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  1. Article: Bacilli in the International Space Station.

    Quagliariello, Andrea / Cirigliano, Angela / Rinaldi, Teresa

    Microorganisms

    2022  Volume 10, Issue 12

    Abstract: Astronauts remote from Earth, not least those who will inhabit the Moon or Mars, are vulnerable to disease due to their reduced immunity, isolation from clinical support, and the disconnect from any buffering capacity provided by the Earth. Here, we ... ...

    Abstract Astronauts remote from Earth, not least those who will inhabit the Moon or Mars, are vulnerable to disease due to their reduced immunity, isolation from clinical support, and the disconnect from any buffering capacity provided by the Earth. Here, we explore potential risks for astronaut health, focusing on key aspects of the biology of
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10122309
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  2. Article: H3 Lysine 4 Methylation Is Required for Full Activation of Genes Involved in α-Ketoglutarate Availability in the Nucleus of Yeast Cells after Diauxic Shift.

    Di Nisio, Elena / Danovska, Svetlana / Condemi, Livia / Cirigliano, Angela / Rinaldi, Teresa / Licursi, Valerio / Negri, Rodolfo

    Metabolites

    2023  Volume 13, Issue 4

    Abstract: We show that ... ...

    Abstract We show that in
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13040507
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  3. Article ; Online: Stereocontrolled synthesis of new iminosugar lipophilic derivatives and evaluation of biological activities.

    De Angelis, Martina / Primitivo, Ludovica / Sappino, Carla / Centrella, Barbara / Lucarini, Claudia / Lanciotti, Lucrezia / Petti, Alessia / Odore, Davide / D'Annibale, Andrea / Macchi, Beatrice / Stefanizzi, Valeria / Cirigliano, Angela / Rinaldi, Teresa / Righi, Giuliana / Ricelli, Alessandra

    Carbohydrate research

    2023  Volume 534, Page(s) 108984

    Abstract: Iminosugars' similarity to carbohydrates determines the exceptional potential for this class of polyhydroxylated alkaloids to serve as potential drug candidates for a wide variety of diseases such as diabetes, lysosomal storage diseases, cancer, ... ...

    Abstract Iminosugars' similarity to carbohydrates determines the exceptional potential for this class of polyhydroxylated alkaloids to serve as potential drug candidates for a wide variety of diseases such as diabetes, lysosomal storage diseases, cancer, bacterial and viral infections. The presence of lipophilic substituents has a significant impact on their biological activities. This work reports the synthesis of three new pyrrolidine lipophilic derivatives O-alkylated in C-6 position. The biological activities of our iminosugars' collection were tested in two cancer cell lines and, due to the pharmaceutical potential, in the model yeast system Saccharomyces cerevisiae to assess their toxicity.
    MeSH term(s) Imino Sugars/pharmacology ; Enzyme Inhibitors
    Chemical Substances Imino Sugars ; Enzyme Inhibitors
    Language English
    Publishing date 2023-11-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2023.108984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: The C-terminal region of yeast ubiquitin-protein ligase Not4 mediates its cellular localization and stress response.

    Palermo, Vanessa / Stirpe, Mariarita / Bianchi, Michele Maria / Rinaldi, Teresa / Cirigliano, Angela / Ragnini-Wilson, Antonella / Falcone, Claudio / Mazzoni, Cristina

    FEMS microbiology letters

    2021  Volume 368, Issue 15

    Abstract: Transient modification of the environment involves the expression of specific genes and degradation of mRNAs and proteins. How these events are linked is poorly understood. CCR4-NOT is an evolutionary conserved complex involved in transcription ... ...

    Abstract Transient modification of the environment involves the expression of specific genes and degradation of mRNAs and proteins. How these events are linked is poorly understood. CCR4-NOT is an evolutionary conserved complex involved in transcription initiation and mRNA degradation. In this paper, we report that the yeast Not4 localizes in cytoplasmic foci after cellular stress. We focused our attention on the functional characterization of the C-terminus of the Not4 protein. Molecular dissection of this region indicates that the removal of the last 120 amino acids, does not affect protein localization and function, in that the protein is still able to suppress the thermosensitivity observed in the not4Δ mutant. In addition, such shortened form of Not4, as well its absence, increases the transcription of stress-responsive genes conferring to the cell high resistance to the oxidative stress. On the contrary, the last C-terminal 211 amino acids are required for proper Not4 localization at cytoplasmic foci after stress. This truncated version of Not4 fails to increase the transcription of the stress genes, is more stable and seems to be toxic to cells undergoing oxidative stress.
    MeSH term(s) Amino Acids ; Repressor Proteins/chemistry ; Repressor Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Stress, Physiological/genetics ; Ubiquitin-Protein Ligases/chemistry ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Amino Acids ; Repressor Proteins ; Saccharomyces cerevisiae Proteins ; MOT2 protein, S cerevisiae (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752343-9
    ISSN 1574-6968 ; 0378-1097
    ISSN (online) 1574-6968
    ISSN 0378-1097
    DOI 10.1093/femsle/fnab097
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1372: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Antifungal and Cytotoxic Activity of Diterpenes and Bisnorsesquiterpenoides from the Latex of

    Ourhzif, El-Mahdi / Ricelli, Alessandra / Stagni, Venturina / Cirigliano, Angela / Rinaldi, Teresa / Bouissane, Latifa / Saso, Luciano / Chalard, Pierre / Troin, Yves / Khouili, Mostafa / Akssira, Mohamed

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 16

    Abstract: Euphorbia ... ...

    Abstract Euphorbia resinifera
    MeSH term(s) Antifungal Agents ; Antineoplastic Agents/pharmacology ; Breast Neoplasms ; Diterpenes/chemistry ; Euphorbia/chemistry ; Female ; Humans ; Latex/chemistry ; Saccharomyces cerevisiae
    Chemical Substances Antifungal Agents ; Antineoplastic Agents ; Diterpenes ; Latex
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27165234
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: Active microbial ecosystem in Iron‐Age tombs of the Etruscan civilization

    Cirigliano, Angela / Mura, Francesco / Cecchini, Adele / Tomassetti, Maria Cristina / Maras, Daniele Federico / Di Paola, Monica / Meriggi, Niccolò / Cavalieri, Duccio / Negri, Rodolfo / Quagliariello, Andrea / Hallsworth, John E. / Rinaldi, Teresa

    Environmental microbiology. 2021 July, v. 23, no. 7

    2021  

    Abstract: Earth's microbial biosphere extends down through the crust and much of the subsurface, including those microbial ecosystems located within cave systems. Here, we elucidate the microbial ecosystems within anthropogenic 'caves'; the Iron‐Age, subterranean ... ...

    Abstract Earth's microbial biosphere extends down through the crust and much of the subsurface, including those microbial ecosystems located within cave systems. Here, we elucidate the microbial ecosystems within anthropogenic 'caves'; the Iron‐Age, subterranean tombs of central Italy. The interior walls of the rock (calcium‐rich macco) were painted ~2500 years ago and are covered with CaCO₃ needles (known as moonmilk). The aims of the current study were to: identify biological/geochemical/biophysical determinants of and characterize bacterial communities involved in CaCO₃ precipitation; challenge the maxim that biogenic activity necessarily degrades surfaces; locate the bacterial cells that are the source of the CaCO₃ precipitate; and gain insight into the kinetics of moonmilk formation. We reveal that this environment hosts communities that consist primarily of bacteria that are mesophilic for temperature and xerotolerance (including Actinobacteria, Bacteroidetes and Proteobacteria); is populated by photosynthetic Cyanobacteria exhibiting heterotrophic nutrition (Calothrix and Chroococcidiopsis); and has CaCO₃ precipitating on the rock surfaces (confirmation that this process is biogenic) that acts to preserve rather than damage the painted surface. We also identified that some community members are psychrotolerant (Polaromonas), acidotolerant or acidophilic (members of the Acidobacteria), or resistant to ionizing radiation (Brevundimonas and Truepera); elucidate the ways in which microbiology impacts mineralogy and vice versa; and reveal that biogenic formation of moonmilk can occur rapidly, that is, over a period of 10 to 56 years. We discuss the paradox that these ecosystems, that are for the most part in the dark and lack primary production, are apparently highly active, biodiverse and biomass‐rich.
    Keywords Acidobacteria ; Actinobacteria ; Bacteroidetes ; Brevundimonas ; Calothrix ; Chroococcidiopsis ; Polaromonas ; acid tolerance ; biosphere ; limestone ; mineralogy ; nutrition ; photosynthesis ; primary productivity ; temperature ; Italy
    Language English
    Dates of publication 2021-07
    Size p. 3957-3969.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.15327
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  7. Article ; Online: Biological Dual-Use Research and Synthetic Biology of Yeast.

    Cirigliano, Angela / Cenciarelli, Orlando / Malizia, Andrea / Bellecci, Carlo / Gaudio, Pasquale / Lioj, Michele / Rinaldi, Teresa

    Science and engineering ethics

    2016  Volume 23, Issue 2, Page(s) 365–374

    Abstract: In recent years, the publication of the studies on the transmissibility in mammals of the H5N1 influenza virus and synthetic genomes has triggered heated and concerned debate within the community of scientists on biological dual-use research; these ... ...

    Abstract In recent years, the publication of the studies on the transmissibility in mammals of the H5N1 influenza virus and synthetic genomes has triggered heated and concerned debate within the community of scientists on biological dual-use research; these papers have raised the awareness that, in some cases, fundamental research could be directed to harmful experiments, with the purpose of developing a weapon that could be used by a bioterrorist. Here is presented an overview regarding the dual-use concept and its related international agreements which underlines the work of the Australia Group (AG) Export Control Regime. It is hoped that the principles and activities of the AG, that focuses on export control of chemical and biological dual-use materials, will spread and become well known to academic researchers in different countries, as they exchange biological materials (i.e. plasmids, strains, antibodies, nucleic acids) and scientific papers. To this extent, and with the aim of drawing the attention of the scientific community that works with yeast to the so called Dual-Use Research of Concern, this article reports case studies on biological dual-use research and discusses a synthetic biology applied to the yeast Saccharomyces cerevisiae, namely the construction of the first eukaryotic synthetic chromosome of yeast and the use of yeast cells as a factory to produce opiates. Since this organism is considered harmless and is not included in any list of biological agents, yeast researchers should take simple actions in the future to avoid the sharing of strains and advanced technology with suspicious individuals.
    MeSH term(s) Dual Use Research/ethics ; Ethics, Research ; Research Personnel/ethics ; Saccharomyces cerevisiae/genetics ; Synthetic Biology/ethics ; Synthetic Biology/trends
    Language English
    Publishing date 2016-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2136491-6
    ISSN 1471-5546 ; 1353-3452
    ISSN (online) 1471-5546
    ISSN 1353-3452
    DOI 10.1007/s11948-016-9774-1
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  8. Article ; Online: Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae.

    Cirigliano, Angela / Macone, Alberto / Bianchi, Michele Maria / Oliaro-Bosso, Simonetta / Balliano, Gianni / Negri, Rodolfo / Rinaldi, Teresa

    Biochimica et biophysica acta. Molecular and cell biology of lipids

    2018  Volume 1864, Issue 3, Page(s) 290–303

    Abstract: Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle ... ...

    Abstract Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle interactions, we discovered that Erg27p resides mainly in Lipid Droplets (LDs) in respiratory competent cells, while in absence of respiration, is found mostly in the ER. The results presented in this paper demonstrate an interplay between the mitochondrial respiration and ergosterol production: on the one hand, rho° cells show lower ergosterol content when compared with wild type respiratory competent cells, on the other hand, the ergosterol biosynthetic pathway influences the mitochondrial status, since treatment with ketoconazole, which blocks the ergosterol pathway, or the absence of the ERG27 gene, induced rho° production in S. cerevisiae. The loss of mitochondrial DNA in the ∆erg27 strain is fully suppressed by exogenous addition of ergosterol. These data suggest the notion that ergosterol is essential for maintaining the mitochondrial DNA attached to the inner mitochondrial membrane.
    MeSH term(s) Biosynthetic Pathways ; DNA, Mitochondrial/drug effects ; DNA, Mitochondrial/metabolism ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Ergosterol/genetics ; Ergosterol/metabolism ; Gene Expression Regulation, Fungal/genetics ; Ketoconazole/pharmacology ; Lipid Droplets/metabolism ; Mitochondria/metabolism ; Oxidoreductases/metabolism ; Oxidoreductases/physiology ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/physiology ; Sterols/metabolism
    Chemical Substances DNA, Mitochondrial ; Saccharomyces cerevisiae Proteins ; Sterols ; Oxidoreductases (EC 1.-) ; ERG27 protein, S cerevisiae (EC 1.3.1.-) ; Ketoconazole (R9400W927I) ; Ergosterol (Z30RAY509F)
    Language English
    Publishing date 2018-12-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbalip.2018.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1.

    Botta, Lorenzo / Filippi, Silvia / Zippilli, Claudio / Cesarini, Silvia / Bizzarri, Bruno Mattia / Cirigliano, Angela / Rinaldi, Teresa / Paiardini, Alessandro / Fiorucci, Diego / Saladino, Raffaele / Negri, Rodolfo / Benedetti, Pietro

    ACS medicinal chemistry letters

    2020  Volume 11, Issue 5, Page(s) 1035–1040

    Abstract: Artesunic acid and artemisinin are natural substances with promiscuous anticancer activity against different types of cancer cell lines. The mechanism of action of these compounds is associated with the formation of reactive radical species by cleavage ... ...

    Abstract Artesunic acid and artemisinin are natural substances with promiscuous anticancer activity against different types of cancer cell lines. The mechanism of action of these compounds is associated with the formation of reactive radical species by cleavage of the sesquiterpene pharmacophore endoperoxide bridge. Here we suggested topoisomerase 1 as a possible molecular target for the improvement of the anticancer activity of these compounds. In this context, we report that novel hybrid and dimer derivatives of artesunic acid and artemisinin, bearing camptothecin and SN38 as side-chain biological effectors, can inhibit growth of yeast cells overexpressing human topoisomerase 1 and its enzymatic activity
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00131
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  10. Article ; Online: Active microbial ecosystem in Iron-Age tombs of the Etruscan civilization.

    Cirigliano, Angela / Mura, Francesco / Cecchini, Adele / Tomassetti, Maria Cristina / Maras, Daniele Federico / Di Paola, Monica / Meriggi, Niccolò / Cavalieri, Duccio / Negri, Rodolfo / Quagliariello, Andrea / Hallsworth, John E / Rinaldi, Teresa

    Environmental microbiology

    2020  Volume 23, Issue 7, Page(s) 3957–3969

    Abstract: Earth's microbial biosphere extends down through the crust and much of the subsurface, including those microbial ecosystems located within cave systems. Here, we elucidate the microbial ecosystems within anthropogenic 'caves'; the Iron-Age, subterranean ... ...

    Abstract Earth's microbial biosphere extends down through the crust and much of the subsurface, including those microbial ecosystems located within cave systems. Here, we elucidate the microbial ecosystems within anthropogenic 'caves'; the Iron-Age, subterranean tombs of central Italy. The interior walls of the rock (calcium-rich macco) were painted ~2500 years ago and are covered with CaCO
    MeSH term(s) Acidobacteria ; Caves ; Civilization ; Cyanobacteria ; Ecosystem
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.15327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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