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  1. Article ; Online: Consultative issues in surgical neuropathology: a retrospective review of the rationale for submitting cases for expert review.

    Lipp, Eric S / Clark, Alysha C / McLendon, Roger E

    American journal of clinical pathology

    2015  Volume 143, Issue 6, Page(s) 807–811

    Abstract: Objectives: Second opinions on neuropathology cases are sought for a variety of reasons. We investigated the rationales for seeking expert neuropathologic review.: Methods: A retrospective review was done of the correspondence accompanying ... ...

    Abstract Objectives: Second opinions on neuropathology cases are sought for a variety of reasons. We investigated the rationales for seeking expert neuropathologic review.
    Methods: A retrospective review was done of the correspondence accompanying neuropathology cases submitted over a 5-year period. The review used a taxonomy of referral reasons, the submitting diagnoses, and requests for ancillary tests.
    Results: In total, 508 adult cases were submitted, including glioblastoma (n = 94), anaplastic astrocytoma (n = 49), low-grade glioma (n = 49), oligodendroglioma (n = 48), and pituitary adenoma (n = 12). Thirty-nine cases submitted requested ancillary testing. A taxonomy of four categories revealed the following: preliminary diagnosis (n = 228 cases) was the most common reason for requesting review, followed by no diagnosis rendered (n = 183 cases), second opinion (n = 53), and confirmation/quality assurance (n = 43); the remaining case was "other." Overall, 456 cases were submitted by pathologists, 40 by clinicians and 12 by patients.
    Conclusions: Pathologists who predominately submit cases with a preliminary diagnosis rendered seek expert consultation while clinicians seek a second opinion.
    MeSH term(s) Adult ; Brain Neoplasms/diagnosis ; Child ; Female ; Humans ; Male ; Neurology/statistics & numerical data ; Pathology/statistics & numerical data ; Referral and Consultation/statistics & numerical data ; Retrospective Studies
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1309/AJCPWEP1HPX4EDCS
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.

    Lipp, Eric S / Healy, Patrick / Austin, Alan / Clark, Alysha / Dalton, Tara / Perkinson, Kathryn / Herndon, James E / Friedman, Henry S / Friedman, Allan H / Bigner, Darell D / McLendon, Roger E

    Journal of neuropathology and experimental neurology

    2018  Volume 78, Issue 1, Page(s) 57–64

    Abstract: Glioma therapeutic resistance to alkylating chemotherapy is mediated via O6-methylguanine-DNA methyltransferase (MGMT). We hypothesized that a CD45/HAM56/MGMT double-stained cocktail would improve MGMT discrimination in tumor cells versus inflammatory ... ...

    Abstract Glioma therapeutic resistance to alkylating chemotherapy is mediated via O6-methylguanine-DNA methyltransferase (MGMT). We hypothesized that a CD45/HAM56/MGMT double-stained cocktail would improve MGMT discrimination in tumor cells versus inflammatory and endothelial cells (IEC). Total MGMT protein was quantified by IHC on 982 glioblastomas (GBM) and 199 anaplastic astrocytomas. Correcting for IEC was done by a CD45/HAM56/MGMT 2-color cocktail. Lowest IEC infiltrates (IEC "cold spots") were identified to quantitate MGMT as well as the percentage of IEC% in the IEC cold spots. MGMT promoter methylation (PM) was also determined. Among the GBM biopsies, mean uncorrected and corrected MGMT% were 19.87 (range 0-90) and 16.67; mean IEC% was 18.65 (range 1-80). Four hundred and fifty one (45.9%) GBM biopsies were positive MGMT PM. Both uncorrected and corrected MGMT% positivity correlated with PM. All 3 MGMT scores correlated with overall survival (OS) in GBM's. Cold spot IEC% was also positively associated with OS. These effects remained in a multivariate model after adjusting for age and disease status. Prognosis determined by correcting MGMT% score for IEC% is not improved in this analysis. However, IEC COLD SPOT score does provide additional prognostic information that can be gained from this correction method.
    MeSH term(s) Adult ; Aged ; Astrocytoma/genetics ; Biomarkers, Tumor/analysis ; Brain Neoplasms/genetics ; DNA Methylation ; DNA Modification Methylases/analysis ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/analysis ; DNA Repair Enzymes/genetics ; Female ; Humans ; Immunohistochemistry/methods ; Male ; Middle Aged ; Tumor Suppressor Proteins/analysis ; Tumor Suppressor Proteins/genetics
    Chemical Substances Biomarkers, Tumor ; Tumor Suppressor Proteins ; DNA Modification Methylases (EC 2.1.1.-) ; MGMT protein, human (EC 2.1.1.63) ; DNA Repair Enzymes (EC 6.5.1.-)
    Language English
    Publishing date 2018-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nly110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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    Ui II Zs.194: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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