LIVIVO - Search results -

Search results

Result 1 - 10 of total 14

Search options

Article: Beneficial Effects of Palmitoylethanolamide on Expressive Language, Cognition, and Behaviors in Autism: A Report of Two Cases.

Antonucci, Nicola / Cirillo, Alessandra / Siniscalco, Dario

2015 Volume 2015, Page(s) 325061

Abstract: Introduction. Autism spectrum disorders are defined by behavioral and language atypias. Growing body of evidence indicates inflammatory mediators may contribute to the condition. Palmitoylethanolamide (PEA) is naturally occurring and has been available ... ...

Abstract	Introduction. Autism spectrum disorders are defined by behavioral and language atypias. Growing body of evidence indicates inflammatory mediators may contribute to the condition. Palmitoylethanolamide (PEA) is naturally occurring and has been available as a nonprescription medical food supplement in Europe since 2008. PEA has been tested in thousands of human subjects without any noted significant side effects. Here we report the first cases of the administration of PEA to two children with autism. Case Presentations. The first 13-year-old male child (Subject 1) presented with a total IgE of 572 IU/mL (nl < 200) and with low mature CD57(+) natural killer cell counts (32 cells/µL; nl = 60-300 cells/µL) and with significant eczema and allergic stigmata. Expressive language, as measured by mean length of utterance, and overall autism severity as measured by the Childhood Autism Rating Scale, Second Edition, improved significantly. Atopic symptoms diminished. No side effects were reported. The second male child, age 15 (Subject 2), also displayed noticeable and rapid improvements in cognitive, behaviors, and sociability. Conclusion. Currently, there is no definitive treatment for autism condition. Palmitoylethanolamide could be an effective treatment for autism syndrome. We propose appropriate double-blind clinical trials to further explore palmitoylethanolamide efficacy and safety.
Language	English
Publishing date	2015-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2629914-8
ISSN	2090-6838 ; 2090-682X
ISSN (online)	2090-6838
ISSN	2090-682X
DOI	10.1155/2015/325061
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Skewed X-chromosome inactivation plays a crucial role in the onset of symptoms in carriers of Becker muscular dystrophy.

Viggiano, Emanuela / Picillo, Esther / Ergoli, Manuela / Cirillo, Alessandra / Del Gaudio, Stefania / Politano, Luisa

The journal of gene medicine

2017 Volume 19, Issue 4

Abstract: Background: Becker muscular dystrophy (BMD) is an X-linked recessive disorder affecting approximately 1: 18.000 male births. Female carriers are usually asymptomatic, although 2.5-18% may present muscle or heart symptoms. In the present study, the role ... ...

Abstract	Background: Becker muscular dystrophy (BMD) is an X-linked recessive disorder affecting approximately 1: 18.000 male births. Female carriers are usually asymptomatic, although 2.5-18% may present muscle or heart symptoms. In the present study, the role of the X chromosome inactivation (XCI) on the onset of symptoms in BMD carriers was analysed and compared with the pattern observed in Duchenne muscular dystrophy (DMD) carriers. Methods: XCI was determined on the lymphocytes of 36 BMD carriers (both symptomatic and not symptomatic) from 11 families requiring genetic advice at the Cardiomyology and Medical Genetics of the Second University of Naples, using the AR methylation-based assay. Carriers were subdivided into two groups, according to age above or below 50 years. Seven females from the same families known as noncarriers were used as controls. A Student's t-test for nonpaired data was performed to evaluate the differences observed in the XCI values between asymptomatic and symptomatic carriers, and carriers aged above or below 50 years. A Pearson correlation test was used to evaluate the inheritance of the XCI pattern in 19 mother-daughter pairs. Results: The results showed that symptomatic BMD carriers had a skewed XCI with a preferential inactivation of the X chromosome carrying the normal allele, whereas the asymptomatic carriers and controls showed a random XCI. No concordance concerning the XCI pattern was observed between mothers and related daughters. Conclusions: The data obtained in the present study suggest that the onset of symptoms in BMD carriers is related to a skewed XCI, as observed in DMD carriers. Furthermore, they showed no concordance in the XCI pattern inheritance.
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.2952
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5423: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages.

Siniscalco, Dario / Bradstreet, James Jeffrey / Cirillo, Alessandra / Antonucci, Nicola

Journal of neuroinflammation

2014 Volume 11, Page(s) 78

Abstract: Background: Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder. The endocannabinoid system is a key regulator of the immune system via the cannabinoid receptor type 2 (CB2R) which is highly ... ...

Abstract	Background: Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder. The endocannabinoid system is a key regulator of the immune system via the cannabinoid receptor type 2 (CB2R) which is highly expressed on macrophages and microglial cells. We have previously published significant differences in peripheral blood mononuclear cell CB2R gene expression in the autism population. The use of the Gc protein-derived Macrophage Activating Factor (GcMAF), an endogenous glycosylated vitamin D binding protein responsible for macrophage cell activation has demonstrated positive effects in the treatment of autistic children. In this current study, we investigated the in vitro effects of GcMAF treatment on the endocannabinoid system gene expression, as well as cellular activation in blood monocyte-derived macrophages (BMDMs) from autistic patients compared to age-matched healthy developing controls. Methods: To achieve these goals, we used biomolecular, biochemical and immunocytochemical methods. Results: GcMAF treatment was able to normalize the observed differences in dysregulated gene expression of the endocannabinoid system of the autism group. GcMAF also down-regulated the over-activation of BMDMs from autistic children. Conclusions: This study presents the first observations of GcMAF effects on the transcriptionomics of the endocannabinoid system and expression of CB2R protein. These data point to a potential nexus between endocannabinoids, vitamin D and its transporter proteins, and the immune dysregulations observed with autism.
MeSH term(s)	Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Autistic Disorder/pathology ; Case-Control Studies ; Child ; Child, Preschool ; Endocannabinoids/genetics ; Endocannabinoids/metabolism ; Female ; Gene Expression Regulation/drug effects ; Humans ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Macrophage-Activating Factors/pharmacology ; Macrophages/drug effects ; Male ; Phospholipase D/genetics ; Phospholipase D/metabolism ; RNA, Messenger/metabolism ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Signal Transduction/drug effects ; Vitamin D-Binding Protein/pharmacology
Chemical Substances	Endocannabinoids ; Macrophage-Activating Factors ; RNA, Messenger ; Receptor, Cannabinoid, CB2 ; Vitamin D-Binding Protein ; vitamin D-binding protein-macrophage activating factor ; Phospholipase D (EC 3.1.4.4) ; NAPEPLD protein, human (EC 3.1.4.4.) ; Amidohydrolases (EC 3.5.-) ; fatty-acid amide hydrolase (EC 3.5.1.-)
Language	English
Publishing date	2014-04-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1742-2094
ISSN (online)	1742-2094
DOI	10.1186/1742-2094-11-78
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries.

Cirillo, Alessandra / Diniz, Elton / Gadelha, Ary / Asevedo, Elson / Axelrud, Luiza K / Miguel, Eurípedes C / Rohde, Luis Augusto / Bressan, Rodrigo A / Pan, Pedro / Mari, Jair de J

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2020 Volume 42, Issue 4, Page(s) 442–448

Abstract: Objective: Population neuroscience is an emerging field that combines epidemiology and neuroscience to study how genes and the environment shape typical and atypical brain functioning. The objective of this study was to review key studies on population ... ...

Abstract	Objective: Population neuroscience is an emerging field that combines epidemiology and neuroscience to study how genes and the environment shape typical and atypical brain functioning. The objective of this study was to review key studies on population neuroscience from low- and middle-income countries (LMICs) and to identify potential gaps vis-à-vis studies conducted in high-income countries. Methods: We conducted a systematic review to search for longitudinal cohort studies investigating the development of psychiatric disorders in children and adolescents in LMICs. We performed an electronic search in the EMBASE and MEDLINE databases from inception to July 5th, 2019. Results: We found six cohorts from four countries that met our search criteria: three cohorts from Brazil, one from China, one from South Africa, and one from Mauritius. Relevant examples of findings from these studies are reported. Conclusion: Our results demonstrate the impact of the valuable science output these cohort designs promote, allowing LMICs to have a share in frontline global psychiatry research. National and international funding agencies should invest in LMIC population neuroscience in order to promote replication and generalization of research from high-income countries.
MeSH term(s)	Biomedical Research ; Developing Countries ; Humans ; Neurosciences
Language	English
Publishing date	2020-04-03
Publishing country	Brazil
Document type	Journal Article ; Systematic Review
ISSN	1809-452X
ISSN (online)	1809-452X
DOI	10.1590/1516-4446-2019-0761
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Epigenetic findings in autism: new perspectives for therapy.

Siniscalco, Dario / Cirillo, Alessandra / Bradstreet, James Jeffrey / Antonucci, Nicola

International journal of environmental research and public health

2013 Volume 10, Issue 9, Page(s) 4261–4273

Abstract: Autism and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders characterized by dysfunctions in social interactions, communications, restricted interests, and repetitive stereotypic behaviors. Despite extensive genetic and ... ...

Abstract	Autism and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders characterized by dysfunctions in social interactions, communications, restricted interests, and repetitive stereotypic behaviors. Despite extensive genetic and biological research, significant controversy surrounds our understanding of the specific mechanisms of their pathogenesis. However, accumulating evidence points to the involvement of epigenetic modifications as foundational in creating ASD pathophysiology. Epigenetic modifications or the alteration of DNA transcription via variations in DNA methylation and histone modifications but without alterations in the DNA sequence, affect gene regulation. These alterations in gene expression, obtained through DNA methylation and/or histone modifications, result from transcriptional regulatory influences of environmental factors, such as nutritional deficiencies, various toxicants, immunological effects, and pharmaceuticals. As such these effects are epigenetic regulators which determine the final biochemistry and physiology of the individual. In contrast to psychopharmacological interventions, bettering our understanding of how these gene-environmental interactions create autistic symptoms should facilitate the development of therapeutic targeting of gene expression for ASD biomedical care.
MeSH term(s)	Animals ; Child Development Disorders, Pervasive/genetics ; Child Development Disorders, Pervasive/therapy ; Environment ; Epigenesis, Genetic ; Histones/metabolism ; Humans
Chemical Substances	Histones
Language	English
Publishing date	2013-09-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph10094261
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Decreased Numbers of CD57+CD3- Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder.

Siniscalco, Dario / Mijatovic, Tatjana / Bosmans, Eugene / Cirillo, Alessandra / Kruzliak, Peter / Lombardi, Vincent C / De Meirleir, Kenny / Antonucci, Nicola

In vivo (Athens, Greece)

2016 Volume 30, Issue 2, Page(s) 83–89

Abstract: Background/aim: Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a ... ...

Abstract	Background/aim: Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of this malady. The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD. Materials and methods: Three-color flow cytometry-based analysis of fresh peripheral blood samples from children with autism was utilized to measure CD57(+)CD3(-) lymphocytes. Results: A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism. Discussion and conclusion: We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.
MeSH term(s)	Adolescent ; Adult ; Autism Spectrum Disorder/immunology ; Autism Spectrum Disorder/metabolism ; Biomarkers ; CD3 Complex/metabolism ; CD57 Antigens/metabolism ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Immunity, Innate ; Immunophenotyping ; Lymphocyte Count ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Male ; Young Adult
Chemical Substances	Biomarkers ; CD3 Complex ; CD57 Antigens
Language	English
Publishing date	2016-03
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2288: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A new SCAR marker potentially useful to distinguish Italian cattle breeds

Cirillo, Alessandra / Gaudio, Stefania Del / Bernardo, Giovanni Di / Galano, Giovanni / Galderisi, Umberto / Cipollaro, Marilena

Food chemistry. 2012 Jan. 1, v. 130, no. 1

2012

Abstract: In recent years, the safeguarding of Italian native cattle breeds has increased the recovery of these breeds and the promotion of their products by enhancing the application of useful methods to trace the origin of meat products. The random amplified ... ...

Abstract	In recent years, the safeguarding of Italian native cattle breeds has increased the recovery of these breeds and the promotion of their products by enhancing the application of useful methods to trace the origin of meat products. The random amplified polymorphic DNA sequence (RAPD–PCR) followed by characterised amplified region (SCAR) marker approach could be considered an advantageous method to ensure food quality and origin, and represents a further opportunity to recover Italian autochthonous cattle breeds. Here, we report the results of RAPD–PCR using 42 primers and the development of two informative SCAR markers. Ten different clones for each cultivar-specific RAPD fragment were sequenced and database searches of sequence similarity were performed. The method enabled the detection of low amounts of DNA and, because of the relatively short dimension of the amplicon, it was suitable for the analysis of potentially degraded DNA obtained from processed commercial food that contained meat as an ingredient.
Keywords	DNA ; cattle breeds ; clones ; databases ; food quality ; ingredients ; meat ; nucleotide sequences ; random amplified polymorphic DNA technique ; sequence homology
Language	English
Dates of publication	2012-0101
Size	p. 172-176.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2011.06.043
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3634: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Autism spectrum disorders: is mesenchymal stem cell personalized therapy the future?

Siniscalco, Dario / Sapone, Anna / Cirillo, Alessandra / Giordano, Catia / Maione, Sabatino / Antonucci, Nicola

Journal of biomedicine & biotechnology

2012 Volume 2012, Page(s) 480289

Abstract: Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social ... ...

Abstract	Autism and autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders. They are enigmatic conditions that have their origins in the interaction of genes and environmental factors. ASDs are characterized by dysfunctions in social interaction and communication skills, in addition to repetitive and stereotypic verbal and nonverbal behaviours. Immune dysfunction has been confirmed with autistic children. There are no defined mechanisms of pathogenesis or curative therapy presently available. Indeed, ASDs are still untreatable. Available treatments for autism can be divided into behavioural, nutritional, and medical approaches, although no defined standard approach exists. Nowadays, stem cell therapy represents the great promise for the future of molecular medicine. Among the stem cell population, mesenchymal stem cells (MSCs) show probably best potential good results in medical research. Due to the particular immune and neural dysregulation observed in ASDs, mesenchymal stem cell transplantation could offer a unique tool to provide better resolution for this disease.
MeSH term(s)	Child ; Child Development Disorders, Pervasive/surgery ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Precision Medicine/methods
Language	English
Publishing date	2012-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2052552-7
ISSN	1110-7251 ; 1110-7243
ISSN (online)	1110-7251
ISSN	1110-7243
DOI	10.1155/2012/480289
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5540: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Molecular characterization of Italian rice cultivars

Cirillo, Alessandra / Del Gaudio, Stefania / Di Bernardo, Giovanni / Galderisi, Umberto / Cascino, Antonino / Cipollaro, Marilena

Zeitschrift für Lebensmittel-Untersuchung und -Forschung. A, European food research and technology. 2009 Apr., v. 228, no. 6

2009

Abstract: Random amplified polymorphic DNA (RAPD) is an efficient tool to detect DNA polymorphisms and to distinguish different clones and cultivars. We have applied the RAPD technique to distinguish, starting from a single rice seed, among some Italian rice ... ...

Abstract	Random amplified polymorphic DNA (RAPD) is an efficient tool to detect DNA polymorphisms and to distinguish different clones and cultivars. We have applied the RAPD technique to distinguish, starting from a single rice seed, among some Italian rice cultivars from market and from National Institute for research on food and nutrition, Italy. We also estimated the genomic similarity among the rice cultivars object of this study taking advantage of the amplification patterns. Despite the low genomic variability among Italian rice cultivars, RAPD technique allowed us to distinguish among them. This indicates that RAPD can be used routinely to verify the identity of Italian rice cultivars in order to prevent fraudulent commercial activity.
Keywords	DNA ; clones ; cultivars ; markets ; nutrition research ; random amplified polymorphic DNA technique ; rice ; seeds ; Italy
Language	English
Dates of publication	2009-04
Size	p. 875-881.
Publisher	Springer-Verlag
Publishing place	Berlin/Heidelberg
Document type	Article
ZDB-ID	1359456-4
ISSN	1431-4630 ; 1438-2377
ISSN	1431-4630 ; 1438-2377
DOI	10.1007/s00217-008-1000-1
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 792: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Preamplification procedure for the analysis of ancient DNA samples.

Del Gaudio, Stefania / Cirillo, Alessandra / Di Bernardo, Giovanni / Galderisi, Umberto / Thanassoulas, Theodoros / Pitsios, Theodoros / Cipollaro, Marilena

TheScientificWorldJournal

2013 Volume 2013, Page(s) 734676

Abstract: In ancient DNA studies the low amount of endogenous DNA represents a limiting factor that often hampers the result achievement. In this study we extracted the DNA from nine human skeletal remains of different ages found in the Byzantine cemetery of ... ...

Abstract	In ancient DNA studies the low amount of endogenous DNA represents a limiting factor that often hampers the result achievement. In this study we extracted the DNA from nine human skeletal remains of different ages found in the Byzantine cemetery of Abdera Halkidiki and in the medieval cemetery of St. Spiridion in Rhodes (Greece). Real-time quantitative polymerase chain reaction (qPCR) was used to detect in the extracts the presence of PCR inhibitors and to estimate the DNA content. As mitochondrial DNA was detected in all samples, amplification of nuclear targets, as amelogenin and the polymorphism M470V of the transmembrane conductance regulator gene, yielded positive results in one case only. In an effort to improve amplification success, we applied, for the first time in ancient DNA, a preamplification strategy based on TaqMan PreAmp Master Mix. A comparison between results obtained from nonpreamplified and preamplified samples is reported. Our data, even if preliminary, show that the TaqMan PreAmp procedure may improve the sensitivity of qPCR analysis.
MeSH term(s)	Anthropology, Physical/methods ; Base Sequence ; DNA/genetics ; DNA Fingerprinting/methods ; Forensic Genetics/methods ; Greece ; Molecular Sequence Data ; Real-Time Polymerase Chain Reaction/methods ; Sequence Analysis, DNA/methods ; Specimen Handling/methods
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2013-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2075968-X
ISSN	1537-744X ; 1537-744X
ISSN (online)	1537-744X
ISSN	1537-744X
DOI	10.1155/2013/734676
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito