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  1. AU="Claire Hivroz"
  2. AU=Huang L E
  3. AU="More, Jessica"
  4. AU="Eliot, George"
  5. AU="Choi, Kati"
  6. AU="Wiese, Lothar"
  7. AU=Rackova Sylva AU=Rackova Sylva
  8. AU="Akala, Isiaka Olusola"
  9. AU="Nicolás Gonzalo Núñez"
  10. AU="Hernández Solis, Alejandro"
  11. AU="Jadad, Alejandro R"
  12. AU="Lastres, Palma Rico" AU="Lastres, Palma Rico"
  13. AU="Manes, K"
  14. AU="Baugh, Matthew"
  15. AU="Qu, C"
  16. AU="Flett, Heather"
  17. AU="Shueh Lin Lim"
  18. AU="Schröder, Johann"
  19. AU=Butler Taylor
  20. AU="Yang, Fan"
  21. AU="Giacomo Frati"
  22. AU=Kokhaei P
  23. AU="Charikleia Triantopoulou"
  24. AU="Salil Bhargava"
  25. AU="Jong-Eun Lee"
  26. AU="Vargas C, Laura"

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  1. Artikel ; Online: Retrograde and Anterograde Transport of Lat-Vesicles During the Immunological Synapse Formation

    Juan José Saez / Stephanie Dogniaux / Massiullah Shafaq-Zadah / Ludger Johannes / Claire Hivroz / Andrés Ernesto Zucchetti

    Cells, Vol 10, Iss 359, p

    Defining the Finely-Tuned Mechanism

    2021  Band 359

    Abstract: LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments. Upon T cell activation the intracellular pool of ... ...

    Abstract LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments. Upon T cell activation the intracellular pool of LAT is recruited to the immune synapse (IS). We previously described two pathways controlling LAT trafficking: retrograde transport from endosomes to the TGN, and anterograde traffic from the Golgi to the IS. We address the specific role of four proteins, the GTPase Rab6, the t-SNARE syntaxin-16, the v-SNARE VAMP7 and the golgin GMAP210, in each pathway. Using different methods (endocytosis and Golgi trap assays, confocal and TIRF microscopy, TCR-signalosome pull down) we show that syntaxin-16 is regulating the retrograde transport of LAT whereas VAMP7 is regulating the anterograde transport. Moreover, GMAP210 and Rab6, known to contribute to both pathways, are in our cellular context, specifically and respectively, involved in anterograde and retrograde transport of LAT. Altogether, our data describe how retrograde and anterograde pathways coordinate LAT enrichment at the IS and point to the Golgi as a central hub for the polarized recruitment of LAT to the IS. The role that this finely-tuned transport of signaling molecules plays in T-cell activation is discussed.
    Schlagwörter LAT ; T-cell activation ; immune synapse ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

    Irini Evnouchidou / Pascal Chappert / Samira Benadda / Andres Zucchetti / Mirjana Weimershaus / Marcelle Bens / Vivien Caillens / Despoina Koumantou / Sophie Lotersztajn / Peter van Endert / Jean Davoust / Pierre Guermonprez / Claire Hivroz / David A. Gross / Loredana Saveanu

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 16

    Abstract: T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown ... ...

    Abstract T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tumour response in mice with T-specific conditional deletion of IRAP.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Dynamic palmitoylation events following T-cell receptor signaling

    Eliot Morrison / Tatjana Wegner / Andres Ernesto Zucchetti / Miguel Álvaro-Benito / Ashley Zheng / Stefanie Kliche / Eberhard Krause / Britta Brügger / Claire Hivroz / Christian Freund

    Communications Biology, Vol 3, Iss 1, Pp 1-

    2020  Band 9

    Abstract: Morrison et al. find that in T-cells, the palmitoyl acetyltransferase DHHC18 palmitoylates the v-SNARE VAMP7 at Cys183 and show that a mutant that cannot be palmitoylated fails to localise to Golgi and traffic to the immune synapse after T-cell receptor ... ...

    Abstract Morrison et al. find that in T-cells, the palmitoyl acetyltransferase DHHC18 palmitoylates the v-SNARE VAMP7 at Cys183 and show that a mutant that cannot be palmitoylated fails to localise to Golgi and traffic to the immune synapse after T-cell receptor activation. This study highlights the importance of palmitoylation in T-cell signalling.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

    Irini Evnouchidou / Pascal Chappert / Samira Benadda / Andres Zucchetti / Mirjana Weimershaus / Marcelle Bens / Vivien Caillens / Despoina Koumantou / Sophie Lotersztajn / Peter van Endert / Jean Davoust / Pierre Guermonprez / Claire Hivroz / David A. Gross / Loredana Saveanu

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 16

    Abstract: T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown ... ...

    Abstract T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tumour response in mice with T-specific conditional deletion of IRAP.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

    Michael Saitakis / Stéphanie Dogniaux / Christel Goudot / Nathalie Bufi / Sophie Asnacios / Mathieu Maurin / Clotilde Randriamampita / Atef Asnacios / Claire Hivroz

    eLife, Vol

    2017  Band 6

    Abstract: T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young’s modulus range of 0.5 kPa to 100 kPa. ... ...

    Abstract T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young’s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly.
    Schlagwörter T lymphocyte ; rigidity ; TCR ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2017-06-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Correction

    Benoît Carpentier / Paolo Pierobon / Claire Hivroz / Nelly Henry

    PLoS ONE, Vol 4, Iss

    T-Cell Artificial Focal Triggering Tools: Linking Surface Interactions with Cell Response.

    2009  Band 9

    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

    Andres Ernesto Zucchetti / Laurence Bataille / Jean-Marie Carpier / Stéphanie Dogniaux / Mabel San Roman-Jouve / Mathieu Maurin / Michael W. Stuck / Rosa M. Rios / Cosima T. Baldari / Gregory J. Pazour / Claire Hivroz

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 17

    Abstract: The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear. Here the authors show that, in activated T cells, the Golgin GMAP210 specifically ... ...

    Abstract The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear. Here the authors show that, in activated T cells, the Golgin GMAP210 specifically conveys LAT+ vesicles to immune synapse allowing proper T cell activation.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

    Andres Ernesto Zucchetti / Laurence Bataille / Jean-Marie Carpier / Stéphanie Dogniaux / Mabel San Roman-Jouve / Mathieu Maurin / Michael W. Stuck / Rosa M. Rios / Cosima T. Baldari / Gregory J. Pazour / Claire Hivroz

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 17

    Abstract: The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear. Here the authors show that, in activated T cells, the Golgin GMAP210 specifically ... ...

    Abstract The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear. Here the authors show that, in activated T cells, the Golgin GMAP210 specifically conveys LAT+ vesicles to immune synapse allowing proper T cell activation.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: T-cell artificial focal triggering tools

    Benoît Carpentier / Paolo Pierobon / Claire Hivroz / Nelly Henry

    PLoS ONE, Vol 4, Iss 3, p e

    linking surface interactions with cell response.

    2009  Band 4784

    Abstract: T-cell activation is a key event in the immune system, involving the interaction of several receptor ligand pairs in a complex intercellular contact that forms between T-cell and antigen-presenting cells. Molecular components implicated in contact ... ...

    Abstract T-cell activation is a key event in the immune system, involving the interaction of several receptor ligand pairs in a complex intercellular contact that forms between T-cell and antigen-presenting cells. Molecular components implicated in contact formation have been identified, but the mechanism of activation and the link between molecular interactions and cell response remain poorly understood due to the complexity and dynamics exhibited by whole cell-cell conjugates. Here we demonstrate that simplified model colloids grafted so as to target appropriate cell receptors can be efficiently used to explore the relationship of receptor engagement to the T-cell response. Using immortalized Jurkat T cells, we monitored both binding and activation events, as seen by changes in the intracellular calcium concentration. Our experimental strategy used flow cytometry analysis to follow the short time scale cell response in populations of thousands of cells. We targeted both T-cell receptor CD3 (TCR/CD3) and leukocyte-function-associated antigen (LFA-1) alone or in combination. We showed that specific engagement of TCR/CD3 with a single particle induced a transient calcium signal, confirming previous results and validating our approach. By decreasing anti-CD3 particle density, we showed that contact nucleation was the most crucial and determining step in the cell-particle interaction under dynamic conditions, due to shear stress produced by hydrodynamic flow. Introduction of LFA-1 adhesion molecule ligands at the surface of the particle overcame this limitation and elucidated the low TCR/CD3 ligand density regime. Despite their simplicity, model colloids induced relevant biological responses which consistently echoed whole cell behavior. We thus concluded that this biophysical approach provides useful tools for investigating initial events in T-cell activation, and should enable the design of intelligent artificial systems for adoptive immunotherapy.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2009-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Correction

    Benoît Carpentier / Paolo Pierobon / Claire Hivroz / Nelly Henry

    PLoS ONE, Vol 4, Iss

    T-Cell Artificial Focal Triggering Tools: Linking Surface Interactions with Cell Response

    2009  Band 9

    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2009-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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