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  1. AU="Cipolat, Lauriane"
  2. AU="Rhee, Hwanseok"
  3. AU="El-Khatabi, K"
  4. AU="Lee, Seung Hee"
  5. AU=Torres Antoni
  6. AU="Baldacini, Mathieu"
  7. AU="Stahl, Alexander"
  8. AU="Karimbumkara, Seena Narayanan"
  9. AU="Welz Mirosław"
  10. AU="Jintao Ding"
  11. AU="Mei-Fang Chen"

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  1. Artikel: Symptoms of Infarction in Women: Is There a Real Difference Compared to Men? A Systematic Review of the Literature with Meta-Analysis.

    Cardeillac, Martin / Lefebvre, François / Baicry, Florent / Le Borgne, Pierrick / Gil-Jardiné, Cédric / Cipolat, Lauriane / Peschanski, Nicolas / Abensur Vuillaume, Laure

    Journal of clinical medicine

    2022  Band 11, Heft 5

    Abstract: 1) Context: The management of acute coronary syndrome (ACS) is based on a rapid diagnosis. The aim of this study was to focus on the ACS symptoms differences according to gender, in order to contribute to the improvement of knowledge regarding the ... ...

    Abstract (1) Context: The management of acute coronary syndrome (ACS) is based on a rapid diagnosis. The aim of this study was to focus on the ACS symptoms differences according to gender, in order to contribute to the improvement of knowledge regarding the clinical presentation in women. (2) Methods: We searched for relevant literature in two electronic databases, and analyzed the symptom presentation for patients with suspected ACS. Fifteen prospective studies were included, with a total sample size of 10,730. (3) Results: During a suspected ACS, women present more dyspnea, arm pain, nausea and vomiting, fatigue, palpitations and pain at the shoulder than men, with RR (95%CI) of 1.13 [1.10; 1.17], 1.30 [1.05; 1.59], 1,40 [1.26; 1.56], 1.08 [1.01; 1.16], 1.67 [1.49; 1.86], 1.78 [1.02; 3.13], respectively. They are older by (95%CI) 4.15 [2.28; 6.03] years compared to men. The results are consistent in the analysis of the ACS confirmed subgroup. (4) Conclusions: We have shown that there is a gender-based symptomatic difference and a female presentation for ACS. The "typical" or "atypical" semiology of ACS symptoms should no longer be used.
    Sprache Englisch
    Erscheinungsdatum 2022-02-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11051319
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Exploratory study: Evaluation of a symptom checker effectiveness for providing a diagnosis and evaluating the situation emergency compared to emergency physicians using simulated and standardized patients.

    Abensur Vuillaume, Laure / Turpinier, Julien / Cipolat, Lauriane / Arnaud-Dépil-Duval / Dumontier, Thomas / Peschanski, Nicolas / Kieffer, Yann / Barbat, Boris / Riquier, Thomas / Dinot, Vincent / Galland, Joris

    PloS one

    2023  Band 18, Heft 2, Seite(n) e0277568

    Abstract: Background: The overloading of health care systems is an international problem. In this context, new tools such as symptom checker (SC) are emerging to improve patient orientation and triage. This SC should be rigorously evaluated and we can take a cue ... ...

    Abstract Background: The overloading of health care systems is an international problem. In this context, new tools such as symptom checker (SC) are emerging to improve patient orientation and triage. This SC should be rigorously evaluated and we can take a cue from the way we evaluate medical students, using objective structured clinical examinations (OSCE) with simulated patients.
    Objective: The main objective of this study was to evaluate the efficiency of a symptom checker versus emergency physicians using OSCEs as an assessment method.
    Methods: We explored a method to evaluate the ability to set a diagnosis and evaluate the emergency of a situation with simulation. A panel of medical experts wrote 220 simulated patients cases. Each situation was played twice by an actor trained to the role: once for the SC, then for an emergency physician. Like a teleconsultation, only the patient's voice was accessible. We performed a prospective non-inferiority study. If primary analysis had failed to detect non-inferiority, we have planned a superiority analysis.
    Results: The SC established only 30% of the main diagnosis as the emergency physician found 81% of these. The emergency physician was also superior compared to the SC in the suggestion of secondary diagnosis (92% versus 52%). In the matter of patient triage (vital emergency or not), there is still a medical superiority (96% versus 71%). We prove a non-inferiority of the SC compared to the physician in terms of interviewing time.
    Conclusions and relevance: We should use simulated patients instead of clinical cases in order to evaluate the effectiveness of SCs.
    Mesh-Begriff(e) Humans ; Prospective Studies ; Triage/methods ; Physicians ; Voice ; Remote Consultation
    Sprache Englisch
    Erscheinungsdatum 2023-02-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277568
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Lymphopenia and Early Variation of Lymphocytes to Predict In-Hospital Mortality and Severity in ED Patients with SARS-CoV-2 Infection.

    Simon, Maxence / Le Borgne, Pierrick / Lefevbre, François / Chabrier, Sylvie / Cipolat, Lauriane / Remillon, Aline / Baicry, Florent / Bilbault, Pascal / Lavoignet, Charles-Eric / Abensur Vuillaume, Laure

    Journal of clinical medicine

    2022  Band 11, Heft 7

    Abstract: 1) Introduction: Multiple studies have demonstrated that lymphocyte count monitoring is a valuable prognostic tool for clinicians during inflammation. The aim of our study was to determine the prognostic value of delta lymphocyte H24 from admission from ...

    Abstract (1) Introduction: Multiple studies have demonstrated that lymphocyte count monitoring is a valuable prognostic tool for clinicians during inflammation. The aim of our study was to determine the prognostic value of delta lymphocyte H24 from admission from the emergency department for mortality and severity of SARS-CoV-2 infection. (2) Methods: We have made a retrospective and multicentric study in six major hospitals of northeastern France. The patients were hospitalized and had a confirmed diagnosis of SARS-CoV-2 infection. (3): Results: A total of 1035 patients were included in this study. Factors associated with infection severity were CRP > 100 mg/L (OR: 2.51, CI 95%: (1.40−3.71), p < 0.001) and lymphopenia < 800/mm3 (OR: 2.15, CI 95%: (1.42−3.27), p < 0.001). In multivariate analysis, delta lymphocytes H24 (i.e., the difference between lymphocytes values at H24 and upon admission to the ED) < 135 was one of the most significant biochemical factors associated with mortality (OR: 2.23, CI 95%: (1.23−4.05), p = 0.009). The most accurate threshold for delta lymphocytes H24 was 75 to predict severity and 135 for mortality. (4) Conclusion: Delta lymphocytes H24 could be a helpful early screening prognostic biomarker to predict severity and mortality associated with COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2022-03-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11071803
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Platelet-to-Lymphocyte Ratio (PLR) Is Not a Predicting Marker of Severity but of Mortality in COVID-19 Patients Admitted to the Emergency Department: A Retrospective Multicenter Study.

    Simon, Paul / Le Borgne, Pierrick / Lefevbre, François / Cipolat, Lauriane / Remillon, Aline / Dib, Camille / Hoffmann, Mathieu / Gardeur, Idalie / Sabah, Jonathan / Kepka, Sabrina / Bilbault, Pascal / Lavoignet, Charles-Eric / Abensur Vuillaume, Laure

    Journal of clinical medicine

    2022  Band 11, Heft 16

    Abstract: 1) Introduction: In the present study, we investigate the prognostic value of platelet-to-lymphocyte ratio (PLR) as a marker of severity and mortality in COVID-19 infection. (2) Methods: Between 1 March and 30 April 2020, we conducted a multicenter, ... ...

    Abstract (1) Introduction: In the present study, we investigate the prognostic value of platelet-to-lymphocyte ratio (PLR) as a marker of severity and mortality in COVID-19 infection. (2) Methods: Between 1 March and 30 April 2020, we conducted a multicenter, retrospective cohort study of patients with moderate to severe coronavirus 19 (COVID-19), all of whom were hospitalized after being admitted to the emergency department (ED). (3) Results: A total of 1035 patients were included in our study. Neither lymphocytes, platelets or PLR were associated with disease severity. Lymphocyte count was significantly lower and PLR values were significantly higher in the group of patients who died, and both were associated with mortality in the univariate analysis (OR: 0.524, 95% CI: (0.336−0.815), p = 0.004) and (OR: 1.001, 95% CI: (1.000−1.001), p = 0.042), respectively. However, the only biological parameter significantly associated with mortality in the multivariate analysis was platelet count (OR: 0.996, 95% CI: (0.996−1.000), p = 0.027). The best PLR value for predicting mortality in COVID-19 was 356.6 (OR: 3.793, 95% CI: (1.946−7.394), p < 0.001). (4) Conclusion: A high PLR value is however associated with excess mortality.
    Sprache Englisch
    Erscheinungsdatum 2022-08-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11164903
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection.

    Tonduangu, Ndenga / Le Borgne, Pierrick / Lefebvre, François / Alame, Karine / Bérard, Lise / Gottwalles, Yannick / Cipolat, Lauriane / Gennai, Stéphane / Bilbault, Pascal / Lavoignet, Charles-Eric / Abensur Vuillaume, Laure

    Journal of personalized medicine

    2021  Band 11, Heft 12

    Abstract: 1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on ... ...

    Abstract (1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency department (ED) admission. (2) Methods: Between 1 March and 30 April 2020, we carried out a multicenter and retrospective study in six major hospitals of northeast France. The cohort was composed of patients hospitalized for a confirmed diagnosis of moderate to severe COVID-19. (3) Results: A total of 1,035 patients were included in this study. Factors associated with infection severity were the CLR (OR: 1.001, CI 95%: (1.000-1.002),
    Sprache Englisch
    Erscheinungsdatum 2021-12-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11121274
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Le paracétamol : connaissance, usage et risque de surdosage en patientèle urbaine de médecine générale. Étude prospective descriptive transversale.

    Cipolat, Lauriane / Loeb, Ouriel / Latarche, Clotilde / Pape, Elise / Gillet, Pierre / Petitpain, Nadine

    Therapie

    2017  Band 72, Heft 4, Seite(n) 453–463

    Abstract: Introduction: Acetaminophen is the most involved active substance in both unintentional and intentional drug poisoning. However, its availability outside community pharmacies is being debated in France.: Methods: We made, via a self-administered ... ...

    Titelübersetzung Acetaminophen: Knowledge, use and overdose risk in urban patients consulting their general practitioner. A prospective, descriptive and transversal study.
    Abstract Introduction: Acetaminophen is the most involved active substance in both unintentional and intentional drug poisoning. However, its availability outside community pharmacies is being debated in France.
    Methods: We made, via a self-administered questionnaire, a prospective assessment of knowledge, use and acetaminophen overdose risk in patients consulting their general practitioner, in the Metz Métropole urban area, between May 2015 and February 2016. We estimated the prevalence of potential unintentional overdosage by capture-recapture method.
    Results: Among 819 responding patients, only 17.9 % had a sufficient knowledge and 20.3 % were at risk for potential unintentional overdose. The risk was higher for patients aged over 55 years or belonging to socioprofessional categories of laborers and inactive. A good knowledge score was a protective factor for overdose risk (P<0.0001). The liver toxicity of acetaminophen was particularly unknown. The prevalence of potential unintentional acetaminophen overdose was estimated at 1 to2 % of the population.
    Conclusion: Proposing acetaminophen outside of pharmacies cannot be recommended in France in such conditions. Information campaigns are needed to limit the risk of unintentional overdose and its consequences on liver toxicity.
    Sprache Französisch
    Erscheinungsdatum 2017-09
    Erscheinungsland France
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2016.12.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Neutrophil-to-Lymphocyte Ratio and Early Variation of NLR to Predict In-Hospital Mortality and Severity in ED Patients with SARS-CoV-2 Infection.

    Abensur Vuillaume, Laure / Le Borgne, Pierrick / Alamé, Karine / Lefebvre, François / Bérard, Lise / Delmas, Nicolas / Cipolat, Lauriane / Gennai, Stéphane / Bilbault, Pascal / Lavoignet, Charles-Eric / On Behalf Of The Crems Network Clinical Research In Emergency Medicine And Sepsis

    Journal of clinical medicine

    2021  Band 10, Heft 12

    Abstract: 1) Introduction: The neutrophil-to lymphocyte ratio is valued as a predictive marker in several inflammatory diseases. For example, an increasing NLR is a risk factor of mortality in sepsis. It also appears to be helpful in other settings such as cancer. ...

    Abstract (1) Introduction: The neutrophil-to lymphocyte ratio is valued as a predictive marker in several inflammatory diseases. For example, an increasing NLR is a risk factor of mortality in sepsis. It also appears to be helpful in other settings such as cancer. The aim of our work was to study the prognostic value of NLR for disease severity and mortality in patients infected with SARS-CoV-2 upon their admission to the Emergency Department (ED) and its early variation (ΔNLR) in the first 24 h of management (H-24). (2) Methods: Between 1 March and 30 April 2020, we conducted a multicenter and retrospective cohort study of patients with moderate or severe coronavirus disease 19 (COVID-19), who were all hospitalized after presenting to the ED. (3) Results: A total of 1035 patients were included in our study. Factors associated with infection severity were C-reactive protein level (OR: 1.007, CI 95%: [1.005-1.010],
    Sprache Englisch
    Erscheinungsdatum 2021-06-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10122563
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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