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Book ; Online ; E-Book: Complications of anorectal surgery

Abcarian, Herand / Cintron, Jose R. / Nelson, Richard L.

prevention and management

2017

Author's details	Herand Abcarian, Jose Cintron, Richard L. Nelson editors
Language	English
Size	1 Online-Ressource (xii, 329 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019396414
ISBN	978-3-319-48406-8 ; 9783319484044 ; 3-319-48406-0 ; 3319484044
DOI	10.1007/978-3-319-48406-8
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Hydrophilic interaction chromatography with aerosol-based detectors (ELSD, CAD, NQAD) for polar compounds lacking a UV chromophore in an intravenous formulation.

Cintrón, José M / Risley, Donald S

Journal of pharmaceutical and biomedical analysis

2013 Volume 78-79, Page(s) 14–18

Abstract: In this work, a high performance liquid chromatography (HPLC) method is reported for the separation and quantitation of a drug substance that is highly polar and lacking a chromophore in a mannitol intravenous (IV) formulation. Three polar stationary ... ...

Abstract	In this work, a high performance liquid chromatography (HPLC) method is reported for the separation and quantitation of a drug substance that is highly polar and lacking a chromophore in a mannitol intravenous (IV) formulation. Three polar stationary phases operated in hydrophilic interaction chromatography (HILIC) mode were evaluated in conjunction with an Alltech 800 ELSD detector. These columns were evaluated with respect to chromatographic properties such as buffer, pH and organic concentrations to identify the best stationary phase. The chromatographic method was then validated for the determination of mGlu2/3 receptor agonist (-)-(1R, 4S, 5S, 6S)-4-Amino-2-sulfonylbicyclo [3.1.0] hexane-4,6-dicarboxylic acid (LY404039) content in a mannitol IV formulation with respect to linearity (R(2) of 0.9997), repeatability (%RSD of 0.36%), accuracy, solution stability (99.56% after 24h), specificity, intra-assay precision (%RSD 0.48%) and limit of detection (LOD, ∼50 μg/mL). In addition to the Alltech 800 ELSD detector, several other aerosol-based detectors were investigated for reproducibility, linearity and LOD. These additional detectors consisted of an Alltech 3300 evaporative light scattering detector (ELSD), a nano quantity analyte detector (NQAD) and a charged aerosol detector (CAD). Based on the data from this report, a feasible isocratic LC method was achieved using a TSKgel Amide-80 column with mobile phase conditions of 30% water with 0.2% trifluoroacetic acid (TFA) and 70% acetonitrile (ACN) using any of the four aerosol-based detectors for detection and quantitation.
MeSH term(s)	Aerosols ; Chromatography, Liquid/methods ; Hydrophobic and Hydrophilic Interactions ; Limit of Detection ; Reproducibility of Results ; Ultraviolet Rays
Chemical Substances	Aerosols
Language	English
Publishing date	2013-05-05
Publishing country	England
Document type	Journal Article ; Validation Studies
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2013.01.022
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Article: Hydrophilic interaction chromatography with aerosol-based detectors (ELSD, CAD, NQAD) for polar compounds lacking a UV chromophore in an intravenous formulation

Cintrón, José M / Risley, Donald S

Journal of pharmaceutical and biomedical analysis. 2013 May 5, v. 78-79

2013

Abstract	In this work, a high performance liquid chromatography (HPLC) method is reported for the separation and quantitation of a drug substance that is highly polar and lacking a chromophore in a mannitol intravenous (IV) formulation. Three polar stationary phases operated in hydrophilic interaction chromatography (HILIC) mode were evaluated in conjunction with an Alltech 800 ELSD detector. These columns were evaluated with respect to chromatographic properties such as buffer, pH and organic concentrations to identify the best stationary phase. The chromatographic method was then validated for the determination of mGlu2/3 receptor agonist (−)-(1R, 4S, 5S, 6S)-4-Amino-2-sulfonylbicyclo [3.1.0] hexane-4,6-dicarboxylic acid (LY404039) content in a mannitol IV formulation with respect to linearity (R² of 0.9997), repeatability (%RSD of 0.36%), accuracy, solution stability (99.56% after 24h), specificity, intra-assay precision (%RSD 0.48%) and limit of detection (LOD, ∼50μg/mL). In addition to the Alltech 800 ELSD detector, several other aerosol-based detectors were investigated for reproducibility, linearity and LOD. These additional detectors consisted of an Alltech 3300 evaporative light scattering detector (ELSD), a nano quantity analyte detector (NQAD) and a charged aerosol detector (CAD). Based on the data from this report, a feasible isocratic LC method was achieved using a TSKgel Amide-80 column with mobile phase conditions of 30% water with 0.2% trifluoroacetic acid (TFA) and 70% acetonitrile (ACN) using any of the four aerosol-based detectors for detection and quantitation.
Keywords	acetonitrile ; aerosols ; agonists ; detection limit ; detectors ; drugs ; high performance liquid chromatography ; hydrophilic interaction chromatography ; intravenous injection ; light scattering ; mannitol ; pH ; polar compounds
Language	English
Dates of publication	2013-0505
Size	p. 14-18.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	604917-5
ISSN	0731-7085
ISSN	0731-7085
DOI	10.1016/j.jpba.2013.01.022
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Findings on Colonoscopy after Diverticulitis: A Multicenter Review.

Studniarek, Adam / Kochar, Kunal / Warner, Christina / Eftaiha, Saleh / Naffouj, Sandra / Borsuk, Daniel J / Mellgren, Anders / Park, John J / Cintron, Jose / Harrison, Jacqueline

The American surgeon

2020 Volume 85, Issue 12, Page(s) 1381–1385

Abstract: Diverticular disease is a common problem where patients with diverticulosis have a 1-4 per cent risk of acute diverticulitis. Current guidelines recommend a colonoscopy after.the resolution of acute diverticulitis. The aim of this study was to evaluate ... ...

Abstract	Diverticular disease is a common problem where patients with diverticulosis have a 1-4 per cent risk of acute diverticulitis. Current guidelines recommend a colonoscopy after.the resolution of acute diverticulitis. The aim of this study was to evaluate the yield of significant findings on colonoscopy after an episode of diverticulitis. This is a retrospective analysis of patients who underwent colonoscopy after an episode of diverticulitis between November 2005 and August 2017 at three major teaching hospitals. Advanced adenomas were defined as adenomas ≥1 cm, serrated adenomas, and tubulovillous or villous adenomas. A total of 584 patients (298 males; 51%) underwent colonoscopy for a history of diverticulitis after resolution of acute symptoms. Colonoscopy was complete in 488 patients (84%). Among these 488 patients, 446 had diverticular disease, 31 had advanced adenomas, and four had adenocarcinomas. Colonoscopies were incomplete in 96 patients (16%). Forty-six of those patients underwent surgery. The overall incidence of advanced adenomas and adenocarcinomas was 32 (5.4%) and nine (1.5%), respectively. In our study, the prevalence of advanced adenomas and adenocarcinomas was relatively high compared with the average risk individuals. Our findings support that patients after an episode of diverticulitis should continue to get a colonoscopy.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/epidemiology ; Adenoma/diagnosis ; Adenoma/epidemiology ; Adult ; Aged ; Aged, 80 and over ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/epidemiology ; Colonoscopy/statistics & numerical data ; Diverticulitis/therapy ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2020-01-07
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
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Article: Very high-pressure capillary liquid chromatography assisted by voltage.

Cintrón, José M / Colón, Luis A

Journal of chromatography. A

2006 Volume 1106, Issue 1-2, Page(s) 131–138

Abstract: Capillary liquid chromatography at moderately high pressures and capillary electrochromatography (CEC) have been combined to drive the mobile phase through capillary columns packed with small diameter particles. In a column packed with 1.5 microm ... ...

Abstract	Capillary liquid chromatography at moderately high pressures and capillary electrochromatography (CEC) have been combined to drive the mobile phase through capillary columns packed with small diameter particles. In a column packed with 1.5 microm nonporous particles, linear velocities near 3mm/s were observed when combining inlet pressures of 690 bar (10,000 psi) and an applied voltage of 25 kV. Optimum linear velocity for the column was achieved using a pressure-voltage combination of 350 bar (5000 psi) and 5 kV. Separation efficiencies at near optimum linear velocity agreed with those predicted by the van Deemter equation for liquid chromatography. Retention factors were observed to decrease under pressure-voltage combination as the voltage was increased; such a behavior has been attributed to Joule heating effects.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Electrochemistry/methods
Language	English
Publishing date	2006-02-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2005.05.053
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Article: New techniques in the treatment of common perianal diseases: stapled hemorrhoidopexy, botulinum toxin, and fibrin sealant.

Singer, Marc / Cintron, Jose

The Surgical clinics of North America

2006 Volume 86, Issue 4, Page(s) 937–967

Abstract: There have been several recent advances in the treatment of common perianal diseases. Stapled hemorrhoidopexy is a procedure of hemorrhoidal fixation, combining the benefits of rubber band ligation into an operative technique. The treatment of anal ... ...

Abstract	There have been several recent advances in the treatment of common perianal diseases. Stapled hemorrhoidopexy is a procedure of hemorrhoidal fixation, combining the benefits of rubber band ligation into an operative technique. The treatment of anal fissure has typically relied upon internal sphincterotomy; however, it carries a risk of incontinence. The injection of botulinum toxin represents a new form of sphincter relaxation, without division of any sphincter muscle; morbidity is minimal and results are promising. For the treatment of fistula in a fistulotomy remains the gold standard, however, it carries significant risk of incontinence. Use of fibrin sealant to treat fistulae has been met with variable success. It offers sealing of the tract, and then provides scaffolding for native tissue ingrowth.
MeSH term(s)	Botulinum Toxins/therapeutic use ; Fibrin Tissue Adhesive/therapeutic use ; Fissure in Ano/therapy ; Hemorrhoids/therapy ; Humans ; Rectal Fistula/therapy ; Surgical Stapling ; Tissue Adhesives/therapeutic use
Chemical Substances	Fibrin Tissue Adhesive ; Tissue Adhesives ; Botulinum Toxins (EC 3.4.24.69)
Language	English
Publishing date	2006-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	215713-5
ISSN	1558-3171 ; 0039-6109
ISSN (online)	1558-3171
ISSN	0039-6109
DOI	10.1016/j.suc.2006.06.009
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Article ; Online: Anal Adenocarcinoma: Outcomes in an Uncommon Malignancy.

Bertelson, Noelle / Blumetti, Jennifer / Cintron, Jose / Harrison, Jacquelyn / Chaudhry, Vivek / Abcarian, Herand

The American surgeon

2015 Volume 81, Issue 11, Page(s) 1114–1117

Abstract: Adenocarcinoma is an uncommon malignancy of the anal canal. Although it is recognized as an aggressive disease, optimal management and long-term outcomes are not well established. Patients diagnosed with anal adenocarcinoma were identified from a cancer ... ...

Abstract	Adenocarcinoma is an uncommon malignancy of the anal canal. Although it is recognized as an aggressive disease, optimal management and long-term outcomes are not well established. Patients diagnosed with anal adenocarcinoma were identified from a cancer database. Their charts were reviewed for patient and disease characteristics, management, and outcomes. Eighteen patient charts from 1997 to 2012 were reviewed. Nine patients presented with stage II disease, five with stage III, three with stage IV, and one was inadequately staged before chemoradiation. One patient refused treatment, one patient went straight to abdominoperineal resection, 13 patients underwent initial chemoradiation therapy, and three underwent palliative chemotherapy. Of the 13 patients who received neoadjuvant therapy, eight underwent subsequent radical resection; three progressed during neoadjuvant and became unresectable, one had complete pathologic response and was observed, and one did not complete neoadjuvant and was lost to follow-up. Two patients with stage II disease were disease free over eight years, and one was disease free after 26 months; four patients had persistent or recurrent local disease, and 10 developed metastatic disease. Seven patients died with disease at a median 16 months, and the other seven were alive with disease at a median follow-up of 10 months. Patients with anal adenocarcinoma present at advanced stages, and cure is rare. Although chemoradiation followed by abdominoperineal resection is the most common management strategy, the potential for curative resection and long-term disease free survival is minimal, regardless of stage at presentation.
MeSH term(s)	Adenocarcinoma/surgery ; Adenocarcinoma/therapy ; Anus Neoplasms/surgery ; Anus Neoplasms/therapy ; Chemoradiotherapy, Adjuvant ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
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Article: Improved performance on the American Board of Surgery in-training examination: a personal or collective effort?

Chaer, Rabih A / Cintron, Jose R

Archives of surgery (Chicago, Ill. : 1960)

2004 Volume 139, Issue 9, Page(s) 1025–6; author reply 1026

MeSH term(s)	Education, Medical, Graduate/standards ; Educational Measurement/methods ; General Surgery/standards ; Internship and Residency ; Reading ; Specialty Boards/standards ; United States
Language	English
Publishing date	2004-09
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80055-7
ISSN	1538-3644 ; 0004-0010 ; 0096-6908 ; 0272-5533
ISSN (online)	1538-3644
ISSN	0004-0010 ; 0096-6908 ; 0272-5533
DOI	10.1001/archsurg.139.9.1025-b
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Article: Organo-silica nano-particles used in ultrahigh-pressure liquid chromatography.

Cintrón, José M / Colón, Luis A

The Analyst

2002 Volume 127, Issue 6, Page(s) 701–704

Abstract: A simple one-step process was used to synthesize uniform, spherical organosilica nano-particles containing octadecyl moieties. These nano-particles, having a diameter of 670 nm, were slurry packed into fused-silica capillary tubes of 50 microm internal ... ...

Abstract	A simple one-step process was used to synthesize uniform, spherical organosilica nano-particles containing octadecyl moieties. These nano-particles, having a diameter of 670 nm, were slurry packed into fused-silica capillary tubes of 50 microm internal diameter and tested for use in ultrahigh-pressure liquid chromatography (UHPLC) at inlet pressures of about 50,000 psi (approximately 3,500 bar), providing for the use of HPLC with nano-particle packed columns. The retention characteristics of a column packed with the organo-nano-particles were shown to be stable under acidic (pH < 1) and basic (pH > 11) conditions. Fast analysis times and relatively high separation efficiencies (approximately 500,000 plates m(-1)) were obtained under the conditions used.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Microscopy, Electron ; Microspheres ; Nanotechnology ; Organosilicon Compounds
Chemical Substances	Organosilicon Compounds
Language	English
Publishing date	2002-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	210747-8
ISSN	0003-2654
ISSN	0003-2654
DOI	10.1039/b203236h
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Article ; Online: Endometriosis-induced acute small and large bowel obstruction: rare clinical entities.

Chaer, Rabih / Sam, Albert / Teresi, Miguel / Cintron, Jose

The New Zealand medical journal

2005 Volume 118, Issue 1217, Page(s) U1521

Abstract: The extragonadal manifestations of intestinal endometriosis necessitating immediate abdominal surgical exploration are, to date, sparsely represented within the literature. We present two cases of acute complete small and large bowel obstruction ... ...

Abstract	The extragonadal manifestations of intestinal endometriosis necessitating immediate abdominal surgical exploration are, to date, sparsely represented within the literature. We present two cases of acute complete small and large bowel obstruction secondary to endometriosis, requiring emergent laparotomy; and review the pertinent literature.
MeSH term(s)	Abdominal Pain/etiology ; Adult ; Cecal Diseases/etiology ; Cecal Diseases/surgery ; Colonic Diseases/etiology ; Colonic Diseases/surgery ; Endometriosis/complications ; Female ; Humans ; Ileal Diseases/etiology ; Ileal Diseases/surgery ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Pelvic Pain/etiology
Language	English
Publishing date	2005-06-24
Publishing country	New Zealand
Document type	Case Reports ; Journal Article
ZDB-ID	390590-1
ISSN	1175-8716 ; 0028-8446 ; 0110-7704
ISSN (online)	1175-8716
ISSN	0028-8446 ; 0110-7704
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