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  1. Article ; Online: Editorial: The future of inflammatory bowel disease management.

    Ciorba, Matthew A

    Current opinion in gastroenterology

    2022  Volume 38, Issue 4, Page(s) 319–320

    MeSH term(s) Chronic Disease ; Humans ; Inflammatory Bowel Diseases/therapy
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2072: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Clostridium difficile in inflammatory bowel disease.

    Alhobayb, Tamara / Ciorba, Matthew A

    Current opinion in gastroenterology

    2023  Volume 39, Issue 4, Page(s) 257–262

    Abstract: Purpose of review: The chronic inflammatory bowel diseases (IBD), Crohn's disease, and ulcerative colitis, are associated with an increased risk of symptomatic Clostridium difficile infection (CDI). CDI may also masquerade as an IBD flare and complicate ...

    Abstract Purpose of review: The chronic inflammatory bowel diseases (IBD), Crohn's disease, and ulcerative colitis, are associated with an increased risk of symptomatic Clostridium difficile infection (CDI). CDI may also masquerade as an IBD flare and complicate IBD management. This review provides a comprehensive overview of the epidemiology, diagnosis, and treatment of CDI in IBD patients.
    Recent findings: CDI remains common in IBD with complications including flares in disease activity, recurrent CDI episodes, and prolonged hospital stays. Newer IBD therapeutics including vedolizumab, ustekinumab, and tofacitinib are less likely to cause severe CDI. A high index of suspicion, rapid testing via a two-step method, and prompt treatment with vancomycin or fidaxomicin are paramount to managing CDI in IBD patients. Strategies to prevent recurrent CDI (rCDI) include the monoclonal antibody bezlotoxumab as well as fecal microbiota transplantation (FMT). FMT has a robust profile of safety and effectiveness in preventing rCDI in adults and children.
    Summary: Clinicians must remain vigilant in the prompt diagnosis and treatment of CDI in IBD patients. Corticosteroids, unnecessary antibiotics, and ongoing colonic inflammatory disease are modifiable risk factors. Improved infection control measures, newer IBD medications, and using effective CDI treatments will facilitate a reduced burden of severe CDI and complications for IBD patients.
    MeSH term(s) Adult ; Child ; Humans ; Clostridioides difficile ; Recurrence ; Inflammatory Bowel Diseases/therapy ; Inflammatory Bowel Diseases/drug therapy ; Crohn Disease/complications ; Colitis, Ulcerative/complications ; Clostridium Infections/diagnosis ; Clostridium Infections/epidemiology ; Clostridium Infections/therapy ; Fecal Microbiota Transplantation/methods ; Colonic Diseases/complications
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2072: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Nonmicrobial Activation of TLRs Controls Intestinal Growth, Wound Repair, and Radioprotection.

    Stenson, William F / Ciorba, Matthew A

    Frontiers in immunology

    2021  Volume 11, Page(s) 617510

    Abstract: TLRs, key components of the innate immune system, recognize microbial molecules. However, TLRs also recognize some nonmicrobial molecules. In particular, TLR2 and TLR4 recognize hyaluronic acid, a glycosaminoglycan in the extracellular matrix. In ... ...

    Abstract TLRs, key components of the innate immune system, recognize microbial molecules. However, TLRs also recognize some nonmicrobial molecules. In particular, TLR2 and TLR4 recognize hyaluronic acid, a glycosaminoglycan in the extracellular matrix. In neonatal mice endogenous hyaluronic acid binding to TLR4 drives normal intestinal growth. Hyaluronic acid binding to TLR4 in pericryptal macrophages results in cyclooxygenase2- dependent PGE
    MeSH term(s) Animals ; Cell Proliferation/physiology ; Humans ; Intestinal Mucosa/metabolism ; Intestines/growth & development ; Radiation Effects ; Toll-Like Receptors/metabolism ; Wound Healing/physiology
    Chemical Substances Toll-Like Receptors
    Language English
    Publishing date 2021-01-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.617510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Serotonin Receptors Regulate Inflammatory Response in Experimental Colitis.

    Alvarado, David M / Ciorba, Matthew A

    The Journal of nutrition

    2020  Volume 150, Issue 7, Page(s) 1678–1679

    MeSH term(s) Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Dextran Sulfate/toxicity ; Inflammation/etiology ; Inflammation/prevention & control ; Mice ; Receptors, Serotonin/genetics ; Receptors, Serotonin/metabolism ; Tryptophan/therapeutic use
    Chemical Substances Receptors, Serotonin ; Tryptophan (8DUH1N11BX) ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/nxaa160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.205: Show issues Location:
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  5. Article ; Online: Advances in understanding and improving gastrointestinal symptoms during supportive and palliative care: a decade of progress.

    Ciorba, Matthew A

    Current opinion in supportive and palliative care

    2016  Volume 10, Issue 2, Page(s) 149–151

    MeSH term(s) Antineoplastic Agents/adverse effects ; Gastrointestinal Diseases/therapy ; Gastrointestinal Microbiome/physiology ; Humans ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Palliative Care/methods ; Quality of Life ; Radiotherapy/adverse effects ; Terminal Care/methods
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6946: Show issues Location:
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  6. Article ; Online: The LRRC family of BK channel regulatory subunits: potential roles in health and disease.

    Gonzalez-Perez, Vivian / Zhou, Yu / Ciorba, Matthew A / Lingle, Christopher J

    The Journal of physiology

    2022  Volume 600, Issue 6, Page(s) 1357–1371

    Abstract: Large conductance ... ...

    Abstract Large conductance K
    MeSH term(s) Animals ; Colon/metabolism ; Female ; Hair Cells, Auditory, Inner/metabolism ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism ; Large-Conductance Calcium-Activated Potassium Channels/genetics ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Protein Domains
    Chemical Substances LRRC52 protein, mouse ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits ; Large-Conductance Calcium-Activated Potassium Channels ; Membrane Proteins
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP281952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.65: Show issues Location:
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  7. Article ; Online: Scap and the intestinal epithelial stem cell niche: new insights from lipid biology.

    Ciorba, Matthew A

    Journal of lipid research

    2015  Volume 56, Issue 8, Page(s) 1381–1382

    MeSH term(s) Animals ; Female ; Humans ; Intestinal Mucosa/growth & development ; Intestinal Mucosa/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Membrane Proteins/metabolism ; Sterols/biosynthesis
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Sterols
    Language English
    Publishing date 2015-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.C061309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 175: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels.

    Zeng, Qiru / Antia, Avan / Casorla-Perez, Luis Alberto / Puray-Chavez, Maritza / Kutluay, Sebla B / Ciorba, Matthew A / Ding, Siyuan

    mBio

    2024  Volume 15, Issue 3, Page(s) e0228723

    Abstract: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A number of calpain inhibitors show ... ...

    Abstract Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A number of calpain inhibitors show excellent antiviral activities against SARS-CoV-2 by targeting the viral main protease (M
    Importance: Many efforts in small-molecule screens have been made to counter SARS-CoV-2 infection by targeting the viral main protease, the major element that processes viral proteins after translation. Here, we discovered that calpain inhibitors further block SARS-CoV-2 infection in a main protease-independent manner. We identified the host cysteine protease calpain-2 as an important positive regulator of the cell surface levels of SARS-CoV-2 cellular receptor ACE2 and, thus, a facilitator of viral infection. By either pharmacological inhibition or genetic knockout of calpain-2, the SARS-CoV-2 binding to host cells is blocked and viral infection is decreased. Our findings highlight a novel mechanism of ACE2 regulation, which presents a potential new therapeutic target. Since calpain inhibitors also potently interfere with the viral main protease, our data also provide a mechanistic understanding of the potential use of calpain inhibitors as dual inhibitors (entry and replication) in the clinical setting of COVID-19 diseases. Our findings bring mechanistic insights into the cellular process of SARS-CoV-2 entry and offer a novel explanation to the mechanism of activities of calpain inhibitors.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Calpain/metabolism ; Calpain/pharmacology ; Angiotensin-Converting Enzyme 2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Antiviral Agents/pharmacology ; Virus Internalization
    Chemical Substances spike protein, SARS-CoV-2 ; Calpain (EC 3.4.22.-) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Spike Glycoprotein, Coronavirus ; Antiviral Agents
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02287-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 Omicron BA.1 Variant Infection of Human Colon Epithelial Cells.

    Antia, Avan / Alvarado, David M / Zeng, Qiru / Casorla-Perez, Luis A / Davis, Deanna L / Sonnek, Naomi M / Ciorba, Matthew A / Ding, Siyuan

    Viruses

    2024  Volume 16, Issue 4

    Abstract: The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022. Studies indicate that Omicron replicates less efficiently in lung tissue compared to the ... ...

    Abstract The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022. Studies indicate that Omicron replicates less efficiently in lung tissue compared to the ancestral strain. However, the infectivity of Omicron in the gastrointestinal tract is not fully defined, despite the fact that 70% of COVID-19 patients experience digestive disease symptoms. Here, using primary human colonoids, we found that, regardless of individual variability, Omicron infects colon cells similarly or less effectively than the ancestral strain or the Delta variant. The variant induced limited type III interferon expression and showed no significant impact on epithelial integrity. Further experiments revealed inefficient cell-to-cell spread and spike protein cleavage in the Omicron spike protein, possibly contributing to its lower infectious particle levels. The findings highlight the variant-specific replication differences in human colonoids, providing insights into the enteric tropism of Omicron and its relevance to long COVID symptoms.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; SARS-CoV-2/pathogenicity ; Colon/virology ; COVID-19/virology ; Epithelial Cells/virology ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/genetics ; Virus Replication ; Interferon Lambda
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Interferon Lambda
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16040634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reply to the Letter to the Editor: Derivation and Internal Validation of a Clinical Prediction Tool to Predict Nonalcoholic Fatty Liver Disease in Patients With Crohn's Disease.

    McHenry, Scott / Ciorba, Matthew A / Deepak, Parakkal

    Inflammatory bowel diseases

    2020  Volume 26, Issue 6, Page(s) e46

    MeSH term(s) Crohn Disease/complications ; Crohn Disease/diagnosis ; Humans ; Non-alcoholic Fatty Liver Disease/diagnosis
    Language English
    Publishing date 2020-02-04
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izaa043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4530: Show issues Location:
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