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Article ; Online: Evaluation of serum placenta-specific gene 8 protein, total antioxidant capacity, interleukin-10, interleukin-17A, interleukin-21 and interleukin-33 levels in Turkish women with gestational diabetes mellitus.

Ciraci, Enver / Elgun, Tugba / Gok Yurttas, Asiye / Cagin Kuzey, Hazel / Ekenoglu Merdan, Yagmur / Sait Toprak, Muhammed / Tetik, Sermin

Endocrinologia, diabetes y nutricion

2024 Volume 71, Issue 1, Page(s) 12–18

Abstract: Purpose: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that begins or is diagnosed during pregnancy. Our study aimed to establish a correlation between proinflammatory and anti-inflammatory response in order to be able to ... ...

Abstract	Purpose: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that begins or is diagnosed during pregnancy. Our study aimed to establish a correlation between proinflammatory and anti-inflammatory response in order to be able to develop treatment strategies and determine early diagnosis biomarkers in the sera of cases diagnosed with GDM. Moreover, we aimed to investigate interleukin (IL), placenta-specific gene 8 protein (PLAC8) and total antioxidant capacity (TAC) in patients with GDM. Methods: A total of 121 patients were included in the study. These were divided into four patient groups: pregnant and diagnosed with DM (P-GDM, n=30); pregnant and not diagnosed with DM (P-NGDM, n=32); non-pregnant diagnosed with DM (NP-DM, n=29) and non-pregnant and not diagnosed with DM (NPNDM, n=30). IL-10, IL-17A, IL-21, IL-33, PLAC8 and TAC determinations from patients were evaluated by ELISA (Enzyme-Linked ImmunoSorbent Assay) method. Results: IL-10 and IL-33 concentrations were found to be significantly higher in P-GDM and NP-DM patient groups compared to P-NGDM and NP-NDM groups (p<0.001). The PLAC8 level in the P-GDM patient group (20.38±5.37) was determined to be significantly higher than in the P-NGDM patient group (3.41±2.17, p<0.001). TAC in the P-NGDM and NP-NDM groups (12.42±2.31 vs. 12.96±3.78, p<0.001) was determined to be significantly higher than in the P-GDM and NP-DM groups (4.8±0.52 vs. 2.21±0.71, p<0.001). Discussion: The fact that the importance of PLAC8 level and TAC in the diagnosis and follow-up of GDM in pregnancy is demonstrated for the first time in this study shows that it is unique.
MeSH term(s)	Pregnancy ; Humans ; Female ; Diabetes, Gestational ; Interleukin-17 ; Interleukin-10 ; Interleukin-33 ; Antioxidants ; Interleukins ; Proteins
Chemical Substances	interleukin-21 (MKM3CA6LT1) ; Interleukin-17 ; Interleukin-10 (130068-27-8) ; Interleukin-33 ; Antioxidants ; Interleukins ; PLAC8 protein, human ; Proteins
Language	English
Publishing date	2024-02-01
Publishing country	Spain
Document type	Journal Article
ISSN	2530-0180
ISSN (online)	2530-0180
DOI	10.1016/j.endien.2024.02.002
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Article ; Online: Acute acalculous cholecystitis as an early manifestation of COVID-19: case report and literature review.

D'Introno, Alessia / Gatti, Pietro / Manca, Giuseppe / D'Amuri, Alessandro / Minniti, Salvatore / Ciracì, Emanuela

Acta bio-medica : Atenei Parmensis

2022 Volume 93, Issue S1, Page(s) e2022207

Abstract: Background: The novel coronavirus disease 2019 (COVID-19) has rapidly spread worldwide since the outbreak in Wuhan, China, in 2019, becoming a major threat to public health. The most common symptoms are fever, dry cough, shortness of breath, but subjects ...

Abstract	Background: The novel coronavirus disease 2019 (COVID-19) has rapidly spread worldwide since the outbreak in Wuhan, China, in 2019, becoming a major threat to public health. The most common symptoms are fever, dry cough, shortness of breath, but subjects with COVID-19 may also manifest gastrointestinal symptoms, and in a few cases an involvement of the gallbladder has been observed. Case report: Here we present a case of 50-year-old male with SARS-CoV-2 infection who had abdominal pain, vomiting and diarrhea without respiratory symptoms and was finally diagnosed as acute acalculous cholecystitis (AAC). Laparoscopic cholecystectomy was performed and found a gangrenous gallbladder; the real-time reverse transcription polymerase chain reaction SARS-CoV-2 nucleic acid assay of the bile was negative. We also made a review of the literature and try to understand the hypothetic role of SARS-CoV-2 in the pathogenesis of AAC. Conclusions: We highlighted that it is noteworthy to look at gastrointestinal symptoms in patients with SARS-CoV-2 infection and take into account AAC as a possible complication of COVID-19. Although more evidence is needed to better elucidate the role of the pathogenic mechanisms of the SARS-CoV-2 in AAC, it is conceivable that the hepatobiliary system could be a potential target of SARS-CoV-2.
MeSH term(s)	Acalculous Cholecystitis/diagnosis ; Acalculous Cholecystitis/etiology ; COVID-19/complications ; Cholecystectomy, Laparoscopic ; Humans ; Male ; Middle Aged ; Public Health ; SARS-CoV-2
Language	English
Publishing date	2022-06-29
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v93iS1.12760
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Article ; Online: Ultrasound-guided percutaneous irreversible electroporation of hepatic and abdominal tumors not eligible for surgery or thermal ablation: a western report on safety and efficacy.

Giorgio, A / Amendola, F / Calvanese, A / Ingenito, E / Santoro, B / Gatti, P / Ciracì, E / Matteucci, P / Giorgio, V

Journal of ultrasound

2019 Volume 22, Issue 1, Page(s) 53–58

Abstract: Purpose: To report our first results on sixteen patients affected by liver and abdominal malignant tumors, unfit for surgery or thermal ablation, treated with US-guided percutaneous irreversible electroporation (IRE).: Methods: From June 2014 to ... ...

Abstract	Purpose: To report our first results on sixteen patients affected by liver and abdominal malignant tumors, unfit for surgery or thermal ablation, treated with US-guided percutaneous irreversible electroporation (IRE). Methods: From June 2014 to December 2016, all patients meeting the inclusion criteria (malignant hepatic or abdominal tumors not eligible for resection or thermal ablation) and not meeting the exclusion criteria (heart arrhythmia, pro-hemorrhagic hematological alterations, tumor size > 8 cm, presence of a biliary metallic stent) referred to our institutions were prospectively enrolled to undergo percutaneous US-guided irreversible electroporation (IRE). Sixteen patients (age range 59-68 years, mean 63; 7 females) with 18 tumors (diameter range 1.3-7.5 cm) fulfilled the inclusion criteria and were included in the study. Data concerning efficacy (tested by a 1-week CEUS and a 4-week enhanced CT and/or enhanced MRI) and safety were recorded during a 18-month follow up. Results: All patients completed a 35-50-min procedure without complications. One patient with 6 cm Klatskin tumor also underwent a second session for 1 month. A 1-week CEUS and a 4-week e-CT and/or e-MRI arterial phase contrast enhancement analysis showed an overall reduction of arterial flow with confirmation of unenhanced lesions for seven nodules. After 1-18 months of follow up, no major complications were recorded and no tumor-related death occurred. The lesions of two patients disappeared 3 and 6 months after their treatment, respectively. Conclusions: IRE is a promising ablation modality in the treatment of malignant hepatic and abdominal tumors unsuitable for resection or thermal ablation.
MeSH term(s)	Abdominal Neoplasms/diagnostic imaging ; Abdominal Neoplasms/therapy ; Aged ; Electroporation ; Female ; Follow-Up Studies ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome ; Tumor Burden ; Ultrasonography, Interventional
Language	English
Publishing date	2019-03-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-019-00372-7
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Article ; Online: Melt rates in the kilometer-size grounding zone of Petermann Glacier, Greenland, before and during a retreat.

Ciracì, Enrico / Rignot, Eric / Scheuchl, Bernd / Tolpekin, Valentyn / Wollersheim, Michael / An, Lu / Milillo, Pietro / Bueso-Bello, Jose-Luis / Rizzoli, Paola / Dini, Luigi

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 20, Page(s) e2220924120

Abstract: Warming of the ocean waters surrounding Greenland plays a major role in driving glacier retreat and the contribution of glaciers to sea level rise. The melt rate at the junction of the ocean with grounded ice-or grounding line-is, however, not well known. ...

Abstract	Warming of the ocean waters surrounding Greenland plays a major role in driving glacier retreat and the contribution of glaciers to sea level rise. The melt rate at the junction of the ocean with grounded ice-or grounding line-is, however, not well known. Here, we employ a time series of satellite radar interferometry data from the German TanDEM-X mission, the Italian COSMO-SkyMed constellation, and the Finnish ICEYE constellation to document the grounding line migration and basal melt rates of Petermann Glacier, a major marine-based glacier of Northwest Greenland. We find that the grounding line migrates at tidal frequencies over a kilometer-wide (2 to 6 km) grounding zone, which is one order of magnitude larger than expected for grounding lines on a rigid bed. The highest ice shelf melt rates are recorded within the grounding zone with values from 60 ± 13 to 80 ± 15 m/y along laterally confined channels. As the grounding line retreated by 3.8 km in 2016 to 2022, it carved a cavity about 204 m in height where melt rates increased from 40 ± 11 m/y in 2016 to 2019 to 60 ± 15 m/y in 2020 to 2021. In 2022, the cavity remained open during the entire tidal cycle. Such high melt rates concentrated in kilometer-wide grounding zones contrast with the traditional plume model of grounding line melt which predicts zero melt. High rates of simulated basal melting in grounded glacier ice in numerical models will increase the glacier sensitivity to ocean warming and potentially double projections of sea level rise.
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2220924120
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Article ; Online: Treatment of Hydatid Liver Cyst With Double Percutaneous Aspiration and Ethanol Injection Under Ultrasound Guidance: 6.5-Year Median Follow-up Analysis.

Giorgio, Antonio / De Luca, Massimo / Gatti, Pietro / Ciraci', Emanuela / Montesarchio, Luca / Santoro, Bruno / Di Sarno, Antonella / Coppola, Carmine / Giorgio, Valentina

Cardiovascular and interventional radiology

2021 Volume 44, Issue 8, Page(s) 1214–1222

Abstract: Purpose: Although hydatid liver cyst (HLC) is a benign disease, treatment is recommended to avoid life-threatening complications. There are several treatment options for HLC: "wait-and-watch," medical or surgical or percutaneous treatment. The purpose ... ...

Abstract	Purpose: Although hydatid liver cyst (HLC) is a benign disease, treatment is recommended to avoid life-threatening complications. There are several treatment options for HLC: "wait-and-watch," medical or surgical or percutaneous treatment. The purpose of this study was to assess the long-term effectiveness of an alternative of the traditional percutaneous PAIR procedure, called double percutaneous aspiration and ethanol injection (D-PAI). Materials and methods: This prospective, non-randomized study was conducted from 1988 to 2019 using DPAI procedure characterized by no reaspiration of the ethanol injected to replace the aspirated fluid and repetition of the procedure after 3-7 days. Results: Two hundred and three patients with 290 HLCs underwent D-PAI. Two hundred and two HLC (160 patients) were univesicular cysts and 88 (43 patient) were multivesicular. Seventeen patients underwent one D-PAI session, 15 patients two sessions, and 18 up to four sessions. The follow-up ranged 0.9-21 years (median 6.5 years). On ultrasound, 188 cysts (64.8%) disappeared; 57 cysts (19.7%) became solid (inactive) and 45 (15.5%) showed a small inactive residual component. Parasitologic cure was very high. The overall response to D-PAI was higher than 90% considering also the procedures carried out after the first D-PAI at the time of recurrence. One patient died for anaphylactic shock. The hospital stay ranged 1-3 days. Smaller cysts (< 5 cm) healed sooner than larger cysts (p < 0.001). Conclusions: Long-term analysis showed that D-PAI is a safe and effective option in percutaneous treatment of viable HLC, except for CE2/CE3b in which the recurrences can be observed. This inexpensive and simple procedure can be applied everywhere and especially in developing countries.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Echinococcosis, Hepatic/drug therapy ; Echinococcosis, Hepatic/surgery ; Ethanol/administration & dosage ; Follow-Up Studies ; Humans ; Injections, Intralesional ; Length of Stay ; Liver/surgery ; Male ; Middle Aged ; Prospective Studies ; Suction/methods ; Treatment Outcome ; Ultrasonography, Interventional/methods ; Young Adult
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2021-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-021-02839-9
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Article ; Online: Retraction notice to "Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells" [Int. J. Biochem. Cell Biol. 43 (2011) 775-783].

Martino, Sabat / Tiribuzi, Roberto / Ciraci, Elisa / Makrypidi, Georgia / D'Angelo, Francesco / di Girolamo, Ilaria / Gritti, Angela / de Angelis, Gabriella M Cusella / Papaccio, Gianpaolo / Sampaolesi, Maurilio / Berardi, Anna Concetta / Datti, Alessandro / Orlacchio, Aldo

The international journal of biochemistry & cell biology

2022 Volume 147, Page(s) 106223

Language	English
Publishing date	2022-05-18
Publishing country	Netherlands
Document type	Journal Article ; Retraction of Publication
ZDB-ID	1228429-4
ISSN	1878-5875 ; 1357-2725
ISSN (online)	1878-5875
ISSN	1357-2725
DOI	10.1016/j.biocel.2022.106223
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Article ; Online: Hepatocellular carcinoma tumor thrombus entering the inferior vena cava treated with percutaneous RF ablation: a case report.

Gatti, Pietro / Giorgio, Antonio / Ciracì, Emanuela / Roberto, Italia / Anglani, Alessandro / Sergio, Spano / Rizzello, Fernando / Giorgio, Valentina / Semeraro, Stefano

Journal of ultrasound

2019 Volume 22, Issue 3, Page(s) 363–370

Abstract: Purpose: Hepatocellular carcinoma (HCC) is the most common form of liver cancer. In advanced cancer stages (metastatic disease and/or vascular invasion), the generally accepted standard of care is systemic therapy using sorafenib as first-line treatment ...

Abstract	Purpose: Hepatocellular carcinoma (HCC) is the most common form of liver cancer. In advanced cancer stages (metastatic disease and/or vascular invasion), the generally accepted standard of care is systemic therapy using sorafenib as first-line treatment and, recently, regorafenib and nivolumab as second-line treatment, but the quality of life and the prognosis of patients remain very poor. Our paper reports a case of US-guided radiofrequency ablation (RFA) of both intraparenchymal HCC and inferior vena cava tumor thrombus. Methods: We treated a patient with HCC associated with tumor thrombus extending into vena cava after failure of sorafenib therapy using US-guided radiofrequency ablation (RFA). Results: A good radiological and clinical response was observed in association with excellent tolerability. The patient has been followed up for 15 months from the ablation, is alive, and is in a good clinical condition without evidence of tumor recurrence. Conclusion: This is the first case in which this minimally invasive percutaneous procedure has been successfully used to treat an HCC thrombus entering the vena cava.
MeSH term(s)	Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/surgery ; Humans ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Neoplastic Cells, Circulating ; Radiofrequency Ablation/methods ; Surgery, Computer-Assisted ; Ultrasonography, Interventional ; Vena Cava, Inferior
Keywords	covid19
Language	English
Publishing date	2019-03-12
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-019-00361-w
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Book ; Online: A case study of mesospheric planetary waves observed over a three-radar network using empirical mode decomposition

Kishore, Pangaluru / Velicogna, Isabella / Sutterley, Tyler C. / Mohajerani, Yara / Ciracì, Enrico / Madhavi, Gummadipudi Nagasai

eISSN: 1432-0576

2019

Abstract: In this paper an attempt is made to study equatorial Kelvin waves using a network of three radars: Kototabang (0.204 ∘ S, 100.320 ∘ E) meteor radar, Pameungpeuk (7.646 ∘ S, 107.688 ∘ E) medium-frequency radar, and Pontianak (0.003 ∘ S, 109.367 ∘ E) ... ...

Abstract	In this paper an attempt is made to study equatorial Kelvin waves using a network of three radars: Kototabang (0.204 ∘ S, 100.320 ∘ E) meteor radar, Pameungpeuk (7.646 ∘ S, 107.688 ∘ E) medium-frequency radar, and Pontianak (0.003 ∘ S, 109.367 ∘ E) medium-frequency radar. We have used the continuous data gathered from the three radars during April–May 2010. Empirical mode decomposition (EMD), Lomb–Scargle periodogram (LSP) analysis, and wavelet techniques are used to study the temporal and altitude structures of planetary waves. Here, we used a novel technique called EMD to extract the planetary waves from wind data. The planetary waves of ∼ 6.5 and ∼ 3.6 days periodicity are observed in all three radar stations with peak amplitudes of about 12 and 11 m s −1 , respectively. The 3.6-day wave has an average vertical wavelength from the three radars of about 42 km. The 3.6- and 6.5-day planetary waves are particularly strong in the zonal wind component. We find that the two waves are present at the 84–94 km height region. The observed features of the 3.6- and 6.5-day waves at the three tropical-latitude stations show some correspondence with the results reported for the equatorial-latitude stations. Keywords. Electromagnetics (wave propagation) – history of geophysics (atmospheric sciences) – meteorology and atmospheric dynamics (middle atmosphere dynamics)
Subject code	333
Language	English
Publishing date	2019-02-22
Publishing country	de
Document type	Book ; Online
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Article: Intrahepatic Cholangiocarcinoma and Thermal Ablation: Long-term Results of An Italian Retrospective Multicenter Study.

Giorgio, Antonio / Gatti, Pietro / Montesarchio, Luca / Santoro, Bruno / Dell'Olio, Andrea / Crucinio, Nicola / Coppola, Carmine / Scarano, Ferdinando / Biase, Fabio De / Ciracì, Emanuela / Semeraro, Stefano / Giorgio, Valentina

Journal of clinical and translational hepatology

2019 Volume 7, Issue 4, Page(s) 287–292

Abstract: Background and Aims: ...

Abstract	Background and Aims:
Keywords	covid19
Language	English
Publishing date	2019-11-27
Publishing country	China
Document type	Journal Article
ZDB-ID	3019822-7
ISSN	2310-8819 ; 2225-0719
ISSN (online)	2310-8819
ISSN	2225-0719
DOI	10.14218/JCTH.2019.00036
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Book ; Online: Estimating changes of temperatures and precipitation extremes in India using the Generalized Extreme Value (GEV) distribution

Pangaluru, Kishore / Velicogna, Isabella / C. Sutterley, Tyler / Mohajerani, Yara / Ciraci, Enrico / Sompalli, Jyothi / Saranga, Vijaya Bhaskara Rao

eISSN: 1607-7938

2018

Abstract: Changes in extreme temperature and precipitation may give some of the largest significant societal and ecological impacts. For changes in the magnitude of extreme temperature and precipitation over India, we used a statistical model of generalized ... ...

Abstract	Changes in extreme temperature and precipitation may give some of the largest significant societal and ecological impacts. For changes in the magnitude of extreme temperature and precipitation over India, we used a statistical model of generalized extreme value (GEV) distribution. The GEV statistical distribution is a time-dependent distribution with different time scales of variability bounded by a precipitation, maximum (T max ), and minimum (T min ) temperature extremes and also assessed their possibility changes are evaluated and quantified over India is presented. The GEV-based method is applied on both precipitation and temperature extremes over India during the 20 th and 21 st centuries using multiple coupled climate models taking an interest in the Coupled Model Intercomparison Project Phase 5 (CMIP5) and observational datasets. The regional means of historical warm extreme temperatures are 34.89, 36.42, and 38.14 °C for three different (10, 20, and 50-year) periods, respectively; whereas the cold extreme mean temperatures are 7.75, 4.19, and −1.57 °C. It indicates that 20 th century cold extreme temperatures have relatively larger variations than the warm extremes. As for the future, the CMIP5 models of warm extreme regional mean values increase from 0.33 to 0.75 °C in all return periods (10-, 20-, and 50-year periods), while in the case of cold extreme means values vary between 0.58 and 2.29 °C. In the future, cold extreme values have a larger increasing rate over the northwest, northeast, some parts of north-central, and Inter Peninsula regions. The CRU precipitation extremes are larger than the historical extreme precipitation in all three (10, 20, and 50-year) return-periods.
Subject code	333
Language	English
Publishing date	2018-11-08
Publishing country	de
Document type	Book ; Online
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