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  1. AU="Cirino, Raphael Henrique Déa"
  2. AU="Galiano, Michele"
  3. AU="Tarabal, Vinícius S"
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  1. Article ; Online: Stroke-related mortality analysis in Paraná, Brazil, over 10 years.

    Ducci, Renata Dal-Prá / Tessaro, Camila Lorenzini / Fontes, Daniela Piera / Fraga, Gabriel Schier de / Cirino, Raphael Henrique Déa / Neto, Francisco Diego Negrão Lopes / Zetola, Viviane de Hiroki Flumignan / Lange, Marcos Christiano

    Arquivos de neuro-psiquiatria

    2022  Volume 80, Issue 11, Page(s) 1083–1089

    Abstract: Background: Stroke is the second leading cause of death and disability around the world.: Objective: The purpose of this study is to evaluate the age- and sex-specific mortality rates related to stroke in the state of Paraná, Brazil, between 2007 and ...

    Title translation Análise da mortalidade relacionada ao acidente vascular cerebral no estado do Paraná, Brasil, ao longo de 10 anos.
    Abstract Background: Stroke is the second leading cause of death and disability around the world.
    Objective: The purpose of this study is to evaluate the age- and sex-specific mortality rates related to stroke in the state of Paraná, Brazil, between 2007 and 2016.
    Methods: In this cross-sectional study, residents in the state of Paraná were selected by death certificates (from 2007-2016); the basic cause of death was stroke. A descriptive analysis was performed, and mortality rates were calculated with a 95% confidence interval (95% CI) for each year.
    Results: From 2007 to 2016, there were 62,607 deaths in the state of Paraná due to stroke. Most individuals had medical assistance before death (85.7% in 2007 versus 83.9% in 2016), and most of these deaths occurred in hospitals (73.6% in 2007 versus 74.8% in 2016). Death rates due to stroke increased from 138 (95% CI 135-142) to 163 (95% CI 159-166) per 100,000 inhabitants. This raise occurred mainly in those over 79 years old. For the ages groups of 34 to 44 and 44 to 54 years, mortality rate decreased.
    Conclusions: In the past 15 years, despite the advances in the diagnosis and treatment of stroke, there has been an increase in mortality due to stroke in the state of Paraná. This fact is possibly associated with the aging of the population because there was a more pronounced increase in the group over 79 years old. Thus, new health strategies are necessary to improve the survival and quality of life of poststroke individuals.
    MeSH term(s) Male ; Female ; Humans ; Aged ; Brazil/epidemiology ; Cross-Sectional Studies ; Quality of Life ; Stroke ; Hospitals ; Cause of Death ; Mortality
    Language English
    Publishing date 2022-12-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0042-1758398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enzyme Replacement Therapy Decreases Left Ventricular Mass Index in Patients with Hunter Syndrome?

    do Valle, Daniel Almeida / Cirino, Raphael Henrique Déa / Santos, Mara Lúcia Schmitz Ferreira / Pellissari, Eliana Costa / Scola, Rosana Herminia

    Pediatric cardiology

    2019  Volume 41, Issue 2, Page(s) 361–365

    Abstract: Although enzyme replacement therapy (ERT) has shown benefit in improving cardiac systolic function in a murine model of cardiomyopathy associated with Hunter syndrome, few studies have analyzed its effect in humans. We evaluated the effect of ERT on ... ...

    Abstract Although enzyme replacement therapy (ERT) has shown benefit in improving cardiac systolic function in a murine model of cardiomyopathy associated with Hunter syndrome, few studies have analyzed its effect in humans. We evaluated the effect of ERT on patients with Hunter syndrome-related cardiomyopathy. We performed a retrospective analysis of serial transthoracic echocardiograms performed before and over the first 5 years after treatment initiation, in 14 patients with Hunter syndrome. An important cardiac remodeling occurred in all patients in this study. There was a significant reduction in left ventricular mass index from 70.88 to 26.75 g/m
    MeSH term(s) Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/etiology ; Echocardiography ; Enzyme Replacement Therapy/methods ; Female ; Humans ; Male ; Middle Aged ; Mucopolysaccharidosis II/complications ; Mucopolysaccharidosis II/drug therapy ; Retrospective Studies ; Ventricular Remodeling/drug effects
    Language English
    Publishing date 2019-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-019-02267-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Stroke-related mortality analysis in Paraná, Brazil, over 10 years

    Ducci, Renata Dal-Prá / Tessaro, Camila Lorenzini / Fontes, Daniela Piera / Fraga, Gabriel Schier de / Cirino, Raphael Henrique Déa / Neto, Francisco Diego Negrão Lopes / Zetola, Viviane de Hiroki Flumignan / Lange, Marcos Christiano

    Arquivos de Neuro-Psiquiatria

    2022  Volume 80, Issue 11, Page(s) 1083–1089

    Abstract: Background: Stroke is the second leading cause of death and disability around the world.: Objective: The purpose of this study is to evaluate the age- and sex-specific mortality rates related to stroke in the state of Paraná, Brazil, between 2007 and ...

    Abstract Background: Stroke is the second leading cause of death and disability around the world.
    Objective: The purpose of this study is to evaluate the age- and sex-specific mortality rates related to stroke in the state of Paraná, Brazil, between 2007 and 2016.
    Methods: In this cross-sectional study, residents in the state of Paraná were selected by death certificates (from 2007–2016); the basic cause of death was stroke. A descriptive analysis was performed, and mortality rates were calculated with a 95% confidence interval (95% CI) for each year.
    Results: From 2007 to 2016, there were 62,607 deaths in the state of Paraná due to stroke. Most individuals had medical assistance before death (85.7% in 2007 versus 83.9% in 2016), and most of these deaths occurred in hospitals (73.6% in 2007 versus 74.8% in 2016). Death rates due to stroke increased from 138 (95% CI 135–142) to 163 (95% CI 159–166) per 100,000 inhabitants. This raise occurred mainly in those over 79 years old. For the ages groups of 34 to 44 and 44 to 54 years, mortality rate decreased.
    Conclusions: In the past 15 years, despite the advances in the diagnosis and treatment of stroke, there has been an increase in mortality due to stroke in the state of Paraná. This fact is possibly associated with the aging of the population because there was a more pronounced increase in the group over 79 years old. Thus, new health strategies are necessary to improve the survival and quality of life of poststroke individuals.
    Keywords Stroke ; Mortality ; Epidemiology ; Health Services ; Acidente Vascular Cerebral ; Mortalidade ; Epidemiologia ; Serviços de Saúde
    Language English
    Publishing date 2022-11-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0042-1758398
    Database Thieme publisher's database

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  4. Article ; Online: Evaluation of Left-Sided Heart Chambers With Novel Echocardiographic Techniques in Men With Duchenne or Becker Muscular Dystrophy.

    Cirino, Raphael Henrique Déa / Scola, Rosana Herminia / Ducci, Renata Dal-Prá / Camarozano, Ana Cristina / Kay, Claudia Suemi Kamoi / Lorenzoni, Paulo José / Werneck, Lineu Cesar / Carmes, Eliane Ribeiro / da Cunha, Claudio Leinig Pereira

    The American journal of cardiology

    2018  Volume 123, Issue 6, Page(s) 972–978

    Abstract: Left ventricular systolic dysfunction (LVSD) is a common finding in patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies. Novel echocardiographic techniques have been used for the detection of LVSD in several heart diseases. We aim to ... ...

    Abstract Left ventricular systolic dysfunction (LVSD) is a common finding in patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies. Novel echocardiographic techniques have been used for the detection of LVSD in several heart diseases. We aim to compare cardiac anatomic and functional data studied by three-dimensional (3DE) and two-dimensional (2DE) echocardiography and to analyze the myocardial strain for the detection of early LVSD in DMD and BMD patients. We performed a cross-sectional study of 46 DMD and 14 BMD patients. We measured left atrium volume and left ventricle volumes and ejection fraction using 3DE and 2DE techniques. Myocardial strain analysis was derived from global longitudinal strain (GLS) measurements. GLS was measured by 2DE with the speckle tracking technique. The correlation between 3DE and 2DE for the measurement of left atrium volume as well as left ventricle diastolic and systolic volumes was strong. 2DE presented larger left atrium and left ventricle volumes. Left ventricle ejection fraction was similar between the two techniques. Myocardial strain analysis was able to detect early LVSD in 50.0% of DMD patients and in 9.1% of BMD patients. In conclusion, two-dimensional echocardiography appears to be a good alternative for the anatomical and functional evaluation of the left heart chambers in DMD and BMD patients. Myocardial strain analysis detects early LVSD in a sizable portion of patients with dystrophinopathies.
    MeSH term(s) Adolescent ; Atrial Function, Left/physiology ; Child ; Echocardiography, Three-Dimensional/methods ; Heart Atria/diagnostic imaging ; Heart Atria/physiopathology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Male ; Muscular Dystrophy, Duchenne/complications ; Reproducibility of Results ; Retrospective Studies ; Systole ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2018-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2018.12.011
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  5. Article ; Online: Predictors of early left ventricular systolic dysfunction in duchenne muscular dystrophy patients.

    Cirino, Raphael Henrique Déa / Scola, Rosana Herminia / Ducci, Renata Dal-Prá / Wermelinger, Ana Cristina Camarozano / Kay, Claudia Suemi Kamoi / Lorenzoni, Paulo José / Werneck, Lineu Cesar / Carmes, Eliane Ribeiro / Da Cunha, Claudio Leinig Pereira

    Muscle & nerve

    2018  

    Abstract: Introduction: Early detection of left ventricular systolic dysfunction (LVSD) is important for therapeutic strategies for Duchenne muscular dystrophy (DMD) patients. We analyzed myocardial strain using echocardiography for early detection of LVSD and ... ...

    Abstract Introduction: Early detection of left ventricular systolic dysfunction (LVSD) is important for therapeutic strategies for Duchenne muscular dystrophy (DMD) patients. We analyzed myocardial strain using echocardiography for early detection of LVSD and determined the predictors of early LVSD.
    Methods: This investigation was a cross-sectional study of 40 DMD patients with normal left ventricular ejection fraction. Global longitudinal strain (GLS) was used to analyze subtle disturbances in longitudinal contraction of the myocardium. Patients were determined to have early LVSD (GLS > -18) or normal left ventricular systolic function (GLS ≤ -18).
    Results: Patients who had early LVSD were older and had a higher frequency of corticosteroid therapy and of mutations in exons 45, 46, 47, 48, 49, 50, and 52.
    Discussion: Myocardial strain measurements are useful for the early diagnosis of LVSD in DMD patients. Older age, use of corticosteroids, and mutations within the "hot-spot" region of the DMD gene are associated with early LVSD. Muscle Nerve, 2018.
    Language English
    Publishing date 2018-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.26102
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  6. Article ; Online: Smoking cessation among patients at a university hospital in Curitiba, Brazil.

    Silva, Rodney Luiz Frare e / Carmes, Eliane Ribeiro / Schwartz, Alain Felipe / Blaszkowski, Denise de Souza / Cirino, Raphael Henrique Déa / Ducci, Renata Dal-Prá

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2011  Volume 37, Issue 4, Page(s) 480–487

    Abstract: Objective: To determine the prevalence of smoking and the frequency of smoking cessation counseling among patients at a university hospital, as well as to compare smokers and former smokers in terms of smoking history.: Methods: A cross-sectional ... ...

    Abstract Objective: To determine the prevalence of smoking and the frequency of smoking cessation counseling among patients at a university hospital, as well as to compare smokers and former smokers in terms of smoking history.
    Methods: A cross-sectional study involving 629 patients at the Federal University of Paraná Hospital de Clínicas, located in the city of Curitiba, Brazil.
    Results: Of the 629 patients, 206 (32.7%) were male, 76 (12.1%) were smokers, 179 (28.5%) were former smokers, and 374 (59.5%) were nonsmokers. The mean age of the patients was 49.9 ± 15.0 years (range, 18-84 years). Of the 76 smokers and 179 former smokers, 72 (94.7%) and 166 (92.7%), respectively, were questioned about tobacco use. Smoking history and degree of nicotine dependence were higher among the former smokers (p = 0.0292 and p = 0.0125, respectively). Gender, age at smoking initiation, physician inquiry about tobacco use, and smoking cessation counseling were comparable between the two groups. The smoking cessation rate was 0.70. The prevalence of heavy smoking varied by gender and by age bracket, being higher in males and in the 41-70 year age bracket.
    Conclusions: The smoking prevalence in this group of patients was lower than that reported for patients at another university hospital, for adults in Curitiba, and for adults in Brazil. The smoking cessation rate was higher in these patients than in the general population of Curitiba. Smokers and former smokers differed regarding age, smoking history, and degree of nicotine dependence. Heavy smoking and a moderate or high degree of nicotine dependence were not obstacles to smoking cessation.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Brazil/epidemiology ; Counseling/statistics & numerical data ; Cross-Sectional Studies ; Female ; Hospitals, University/statistics & numerical data ; Humans ; Male ; Middle Aged ; Prevalence ; Sex Distribution ; Sex Factors ; Smoking/epidemiology ; Smoking Cessation/psychology ; Smoking Cessation/statistics & numerical data ; Young Adult
    Language Portuguese
    Publishing date 2011-11-01
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.1590/s1806-37132011000400010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: General practice physician knowledge about headache: evaluation of the municipal continual medical education program.

    Kowacs, Pedro André / Twardowschy, Carlos Alexandre / Piovesan, Elcio Juliato / Dal-Prá Ducci, Renata / Cirino, Raphael Henrique Déa / Hamdar, Fátima / Chomatas, Eliane Regina da Veiga / Marty, Inês Kultchek

    Arquivos de neuro-psiquiatria

    2009  Volume 67, Issue 3A, Page(s) 595–599

    Abstract: Objective: Headache is a common condition not always managed satisfactorily by primary care providers (PCPs). In an effort to improve headache care, the Curitiba City Hall in consortia with Hospital de Clínicas da Universidade Federal do Paraná - Brazil ...

    Abstract Objective: Headache is a common condition not always managed satisfactorily by primary care providers (PCPs). In an effort to improve headache care, the Curitiba City Hall in consortia with Hospital de Clínicas da Universidade Federal do Paraná - Brazil developed an educational program directed to the PCPs. The goal of the project was to evaluate, to update and to train the PCP on headache knowledge and care.
    Method: The program was designed to have a theoretical phase and a practical phase. Knowledge on headache and medical care of headache were surveyed before and after the theoretical phase thorough a specific questionnaire.
    Results: Significant improvement in post-CME scores on headache prevalence (p<0.001), migraine diagnosis (p<0.001) and management (p=0.01), secondary headache diagnosis (p=0.005) and management (p=0.005) was reached by the respondents.
    Conclusion: Improvement in post-CME scores confirms that the program had a significant immediate impact on the PCPs knowledge directly affecting the patient's health.
    MeSH term(s) Clinical Competence ; Education, Medical, Continuing ; Family Practice/education ; Headache/diagnosis ; Headache/therapy ; Humans ; Practice Patterns, Physicians' ; Surveys and Questionnaires
    Language English
    Publishing date 2009-05-13
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1590/s0004-282x2009000400004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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