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  1. Article ; Online: Biophysical stimulation for

    Korolj, Anastasia / Wang, Erika Yan / Civitarese, Robert A / Radisic, Milica

    Clinical science (London, England : 1979)

    2017  Volume 131, Issue 13, Page(s) 1393–1404

    Abstract: Engineering functional cardiac tissues remains an ongoing significant challenge due to the complexity of the native environment. However, our growing understanding of key parameters of ... ...

    Abstract Engineering functional cardiac tissues remains an ongoing significant challenge due to the complexity of the native environment. However, our growing understanding of key parameters of the
    MeSH term(s) Cells, Cultured ; Coculture Techniques ; Electric Stimulation/methods ; Humans ; Hydrogels ; Models, Cardiovascular ; Myocardium/cytology ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/physiology ; Physical Stimulation/methods ; Tissue Engineering/methods ; Tissue Scaffolds
    Chemical Substances Hydrogels
    Language English
    Publishing date 2017-07-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20170055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Exercise becomes brain: sustained aerobic exercise enhances hippocampal neurogenesis.

    Tharmaratnam, Tharmegan / Civitarese, Robert A / Tabobondung, Tyler / Tabobondung, Taylor A

    The Journal of physiology

    2016  Volume 595, Issue 1, Page(s) 7–8

    MeSH term(s) Brain ; Exercise ; Hippocampus ; Neurogenesis ; Physical Conditioning, Animal
    Language English
    Publishing date 2016-10-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP272761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  3. Article ; Online: Role of integrins in mediating cardiac fibroblast-cardiomyocyte cross talk: a dynamic relationship in cardiac biology and pathophysiology.

    Civitarese, Robert A / Kapus, Andras / McCulloch, Christopher A / Connelly, Kim A

    Basic research in cardiology

    2017  Volume 112, Issue 1, Page(s) 6

    Abstract: Integrins are a family of heterodimeric proteins expressed by cardiac fibroblasts and cardiomyocytes that provide critical adhesive and signaling functions through their interactions with the extracellular matrix (ECM) and the actin cytoskeleton. These ... ...

    Abstract Integrins are a family of heterodimeric proteins expressed by cardiac fibroblasts and cardiomyocytes that provide critical adhesive and signaling functions through their interactions with the extracellular matrix (ECM) and the actin cytoskeleton. These adhesive processes are important for paracrine signaling, ECM homeostasis and for the intercellular interactions that impact cardiac cell biology and pathophysiological adaptation in disease. Despite considerable progress, our understanding of the interplay between cardiac cells, the ECM and integrins remains largely elusive. In this review, we examine the role of integrins in adhesive and signaling functions, and how these functions enable communication between cardiac fibroblasts, cardiomyocytes and the ECM. These processes strongly influence cardiac development and, later, the progression into cardiac disease. An improved understanding of this multi-dimensional system in cardiac tissues is needed to decipher the biological, spatiotemporal and mechanical cues that regulate cardiac health and the manifestation of cardiac disease. Greater insight into integrin function in cardiac tissues may also suggest new treatments for the prevention of heart failure.
    MeSH term(s) Animals ; Extracellular Matrix/metabolism ; Fibroblasts/metabolism ; Heart Diseases/physiopathology ; Humans ; Integrins/metabolism ; Myocytes, Cardiac/metabolism ; Receptor Cross-Talk/physiology
    Chemical Substances Integrins
    Language English
    Publishing date 2017-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-016-0598-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: The α11 integrin mediates fibroblast-extracellular matrix-cardiomyocyte interactions in health and disease.

    Civitarese, Robert A / Talior-Volodarsky, Ilana / Desjardins, Jean-Francois / Kabir, Golam / Switzer, Jennifer / Mitchell, Melissa / Kapus, Andras / McCulloch, Christopher A / Gullberg, Donald / Connelly, Kim A

    American journal of physiology. Heart and circulatory physiology

    2016  Volume 311, Issue 1, Page(s) H96–H106

    Abstract: Excessive cardiac interstitial fibrosis impairs normal cardiac function. We have shown that the α11β1 (α11) integrin mediates fibrotic responses to glycated collagen in rat myocardium by a pathway involving transforming growth factor-β. Little is known ... ...

    Abstract Excessive cardiac interstitial fibrosis impairs normal cardiac function. We have shown that the α11β1 (α11) integrin mediates fibrotic responses to glycated collagen in rat myocardium by a pathway involving transforming growth factor-β. Little is known of the role of the α11 integrin in the developing mammalian heart. Therefore, we examined the impact of deletion of the α11 integrin in wild-type mice and in mice treated with streptozotocin (STZ) to elucidate the role of the α11 integrin in normal cardiac homeostasis and in the pathogenesis of diabetes-related fibrosis. As anticipated, cardiac fibrosis was reduced in α11 integrin knockout mice (α11(-/-); C57BL/6 background) treated with STZ compared with STZ-treated wild-type mice (P < 0.05). Unexpectedly, diastolic function was impaired in both vehicle and STZ-treated α11(-/-) mice, as shown by the decreased minimum rate of pressure change and prolonged time constant of relaxation in association with increased end-diastolic pressure (all P < 0.05 compared with wild-type mice). Accordingly, we examined the phenotype of untreated α11(-/-) mice, which demonstrated a reduced cardiomyocyte cross-sectional cell area and myofibril thickness (all P < 0.05 compared with wild-type mice) and impaired myofibril arrangement. Immunostaining for desmin and connexin 43 showed abnormal intermediate filament organization at intercalated disks and impaired gap-junction development. Overall, deletion of the α11 integrin attenuates cardiac fibrosis in the mammalian mouse heart and reduces ECM formation as a result of diabetes. Furthermore, α11 integrin deletion impairs cardiac function and alters cardiomyocyte morphology. These findings shed further light on the poorly understood interaction between the fibroblast-cardiomyocyte and the ECM.
    MeSH term(s) Animals ; Cell Size ; Connexin 43/metabolism ; Desmin/metabolism ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Cardiomyopathies/genetics ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/pathology ; Diabetic Cardiomyopathies/physiopathology ; Extracellular Matrix/metabolism ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis ; Genotype ; Integrin alpha Chains/deficiency ; Integrin alpha Chains/genetics ; Integrin alpha Chains/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Myofibrils/metabolism ; Myofibrils/pathology ; Phenotype ; Signal Transduction ; Streptozocin ; Stroke Volume ; Ventricular Dysfunction, Left/genetics ; Ventricular Dysfunction, Left/metabolism ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left ; Ventricular Pressure ; Ventricular Remodeling
    Chemical Substances Connexin 43 ; Desmin ; GJA1 protein, mouse ; Integrin alpha Chains ; integrin alpha11, mouse ; Streptozocin (5W494URQ81)
    Language English
    Publishing date 2016-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00918.2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  5. Article: Flexible shape-memory scaffold for minimally invasive delivery of functional tissues.

    Montgomery, Miles / Ahadian, Samad / Davenport Huyer, Locke / Lo Rito, Mauro / Civitarese, Robert A / Vanderlaan, Rachel D / Wu, Jun / Reis, Lewis A / Momen, Abdul / Akbari, Saeed / Pahnke, Aric / Li, Ren-Ke / Caldarone, Christopher A / Radisic, Milica

    Nature materials

    2017  Volume 16, Issue 10, Page(s) 1038–1046

    Abstract: Despite great progress in engineering functional tissues for organ repair, including the heart, an invasive surgical approach is still required for their implantation. Here, we designed an elastic and microfabricated scaffold using a biodegradable ... ...

    Abstract Despite great progress in engineering functional tissues for organ repair, including the heart, an invasive surgical approach is still required for their implantation. Here, we designed an elastic and microfabricated scaffold using a biodegradable polymer (poly(octamethylene maleate (anhydride) citrate)) for functional tissue delivery via injection. The scaffold's shape memory was due to the microfabricated lattice design. Scaffolds and cardiac patches (1 cm × 1 cm) were delivered through an orifice as small as 1 mm, recovering their initial shape following injection without affecting cardiomyocyte viability and function. In a subcutaneous syngeneic rat model, injection of cardiac patches was equivalent to open surgery when comparing vascularization, macrophage recruitment and cell survival. The patches significantly improved cardiac function following myocardial infarction in a rat, compared with the untreated controls. Successful minimally invasive delivery of human cell-derived patches to the epicardium, aorta and liver in a large-animal (porcine) model was achieved.
    MeSH term(s) Allografts ; Animals ; Aorta/metabolism ; Aorta/pathology ; Aorta/surgery ; Biodegradable Plastics/chemistry ; Cell Survival ; Cells, Immobilized/metabolism ; Cells, Immobilized/pathology ; Cells, Immobilized/transplantation ; Elasticity ; Heterografts ; Humans ; Liver/metabolism ; Liver/pathology ; Liver/surgery ; Materials Testing ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/surgery ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/transplantation ; Pericardium/metabolism ; Pericardium/pathology ; Pericardium/surgery ; Rats ; Swine ; Tissue Scaffolds/chemistry
    Chemical Substances Biodegradable Plastics
    Language English
    Publishing date 2017-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/nmat4956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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