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  1. Article ; Online: Clinical Relevance and Interplay between miRNAs in Influencing Glioblastoma Multiforme Prognosis.

    Epistolio, Samantha / Dazio, Giulia / Zaed, Ismail / Sahnane, Nora / Cipriani, Debora / Polinelli, Francesco / Barizzi, Jessica / Spina, Paolo / Stefanini, Federico Mattia / Cerati, Michele / Balbi, Sergio / Mazzucchelli, Luca / Sessa, Fausto / Pesce, Gianfranco Angelo / Reinert, Michael / Cardia, Andrea / Marchi, Francesco / Frattini, Milo

    Cells

    2024  Volume 13, Issue 3

    Abstract: Glioblastoma multiforme (GBM) is usually treated with surgery followed by adjuvant partial radiotherapy combined with temozolomide (TMZ) chemotherapy. Recent studies demonstrated a better survival and good response to TMZ in methylguanine-DNA ... ...

    Abstract Glioblastoma multiforme (GBM) is usually treated with surgery followed by adjuvant partial radiotherapy combined with temozolomide (TMZ) chemotherapy. Recent studies demonstrated a better survival and good response to TMZ in methylguanine-DNA methyltransferase (
    MeSH term(s) Humans ; Glioblastoma/metabolism ; MicroRNAs/metabolism ; Dacarbazine/therapeutic use ; Clinical Relevance ; Temozolomide/pharmacology ; Temozolomide/therapeutic use
    Chemical Substances MicroRNAs ; Dacarbazine (7GR28W0FJI) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13030276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Surgical closure of spinal cerebrospinal fluid leaks improves symptoms in patients with superficial siderosis.

    El Rahal, Amir / Haupt, Benedikt / Fung, Christian / Cipriani, Debora / Häni, Levin / Lützen, Niklas / Dobrocky, Tomas / Piechowiak, Eike / Schnell, Oliver / Raabe, Andreas / Wolf, Katharina / Urbach, Horst / Kraus, Luisa Mona / Volz, Florian / Beck, Jürgen

    European journal of neurology

    2023  Volume 31, Issue 3, Page(s) e16122

    Abstract: Background and purpose: Spinal cerebrospinal fluid (CSF) leaks may cause a myriad of symptoms, most common being orthostatic headache. In addition, ventral spinal CSF leaks are a possible etiology of superficial siderosis (SS), a rare condition ... ...

    Abstract Background and purpose: Spinal cerebrospinal fluid (CSF) leaks may cause a myriad of symptoms, most common being orthostatic headache. In addition, ventral spinal CSF leaks are a possible etiology of superficial siderosis (SS), a rare condition characterized by hemosiderin deposits in the central nervous system (CNS). The classical presentation of SS involves ataxia, bilateral hearing loss, and myelopathy. Unfortunately, treatment options are scarce. This study was undertaken to evaluate whether microsurgical closure of CSF leaks can prevent further clinical deterioration or improve symptoms of SS.
    Methods: This cohort study was conducted using data from a prospectively maintained database in two large spontaneous intracranial hypotension (SIH) referral centers in Germany and Switzerland of patients who meet the modified International Classification of Headache Disorders, 3rd edition criteria for SIH. Patients with spinal CSF leaks were screened for the presence of idiopathic infratentorial symmetric SS of the CNS.
    Results: Twelve patients were included. The median latency between the onset of orthostatic headaches and symptoms attributed to SS was 9.5 years. After surgical closure of the underlying spinal CSF leak, symptoms attributed to SS improved in seven patients and remained stable in three. Patients who presented within 1 year after the onset of SS symptoms improved, but those who presented in 8-12 years did not improve. We could show a significant association between patients with spinal longitudinal extrathecal collections and SS.
    Conclusions: Long-standing untreated ventral spinal CSF leaks can lead to SS of the CNS, and microsurgical sealing of spinal CSF leaks might stop progression and improve symptoms in patients with SS in a time-dependent manner.
    MeSH term(s) Humans ; Siderosis/complications ; Siderosis/surgery ; Cohort Studies ; Cerebrospinal Fluid Leak/surgery ; Cerebrospinal Fluid Leak/complications ; Intracranial Hypotension/etiology ; Intracranial Hypotension/surgery ; Intracranial Hypotension/diagnosis ; Central Nervous System ; Headache/etiology ; Headache/surgery
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16122
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4738: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 592: Show issues

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  3. Article ; Online: Cerebral Abscess Caused by Listeria monocytogenes: Case Report and Literature Review.

    Cipriani, Debora / Trippel, Michael / Buttler, Klaus-Jürgen / Rohr, Eva / Wagner, Dirk / Beck, Jürgen / Schnell, Oliver

    Journal of neurological surgery. Part A, Central European neurosurgery

    2021  Volume 83, Issue 2, Page(s) 194–205

    Abstract: Background:  : Case presentation:  We describe the case of a 69-year-old homeless patient with a brain abscess due to : Conclusions:  This case highlights the need to drain cerebral abscesses and culture pus to correctly treat patients with ... ...

    Abstract Background:  
    Case presentation:  We describe the case of a 69-year-old homeless patient with a brain abscess due to
    Conclusions:  This case highlights the need to drain cerebral abscesses and culture pus to correctly treat patients with antibiotics, especially given the high mortality rate of this infectious entity.
    MeSH term(s) Aged ; Ampicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Brain Abscess/diagnostic imaging ; Brain Abscess/drug therapy ; Brain Abscess/surgery ; Drainage/adverse effects ; Humans ; Listeria monocytogenes
    Chemical Substances Anti-Bacterial Agents ; Ampicillin (7C782967RD)
    Language English
    Publishing date 2021-09-08
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2651663-9
    ISSN 2193-6323 ; 2193-6315
    ISSN (online) 2193-6323
    ISSN 2193-6315
    DOI 10.1055/s-0041-1729174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.130: Show issues Location:
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  4. Article: Identification of MGMT Downregulation Induced by miRNA in Glioblastoma and Possible Effect on Temozolomide Sensitivity.

    Cardia, Andrea / Epistolio, Samantha / Zaed, Ismail / Sahnane, Nora / Cerutti, Roberta / Cipriani, Debora / Barizzi, Jessica / Spina, Paolo / Stefanini, Federico Mattia / Cerati, Michele / Balbi, Sergio / Mazzucchelli, Luca / Sessa, Fausto / Pesce, Gianfranco Angelo / Reinert, Michael / Frattini, Milo / Marchi, Francesco

    Journal of clinical medicine

    2023  Volume 12, Issue 5

    Abstract: Glioblastoma multiforme (GBM) remains one of the tumors with the worst prognosis. In recent years, a better overall survival (OS) has been described in cases subjected to Gross Total Resection (GTR) that were presenting hypermethylation of Methylguanine- ... ...

    Abstract Glioblastoma multiforme (GBM) remains one of the tumors with the worst prognosis. In recent years, a better overall survival (OS) has been described in cases subjected to Gross Total Resection (GTR) that were presenting hypermethylation of Methylguanine-DNA methyltransferase (MGMT) promoter. Recently, also the expression of specific miRNAs involved in MGMT silencing has been related to survival. In this study, we evaluate MGMT expression by immunohistochemistry (IHC), MGMT promoter methylation and miRNA expression in 112 GBMs and correlate the data to patients' clinical outcomes. Statistical analyses demonstrate a significant association between positive MGMT IHC and the expression of miR-181c, miR-195, miR-648 and miR-767.3p between unmethylated cases and the low expression of miR-181d and miR-648 and between methylated cases and the low expression of miR-196b. Addressing the concerns of clinical associations, a better OS has been described in presence of negative MGMT IHC, in methylated patients and in the cases with miR-21, miR-196b overexpression or miR-767.3 downregulation. In addition, a better progression-free survival (PFS) is associated with MGMT methylation and GTR but not with MGMT IHC and miRNA expression. In conclusion, our data reinforce the clinical relevance of miRNA expression as an additional marker to predict efficacy of chemoradiation in GBM.
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12052061
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  5. Article: Hydrocephalus Shunting in Supratentorial Glioblastoma: Functional Outcomes and Management.

    El Rahal, Amir / Cipriani, Debora / Fung, Christian / Hohenhaus, Marc / Sveikata, Lukas / Straehle, Jakob / Shah, Mukesch Johannes / Heiland, Henrik Dieter / Beck, Jürgen / Schnell, Oliver

    Frontiers in oncology

    2022  Volume 12, Page(s) 796105

    Abstract: Background: Glioblastoma is the most common and the most challenging to treat adult primary central nervous system tumor. Although modern management strategies modestly improved the overall survival, the prognosis remains dismal associated with poor ... ...

    Abstract Background: Glioblastoma is the most common and the most challenging to treat adult primary central nervous system tumor. Although modern management strategies modestly improved the overall survival, the prognosis remains dismal associated with poor life quality and the clinical course often dotted by treatment side effects and cognitive decline. Functional deterioration might be caused by obstructive or communicating hydrocephalus but due to poor overall prognosis surgical treatment options are often limited and its optimal management strategies remain elusive. We aimed to investigate risk factors, treatment options and outcomes for tumor-associated hydrocephalus in a contemporary 10 years cohort of glioblastoma patients.
    Methods: We reviewed electronic health records of 1800 glioblastoma patients operated at the Department of Neurosurgery, Medical Center - University of Freiburg from 2009 to 2019. Demographics, clinical characteristics and radiological features were analyzed. Univariate analysis for nominal variables was performed either by Fisher's exact test or Chi-square test, as appropriate.
    Results: We identified 39 glioblastoma patients with symptomatic communicating hydrocephalus treated by ventricular shunting (incidence 2.1%). Opening of the ventricular system during a previous tumor resection was associated with symptomatic hydrocephalus (p<0.05). There was also a trend toward location (frontal and temporal) and larger tumor volume. Number of craniotomies before shunting was not considered as a risk factor. Shunting improved hydrocephalus symptoms in 95% of the patients and Karnofsky Performance Score (KPS) could be restored after shunting. Of note, 75% of the patients had a post-shunting oncological treatment such as radiotherapy or chemotherapy, most prevalently chemotherapy. Infection (7.7%) and over- or under drainage (17.9%) were the most common complications requiring shunt revision in ten patients (25.6%), No peritoneal metastasis was found. The median overall survival (OS) was 385 days and the median post shunting survival was 135 days.
    Conclusion: Ventricular system opening was identified as a risk factor for communicating hydrocephalus in glioblastoma patients. Although glioblastoma treatment remains challenging, shunting improved hydrocephalus-related functional status and may be considered even in a palliative setting for symptom relief.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.796105
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  6. Article ; Online: Postural changes in optic nerve and optic nerve sheath diameters in postural orthostatic tachycardia syndrome and spontaneous intracranial hypotension: A cohort study.

    Cipriani, Debora / Rodriguez, Belén / Häni, Levin / Zimmermann, Raya / Fichtner, Jens / Ulrich, Christian T / Raabe, Andreas / Beck, Jürgen / Z'Graggen, Werner J

    PloS one

    2019  Volume 14, Issue 10, Page(s) e0223484

    Abstract: Background: Postural orthostatic tachycardia syndrome is a disorder of the autonomic nervous system. Approximately 30% of patients experience orthostatic headaches. Orthostatic headaches also are a hallmark symptom in spontaneous intracranial ... ...

    Abstract Background: Postural orthostatic tachycardia syndrome is a disorder of the autonomic nervous system. Approximately 30% of patients experience orthostatic headaches. Orthostatic headaches also are a hallmark symptom in spontaneous intracranial hypotension. While the cause of orthostatic headaches in spontaneous intracranial hypotension can be linked to the cerebrospinal fluid loss at the spinal level and consecutively reduced intracranial pressure in the upright position, the cause of orthostatic headaches in postural orthostatic tachycardia syndrome still remains unknown. The present study examined orthostatic changes of intracranial pressure using dynamic ultrasound of the optic nerve and optic nerve sheath diameter in postural orthostatic tachycardia syndrome, spontaneous intracranial hypotension and healthy subjects.
    Methods: Data was obtained from postural orthostatic tachycardia syndrome patients with (n = 7) and without orthostatic headaches (n = 7), spontaneous intracranial hypotension patients (n = 5) and healthy subjects (n = 8). All participants underwent high-resolution transorbital ultrasound in the supine and upright position to assess optic nerve and optic nerve sheath diameter.
    Results: Group differences were found in percentage deviations when changing position of optic nerve sheath diameter (p < 0.01), but not regarding the optic nerve diameter. Pairwise comparisons indicated differences in optic nerve sheath diameter only between spontaneous intracranial hypotension and the other groups. No differences were found between postural orthostatic tachycardia syndrome patients with and without orthostatic headaches.
    Conclusion: This study shows that the size of the optic nerve sheath diameter dynamically decreases during orthostatic stress in spontaneous intracranial hypotension, but not in postural orthostatic tachycardia syndrome with or without orthostatic headaches, which indicates different underlying causes.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Intracranial Hypertension/complications ; Intracranial Hypertension/diagnostic imaging ; Male ; Middle Aged ; Optic Nerve/diagnostic imaging ; Postural Orthostatic Tachycardia Syndrome/complications ; Postural Orthostatic Tachycardia Syndrome/diagnostic imaging ; Posture ; Ultrasonography
    Language English
    Publishing date 2019-10-09
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0223484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Conference proceedings: Hydrocephalus in supratentorial glioblastoma – risk factors, indications and outcome

    El Rahal, Amir / Cipriani, Debora / Hohenhaus, Marc / Shah, Mukesch Johannes / Heiland, Dieter Henrik / Fung, Christian / Beck, Jürgen / Schnell, Oliver

    2021  , Page(s) P134

    Title translation Hydrocephalus bei supratentoriellen Glioblastomen – Risikofaktoren, Indikationen und Outcome
    Event/congress 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-06-04
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dgnc422
    Database German Medical Science

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  8. Article: Cerebral Abscess Caused by Listeria monocytogenes: Case Report and Literature Review

    Cipriani, Debora / Trippel, Michael / Buttler, Klaus-Jürgen / Rohr, Eva / Wagner, Dirk / Beck, Jürgen / Schnell, Oliver

    Journal of Neurological Surgery Part A: Central European Neurosurgery

    2021  Volume 83, Issue 02, Page(s) 194–205

    Abstract: Background: Listeria monocytogenes is an opportunistic gram-positive, facultative intracellular bacterium that causes invasive diseases mostly in pregnant women and immunosuppressed patients. Despite the predilection toward the central nervous system ( ... ...

    Abstract Background: Listeria monocytogenes is an opportunistic gram-positive, facultative intracellular bacterium that causes invasive diseases mostly in pregnant women and immunosuppressed patients. Despite the predilection toward the central nervous system (CNS), it usually causes meningitis and meningoencephalitis, whereas brain abscesses are very uncommon.
    Case presentation: We describe the case of a 69-year-old homeless patient with a brain abscess due to L. monocytogenes who was successfully treated surgically by a guided stereotactic aspiration and antibiotic therapy with ampicillin and gentamicin. Our patient was discharged after 4 weeks of therapy without neurologic deficits. Additionally, we provide a review of the literature of brain abscesses caused by L. monocytogenes
    Conclusions: This case highlights the need to drain cerebral abscesses and culture pus to correctly treat patients with antibiotics, especially given the high mortality rate of this infectious entity.
    Keywords brain abscess ; meningitis ; immunocompromised
    Language English
    Publishing date 2021-09-08
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2651663-9
    ISSN 2193-6323 ; 2193-6315
    ISSN (online) 2193-6323
    ISSN 2193-6315
    DOI 10.1055/s-0041-1729174
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.130: Show issues Location:
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  9. Conference proceedings: Electrophysiological mapping revealed spatial and temporal heterogeneity of cell-communication in glioblastoma multiforme

    Cipriani, Debora / Franco, Pamela / Joseph, Kevin / Beck, Jürgen / Schnell, Oliver / Heiland, Dieter Henrik

    2019  , Page(s) V257

    Title translation Elektrophysiologische Kartierung offenbarte räumliche und zeitliche Heterogenität der Zellkommunikation bei Glioblastoma multiforme
    Event/congress 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie; Würzburg; Deutsche Gesellschaft für Neurochirurgie; 2019
    Keywords Medizin, Gesundheit
    Publishing date 2019-05-08
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19dgnc276
    Database German Medical Science

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  10. Conference proceedings: Treatment of ventral spinal CSF leaks improves symptoms in patients with superficial siderosis

    Haupt, Benedikt / Fung, Christian / Cipriani, Debora / Häni, Levin / Lützen, Niklas / Dobrocky, Tomas / Raabe, Andreas / Kraus, Luisa / Beck, Jürgen / El Rahal, Amir

    2022  , Page(s) P148

    Title translation Behandlung von ventralen Liquorlecks führt zu einer Verbesserung der Symptome bei Patienten mit Superfizieller Siderose
    Event/congress 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-05-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dgnc461
    Database German Medical Science

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