LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 30

Search options

  1. Book ; Online: Free Radical Research in Cancer

    Čipak Gašparović, Ana / Čipak Gašparović, Ana

    2020  

    Keywords Technology: general issues ; NQO1 ; NQO1*2 ; polymorphism ; quinone ; breast cancer ; menadione ; lapachone ; doxorubicin ; ascorbate ; oxidative stress ; reactive oxygen species ; sperm ; cancer chemotherapy ; antioxidant therapy ; antioxidant proteins ; chemoresistance ; oxaliplatin ; 5-Fluorouracil ; myelodysplastic syndromes ; carbonylation ; deferasirox ; ovary ; calcium channel ; Trolox ; granulosa cell tumor ; cell death ; mitochondria ; photodynamic therapy ; singlet oxygen ; nitric oxide ; light ; combination therapy ; antioxidants ; bleomycin ; cancer treatment ; chemotherapy-induced toxicity ; cisplatin ; free radicals ; methotrexate ; ozone therapy ; lung cancer ; cancer metabolism ; reactive oxygen species (ROS) ; therapy resistance ; new therapeutic strategies ; breast cancer stem cells ; 4-hydroxy-2-nonenal ; extracellular matrix ; NRF2 ; bardoxolone methyl ; prostate cancer ; castration-resistant prostate cancer ; androgen receptor (AR), AR-V7 ; anti-androgen ; enzalutamide ; androgen deprivation therapy ; cancer ; antioxidant ; triphala ; ayurveda ; chemoprevention and chemotherapy ; n/a
    Size 1 electronic resource (192 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021043919
    ISBN 9783039360895 ; 3039360892
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Free Radical Research in Cancer.

    Čipak Gašparović, Ana

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 2

    Abstract: It can be challenging to find efficient therapy for cancer due to its biological diversity [ ... ]. ...

    Abstract It can be challenging to find efficient therapy for cancer due to its biological diversity [...].
    Language English
    Publishing date 2020-02-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9020157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: AQP3 and AQP5-Potential Regulators of Redox Status in Breast Cancer.

    Milković, Lidija / Čipak Gašparović, Ana

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 9

    Abstract: Breast cancer is still one of the leading causes of mortality in the female population. Despite the campaigns for early detection, the improvement in procedures and treatment, drastic improvement in survival rate is omitted. Discovery of aquaporins, at ... ...

    Abstract Breast cancer is still one of the leading causes of mortality in the female population. Despite the campaigns for early detection, the improvement in procedures and treatment, drastic improvement in survival rate is omitted. Discovery of aquaporins, at first described as cellular plumbing system, opened new insights in processes which contribute to cancer cell motility and proliferation. As we discover new pathways activated by aquaporins, the more we realize the complexity of biological processes and the necessity to fully understand the pathways affected by specific aquaporin in order to gain the desired outcome-remission of the disease. Among the 13 human aquaporins, AQP3 and AQP5 were shown to be significantly upregulated in breast cancer indicating their role in the development of this malignancy. Therefore, these two aquaporins will be discussed for their involvement in breast cancer development, regulation of oxidative stress and redox signalling pathways leading to possibly targeting them for new therapies.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Aquaporin 5/genetics ; Aquaporin 5/metabolism ; Biomarkers ; Breast Neoplasms/etiology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Disease Susceptibility ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Multigene Family ; Oxidation-Reduction ; Oxidative Stress
    Chemical Substances AQP3 protein, human ; AQP5 protein, human ; Antioxidants ; Aquaporin 5 ; Biomarkers ; Aquaporin 3 (158801-98-0)
    Language English
    Publishing date 2021-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26092613
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance.

    Milković, Lidija / Mlinarić, Monika / Lučić, Ivan / Čipak Gašparović, Ana

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that ... ...

    Abstract Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. These proteins are not directly responsible for MDR, but they support the survival of cancer cells under stress conditions.
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245747
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Free Radical Research in Cancer

    Čipak Gašparović, Ana

    Antioxidants. 2020 Feb. 15, v. 9, no. 2

    2020  

    Abstract: It can be challenging to find efficient therapy for cancer due to its biological diversity [ ... ] ...

    Abstract It can be challenging to find efficient therapy for cancer due to its biological diversity [...]
    Keywords biodiversity ; free radicals ; neoplasms ; therapeutics
    Language English
    Dates of publication 2020-0215
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9020157
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Role of NRF2 and reactive aldehydes in acute cellular rejection in liver transplant recipients.

    Tomulic Brusich, Katarina / Škrtić, Anita / Sobočan, Nikola / Acan, Ivana / Čipak Gašparović, Ana

    Pathology, research and practice

    2023  Volume 250, Page(s) 154826

    Abstract: Objective: To evaluate the level of oxidative stress and antioxidative response in the transplanted liver and its role in acute cellular rejection (ACR). Particular attention was paid to ACR diagnosis in patients with hepatitis C (HCV), as ... ...

    Abstract Objective: To evaluate the level of oxidative stress and antioxidative response in the transplanted liver and its role in acute cellular rejection (ACR). Particular attention was paid to ACR diagnosis in patients with hepatitis C (HCV), as histopathological features of ACR and viral disease recurrence overlap.
    Methods: This retrospective study included 40 liver transplant patients who underwent liver transplantation with two consecutive liver biopsies performed during one hospitalization period: 1.) initial biopsy of the donor liver (before implantation) and 2.) indication biopsy (after suspected ACR). Based on the etiology, patients were divided into two groups: 22 patients with alcoholic liver cirrhosis (EtOH group) and 18 patients with hepatitis C cirrhosis (HCV group). We analyzed the presence of acrolein, HNE (4-hydroxynonenal), and the major antioxidant transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) in both biopsies.
    Results: The presence of acrolein and HNE in both biopsies indicates increased oxidative stress, while the decrease in these aldehydes in the indication biopsies indicates a decrease in oxidative stress over time, reflecting liver graft recovery. The absence of NRF2 in both biopsies reflects significantly reduced antioxidant protection in patients undergoing liver transplantation.
    Conclusion: The results support the role of oxidative stress in the pathogenesis of ACR. The presence of acrolein and the absence of HNE in the indication biopsy in patients with ACR could contribute to the diagnosis of ACR in clinical practice when functional antibodies are tested in the clinical setting.
    Language English
    Publishing date 2023-09-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2023.154826
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud III Zs.20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Nuclear localization of NRF2 in stroma of HER2 positive and triple-negative breast cancer.

    Orešić, Tomislav / Bubanović, Sanda / Ramić, Snježana / Šarčević, Božena / Čipak Gašparović, Ana

    Pathology, research and practice

    2023  Volume 248, Page(s) 154662

    Abstract: Breast cancer is one of the leading causes of cancer-related mortality in women. During tumor growth, periods of hypoxia are followed by reoxygenation due to neovascularisation leading to disturbed redox homeostasis. ROS (Reactive Oxygen Species) ... ...

    Abstract Breast cancer is one of the leading causes of cancer-related mortality in women. During tumor growth, periods of hypoxia are followed by reoxygenation due to neovascularisation leading to disturbed redox homeostasis. ROS (Reactive Oxygen Species) produced under hypoxia activate HIF1α. ROS can also activate the major antioxidant transcription factor NRF2, but also cause damage to biomolecules. Lipids are susceptible to peroxidation, as evidenced by the formation of reactive aldehydes, among which, HNE (4-hydroxynonenal) is the most studied one. Knowing that HIF1α (Hypoxia Inducing Factor 1α) is associated with breast cancer malignancy, we aimed to investigate its correlation with HNE and NRF2 (Nuclear factor erythroid 2-related factor 2). Our results show that HIF1α is activated in breast cancer, indicating an increase in ROS but not followed by HNE production. On the other hand, NRF2 was increased in all types of breast cancer suggesting that oxidative stress is present in these pathologies, but also supporting HIF1α. Interestingly, NRF2 was activated in HER2 positive and TNBC, indicating the role of stromal NRF2 in breast cancer malignancy.
    MeSH term(s) Humans ; Female ; Triple Negative Breast Neoplasms/pathology ; Reactive Oxygen Species ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Hypoxia
    Chemical Substances Reactive Oxygen Species ; NF-E2-Related Factor 2
    Language English
    Publishing date 2023-07-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2023.154662
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud III Zs.20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Deciphering Common Traits of Breast and Ovarian Cancer Stem Cells and Possible Therapeutic Approaches.

    Lučić, Ivan / Kurtović, Matea / Mlinarić, Monika / Piteša, Nikolina / Čipak Gašparović, Ana / Sabol, Maja / Milković, Lidija

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier ... ...

    Abstract Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier diagnosis of BC, at a stage when the cancer is more likely to respond to therapy, which does not exist for OC, more than 50% of both cancers are diagnosed at an advanced stage. Initial therapy can put the cancer into remission. However, recurrences occur frequently in both BC and OC, which are highly cancer-subtype dependent. Therapy resistance is mainly attributed to a rare subpopulation of cells, named cancer stem cells (CSC) or tumor-initiating cells, as they are capable of self-renewal, tumor initiation, and regrowth of tumor bulk. In this review, we will discuss the distinctive markers and signaling pathways that characterize CSC, their interactions with the tumor microenvironment, and the strategies they employ to evade immune surveillance. Our focus will be on identifying the common features of breast cancer stem cells (BCSC) and ovarian cancer stem cells (OCSC) and suggesting potential therapeutic approaches.
    MeSH term(s) Female ; Humans ; Breast/metabolism ; Breast Neoplasms/metabolism ; Neoplastic Stem Cells/metabolism ; Ovarian Neoplasms/metabolism ; Tumor Microenvironment
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310683
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells.

    Mlinarić, Monika / Lučić, Ivan / Milković, Lidija / da Silva, Inês V / Tartaro Bujak, Ivana / Musani, Vesna / Soveral, Graça / Čipak Gašparović, Ana

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Aquaporin 3 (AQP3) is a peroxiporin, a membrane protein that channels hydrogen peroxide in addition to water and glycerol. AQP3 expression also correlates with tumor progression and malignancy and is, therefore, a potential target in breast cancer ... ...

    Abstract Aquaporin 3 (AQP3) is a peroxiporin, a membrane protein that channels hydrogen peroxide in addition to water and glycerol. AQP3 expression also correlates with tumor progression and malignancy and is, therefore, a potential target in breast cancer therapy. In addition, epithelial growth factor receptor (EGFR) plays an important role in breast cancer. Therefore, we investigated whether disruption of the lipid raft harboring EGFR could affect AQP3 expression, and conversely, whether AQP3 silencing would affect the EGFR/phosphoinositide-3-kinase (PI3K)/Protein kinase B (PKB or Akt) signaling pathway in breast cancer cell lines with different malignant capacities. We evaluated H
    MeSH term(s) Female ; Humans ; Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Epidermal Growth Factor/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
    Chemical Substances AQP3 protein, human ; Aquaporin 3 (158801-98-0) ; Epidermal Growth Factor (62229-50-9) ; ErbB Receptors (EC 2.7.10.1) ; Hydrogen Peroxide (BBX060AN9V) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098133
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer.

    Podolski-Renić, Ana / Čipak Gašparović, Ana / Valente, Andreia / López, Óscar / Bormio Nunes, Julia H / Kowol, Christian R / Heffeter, Petra / Filipović, Nenad R

    European journal of medicinal chemistry

    2024  Volume 270, Page(s) 116363

    Abstract: Overcoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In this respect, Schiff base-related compounds (bearing a ... ...

    Abstract Overcoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In this respect, Schiff base-related compounds (bearing a R
    MeSH term(s) Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Schiff Bases/pharmacology ; Schiff Bases/chemistry ; Drug Resistance, Multiple ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Neoplasms/drug therapy
    Chemical Substances Coordination Complexes ; Schiff Bases ; Antineoplastic Agents
    Language English
    Publishing date 2024-03-29
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116363
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top