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  1. Article ; Online: Translating policy to place

    Matthew G. Kirby / Alister J. Scott / Claire L. Walsh

    Ecosystems and People, Vol 19, Iss

    exploring cultural ecosystem services in areas of Green Belt through participatory mapping

    2023  Volume 1

    Abstract: ABSTRACTGreen Belts are longstanding planning designations, which primarily seek to prevent urban sprawl. Importantly, they form the open spaces close to where most people live, but we lack clarity over how Green Belts are used and valued by publics, and ...

    Abstract ABSTRACTGreen Belts are longstanding planning designations, which primarily seek to prevent urban sprawl. Importantly, they form the open spaces close to where most people live, but we lack clarity over how Green Belts are used and valued by publics, and the cultural ecosystem services they provide. To address this policy and research gap, a public participatory mapping survey was conducted on the North-East England Green Belt, with 779 respondents plotting 2388 points. The results show for the first time that in addition to being a planning policy zone, Green Belts are important, and widely used open spaces for ‘everyday nature’, providing several cultural ecosystem services including recreation, connection with nature, sense of place and aesthetic value. Several factors were found to influence the supply of cultural ecosystem services in Green Belts, including proximity to urban areas, woodland land cover and access designations. Whereas most demand pressures on Green Belts were on public rights-of-way, nature designations and deciduous woodlands. Pervasive barriers inhibiting Green Belt’s full potential were identified including management issues, concerns over personal safety and lack of access. We argue that opportunities to further enhance the cultural ecosystem services provided Green Belts and peri-urban landscapes more broadly, not only come from planning policies themselves, but from the design and delivery of approaches integrating urban, rural and land-use policy silos. The findings have wider implications for policy including potential conflict with future development, and opportunities for greater access to greenspace.
    Keywords Catharina Schulp ; Public Participatory Geographic Information Systems (PPGIS) ; public participatory mapping ; ecosystem services ; peri-urban ; recreation ; Human ecology. Anthropogeography ; GF1-900 ; Environmental sciences ; GE1-350
    Subject code 710
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Prevalence and risk factors of childhood diarrhea among wastewater irrigating urban farming households in Addis Ababa

    Adane Sirage Ali / Sirak Robele Gari / Michaela L. Goodson / Claire L. Walsh / Bitew K. Dessie / Argaw Ambelu

    PLoS ONE, Vol 18, Iss

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Prevalence and risk factors of childhood diarrhea among wastewater irrigating urban farming households in Addis Ababa.

    Adane Sirage Ali / Sirak Robele Gari / Michaela L Goodson / Claire L Walsh / Bitew K Dessie / Argaw Ambelu

    PLoS ONE, Vol 18, Iss 11, p e

    2023  Volume 0288425

    Abstract: Introduction Childhood diarrhea is one of the major contributors to the morbidity of under-five children in Ethiopia. Although researchers determine the risk factors varyingly, the exposure route to the pathogens is usually complicated. This study aims ... ...

    Abstract Introduction Childhood diarrhea is one of the major contributors to the morbidity of under-five children in Ethiopia. Although researchers determine the risk factors varyingly, the exposure route to the pathogens is usually complicated. This study aims to investigate the prevalence and risk factors of diarrhea among children under the age of five among wastewater irrigation farming households in Addis Ababa, Ethiopia. Methods Cross-sectional study was conducted among 402 farming households from November 2021 to February 2022. Data was collected using a face-to-face interviewer-administered questionnaire. Stata version 14 software was used to analyze data. Factors associated with the prevalence of diarrhea was identified using binary logistic regression. Multivariable analysis was carried out to determine an adjusted odds ratio at a confidence level of 95% and level of significance at 0.05. Results The overall prevalence of under-five children diarrheal cases was 22.3%. The odds of diarrhea are associated with a multitude of variables. Major wastewater-related determinants associated with diarrhea are body washing with irrigation water [AOR: 37.7, 95%CI (3.1, 358)], contaminated cloth with irrigation water [AOR:10.8,95%CI(0.6, 205)], use of protective clothing during farm work [28.9,95%CI (3.9, 215)], use of farm work cloths at home [AOR: 31.7, 95%CI (4.4, 226)], and bringing unwashed farm tools to home [94 (5.7, 1575)]. Conclusion The high prevalence of under-five children diarrheal disease among wastewater irrigation households was strongly associated with factors related to occupational exposure. Thus, to decrease childhood diarrheal among urban agriculture farmers, appropriate precautions need to be taken.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A multiscale X-ray phase-contrast tomography dataset of a whole human left lung

    R. Patrick Xian / Claire L. Walsh / Stijn E. Verleden / Willi L. Wagner / Alexandre Bellier / Sebastian Marussi / Maximilian Ackermann / Danny D. Jonigk / Joseph Jacob / Peter D. Lee / Paul Tafforeau

    Scientific Data, Vol 9, Iss 1, Pp 1-

    2022  Volume 10

    Abstract: Measurement(s) Human left lung Technology Type(s) X-Ray Phase-Contrast ... ...

    Abstract Measurement(s) Human left lung Technology Type(s) X-Ray Phase-Contrast Imaging
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A Systems Framework for Infrastructure Business Models for Resilient and Sustainable Urban Areas

    Claire L. Walsh / Stephanie Glendinning / Richard J. Dawson / Peter O'Brien / Oliver Heidrich / Christopher D. F. Rogers / John R. Bryson / Phil Purnell

    Frontiers in Sustainable Cities, Vol

    2022  Volume 4

    Abstract: Sustainable Development Goal 11 calls for inclusive, safe, resilient and sustainable cities. Urban areas comprise interconnected infrastructure systems that deliver services that support all aspects of daily life. Despite their important contribution to ... ...

    Abstract Sustainable Development Goal 11 calls for inclusive, safe, resilient and sustainable cities. Urban areas comprise interconnected infrastructure systems that deliver services that support all aspects of daily life. Despite their important contribution to modern life current infrastructure business models typically under-estimate the long-term economic, social and environmental benefits of infrastructure. Therefore, new infrastructure business models are required that: (i) target urban areas or regions at a local scale where there is the greatest scope for innovation, (ii) target specific challenges or needs (i.e., where there is a clear driver for innovation), and (iii) tackle the issue of the flawed economic cost-benefit model for assessing the viability of infrastructure investments. This paper presents a framework that promotes multiple stakeholders to working together, and by focusing on outcomes to develop alternative infrastructure solutions and business models that deliver multiple values to multiple stakeholders. By explicitly mapping these values over time and space, the interdependencies between infrastructures are revealed, along with an expanded perception of the value being brought about by that infrastructure. Moreover, the broader consideration of value also increases the number of stakeholders beneficiaries, the value network, and subsequently identify how they can support the infrastructure intervention by formulating alternative funding and financing mechanisms. A series of case studies to achieve resilience, sustainability and regeneration outcomes are used to show how the framework can be utilized to unlock investment in infrastructure in situations where traditional approaches have failed.
    Keywords infrastructure ; business models ; values ; systems ; sustainability ; resilience ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 380
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Multi-sector mitigation strategies at the neighbourhood scale

    Palermo, Valentina / Claire L. Walsh / Richard J. Dawson / Alberto Fichera / Giuseppe Inturri

    Journal of cleaner production. 2018 June 20, v. 187

    2018  

    Abstract: Climate change mitigation in urban areas requires a portfolio of policies and practices that are implemented across a range of scales and sectors. The local scale allows the development and implementation of site specific strategies to address climate ... ...

    Abstract Climate change mitigation in urban areas requires a portfolio of policies and practices that are implemented across a range of scales and sectors. The local scale allows the development and implementation of site specific strategies to address climate change in urban areas that have been proven to be more efficient, especially within buildings. But these must be within the wider context of transport and other energy consumption. A unique integrated assessment methodology for the analysis of energy at the neighbourhood scale that considers the key sectors of buildings, transport and outdoor lighting has been developed. The influence of key drivers of energy consumption: land use, technology, infrastructure design, are considered to assess how neighbourhood choices impact upon wider energy usage, such as transport emissions. Applied to a neighbourhood in Italy, results show that building retrofit has the greatest benefit, of up to 60%. However, by transitioning to a mixed land use neighbourhood, growing local employment and improving the transit network, reductions of 80% can be achieved in line with the requirements of the Paris Agreement. The method highlights the importance of taking a multi-sector and multi-scale approach to considering neighbourhood mitigation.
    Keywords United Nations Framework Convention on Climate Change ; buildings ; climate change ; emissions ; employment ; energy use and consumption ; infrastructure ; issues and policy ; land use ; lighting ; urban areas ; Italy
    Language English
    Dates of publication 2018-0620
    Size p. 893-902.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2018.03.223
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

    Maximilian Ackermann / Jan C. Kamp / Christopher Werlein / Claire L. Walsh / Helge Stark / Verena Prade / Rambabu Surabattula / Willi L. Wagner / Catherine Disney / Andrew J. Bodey / Thomas Illig / Diana J. Leeming / Morten A. Karsdal / Alexandar Tzankov / Peter Boor / Mark P. Kühnel / Florian P. Länger / Stijn E. Verleden / Hans M. Kvasnicka /
    Hans H. Kreipe / Axel Haverich / Stephen M. Black / Axel Walch / Paul Tafforeau / Peter D. Lee / Marius M. Hoeper / Tobias Welte / Benjamin Seeliger / Sascha David / Detlef Schuppan / Steven J. Mentzer / Danny D. Jonigk

    EBioMedicine, Vol 85, Iss , Pp 104296- (2022)

    2022  

    Abstract: Summary: Background: COVID-19 is characterized by a heterogeneous clinical presentation, ranging from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with severe lung disease die from COVID-19 and a substantial number of ... ...

    Abstract Summary: Background: COVID-19 is characterized by a heterogeneous clinical presentation, ranging from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with severe lung disease die from COVID-19 and a substantial number of survivors develop long-COVID. Our objective was to provide comprehensive insights into the pathophysiology of severe COVID-19 and to identify liquid biomarkers for disease severity and therapy response. Methods: We studied a total of 85 lungs (n = 31 COVID autopsy samples; n = 7 influenza A autopsy samples; n = 18 interstitial lung disease explants; n = 24 healthy controls) using the highest resolution Synchrotron radiation-based hierarchical phase-contrast tomography, scanning electron microscopy of microvascular corrosion casts, immunohistochemistry, matrix-assisted laser desorption ionization mass spectrometry imaging, and analysis of mRNA expression and biological pathways. Plasma samples from all disease groups were used for liquid biomarker determination using ELISA. The anatomic/molecular data were analyzed as a function of patients’ hospitalization time. Findings: The observed patchy/mosaic appearance of COVID-19 in conventional lung imaging resulted from microvascular occlusion and secondary lobular ischemia. The length of hospitalization was associated with increased intussusceptive angiogenesis. This was associated with enhanced angiogenic, and fibrotic gene expression demonstrated by molecular profiling and metabolomic analysis. Increased plasma fibrosis markers correlated with their pulmonary tissue transcript levels and predicted disease severity. Plasma analysis confirmed distinct fibrosis biomarkers (TSP2, GDF15, IGFBP7, Pro-C3) that predicted the fatal trajectory in COVID-19. Interpretation: Pulmonary severe COVID-19 is a consequence of secondary lobular microischemia and fibrotic remodelling, resulting in a distinctive form of fibrotic interstitial lung disease that contributes to long-COVID. Funding: This project was made possible by a number of ...
    Keywords COVID-19 ; Intussusceptive angiogenesis ; Fibrogenesis ; Biomarkers ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

    Daniyal J Jafree / Dale Moulding / Maria Kolatsi-Joannou / Nuria Perretta Tejedor / Karen L Price / Natalie J Milmoe / Claire L Walsh / Rosa Maria Correra / Paul JD Winyard / Peter C Harris / Christiana Ruhrberg / Simon Walker-Samuel / Paul R Riley / Adrian S Woolf / Peter J Scambler / David A Long

    eLife, Vol

    2019  Volume 8

    Abstract: Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ. We performed three- ... ...

    Abstract Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ. We performed three-dimensional imaging to characterize lymphatic vessel formation in the mammalian embryonic kidney at single-cell resolution. In mouse, we visually and quantitatively assessed the development of kidney lymphatic vessels, remodeling from a ring-like anastomosis under the nascent renal pelvis; a site of VEGF-C expression, to form a patent vascular plexus. We identified a heterogenous population of lymphatic endothelial cell clusters in mouse and human embryonic kidneys. Exogenous VEGF-C expanded the lymphatic population in explanted mouse embryonic kidneys. Finally, we characterized complex kidney lymphatic abnormalities in a genetic mouse model of polycystic kidney disease. Our study provides novel insights into the development of kidney lymphatic vasculature; a system which likely has fundamental roles in renal development, physiology and disease.
    Keywords kidney ; lymphatics ; vessels ; development ; kidney disease ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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