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  1. Article: Successful treatment of exfoliative cheilitis with dupilumab: A case report.

    Cino, Daniela / Gavigan, Genevieve

    SAGE open medical case reports

    2023  Volume 11, Page(s) 2050313X231193076

    Abstract: This case report describes the first known successful treatment of exfoliative cheilitis with the interleukin-4 receptor alpha antagonist dupilumab in an adult patient. With no response to topical tacrolimus, hydrocortisone, dapsone, crisaborole or ... ...

    Abstract This case report describes the first known successful treatment of exfoliative cheilitis with the interleukin-4 receptor alpha antagonist dupilumab in an adult patient. With no response to topical tacrolimus, hydrocortisone, dapsone, crisaborole or systemic doxycycline, low dose isotretinoin, or methotrexate, she had resolution with off-label dupilumab after 4 months of treatment.
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X231193076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Palmoplantar Pustulosis: Clinical Characteristics and Variability in Therapeutic Approaches.

    Seale, Emily / Li, Heidi Oi-Yee / Waugh, Miranda / Cino, Daniela / Marzario, Barbara / Kirchhof, Mark G

    Journal of cutaneous medicine and surgery

    2023  Volume 28, Issue 1, Page(s) 88–89

    MeSH term(s) Humans ; Psoriasis/drug therapy ; Acute Disease ; Chronic Disease ; Exanthema
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Letter
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754231211343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4987: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Poly(I:C)-Mediated Death of Human Prostate Cancer Cell Lines Is Induced by Interleukin-27 Treatment.

    Kourko, Olena / Smyth, Robin / Cino, Daniela / Seaver, Kyle / Petes, Carlene / Eo, So Young / Basta, Sam / Gee, Katrina

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2019  Volume 39, Issue 8, Page(s) 483–494

    Abstract: Interleukin (IL)-27 is a promising anti-cancer cytokine with therapeutic potential. Exhibiting overlapping properties with type I and II interferons (IFNs), IL-27 impacts cancer cell viability and immune cell activity. Known to modulate toll-like ... ...

    Abstract Interleukin (IL)-27 is a promising anti-cancer cytokine with therapeutic potential. Exhibiting overlapping properties with type I and II interferons (IFNs), IL-27 impacts cancer cell viability and immune cell activity. Known to modulate toll-like receptor (TLR) expression, we investigated whether IL-27 affected TLR-mediated death in cancer cells. Using DU145 and PC3 cell lines as models of prostate cancer, we investigated whether IL-27 and IFN-γ affect TLR3-mediated cell death. Our results demonstrate that when IL-27 or IFN-γ is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death. IL-27 and IFN-γ enhanced TLR3 expression, suggesting a mechanism for sensitization to cell death. Further, PC3 cells were more sensitive to IL-27/poly(I:C)-induced cell death compared with DU145 cells. This correlated with higher production of IFN-β and inducible protein-10 versus IL-6 in response to treatment of PC3 cells compared with DU145. Taken together, this study demonstrates a potential role for IL-27 in the treatment of prostate cancer.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Interleukin-27/pharmacology ; Male ; PC-3 Cells ; Poly I-C/pharmacology ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Structure-Activity Relationship ; Tumor Cells, Cultured
    Chemical Substances Antineoplastic Agents ; Interleukin-27 ; Poly I-C (O84C90HH2L)
    Language English
    Publishing date 2019-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2018.0166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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