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  1. Article: The comparison of the phytochemical composition, antioxidant and enzyme inhibition activity of two moss species: Plagiomnium ellipticum (Brid.) T. Kop. and Antitrichia californica Sull., from southwest ecological region in Turkey

    Onder, Alev / Yıldız, Aybala / Cinar, Ahsen Sevde / Zengin, Gokhan / Ak, Gunes / Ozenoğlu, Hatice

    Natural product research. 2022 May 23, v. 36, no. 10

    2022  

    Abstract: A limited number of mosses have been studied regarding antioxidant activity and enzyme inhibition effects. In the present study, the phytochemical content, antioxidant, and enzyme inhibition properties of the ether extracts from T.J.Kop.. were ... ...

    Abstract A limited number of mosses have been studied regarding antioxidant activity and enzyme inhibition effects. In the present study, the phytochemical content, antioxidant, and enzyme inhibition properties of the ether extracts from T.J.Kop.. were investigated as promising bryophyte sources. The ether extracts of P. ellipticum had the highest flavonoid content (52.41 ± 0.52, Rutin equivalent), and A. californica had the highest total phenolic content (25.84 ± 0.23, Gallic acid equivalent). While the P. ellipticum had the highest ABTS (mg TE/g extract) 6.60 ± 0.4); A. californica showed the highest metal chelating capacity (mg EDTA/g extract) with the values of 51.46 ± 0.26. In the enzyme activity tests, almost all values of the species were closed the each other, but P. ellipticum was exhibited higher tyrosinase activity (mg/KAE/g extract) with 48.64 ± 1.02. The results have indicated for the first time the potential importance of the selected mosses.
    Keywords Antitrichia californica ; Plagiomnium ; antioxidant activity ; antioxidants ; chemical constituents of plants ; ecoregions ; enzyme activity ; enzyme inhibition ; gallic acid ; mosses and liverworts ; research ; rutin
    Language English
    Dates of publication 2022-0523
    Size p. 2660-2665.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1916745
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Coumarins from Seseli petraeum M. Bieb. (Apiaceae) and their α-glucosidase inhibitory activity

    Onder, Alev / Cinar, Ahsen Sevde / Baran, Merve Yuzbasioglu / Kuruüzüm-Uz, Ayşe / Trendafilova, Antoaneta

    SAAB South African journal of botany. 2022 Jan., v. 144

    2022  

    Abstract: Seseli L. species from the Apiaceae family are well-known medicinal plants with rich bioactive components. In the present study, the phytochemical investigation of the n-hexane extract of the aerial parts from Seseli petraeum M. Bieb., a fairly narrow ... ...

    Abstract Seseli L. species from the Apiaceae family are well-known medicinal plants with rich bioactive components. In the present study, the phytochemical investigation of the n-hexane extract of the aerial parts from Seseli petraeum M. Bieb., a fairly narrow growing plant on the northern side of Turkey, led to the isolation of one new pyranocoumarin called 3′-isovaleryl-4′-oxo-lomatin (petracoumarin, (1) along with 12 known coumarins octanoyllomatin (2), selinidin (3), anomalin (4), 3′-isobutryl-lomatin (5), 3′-angeloyl-4′-isovaleryl-cis-khellactone (6), 3′-isovaleryl-4′-angeloyl-cis-khellactone (7), calipteryxin (8), samidin (9), 4′-senecioyl-cis-khellactone (10), 3′-senecioyl-cis-khellactone (11), cis-khellactone (12) and angelicin (13), and six plant sterols (campesterol, stigmasterol, β-sitosterol, stigmastanol, stigma-7-en-3-ol and γ-ergosterol, 14–19). The structures of the coumarins were elucidated by spectroscopic methods, including extensive 1D/2D NMR, and MS techniques. In addition, several coumarins have been tested for their inhibitory activity against α-amylase and α-glucosidase enzymes. The coumarins exhibited notable inhibitory activity against the α-glucosidase enzyme and low inhibitory potential against α-amylase. Among the tested compounds, octanoyllomatin (2) was found to be the best inhibitor of α-glucosidase with IC₅₀ = 69.00 ± 0.43 µg/mL. The promising results will guide our future studies and suggest that more detailed studies can be done on in vivo models.
    Keywords Seseli ; alpha-amylase ; campesterol ; coumarins ; hexane ; stigmasterol
    Language English
    Dates of publication 2022-01
    Size p. 458-463.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2126918-X
    ISSN 0254-6299
    ISSN 0254-6299
    DOI 10.1016/j.sajb.2021.09.022
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: The characterization of phenolic compounds via LC-ESI-MS/MS, antioxidant, enzyme inhibitory activities of Salvia absconditiflora, Salvia sclarea, and Salvia palaestina: A comparative analysis

    Onder, Alev / Izgi, Mehmet Necat / Cinar, Ahsen Sevde / Zengin, Gokhan / Yilmaz, Mustafa Abdullah

    SAAB South African journal of botany. 2022 Nov., v. 150

    2022  

    Abstract: Salvia L. genus, one of the medicinal and aromatic plants belonging to the Lamiaceae family, is represented by many endemic species in temperate regions worldwide. The Salvia species have plenty of usages in traditional medicine, important ... ...

    Abstract Salvia L. genus, one of the medicinal and aromatic plants belonging to the Lamiaceae family, is represented by many endemic species in temperate regions worldwide. The Salvia species have plenty of usages in traditional medicine, important pharmacological effects and economic value. In this context, this study was conducted to evaluate the chemical profile and potential bioactivity of ethyl acetate extracts from 3 different Salvia species; Salvia absconditiflora (Salvia cryptantha- an endemic species), S. sclarea and S. palaestina collected from different localities in Anatolia. Total phenolic-flavonoid contents, antioxidant properties and enzyme inhibition experiments were investigated in tested Salvia species. The phenolic profiles were also determined by liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The analysis revealed the presence of phenolic compounds in ethyl acetate extracts such as cynaroside, rosmarinic acid, cosmosiin, luteolin, apigenin and acacetin. The highest level of phenolic components was detected in S. absconditiflora with 74.16 mg GAE/g. The best radical scavenging and reducing abilities were found in S. absconditiflora (DPPH: 251.39 mg TE/g; ABTS: 340.16 mg TE/g; CUPRAC: 496.20 mg TE/g; FRAP: 322.94 mg TE/g). Moreover, the inhibition of AChE, BChE, and α-amylase has also been studied. The most potent AChE inhibitory ability was recorded in S. sclarea (4.00 mg GALAE/g), followed by S. palaestina (3.38 mg GALAE/g) and S. absconditiflora (3.01 mg GALAE/g). The extracts exhibited similar amylase inhibitory effects. These results reveal that Salvia species [S. absconditiflora (S. cryptantha), S. sclarea and S. palaestina] confirming their potential can be rich sources of promising bioactive compounds as a starting point for further analysis. In addition, it is thought that this study may be the new report for the construction of helpful databases in terms of shedding light on future research and researchers with the valuable information obtained about these economically important Salvia species.
    Keywords Salvia absconditiflora ; Salvia sclarea ; Turkey (country) ; alpha-amylase ; antioxidants ; apigenin ; economic valuation ; enzyme inhibition ; ethyl acetate ; indigenous species ; luteolin ; rosmarinic acid ; tandem mass spectrometry ; traditional medicine
    Language English
    Dates of publication 2022-11
    Size p. 313-322.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2126918-X
    ISSN 0254-6299
    ISSN 0254-6299
    DOI 10.1016/j.sajb.2022.07.030
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: The comparison of the phytochemical composition, antioxidant and enzyme inhibition activity of two moss species:

    Onder, Alev / Yıldız, Aybala / Cinar, Ahsen Sevde / Zengin, Gokhan / Ak, Gunes / Ozenoğlu, Hatice

    Natural product research

    2021  Volume 36, Issue 10, Page(s) 2660–2665

    Abstract: A limited number of mosses have been studied regarding antioxidant activity and enzyme inhibition effects. In the present study, the phytochemical content, antioxidant, and enzyme inhibition properties of the ether extracts from T.J.Kop.. were ... ...

    Abstract A limited number of mosses have been studied regarding antioxidant activity and enzyme inhibition effects. In the present study, the phytochemical content, antioxidant, and enzyme inhibition properties of the ether extracts from T.J.Kop.. were investigated as promising bryophyte sources. The ether extracts of
    MeSH term(s) Antioxidants/chemistry ; Antioxidants/pharmacology ; Bryophyta ; Ethers ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Turkey
    Chemical Substances Antioxidants ; Ethers ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1916745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation of the Antioxidant Potency of

    Önder, Alev / Çinar, Ahsen Sevde / Yilmaz Sarialtin, Sezen / Izgi, Mehmet Necat / Çoban, Tülay

    Turkish journal of pharmaceutical sciences

    2020  Volume 17, Issue 2, Page(s) 197–202

    Abstract: Objectives: In the present study, the antioxidant potency of ethyl acetate (AcOEt) and methanol (MeOH) extracts from the aerial parts of : Materials and methods: Seseli: Results: The highest activities as a scavenger of DPPH radicals were found in ...

    Abstract Objectives: In the present study, the antioxidant potency of ethyl acetate (AcOEt) and methanol (MeOH) extracts from the aerial parts of
    Materials and methods: Seseli
    Results: The highest activities as a scavenger of DPPH radicals were found in the AcOEt extracts of
    Conclusion: This report gives important information about the antioxidant capacity of
    Language English
    Publishing date 2020-04-24
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2238484-4
    ISSN 2148-6247 ; 2148-6247
    ISSN (online) 2148-6247
    ISSN 2148-6247
    DOI 10.4274/tjps.galenos.2019.80488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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