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Article ; Online: Acalcolous Hemorrhagic Cholecystitis and SARS-CoV-2 Infection.

Cirillo, Bruno / Brachini, Gioia / Crocetti, Daniele / Sapienza, Paolo / Mingoli, Andrea

2020 Volume 107, Issue 11, Page(s) e524

MeSH term(s)	Aged ; COVID-19/epidemiology ; Cholecystectomy/methods ; Cholecystitis/diagnosis ; Cholecystitis/epidemiology ; Cholecystitis/surgery ; Comorbidity ; Humans ; Male ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-08-21
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1002/bjs.11992
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Article ; Online: Severe blunt renal injury after motorcycle accident: failure of the conservative management.

Brachini, Gioia / Cirillo, Bruno / Sapienza, Paolo / Lapolla, Pierfrancesco / Meneghini, Simona / Simonelli, Luigi / Mingoli, Andrea

Annali italiani di chirurgia

2021 Volume 92, Page(s) 518–520

Abstract: We report the case of a patient who presented after a motorcycle accident a grade IV kidney lesion primarily treated with a NOM, which failed. We discuss the possibility at admission to select a subgroup of patients with a high grade (IV and V) kidney ... ...

Abstract	We report the case of a patient who presented after a motorcycle accident a grade IV kidney lesion primarily treated with a NOM, which failed. We discuss the possibility at admission to select a subgroup of patients with a high grade (IV and V) kidney trauma in whom NOM might fail. KEY WORDS: Kidney Trauma, High grade renal trauma, Non operative management.
MeSH term(s)	Accidents ; Conservative Treatment ; Humans ; Injury Severity Score ; Kidney/injuries ; Motorcycles ; Retrospective Studies ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/therapy
Language	English
Publishing date	2021-11-18
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score.

Cruciata, Alessia / Volpicelli, Lorenzo / Di Bari, Silvia / Iaiani, Giancarlo / Cirillo, Bruno / Pugliese, Francesco / Pellegrino, Daniela / Galardo, Gioacchino / Taliani, Gloria

Viruses

2022 Volume 14, Issue 3

Abstract: This monocentric, retrospective, two-stage observational study aimed to recognize the risk factors for a poor outcome in patients hospitalized with SARS-CoV-2 infection, and to develop and validate a risk score that identifies subjects at risk of ... ...

Abstract	This monocentric, retrospective, two-stage observational study aimed to recognize the risk factors for a poor outcome in patients hospitalized with SARS-CoV-2 infection, and to develop and validate a risk score that identifies subjects at risk of worsening, death, or both. The data of patients with SARS-CoV-2 infection during the first wave of the pandemic were collected and analyzed as a derivation cohort. Variables with predictive properties were used to construct a prognostic score, which was tried out on a validation cohort enrolled during the second wave. The derivation cohort included 494 patients; the median age was 62 and the overall fatality rate was 22.3%. In a multivariable analysis, age, oxygen saturation, neutrophil-to-lymphocyte ratio, C-reactive protein and lactate dehydrogenase were independent predictors of death and composed the score. A cutoff value of 3 demonstrated a sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of 93.5%, 68.5%, 47.4% and 97.2% for death, and 84.9%, 84.5%, 79.6% and 87.9% for worsening, respectively. The validation cohort included 415 subjects. The score application showed a Se, Sp, PPV and NPV of 93.4%, 61.6%, 29.5% and 98.1% for death, and 81%, 76.3%, 72.1% and 84.1% for worsening, respectively. We propose a new clinical, easy and reliable score to predict the outcome in hospitalized SARS-CoV-2 patients.
MeSH term(s)	COVID-19/diagnosis ; Humans ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2022-03-20
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14030642
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Risk of Seven-Day Worsening and Death: A New Clinically Derived COVID-19 Score

Cruciata, Alessia / Volpicelli, Lorenzo / Di Bari, Silvia / Iaiani, Giancarlo / Cirillo, Bruno / Pugliese, Francesco / Pellegrino, Daniela / Galardo, Gioacchino / Taliani, Gloria

Viruses. 2022 Mar. 20, v. 14, no. 3

2022

Abstract	This monocentric, retrospective, two-stage observational study aimed to recognize the risk factors for a poor outcome in patients hospitalized with SARS-CoV-2 infection, and to develop and validate a risk score that identifies subjects at risk of worsening, death, or both. The data of patients with SARS-CoV-2 infection during the first wave of the pandemic were collected and analyzed as a derivation cohort. Variables with predictive properties were used to construct a prognostic score, which was tried out on a validation cohort enrolled during the second wave. The derivation cohort included 494 patients; the median age was 62 and the overall fatality rate was 22.3%. In a multivariable analysis, age, oxygen saturation, neutrophil-to-lymphocyte ratio, C-reactive protein and lactate dehydrogenase were independent predictors of death and composed the score. A cutoff value of 3 demonstrated a sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of 93.5%, 68.5%, 47.4% and 97.2% for death, and 84.9%, 84.5%, 79.6% and 87.9% for worsening, respectively. The validation cohort included 415 subjects. The score application showed a Se, Sp, PPV and NPV of 93.4%, 61.6%, 29.5% and 98.1% for death, and 81%, 76.3%, 72.1% and 84.1% for worsening, respectively. We propose a new clinical, easy and reliable score to predict the outcome in hospitalized SARS-CoV-2 patients.
Keywords	C-reactive protein ; COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; death ; lactate dehydrogenase ; mortality ; observational studies ; oxygen ; pandemic
Language	English
Dates of publication	2022-0320
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14030642
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Role of lung ultrasound in patients requiring emergency surgery during COVID-19 Pandemic.

Brachini, Gioia / Sapienza, Paolo / Cirillo, Bruno / Fonsi, Giovanni Battista / Crocetti, Daniele / Mingoli, Andrea

The British journal of surgery

2020 Volume 107, Issue 13, Page(s) e669

Keywords	covid19
Language	English
Publishing date	2020-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1002/bjs.12052
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Guidelines for the Treatment of Abdominal Abscesses in Acute Diverticulitis: An Umbrella Review.

Cirocchi, Roberto / Duro, Francesca / Avenia, Stefano / Capitoli, Matteo / Tebala, Giovanni Domenico / Allegritti, Massimiliano / Cirillo, Bruno / Brachini, Gioia / Sapienza, Paolo / Binda, Gian Andrea / Mingoli, Andrea / Fedeli, Piergiorgio / Nascimbeni, Riccardo

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: Background: This systematic umbrella review aims to investigate and provide an analysis of guidelines regarding the treatment of diverticular abscesses.: Material and methods: A systematic literature search was performed using the Cochrane Overviews ... ...

Abstract	Background: This systematic umbrella review aims to investigate and provide an analysis of guidelines regarding the treatment of diverticular abscesses. Material and methods: A systematic literature search was performed using the Cochrane Overviews of Reviews model and the 'Clinical Practice Guidelines'; at the end of initial search, only 12 guidelines were included in this analysis. The quality of the guidelines was assessed by adopting the "Appraisal of Guidelines for Research and Evaluation II" (AGREE II). The comparative analysis of these guidelines has highlighted the presence of some differences regarding the recommendations on the treatment of diverticular abscesses. In particular, there are some controversies about the diameter of abscess to be used in order to decide between medical treatment and percutaneous drainage. Different guidelines propose different abscess diameter cutoffs, such as 3 cm, 4-5 cm, or 4 cm, for distinguishing between small and large abscesses. Conclusions: Currently, different scientific societies recommend that diverticular abscesses with diameters larger than 3 cm should be considered for percutaneous drainage whereas abscesses with diameters smaller than 3 cm could be appropriately treated by medical therapy with antibiotics; only a few guidelines suggest the use of percutaneous drainage for abscesses with a diameter greater than 4 cm. The differences among guidelines are the consequence of the different selection of scientific evidence. In conclusion, our evaluation has revealed the importance of seeking new scientific evidence with higher quality to either confirm, reinforce or potentially weaken the existing recommendations from different societies.
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175522
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Systematic Review of Varying Definitions and the Clinical Significance of Fredet's Fascia in the Era of Complete Mesocolic Excision.

Brachini, Gioia / Cirillo, Bruno / Matteucci, Matteo / Cirocchi, Roberto / Tebala, Giovanni Domenico / Cavaliere, Davide / Giacobbi, Lorenza / Papa, Veronica / Solaini, Leonardo / Avenia, Stefano / D'Andrea, Vito / Davies, Justin / Fedeli, Piergiorgio / De Santis, Elena

Journal of clinical medicine

2023 Volume 12, Issue 19

Abstract: Background: Fredet's fascia represents a crucial landmark for vascular surgical anatomy, especially in minimally invasive complete mesocolic excision (CME) for right-sided colon adenocarcinoma. Fredet's fascia allows access to the gastrocolic trunk of ... ...

Abstract	Background: Fredet's fascia represents a crucial landmark for vascular surgical anatomy, especially in minimally invasive complete mesocolic excision (CME) for right-sided colon adenocarcinoma. Fredet's fascia allows access to the gastrocolic trunk of Henle (GCTH), the most critical step in both open and minimally invasive right-sided CME techniques. Despite this, a recent workshop of expert surgeons on the standardization of the laparoscopic right hemicolectomy with CME did not recognize or include the term of Fredet's fascia or area. Hence, we undertook a systematic review of articles that include the terms "Fredet's fascia or area", or synonyms thereof, with special emphasis on the types of articles published, the nationality, and the relevance of this area to surgical treatments. Methods: We conducted a systematic review up to 15 July 2022 on PubMed, WOS, SCOPUS, and Google Scholar. Results: The results of the study revealed that the term "Fredet's fascia" is poorly used in the English language medical literature. In addition, the study found controversial and conflicting data among authors regarding the definition of "Fredet's fascia" and its topographical limits. Conclusions: Knowledge of Fredet's fascia's surgical relevance is essential for colorectal surgeons to avoid accidental injuries to the superior mesenteric vascular pedicle during minimally invasive right hemicolectomies with CME. In order to avoid confusion and clarify this fascia for future use, we suggest moving beyond the use of the eponymous term by using a "descriptive term" instead, based on the fascia's anatomic structure. Fredet's fascia could, therefore, be more appropriately renamed "sub-mesocolic pre-duodenopancreatic fascia".
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12196233
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Management of Acute Cholecystitis in High-Risk Patients: Percutaneous Gallbladder Drainage as a Definitive Treatment vs. Emergency Cholecystectomy-Systematic Review and Meta-Analysis.

Cirocchi, Roberto / Amato, Lavinia / Ungania, Serena / Buononato, Massimo / Tebala, Giovanni Domenico / Cirillo, Bruno / Avenia, Stefano / Cozza, Valerio / Costa, Gianluca / Davies, Richard Justin / Sapienza, Paolo / Coccolini, Federico / Mingoli, Andrea / Chiarugi, Massimo / Brachini, Gioia

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: Background: This systematic review aims to investigate whether percutaneous transhepatic gallbladder biliary drainage (PTGBD) is superior to emergency cholecystectomy (EC) as a definitive treatment in high-risk patients with acute cholecystitis (AC).: ...

Abstract	Background: This systematic review aims to investigate whether percutaneous transhepatic gallbladder biliary drainage (PTGBD) is superior to emergency cholecystectomy (EC) as a definitive treatment in high-risk patients with acute cholecystitis (AC). Material and methods: A systematic literature search was performed until December 2022 using the Scopus, Medline/PubMed and Web of Science databases. Results: Seventeen studies have been included with a total of 783,672 patients (32,634 treated with PTGBD vs. 4663 who underwent laparoscopic cholecystectomy, 343 who had open cholecystectomy and 746,032 who had some form of cholecystectomy, but without laparoscopic or open approach being specified). An analysis of the results shows that PTGBD, despite being less invasive, is not associated with lower morbidity with respect to EC (RR 0.77 95% CI [0.44 to 1.34]; I Conclusions: In our systematic review, the majority of studies have very low-quality evidence and more RCTs are needed; furthermore, PTGBD is inferior in the treatment of AC in high-risk patients. The definition of high-risk patients is important in interpreting the results, but the methods of assessment and definitions differ between studies. The results of our systematic review and meta-analysis failed to demonstrate any advantage of using PTGBD over ER as a definitive treatment of AC in critically ill patients, which suggests that EC should be considered as the treatment of choice even in very high-risk patients. Most likely, the inferiority of PTGBD versus early LC for high-risk patients is related to an association of various patient-side factor conditions and the severity of acute cholecystitis.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12154903
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Article: Systematic Review and Meta-Analysis of the Variants of the Obturatory Artery.

Brachini, Gioia / Matteucci, Matteo / Sapienza, Paolo / Cirocchi, Roberto / Favilli, Alessandro / Avenia, Stefano / Cheruiyot, Isaac / Tebala, Giovanni / Fedeli, Piergiorgio / Davies, Justin / Randolph, Justus / Cirillo, Bruno

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: Background: Knowledge of vascular anatomy and its possible variations is essential for performing embolization or revascularization procedures and complex surgery in the pelvis. The obturator artery (OA) is a branch of the anterior division of the ... ...

Abstract	Background: Knowledge of vascular anatomy and its possible variations is essential for performing embolization or revascularization procedures and complex surgery in the pelvis. The obturator artery (OA) is a branch of the anterior division of the internal iliac artery (IIA), and it has the highest frequency of variation among branches of the internal iliac artery. Possible anomalies of the origin of the obturator artery (OA) should be known when performing pelvic and groin surgery, where its control or ligation may be required. The purpose of this systematic review and meta-analysis, based on Sanudo's classification, is to analyze the origin of the obturator artery (OA) and its variants. Methods: Thirteen articles published between 1952 and 2020 were included. Results: The obturator artery (OA) was present in almost all cases (99.8%): the pooled prevalence estimate for the origin from the IIA axis was 77.7% (95% CI 71.8-83.1%) vs. 22.3% (95% CI 16.9-28.2%) for the origin from EIA axis. In most cases, the obturator artery (OA) originated from the anterior division trunk of the internal iliac artery (IIA) (61.6%). Conclusions: Performing preoperative radiological examination to determine the pelvic vascular pattern and having the awareness to evaluate possible changes in the obturator artery can reduce the risk of iatrogenic injury and complications.
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12154932
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Idiopathic spontaneous liver hemorrhage A report of two cases and a review of the literature.

Cirillo, Bruno / Brachini, Gioia / Zambon, Martina / Meneghini, Simona / Fonsi, Giovanni Battista / Simonelli, Luigi / Cicerchia, Pierfranco

Annali italiani di chirurgia

2021 Volume 92, Page(s) 361–364

Abstract: Spontaneous liver hemorrhage (SLH) is a serious, extremely rare, and life-threatening occurrence requiring a multidisciplinary approach. Since diagnosis might be difficult, a high mortality rate is reported. Survival depends on a prompt diagnosis ... ...

Abstract	Spontaneous liver hemorrhage (SLH) is a serious, extremely rare, and life-threatening occurrence requiring a multidisciplinary approach. Since diagnosis might be difficult, a high mortality rate is reported. Survival depends on a prompt diagnosis followed by an appropriate management. If left untreated, SLH progresses, in fact, to a hemorrhagic shock and death. SLH is rarely idiopathic, whereas more commonly is secondary to severe preeclampsia and HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome, hepatocellular carcinoma (HCC), adenoma, focal nodular hyperplasia or hemangioma, and connective tissue diseases. We report two patients presenting with an idiopathic SLH successfully treated with angioembolization, and the results of an extensive literature review. KEY WORDS: Intrahepatic hematoma, Spontaneous liver hemorrhage, Spontaneous liver rupture.
MeSH term(s)	Carcinoma, Hepatocellular ; Female ; HELLP Syndrome/diagnosis ; HELLP Syndrome/therapy ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Liver ; Liver Diseases/diagnosis ; Liver Diseases/therapy ; Liver Neoplasms/complications ; Liver Neoplasms/diagnosis ; Liver Neoplasms/therapy ; Pregnancy ; Rupture, Spontaneous
Language	English
Publishing date	2021-09-15
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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