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  1. Article ; Online: Multimodality Imaging in Management of Adults with Dextro-Transposition of the Great Arteries Post Arterial Switch Operation.

    Conrad, Desireé R / Woo, Jennifer P / Lui, George K / Clark, Daniel E

    CASE (Philadelphia, Pa.)

    2024  Volume 8, Issue 3Part A, Page(s) 162–166

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Case Reports
    ISSN 2468-6441
    ISSN (online) 2468-6441
    DOI 10.1016/j.case.2023.12.028
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  2. Article ; Online: The Bright Side of Myocardial Edema.

    Clark, Daniel E / Hughes, Sean G

    Journal of the American Heart Association

    2021  Volume 10, Issue 22, Page(s) e023731

    MeSH term(s) Edema/etiology ; Humans ; Myocardium
    Language English
    Publishing date 2021-11-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.023731
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  3. Article ; Online: Percutaneous Closure of a Ruptured Sinus of Valsalva Aneurysm under Transesophageal Echocardiography Guidance.

    Li, Xi E / McElhinney, Doff B / Lui, George K / Clark, Daniel E / Woo, Jennifer P

    CASE (Philadelphia, Pa.)

    2024  Volume 8, Issue 3Part A, Page(s) 186–192

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Case Reports
    ISSN 2468-6441
    ISSN (online) 2468-6441
    DOI 10.1016/j.case.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A case report of successful primary percutaneous coronary intervention to an occluded anomalous left main coronary artery arising from the right coronary sinus.

    Wong, Christopher C Y / Pogatchnik, Brian P / Clark, Daniel E / Sharma, Rahul P

    European heart journal. Case reports

    2024  Volume 8, Issue 4, Page(s) ytae192

    Abstract: Background: Anomalous aortic origin of a coronary artery from the opposite sinus is a rare congenital abnormality that may be encountered during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI).: Case ... ...

    Abstract Background: Anomalous aortic origin of a coronary artery from the opposite sinus is a rare congenital abnormality that may be encountered during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI).
    Case summary: A 65-year-old man presented with chest pain and signs of heart failure. Electrocardiogram demonstrated atrial fibrillation with ST elevation in the high lateral leads, and he was taken emergently to the cardiac catheterization laboratory for primary PCI. Coronary angiography identified the culprit to be an occluded anomalous left main coronary artery (LMCA) arising from the right coronary cusp, and primary PCI was successfully performed in the LMCA and the left anterior descending artery (LAD). Computed tomography angiography confirmed a benign retroaortic course of the anomalous LMCA with no additional high-risk features, as well as a new left atrial appendage thrombus. He subsequently developed deep venous thrombosis, acute pulmonary embolism, and acute kidney injury secondary to renal artery embolism with associated infarction. Workup for patent foramen ovale and thrombophilia were negative, and he was discharged in a stable condition. At 2-month follow-up, he was asymptomatic with no evidence of myocardial ischaemia on stress cardiac magnetic resonance imaging.
    Discussion: We present the first reported case of an occluded anomalous LMCA arising from the right coronary sinus in a patient presenting with STEMI. Rapid recognition of this congenital anomaly and selection of an appropriate guide catheter were keys to achieving timely reperfusion and a good outcome in this case.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae192
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  5. Article ; Online: Syncope in an elderly man with hypertrophic obstructive cardiomyopathy.

    Curkovic, Nina B / Clark, Daniel E / Hughes, Sean G

    Heart (British Cardiac Society)

    2022  Volume 108, Issue 18, Page(s) 1437–1500

    MeSH term(s) Aged ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Humans ; Male ; Syncope/diagnosis ; Syncope/etiology
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321222
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    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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  6. Article ; Online: Solution-Phase Synthesis of Vanadium Intercalated 1T'-WS

    Zhu, Kuixin / Tao, Yiyin / Clark, Daniel E / Hong, Wei / Li, Christina W

    Nano letters

    2023  Volume 23, Issue 10, Page(s) 4471–4478

    Abstract: Metal ion intercalation into Group VI transition metal dichalcogenides enables control over their carrier transport properties. In this work, we demonstrate a low-temperature, solution-phase synthetic method to intercalate cationic vanadium complexes ... ...

    Abstract Metal ion intercalation into Group VI transition metal dichalcogenides enables control over their carrier transport properties. In this work, we demonstrate a low-temperature, solution-phase synthetic method to intercalate cationic vanadium complexes into bulk WS
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c00826
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  7. Article: Cardiac Magnetic Resonance in the Evaluation of COVID-19.

    Clark, Daniel E / Aggarwal, Sachin K / Phillips, Neil J / Soslow, Jonathan H / Dendy, Jeffrey M / Hughes, Sean G

    Cardiac failure review

    2022  Volume 8, Page(s) e09

    Abstract: Cardiovascular involvement following COVID-19 is heterogeneous, prevalent and is often missed by echocardiography and serum biomarkers (such as troponin I and brain natriuretic peptide). Cardiac magnetic resonance (CMR) is the gold standard non-invasive ... ...

    Abstract Cardiovascular involvement following COVID-19 is heterogeneous, prevalent and is often missed by echocardiography and serum biomarkers (such as troponin I and brain natriuretic peptide). Cardiac magnetic resonance (CMR) is the gold standard non-invasive imaging modality to phenotype unique populations after COVID-19, such as competitive athletes with a heightened risk of sudden cardiac death, patients with multisystem inflammatory syndrome, and people suspected of having COVID-19 vaccine-induced myocarditis. This review summarises the key attributes of CMR, reviews the literature that has emerged for using CMR for people who may have COVID-19-related complications after COVID-19, and offers expert opinion regarding future avenues of investigation and the importance of reporting findings.
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2960293-2
    ISSN 2057-7559 ; 2057-7540
    ISSN (online) 2057-7559
    ISSN 2057-7540
    DOI 10.15420/cfr.2021.20
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  8. Article ; Online: Myocardial Tissue Oxygenation and Microvascular Blood Volume Measurement Using a Contrast Blood Oxygenation Level-Dependent Imaging Model.

    Dendy, Jeffrey M / Hughes, Sean G / Soslow, Jonathan H / Clark, Daniel E / Paschal, Cynthia B / Gore, John C

    Investigative radiology

    2022  Volume 57, Issue 9, Page(s) 561–566

    Abstract: Objectives: We propose a method of quantitatively measuring drug-induced microvascular volume changes, as well as drug-induced changes in blood oxygenation using calibrated blood oxygen level-dependent magnetic resonance imaging (MRI). We postulate that ...

    Abstract Objectives: We propose a method of quantitatively measuring drug-induced microvascular volume changes, as well as drug-induced changes in blood oxygenation using calibrated blood oxygen level-dependent magnetic resonance imaging (MRI). We postulate that for MRI signals there is a contribution to R2* relaxation rates from static susceptibility effects of the intravascular blood that scales with the blood volume/magnetic field and depends on the oxygenation state of the blood. These may be compared with the effects of an intravascular contrast agent. With 4 R2* measurements, microvascular blood volume (MBV) and tissue oxygenation changes can be quantified with the administration of a vasoactive drug.
    Materials and methods: The protocol examined 12 healthy rats in a prospective observational study. R2* maps were acquired with and without infusion of adenosine, which increases microvascular blood flow, or dobutamine, which increases myocardial oxygen consumption. In addition, R2* maps were acquired after the intravenous administration of a monocrystalline iron oxide nanoparticle, with and without adenosine or dobutamine.
    Results: Total microvascular volume was shown to increase by 10.8% with adenosine and by 25.6% with dobutamine ( P < 0.05). When comparing endocardium versus epicardium, both adenosine and dobutamine demonstrated significant differences between endocardial and epicardial MBV changes ( P < 0.05). Total myocardial oxygenation saturation increased by 6.59% with adenosine and by 1.64% with dobutamine ( P = 0.27). The difference between epicardial and endocardial oxygenation changes were significant with each drug (adenosine P < 0.05, dobutamine P < 0.05).
    Conclusions: Our results demonstrate the ability to quantify microvascular volume and oxygenation changes using calibrated blood oxygen level-dependent MRI, and we demonstrate different responses of adenosine and dobutamine. This method has clinical potential in examining microvascular disease in various disease states without the administration of radiopharmaceuticals or gadolinium-based contrast agents.
    MeSH term(s) Adenosine/pharmacology ; Animals ; Blood Volume/physiology ; Coronary Circulation/physiology ; Dobutamine/pharmacology ; Rats ; Vasodilator Agents/pharmacology
    Chemical Substances Vasodilator Agents ; Dobutamine (3S12J47372) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
    ZDB-ID 80345-5
    ISSN 1536-0210 ; 0020-9996
    ISSN (online) 1536-0210
    ISSN 0020-9996
    DOI 10.1097/RLI.0000000000000871
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 734: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Clinical prediction model: Multisystem inflammatory syndrome in children versus Kawasaki disease.

    Starnes, Lauren S / Starnes, Joseph R / Stopczynski, Tess / Amarin, Justin Z / Charnogursky, Cara / Hayek, Haya / Talj, Rana / Parra, David A / Clark, Daniel E / Patrick, Anna E / Katz, Sophie E / Howard, Leigh M / Peetluk, Lauren / Rankin, Danielle / Spieker, Andrew J / Halasa, Natasha B

    Journal of hospital medicine

    2024  Volume 19, Issue 3, Page(s) 175–184

    Abstract: Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious complication of severe acute respiratory syndrome coronavirus 2 infection. Features of MIS-C overlap with those of Kawasaki disease (KD).: Objective: The study ... ...

    Abstract Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious complication of severe acute respiratory syndrome coronavirus 2 infection. Features of MIS-C overlap with those of Kawasaki disease (KD).
    Objective: The study objective was to develop a prediction model to assist with this diagnostic dilemma.
    Methods: Data from a retrospective cohort of children hospitalized with KD before the coronavirus disease 2019 pandemic were compared to a prospective cohort of children hospitalized with MIS-C. A bootstrapped backwards selection process was used to develop a logistic regression model predicting the probability of MIS-C diagnosis. A nomogram was created for application to individual patients.
    Results: Compared to children with incomplete and complete KD (N = 602), children with MIS-C (N = 105) were older and had longer hospitalizations; more frequent intensive care unit admissions and vasopressor use; lower white blood cell count, lymphocyte count, erythrocyte sedimentation rate, platelet count, sodium, and alanine aminotransferase; and higher hemoglobin and C-reactive protein (CRP) at admission. Left ventricular dysfunction was more frequent in patients with MIS-C, whereas coronary abnormalities were more common in those with KD. The final prediction model included age, sodium, platelet count, alanine aminotransferase, reduction in left ventricular ejection fraction, and CRP. The model exhibited good discrimination with AUC 0.96 (95% confidence interval: [0.94-0.98]) and was well calibrated (optimism-corrected intercept of -0.020 and slope of 0.99).
    Conclusions: A diagnostic prediction model utilizing admission information provides excellent discrimination between MIS-C and KD. This model may be useful for diagnosis of MIS-C but requires external validation.
    MeSH term(s) Child ; Humans ; Alanine Transaminase ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Prospective Studies ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left ; COVID-19/complications ; Sodium ; Systemic Inflammatory Response Syndrome
    Chemical Substances Alanine Transaminase (EC 2.6.1.2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.1002/jhm.13290
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    Zs.A 6276: Show issues Location:
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    Zs.MO 542: Show issues

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  10. Article ; Online: Human Monocytic Ehrlichiosis Associated With Myocarditis and Hemophagocytic Lymphohistiocytosis.

    Dahm, Cherie N / Yang, Bin Q / Clark, Daniel E / Armstrong, William C / Stevenson, Lynne W

    JACC. Case reports

    2020  Volume 2, Issue 3, Page(s) 420–425

    Abstract: We present 3 cases at a single institution of human monocytic ehrlichiosis resulting in myocarditis and hemophagocytic lymphohistiocytosis. Contrary to previously published studies in which case fatalities were only as high as 1%, 2 of the 3 patients we ... ...

    Abstract We present 3 cases at a single institution of human monocytic ehrlichiosis resulting in myocarditis and hemophagocytic lymphohistiocytosis. Contrary to previously published studies in which case fatalities were only as high as 1%, 2 of the 3 patients we discuss experienced a fulminant course resulting in death despite appropriate doxycycline treatment. Human monocytic ehrlichiosis is rarely a cause of myocarditis and hemophagocytic lymphohistiocytosis, but a high degree of suspicion is important because early empirical therapy may decrease morbidity and mortality. (
    Language English
    Publishing date 2020-03-18
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2019.12.042
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