatory muscle tenderness, and awake bruxism in women with chronic temporomandibular ... ...

    Abstract Aims: To evaluate the short-term effects of a standardized first-line noninvasive approach (FL-A) including counseling and self-management strategies on pain, masticatory muscle tenderness, and awake bruxism in women with chronic temporomandibular disorder myalgia (mTMD) and to test whether patients' trait anxiety predicted their response to treatment.
    Methods: FL-A was administered to 14 women with chronic mTMD (mean age ± SD = 33.8 ± 11.1 years; 8 with Graded Chronic Pain Scale [GCPS] grade I and 6 with grade II). Its effects on facial pain, masticatory muscle tenderness, and spontaneous awake bruxism episodes were evaluated using questionnaires, surface electromyography, and quantitative sensory testing. General linear models were used to test FL-A efficacy after 1 (T1) and 2 (T2) months.
    Results: FL-A reduced pain (from baseline [T0] to T2, P = .010), the frequency of awake bruxism episodes (T0 to T1, P = .024), and their intensity by about 30% (T0 to T1, P < .001). Pressure pain thresholds at the masticatory muscle locations increased significantly from T0 to T2 (P < .001). Patients' trait anxiety decreased significantly from T0 to T2 (P = .030). Trait anxiety measured at baseline was not correlated with relative changes in pain (T0 to T2, P = .248).
    Conclusion: In the short term, FL-A reduces facial pain, masticatory muscle tenderness, and awake bruxism in women with chronic mTMD with low disability. A conservative management strategy should be prioritized for the initial management of these patients.
    Mesh-Begriff(e) Bruxism/therapy ; Counseling ; Female ; Humans ; Myalgia/therapy ; Self-Management ; Wakefulness
    Sprache Englisch
    Erscheinungsdatum 2022-03-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2762048-7
    ISSN 2333-0376 ; 2333-0384
    ISSN (online) 2333-0376
    ISSN 2333-0384
    DOI 10.11607/ofph.3037
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  5. Artikel ; Online: A spectroscopic and molecular dynamics study on the aggregation process of a long-acting lipidated therapeutic peptide: the case of semaglutide.

    Venanzi, M / Savioli, M / Cimino, R / Gatto, E / Palleschi, A / Ripani, G / Cicero, D / Placidi, E / Orvieto, F / Bianchi, E

    Soft matter

    2021  Band 16, Heft 44, Seite(n) 10122–10131

    Abstract: The aggregation properties of semaglutide, a lipidated peptide drug agonist of the Glucagon-like peptide 1 receptor recently approved for the treatment of type 2 diabetes, have been investigated by spectroscopic techniques (UV-Vis absorption, steady- ... ...

    Abstract The aggregation properties of semaglutide, a lipidated peptide drug agonist of the Glucagon-like peptide 1 receptor recently approved for the treatment of type 2 diabetes, have been investigated by spectroscopic techniques (UV-Vis absorption, steady-state and time-resolved fluorescence, and electronic circular dichroism) and molecular dynamics simulations. We show that in the micromolar concentration region, in aqueous solution, semaglutide is present as monomeric and dimeric species, with a characteristic monomer-to-dimer transition occurring at around 20 μM. The lipid chain stabilizes a globular morphology of the monomer and dimer species, giving rise to a locally well-defined polar outer surface where the lipid and peptide portions are packed to each other. At very long times, these peptide clusters nucleate the growth of larger aggregates characterized by blue luminescence and a β-sheet arrangement of the peptide chains. The understanding of the oligomerization and aggregation potential of peptide candidates is key for the development of long acting and stable drugs.
    Mesh-Begriff(e) Diabetes Mellitus, Type 2 ; Glucagon-Like Peptides ; Humans ; Molecular Dynamics Simulation ; Peptides
    Chemische Substanzen Peptides ; semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8)
    Sprache Englisch
    Erscheinungsdatum 2021-02-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d0sm01011a
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  6. Buch ; Online: Mystical Science and Practical Religion

    Cimino, Richard

    Muslim, Hindu, and Sikh Discourse on Science and Technology

    2014  

    Abstract: ... Mystical Science and Practical Religion ... uniquely examines the religious discourse of Muslim, Hindu, and Sikh applied science professionals and students. While they each view their respective religions ...

    Abstract Mystical Science and Practical Religion uniquely examines the religious discourse of Muslim, Hindu, and Sikh applied science professionals and students. While they each view their respective religions as the "most scientific," their work reshapes how they practice and conceptualize their faith.
    Sprache Englisch
    Umfang Online-Ressource (113 p)
    Verlag Lexington Books
    Erscheinungsort Lanham
    Dokumenttyp Buch ; Online
    Anmerkung Description based upon print version of record
    ISBN 9780739182277 ; 0739182277
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  7. Artikel ; Online: Dramatic disease regression in a case of HFrEF with end-stage renal failure treated with sacubitril/valsartan and SGLT2i.

    Mapelli, Massimo / Mantegazza, Valentina / Ferrari, Cristina / Cimino, Roberto / Maragna, Riccardo / Pontone, Gianluca / Pepi, Mauro / Agostoni, Piergiuseppe

    ESC heart failure

    2023  Band 10, Heft 3, Seite(n) 2099–2106

    Abstract: The amount of evidence for guideline-directed new heart failure (HFrEF) disease-modifying drugs in the context of chronic kidney disease (CKD) is relatively modest, especially in end-stage CKD. We report a case of dramatic reverse remodelling and disease ...

    Abstract The amount of evidence for guideline-directed new heart failure (HFrEF) disease-modifying drugs in the context of chronic kidney disease (CKD) is relatively modest, especially in end-stage CKD. We report a case of dramatic reverse remodelling and disease regression in a naïve HFrEF young woman on haemodialysis treated with sacubitril/valsartan and SGLT2i. At 10-month follow-up, the patient normalized left ventricle and atrial volumes and improved ejection fraction to the normal range, assessed both by echocardiography and cardiac magnetic resonance. Cardiac biomarkers and exercise performance improved consensually. The haemodialysis protocol and the loop diuretic dose were unchanged within the whole period.
    Mesh-Begriff(e) Female ; Humans ; Heart Failure/complications ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Stroke Volume ; Tetrazoles/therapeutic use ; Valsartan/therapeutic use ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Renal Insufficiency, Chronic/drug therapy
    Chemische Substanzen sacubitril (17ERJ0MKGI) ; Tetrazoles ; Valsartan (80M03YXJ7I)
    Sprache Englisch
    Erscheinungsdatum 2023-03-12
    Erscheinungsland England
    Dokumenttyp Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14344
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  8. Artikel: Influence of individual or group housing of newborn calves on rotavirus and coronavirus infection during the first 2 months of life

    Bertoni, E. A / Bok, M / Vega, C / Martinez, G. M / Cimino, R / Parreño, V

    Tropical animal health and production. 2021 Mar., v. 53, no. 1

    2021  

    Abstract: Bovine rotavirus A (RVA) and bovine coronavirus (CoV) are the two main viral enteropathogens associated with neonatal calf diarrhea. The aim of the present work was to study the impact of group and individual housing systems in the epidemiology of RVA ... ...

    Abstract Bovine rotavirus A (RVA) and bovine coronavirus (CoV) are the two main viral enteropathogens associated with neonatal calf diarrhea. The aim of the present work was to study the impact of group and individual housing systems in the epidemiology of RVA and CoV infection. Eleven calves reared in individual housing (FA) and nine calves in group housing (FB) were monitored during the first 7 weeks of life. Stool and serum samples were screened for RVA and CoV antigens by ELISA. IgG1 antibodies (Ab) to both antigens were also measured. From the 160 fecal samples collected, the proportion of positive samples to RVA and CoV was significantly higher in FB (23.6%) than in FA (9%) (p = 0.03). The geometric mean of colostral IgG1 Ab titers to CoV and RVA in FA (IgG1 anti-CoV 1024 and anti-RVA 1782.9) was lower than in FB (IgG1 anti-CoV 10,321.2 and anti-RVA 4096) at birth. Calves less than 2 weeks of life from FB had a higher risk of being infected by RVA (OR = 4.9; p = 0.01) and CoV (OR = 17.15; p = 0.01) than calves from FA. The obtained results showed that there was higher RVA and CoV shedding in group-housed calves than in individual-housed animals.
    Schlagwörter Bovine coronavirus ; Coronavirus infections ; Rotavirus A ; animal health ; blood serum ; calves ; diarrhea ; enteropathogens ; epidemiology ; group housing ; immunoglobulin G ; neonates ; risk
    Sprache Englisch
    Erscheinungsverlauf 2021-03
    Umfang p. 62.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-020-02540-y
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Potential Remedies for the High Synchrotron-Radiation-Induced Heat Load for Future Highest-Energy-Proton Circular Colliders.

    Cimino, R / Baglin, V / Schäfers, F

    Physical review letters

    2015  Band 115, Heft 26, Seite(n) 264804

    Abstract: We propose a new method for handling the high synchrotron radiation (SR) induced heat load of future circular hadron colliders (like FCC-hh). FCC-hh are dominated by the production of SR, which causes a significant heat load on the accelerator walls. ... ...

    Abstract We propose a new method for handling the high synchrotron radiation (SR) induced heat load of future circular hadron colliders (like FCC-hh). FCC-hh are dominated by the production of SR, which causes a significant heat load on the accelerator walls. Removal of such a heat load in the cold part of the machine, as done in the Large Hadron Collider, will require more than 100 MW of electrical power and a major cooling system. We studied a totally different approach, identifying an accelerator beam screen whose illuminated surface is able to forward reflect most of the photons impinging onto it. Such a reflecting beam screen will transport a significant part of this heat load outside the cold dipoles. Then, in room temperature sections, it could be more efficiently dissipated. Here we will analyze the proposed solution and address its full compatibility with all other aspects an accelerator beam screen must fulfill to keep under control beam instabilities as caused by electron cloud formation, impedance, dynamic vacuum issues, etc. If experimentally fully validated, a highly reflecting beam screen surface will provide a viable and solid solution to be eligible as a baseline design in FCC-hh projects to come, rendering them more cost effective and sustainable.
    Sprache Englisch
    Erscheinungsdatum 2015-12-31
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.115.264804
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  10. Artikel ; Online: Analysis of the reliability of the Italian version of the Oral Behaviours Checklist and the relationship between oral behaviours and trait anxiety in healthy individuals.

    Donnarumma, V / Cioffi, I / Michelotti, A / Cimino, R / Vollaro, S / Amato, M

    Journal of oral rehabilitation

    2018  Band 45, Heft 4, Seite(n) 317–322

    Abstract: Background: The Oral Behaviours Checklist (OBC) is a valid 21-item instrument quantifying the self-reported frequency of oral behaviours. An Italian version (OBC-It) has been released recently. Anxiety and oral behaviours are known to be associated in ... ...

    Abstract Background: The Oral Behaviours Checklist (OBC) is a valid 21-item instrument quantifying the self-reported frequency of oral behaviours. An Italian version (OBC-It) has been released recently. Anxiety and oral behaviours are known to be associated in individuals with oro-facial pain due to temporomandibular disorders (TMD). However, information about this relationship in pain-free individuals is still limited.
    Objectives: The aim of this study was to test the reliability of the OBC-It and its reduced version (OBC-It 6), focusing on tooth clenching-related wake-time oral behaviours, and the effect of patient instructions on reliability. A second aim was to test the association between trait anxiety and oral behaviours in pain-free individuals.
    Methods: Two hundred and eighty-two TMD-free students, divided into 2 groups (Group A, n = 139, mean age ± SD = 22.6 ± 5.4 years; Group B, n = 143, 23.7 ± 4.2 years), filled in the State-Trait Anxiety Inventory and the OBC-It. Group B received instructions about the OBC-It, while Group A did not. After 2 weeks, both groups filled in the OBC-It again. However, Group B was further divided into 2 subgroups, B
    Results: The test-retest reliability of the OBC-It (A: ICC = .87; B
    Conclusions: The OBC-It is a reliable tool but further subjects' instructions might be needed. Trait anxiety has a limited effect on oral behaviours in TMD-free subjects.
    Mesh-Begriff(e) Adult ; Anxiety/diagnosis ; Anxiety/psychology ; Checklist ; Female ; Health Behavior ; Healthy Volunteers ; Humans ; Male ; Oral Health ; Psychometrics ; Reproducibility of Results ; Self Report ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2018-02-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Validation Studies
    ZDB-ID 187079-8
    ISSN 1365-2842 ; 0305-182X
    ISSN (online) 1365-2842
    ISSN 0305-182X
    DOI 10.1111/joor.12614
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